Cost Effectiveness of Insulin Glargine versus Neutral Protamin Hagedorn Insulin in the Treatment of Type 2 Diabetes Patients in Turkey by Ilhan Satman, Hayley Bennett, Candeger Yilmaz, Sazi Imamoglu, Goksun Ayvaz, Abdurrahman Comlekci, Demet Ozkaya, Toros Sahin

“…Insulin treatment is necessary for patients failing to achieve glycaemic control with lifestyle modification or oral antidiabetic drugs. …”
Get full text

Composite cardiovascular risk factor control in US adults with diabetes and relation to social determinants of health: The All of Us research program by Frances Golden, Johnathan Tran, Nathan D. Wong

“…Results: The study revealed low risk factor control with only 27.7 % of participants achieving recommended levels for three or more risk factors (RFs) and 4.9 % for four or more RFs. …”
Get full text

Improved Asphalt Pavement Crack Detection Model Based on Shuffle Attention and Feature Fusion by Tursun Mamat, Abdukeram Dolkun, Runchang He, Yonghui Zhang, Zulipapar Nigat, Hanchen Du

“…Finally, the addition of the transplanted SPP-F module further enhanced accuracy, increasing the mAP by 0.7 percentage points from the previous stage, thus achieving a final mAP of 74.2%. Overall, these modifications resulted in a total improvement of 9.4 percentage points in mAP compared to the original model. …”
Get full text

Effect of Reynolds Number and Property Variation on Fluid Flow and Heat Transfer in the Entrance Region of a Turbine Blade Internal-Cooling Channel by Ben-Mansour R., Al-Hadhrami L.

“…This internal cooling is achieved by pumping a relatively cold fluid through the internal-cooling channels. …”
Get full text

Study of Ultrasound-Assisted Low-Pressure Closed Acid Digestion Method for Trace Element Determination in Rock Samples by Inductively Coupled Plasma Mass Spectrometry by Xijuan Tan, Yunxiu Ren, Ting Liang, Denghong Wang

“…This study demonstrated the essential role of ultrasound irradiation in rock sample decomposition to achieve the high extraction efficiency of trace elements under a low-pressure environment, and the developed approach with promising future applications in geoscience exhibited considerable merits, including a high extraction efficiency, feasible digestion process, less time consumption, and lower safety associated risks.…”
Get full text

Patient-derived response estimates from zero-passage organoids of luminal breast cancer by Róża K. Przanowska, Najwa Labban, Piotr Przanowski, Russell B. Hawes, Kristen A. Atkins, Shayna L. Showalter, Kevin A. Janes

“…Transcriptional changes were measured by RT-qPCR or RNA sequencing (RNA-seq), and organoid phenotypes were quantified by serial brightfield imaging, digital image segmentation, and regression modeling of volumetric growth rates. Results We achieved > 50% success in initiating luminal breast cancer organoids from tumor scrapes and maintaining them to the 14-day zero-passage endpoint. …”
Get full text

Enhancing the understanding of safety and the quality of patient care among medical and health sciences students in interprofessional climate: an interventional study by Salman Yousuf Guraya, Nabil Sulaiman, Ahmed Hasswan, Vida Abdolhamid Salmanpour, Feras Jassim Jirjees, Mohamed Hassan Taha, Jennat Alamara, Sausan A.L. Kawas, Manal Awad, Jacqueline Maria Dias, Leena R. David, Mohamed Aly Haider, Shaista Salman Guraya, Nihar Ranjan Dash, Amal Al-Qallaf, Sarra Shorbagi, Ibrahim Eltayeb Mahmoud

“…Abstract Background Interprofessional education (IPE) plays an essential role in improving healthcare outcomes through achieving shared understanding. Unfortunately, most healthcare professionals have not received training for patient safety (PS) in an interprofessional setting, which can meet the societal medical needs. …”
Get full text

Risk factors and machine learning prediction models for intrahepatic cholestasis of pregnancy by Yingchun Ren, Xiaoying Shan, Gengchao Ding, Ling Ai, Weiying Zhu, Ying Ding, Fuzhou Yu, Yun Chen, Beijiao Wu

“…The AUCs of the selected top five models ranged from 0.9509 to 0.9614. The CatBoost model achieved the best performance, with an AUC of 0.9614 (95% confidence interval, 0.9377–0.9813), an accuracy of 0.9085, a precision of 0.8930, a recall of 0.9059, and a F1-score of 0.8981. …”
Get full text

Machine learning models reveal microbial signatures in healthy human tissues, challenging the sterility of human organs by Anargyros Skoulakis, Anargyros Skoulakis, Giorgos Skoufos, Giorgos Skoufos, Armen Ovsepian, Armen Ovsepian, Artemis G. Hatzigeorgiou, Artemis G. Hatzigeorgiou

“…Unaligned sequencing reads with the human genome were processed using AGAMEMNON, an algorithm for metagenomic microbial quantification, with a reference database comprising bacterial, archaeal, and viral genomes, alongside fungal transcriptomes. …”
Get full text

Clinical teaching practice and effect research of newly recruited nurses in the Department of Stomatology (口腔科新入职护士临床教学实践及效果研究) by LIANG Yu (梁宇), LI Jiahui (李嘉慧), CAI Shuang (蔡爽), SUO Shuai (索帅), ZHI Shengrui (只升睿), LIU Xuewei (刘学伟)

