LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells by Shuxian Zhu, Shiyu Zuo, Chuo Li, Xingjie You, Erlie Jiang, Xiaoming Feng, Yuechen Luo

“…Results Genetic editing of CD38 universal CAR-T cells, including CD38, T cell receptor alpha constant (TRAC), beta-2-microglobulin (B2M), and class II major histocompatibility complex transactivator (CIITA) knockdowns, was successfully achieved. In vitro, LLT1 overexpression boosted CAR-T cell proliferation and antitumor activity, leading to a transcriptional signature characterized by elevated stemness-related markers (SELL, BCL6, TCF7, and CD27) and increased levels of IL-10 and other cytokines. …”
Get full text

The Role of the Organization in Promoting Information Security–Related Behavior Among Resident Physicians in Hospitals in Germany: Cross-Sectional Questionnaire Study by Judith Kraushaar, Sabine Bohnet-Joschko

“…ConclusionsThis study provides new insights into how a high standard of information security compliance among resident physicians could be achieved through strengthening physicians’ security work engagement and awareness. …”
Get full text

Major Adverse Kidney Events in Hospitalized Older Patients With Acute Kidney Injury: Machine Learning–Based Model Development and Validation Study by Xiao-Qin Luo, Ning-Ya Zhang, Ying-Hao Deng, Hong-Shen Wang, Yi-Xin Kang, Shao-Bin Duan

“…Its simplified version achieved an AUROC of 0.744 (95% CI 0.735-0.754) in the external test set. …”
Get full text

Lightweight Cryptographic Algorithms for Guessing Attack Protection in Complex Internet of Things Applications by Mohammad Kamrul Hasan, Muhammad Shafiq, Shayla Islam, Bishwajeet Pandey, Yousef A. Baker El-Ebiary, Nazmus Shaker Nafi, R. Ciro Rodriguez, Doris Esenarro Vargas

“…For the experimental test, a set of plaintexts is used in the simulation—password-sized text and paragraph-sized text—that achieves target fair results compared to the existing algorithms in real-time deep learning networks for IoT applications.…”
Get full text

The Effects of Employee Performance Appraisal on the Company Performance Results: The Mediating Role of HRM Outcomes With an Innovative Application of the Efficiency Index by Marzena Stor

“…This suggests that the EPA used such solutions in conjunction with other HRM subfunctions that stimulated entrepreneurial, creative and innovative behavior of employees in such a way that organizations could achieve better innovation results during the crisis than before it. …”
Get full text

3D-AttenNet model can predict clinically significant prostate cancer in PI-RADS category 3 patients: a retrospective multicenter study by Jie Bao, Litao Zhao, Xiaomeng Qiao, Zhenkai Li, Yanting Ji, Yueting Su, Libiao Ji, Junkang Shen, Jiangang Liu, Jie Tian, Ximing Wang, Hailin Shen, Chunhong Hu

“…Results Our AttenNet models achieved excellent prediction performances in testing cohort of center 4–6 with the area under the receiver operating characteristic curves (AUC) of 0.795 (95% CI: [0.700, 0.891]), 0.963 (95% CI: [0.915, 1]) and 0.922 (95% CI: [0.810, 1]) in predicting PCa, and the corresponding AUCs were 0.827 (95% CI: [0.703, 0.952]) and 0.926 (95% CI: [0.846, 1]) in predicting csPCa in testing cohort of center 4 and center 5. …”
Get full text

Contradictions of students’ motivation for participation in the activities of voluntary organisations by A. V. Starshinova

“…However, ignoring the value content of volunteering in the mass organisation of volunteer youth associations reduces its ability to achieve social, economic, cultural and other altruistic goals. …”
Get full text

Comparison of principal component analysis algorithms for imputation in agrometeorological data in high dimension and reduced sample size. by Valter Cesar de Souza, Sergio Augusto Rodrigues, Luís Roberto Almeida Gabriel Filho

“…In the scenario with 10% missing data, NIPALS-PCA achieved the lowest MAPE (15.4%), followed by EM-PCA (17.0%), while IM recorded a MAPE of 24.7%. …”
Get full text

