Evaluating the World Health Organization’s Hearts Model for Hypertension and Diabetes Management: A Pilot Implementation Study in Guatemala by Irmgardt Alicia Wellmann, Luis Fernando Ayala, Taryn M. Valley, Vilma Irazola, Mark D. Huffman, Michele Heisler, Peter Rohloff, Rocío Donis, Eduardo Palacios, Manuel Ramírez-Zea, David Flood

“…Surveys on feasibility and acceptability among Ministry of Health staff had a median score of 5.0 (IQR: 5.0 to 5.0) and 5.0 (IQR range: 4.8 to 5.0), respectively, exceeding the prespecified benchmark of ≥3.5. Both districts achieved the prespecified benchmark of enrolling ≥25 hypertension patients and ≥25 diabetes patients. …”
Get full text

Efficacy of rifaximin in the treatment of chronic relapsing diverticulitis by S. I. Achkasov, A. I. Moskalyov, Yu. L. Trubachyova, A. F. Filon

“…Rifaximin – is an effective drug for complex conservative treatment of the chronic relapsing diverticulitis, that allows significantly to reduce terms for achievement of complete clinical response.…”
Get full text

Methyltransferase-like 7B participates in bladder cancer via ACSL3 m6A modification in a ferroptosis manner by Jiani He, Changming Dong, Xiandong Song, Zhongkai Qiu, Hao Zhang, Yuanjun Jiang, Tao Liu, Xiaojun Man

“…Method Stable METTL7B knockdown or overexpression were achieved by lentiviral transduction in SW780 and TCCSUP cell lines. …”
Get full text

Using Large Language Models to Detect and Understand Drug Discontinuation Events in Web-Based Forums: Development and Validation Study by William Trevena, Xiang Zhong, Michelle Alvarado, Alexander Semenov, Alp Oktay, Devin Devlin, Aarya Yogesh Gohil, Sai Harsha Chittimouju

“…Among the open-source models tested, BART demonstrated the best performance in detecting DDEs, achieving an F1-score of 0.86, a false positive rate of 2.8%, and a false negative rate of 6.5%, all without any fine-tuning. …”
Get full text

Factors associated with malaria in pregnancy among women attending ANC clinics in selected districts of the Ashanti Region, Ghana by Emmanuel Abu Bonsra, Petra Amankwah Osei, Emmanuel Adjei Kyeremeh, Stephen Adama, Akua Grace Sekyi, Elsie Fafa King

“…Conclusion Age, education, marital status, income, religion and insecticide-treated bed net (ITN) use significantly influence malaria prevalence in pregnancy. To achieve SDG 3 (Good Health and Well-being), particularly Target 3.1 (reducing maternal mortality) and Target 3.3 (ending malaria), the Ghana Health Service and Ministry of Health should prioritize expanding ITN distribution, educational campaigns, and targeted support for vulnerable groups to reduce malaria prevalence during pregnancy and improve maternal health outcomes.…”
Get full text

Ensemble machine learning models for lung cancer incidence risk prediction in the elderly: a retrospective longitudinal study by Songjing Chen, Sizhu Wu

“…Results The DQN model achieved the optimal prediction performance in stratified subgroups, with AUROC ranging from 0.937 to 0.953, recall ranging from 0.932 to 0.943, F 2 -score ranging from 0.929 to 0.946, precision ranging from 0.926 to 0.952, F 1 -score ranging from 0.933 to 0.963 and RMSE ranging from 0.21 to 0.27. …”
Get full text

Treatment of Severe Hypercapnic Respiratory Failure Caused by SARS-CoV-2 Lung Injury with ECCO2R Using the Hemolung Respiratory Assist System by Ramiro Saavedra-Romero, Francisco Paz, John M. Litell, Julia Weinkauf, Carina C. Benson, Lisa Tindell, Kari Williams

“…Standard heparinization was provided intravenously to achieve appropriate levels of anticoagulation during ECCO2R therapy. …”
Get full text

Multi-Fault-Tolerant Operation of Grid-Interfaced Photovoltaic Inverters Using Twin Delayed Deep Deterministic Policy Gradient Agent by Shyamal S. Chand, Branislav Hredzak, Maurizio Cirrincione

“…The designed TD3VOC technique confines the DC link voltage overshoot to 1.05 p.u. and achieves a low current recovery duration of 0.01 s after fault clearance. …”
Get full text

One stage transanal versus one stage laparoscopic-assisted transanal endorectal pull-through in managing Hirschsprung’s disease in pediatric age group; a retrospective study by Ahmed Elrouby, Sameh Shehata, Saber Waheeb, Ahmed Khairi, Doaa AbdAl-Aziz, Baher Looka

“…Furthermore, a shorter hospital stay could be achieved with the aid of laparoscopy. Trial registration Protocol ID: 0306356, Registration number: NCT06419998, 20/05/2024 - Retrospectively registered…”
Get full text

Survey of medication history of patients with stroke after discharge from an acute hospital ward: a case series study by Yuko Fukuda, Risa Ito, Misaki Kakihana, Tsutomu Takahashi, Tetsuji Kanemoto, Toshiyuki Sahara, Masahiko Tsujikawa, Mitsuko Onda

“…Reconsidering patient information sharing between hospital and community pharmacists and establishing a more strengthened sharing system is necessary to achieve seamless pharmacotherapy.…”
Get full text

Evaluating pre-processing and deep learning methods in medical imaging: Combined effectiveness across multiple modalities by Thien B. Nguyen-Tat, Tran Quang Hung, Pham Tien Nam, Vuong M. Ngo