“…Conclusion In accordance with student aptitude, stratified teaching method has achieved good teaching effect and is worth popularizing in clinical teaching of stomatology. …”
Get full text

Fetal cardiac function in pregnancy affected by congenital heart disease: protocol for a multicentre prospective cohort study by Anna Erenbourg, Tracie Barber, Vera Cecotti, Stefano Faiola, Ilaria Fantasia, Tamara Stampaljia, Hagai Avnet, Beata Radzymińska-Chruściel, Neama Meriki, Alec Welsh

“…Based on a previous observed standard deviation, a total sample of 381 pregnancies is required to achieve 80% power to detect a difference of 0.03 in mean myocardial performance index (MPI) with a two-sided type I error rate of 5%. …”
Get full text

Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics f... by Aliosha I. Figueroa-Valdés, Patricia Luz-Crawford, Yeimi Herrera-Luna, Nicolás Georges-Calderón, Cynthia García, Hugo E. Tobar, María Jesús Araya, José Matas, Darío Donoso-Meneses, Catalina de la Fuente, Jimena Cuenca, Eliseo Parra, Fernando Lillo, Cristóbal Varela, María Ignacia Cádiz, Rolando Vernal, Alexander Ortloff, Gino Nardocci, Verónica Castañeda, Catalina Adasme-Vidal, Maximiliano Kunze-Küllmer, Yessia Hidalgo, Francisco Espinoza, Maroun Khoury, Francisca Alcayaga-Miranda

“…While mesenchymal stromal cells (MSC) and their small extracellular vesicles (sEV) hold promise for OA treatment, achieving consistent clinical-grade sEV products remains a significant challenge. …”
Get full text

Endovascular treatment for blood blister ⁃ like aneurysms of internal carotid artery and systematic literature review by ZHOU Lei, WANG Zhong, YANG Guo‐jun, DONG Shi‐biao, LI Nan, ZHU Wei‐wei

“…And one patient still had recurrence after treatment but achieved cure by adjusting antiplatelet therapy regimen; one patient recovered by adjusting antiplatelet therapy regimen. …”
Get full text

Bilevel Optimization of Regular Bus-Subway-Shared Bicycle Cooperative Operation considering Dual Uncertainties by Yunqiang Xue, Tong He, Tao Li, Hongzhi Guan, Yang Qiu

“…The primary objective of this paper is to minimize the overall travel costs for passengers while simultaneously maximizing the operational revenue for the transportation company. This is achieved through the optimization and adjustment of various factors, such as the intervals between regular bus and subway services, the duration of vehicle stops at each station, and the pricing structure for subway and shared bicycle usage. …”
Get full text

S100A8-CAMKK2-AMPK axis confers the protective effects of mild hypothermia against cerebral ischemia-reperfusion injury in rats by Dandan Zhang, Yuting Dai, Xiaoyan Xu, Fuguo Ma, Mingshan Wang, Weiwei Qin

“…To investigate the role of S100A8 in MH treatment of cerebral IR injury, hippocampus-specific S100A8 loss or gain of function was achieved using an adeno-associated virus system. We examined the effect of S100A8 over-expression or knock-down on the function of the SH-SY5Y cell line subjected to oxygen-glucose deprivation reoxygenation (OGDR) injury under MH treatment and delved into the underlying mechanisms. …”
Get full text

Growth of inclined fatigue cracks using the biaxial CJP model by G. Laboviciute, C. J. Christopher, M. N. James, E. A. Patterson

“…The CJP model has been successful in achieving a sensible rationalisation of crack growth rate data for the specimens considered in this work, although some observations are not easily explained. …”
Get full text

Effect of invasive acupuncture on awakening quality after general anesthesia: systematic review and meta-analysis by Fan-dong Bu, Shang-kun Si, Shang-kun Si, Shang-kun Si, Dong-bin Zhang, Yong-liang Chi

“…Currently, the treatment of these complications is mainly achieved through the antagonistic action of specific drugs, but sometimes the antagonistic drugs are not as effective as they should be and can add to the financial burden of the patient. …”
Get full text

Development and validation of a nomogram model for prolonged length of stay in spinal fusion patients: a retrospective analysis by Linghong Wu, Xiaozhong Peng, Yao Lu, Cuiping Fu, Liujun She, Guangwei Zhu, Xianglong Zhuo, Wei Hu, Xiangtao Xie

“…Assessment of the models’ capability to improve classification efficiency was achieved using continuous net reclassification improvement (NRI) and integrated discrimination improvement (IDI). …”
Get full text

Spatial delineation on marine environmental characteristics using fuzzy c-means clustering method by E.D. Lusiana, S. Astutik, N. Nurjannah, A.B. Sambah

“…Nevertheless, the acknowledged biogeographic group of the Indian Ocean indicates that countries must work together to successfully manage marine protected areas and achieve their conservation objectives. This work serves as a baseline for both academic research and ecological assessment, and it will contribute to marine protected areas strategies and conservation efforts in the Lesser Sunda Islands.…”
Get full text

Retrospective observational study of the association of peak blood glucose during the second 24 hours of admission with hospital-acquired complications in non-critical care admissi... by Andrew Georgiou, Getiye Dejenu Kibret, Barbara Depczynski, Sue Mei Lau

“…Less is known about the risk of poorer outcomes according to achieved glycaemia early in the admission.Research design/methods This was a retrospective observational study of patients admitted to non-critical care wards. …”
Get full text