Low regulatory T-cells frequency is associated with graft rejection after small bowel transplantation: Clinical and experimental evidence. by Rodrigo Papa-Gobbi, Pablo Stringa, Maria Virginia Gentilini, Ivana Ivanoff, Mariana Machuca, Nidia Monserrat Arreola, Javier Serradilla, Karla Estefanía-Fernández, Paloma Talayero, María Velayos, Elena Sánchez-Zapardiel, Gabriel Gondolesi, Ane Andrés-Moreno, Martin Rumbo, Francisco Hernández-Oliveros

“…Remarkably, recipients who achieved Treg expansion within the graft remained free of ACR even after discontinuation of the immunosuppressant treatment and this phenomenon was associated with increased levels of serum IL-10.…”
Get full text

Non-print Periodicals in the Wroblewski Library: what does the Collection Tell us about the History of Publishing in Lithuania? by Rima Cicėnienė

“…Currently, the Manuscripts Department has recorded as many as 154 titles of small newspapers. To achieve the goal, first, historiography dedicated to non-print periodicals in Lithuania and the Wroblewski Library will be discussed, the history of object collection in the library will be determined, and the formed collection will be analysed in chronological, geographical, linguistic, typological, and genre aspects. …”
Get full text

Low versus high initial oral glucocorticoid dose for lupus nephritis: a pooled analysis of randomised controlled clinical trials by Amit Saxena, Peter Izmirly, Jill P Buyon, Cristina Sorrento, Janine Sullivan, Monica Gamez-Perez, Jammie Law, Howard Michael Belmont

“…In patients with low-dose oral GC, 25.2% achieved CRR 0.5 at 12 months compared with 27.2% in high-dose groups, p=0.54. …”
Get full text

CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma by Victoria Jennings, Kevin Harrington, Hardev Pandha, Alan Melcher, Adel Samson, Fiona Errington-Mais, Victoria Roulstone, Eva Crespo-Rodriguez, Galabina Bozhanova, Shane Foo, Emmanuel C Patin, Martin McLaughlin, Malin Pedersen, Richard Vile, Joan Kyula, Jehanne Hassan, Lizzie Appleton, Charleen ML Chan Wah Hak, Gabby Baker, Edward Armstrong, Matthew Chiu, Masahiro Ono

“…Targeting CD25 high, antigen-engaged Treg with a depleting anti-CD25 ICI, achieved complete cures in 100% of mice with triple therapy. …”
Get full text

Ultra-low dose dual-layer detector spectral CT for pulmonary nodule screening: image quality and diagnostic performance by Li Ding, Mingwang Chen, Xiaomei Li, Yuting Wu, Jingxu Li, Shuting Deng, Yikai Xu, Zhao Chen, Chenggong Yan

“…Conclusion Ultra-low dose dual-layer detector CT with 91.2% radiation dose reduction achieves sufficient image quality and diagnostic performance of pulmonary nodules. …”
Get full text

Determination of antibiotics in bean sprouts by UHPLC-MS/ MS-internal standard method by ZHANG Xiaoyi, ZHENG Sanyan, ZHANG Xiuyao, LI Ruifen, YANG Shuran

“…Methanol containing 0.1% formic acid and 2.0 mmol·L-1 ammonium formate containing 0.1% formic acid were taken as the mobile phases to conduct gradient elution. The separation was achieved on an ACQUITY PREMIER BEH C18 column. The separated analytes were detected by the electrospray ionization (ESI) in multiple reaction monitoring (MRM) mode, and quantified by internal standard method.ResultsThe 59 kinds of antibiotics in bean sprouts had a good linear relationship in the range of 10 μg·kg-1 to 1 000 μg·kg-1. …”
Get full text

Advances and trends of modern and contemporary research on the geology of coal-measure minerals in China by Yong QIN