“…Our findings show that the Median-Mean Hybrid Filter and Unsharp Masking + Bilateral Filter are the most effective preprocessing methods, achieving an efficiency rate of 87.5%. Among the deep learning models, EfficiencyNet-B4 and MobileNetV2 are the highest performing models with an efficiency ratio of 75%, with MobileNetV2 providing up to 34% shorter runtime compared to other models. …”
Get full text

Sex-based differences in the long-term fate of hippocampal neurons born after a traumatic brain injury by Hannah C. Downing, Hannah C. Downing, Ashley B. Glover, Jessica E. Gebhardt, Jessica E. Gebhardt, Katherine L. Thompson, Kathryn E. Saatman, Kathryn E. Saatman, Kathryn E. Saatman

“…The goal of this study was to examine sex differences in hippocampal neurogenesis in response to a moderate controlled cortical impact brain injury.MethodsIn-vivo labeling of NPCs and tracking of their morphological development into a granule cell was achieved using an inducible Cre recombinase driven by the Ascl1 promoter in a CAG-floxStopTom reporter mouse. …”
Get full text

Enhancing Soil Moisture Prediction in Drought-Prone Agricultural Regions Using Remote Sensing and Machine Learning Approaches by Xizhuoma Zha, Shaofeng Jia, Yan Han, Wenbin Zhu, Aifeng Lv

“…The results indicated that the machine learning model achieved a correlation coefficient (R) of 0.92 for estimating spatial near-surface soil moisture. …”
Get full text

Strategic foresight of staffing needs of innovative development of socio-economic systems by Elena Okunkova

“…This, in turn, will contribute to achieve maximum compliance between the personnel needs of the innovative economy and its formed resource potential.…”
Get full text

A recurrence model for non-puerperal mastitis patients based on machine learning. by Gaosha Li, Qian Yu, Feng Dong, Zhaoxia Wu, Xijing Fan, Lingling Zhang, Ying Yu

“…Furthermore, the model effectively achieved in the external validation group, with an AUC of 0.825.…”
Get full text

Global glucose metabolism rate as diagnostic marker for disorder of consciousness of patients: quantitative FDG-PET study by Dongsheng Liu, Dongsheng Liu, Dongsheng Liu, Nan Wang, Nan Wang, Nan Wang, Ming Song, Ming Song, Ming Song, Xiaoke Chai, Xiaoke Chai, Qiheng He, Tianqing Cao, Dawei Kong, Zhuhuan Song, Guangming Zhang, Lei Liu, Xiaosong Wang, Guoqiang Chen, Shaoya Yin, Shaoya Yin, Shaoya Yin, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Jizong Zhao, Jizong Zhao

“…The best classification rate in the derivation cohort was achieved at a metabolic index of 3.32 (41% of the mean cortical metabolic index in healthy controls).ConclusionOur findings demonstrate that conscious awareness requires a minimum of 41% of normal cortical activity, as indicated by metabolic rates.…”
Get full text

Spatial epidemiology based on the analysis of COVID-19 in Africa by Joyce Akhalakwa Mukolwe, John Kamwele Mutinda, Amos Kipkorir Langat

“…Specifically, the highest case rates were observed in South Africa, Egypt, and Morocco, while vaccination coverage varied widely, with countries like Seychelles achieving over 70% vaccination coverage, while others like South Sudan showed much lower rates (below 10%) in 2022. …”
Get full text

Complete metabolic response as early predictor of long-term efficacy after adoptive T cell therapy using tumor-infiltrating lymphocytes by Rikke Andersen, Troels Holz Borch, Eva Ellebaek, Inge Marie Svane, Helle Westergren Hendel, Kasper Madsen

“…Neither mOS (range 32.2–149.8+) nor median progression-free survival (mPFS; range 20.7–123.4+) were reached for patients with partial response (PR)/CMR (10 patients), whereas patients with PR/non-CMR (12 patients) had a mOS of 28.7 months (p=0.0016) and a mPFS of 7.8 months (p<0.0001).Overall, not achieving a CMR was associated with a short mPFS of 3.2 months, and 97.9% (47/48) of all patients in this group progressed within 12 months.Conclusion: In conclusion, early CMR is a strong predictor of long-term survival after TIL therapy in metastatic melanoma patients. …”
Get full text

Efficacy and Safety of Allisartan Isoproxil/Amlodipine in Patients With Essential Hypertension Uncontrolled by Amlodipine: A Phase III, Multicenter, Double‐Blind, Parallel‐Group, R... by Hongjie Chi, Xin Zhang, Shumei Ma, Gang Pan, Xiaojuan Lian, Yan Chen, Haotian Pei, Zichen Liu, Xiangmin Lin

“…Additionally, a higher proportion of patients achieved both a BP response and target office BP in the ALI/AML group compared to the AML group (51.4% vs. 37.4%, 42.5% vs. 30.6%, both p < 0.05). …”
Get full text

O tempo sentado está associado aos fatores de risco cardiometabólicos em adolescentes? by Gessika Castilho dos Santos, Wagner de Campos, Waynne Ferreira de Faria, Jadson Marcio da Silva, Rodrigo Bozza, Luis Paulo Gomes Mascarenhas, Anderson Zampier Ulbrich, Antonio Stabelini Neto

“…Associações positivas e significativas foram observadas entre o tempo sentado e os valores de circunferência da cintura (β = 0,093; p < 0,05), glicose (β = 0,111; p < 0,05) e pressão arterial diastólica (β = -0,115; p < 0,05) mesmo após o ajuste para a prática de atividade física moderada-vigorosa. De acordo com os achados do presente estudo, conclui-se que os adolescentes que permaneceram maior tempo sentado apresentaram maiores valores de glicose, triglicerídeos e escore de risco cardiometabólico em comparação aos que despenderam menos tempo. …”
Get full text