“…Advances Based on textual research and the analysis of logical relations, this study generalized the advances in research on the geology of CMMs in China into four aspects. (1) Increasingly improved geological theory system of CMMs: China’s classic theoretical system of coal field geology was formed in the second half of the 20th century, and the geological theory system focusing on coals, coal-measure gas, and coal-measure critical metals has been gradually developed since the 21st century. (2) Research on the origin and genesis of coals, advancing the international coal geology: The advancements include the development of the new coal metamorphism theory, the discovery of the world's youngest soft lignite, the reveal of late-stage coalification jumps, the establishment of the ordinary organic petrology, and the comprehensive ascertainment of the formation and evolutionary mechanisms of coals. (3) The unique CMM accumulation, distribution, and metallogenic theory: The specific outcomes include the establishment of multiple sedimentary and structural coal-controlling patterns, the reveal of the fundamental framework of coal accumulation in sea areas, the identification of deposits of various coal-measure critical metals, and the determination of the division schemes for coal-controlling geotectonic units and the metallogenic zones of coal-measure critical metals, and the development of a geological theory system for coalbed methane. (4) Significant achievements in the geological surveys and assessment of special coal resources: Specifically, the methodological system for the geological prediction and assessment of special coal types and high-quality, eco-friendly, and clean coal resources has been developed, the methodological system for the resource potential assessment of tar-rich coals and underground coal gasification has been formed, and the coal resources for related purposes have been preliminarily investigated. …”
Get full text

Enhanced prediction of energy dissipation rate in hydrofoil-crested stepped spillways using novel advanced hybrid machine learning models by Ehsan Afaridegan, Nosratollah Amanian

“…In the testing stage, TabNet-MFO maintained strong performance, achieving a PI of 0.692, while SVR-IWOA showed robust results with a PI of 0.631. …”
Get full text

Priority trends and prospects of blackberry breeding in conditions of Central Russia by L. A. Gruner, B. B. Kornilov

“…This overview substantiates the possibility and expediency of blackberry breeding in Central Russia, where it is in demand, but not widespread in horticulture. Significant achievements of world breeding, which gave modern cultivars a large set of economically important qualities and growing interest in it all over the world, including Russian gardeners, make it relevant to work with blackberries as an object of selection, and as a promising garden plant. …”
Get full text

Historical origin and development of politically motivated criminal offences: Political delicts by Matić Goran D.

“…One of the most important achievements of the European legal culture and thought from humanism and the Renaissance to the most recent times is the establishment of the concept and legal institute of political delict, as a privileged delict - criminal offence regulated by law, in terms of general and legal culture, despite the fact that it has been limited mainly to verbal political actions in democratic states. …”
Get full text

The impact of implementing and sustaining the international guidelines for skin-to-skin contact in the first hour after birth in Uganda by Kajsa Brimdyr, Scovia Nalugo Mbalinda, Anna Blair, Kristin Svensson, Mike Kagawa, Melissa Reyes, Louise Racine Bastarache, Livingstone Kamoga, Edwin Kigozi, Karin Cadwell

“…The PRECESS (Practice Reflection Education and Training Combined with Ethnography for Sustainable Success) methodology provides evidence-based education, process-oriented practice, experiential learning and Interactive Analysis Labs to achieve sustainable best practice. This study aimed to determine if, using PRECESS methodology, the 2023 guideline could be fully implemented and sustained in a regional teaching and referral hospital in Uganda, and whether this resulted in an increase of breastfeeding initiation in the first hour after birth. …”
Get full text

A Fatores determinantes do endividamento dos clubes de futebol brasileiro: uma análise entre os períodos de 2014 e 2020 por meio de regressão quantílica by Alex Eugênio Altrão de Morais, Flávia Vital Januzzi

“…Desde a discussão de uma estrutura ótima proposta por Modigliani e Miller (1958) diversos estudos empíricos buscam comprovar tal contexto. Resultados: Os achados indicam que os fatores de capacidade de geração de caixa e a longevidade do clube no eixo Rio-São Paulo podem determinar a estrutura de capital das entidades nos diversos níveis de endividamento, enquanto a rentabilidade, o tamanho e a capacidade de pagamento das dívidas mostraram-se insignificantes em todos os cenários, contrariando os prescritos pelas teorias modernas da estrutura de capital (Teoria Trade-off e Pecking Order). …”
Get full text