Enhanced fetal hemoglobin production via dual-beneficial mutation editing of the HBG promoter in hematopoietic stem and progenitor cells for β-hemoglobinopathies by Prathibha Babu Chandraprabha, Manoj Kumar K. Azhagiri, Vigneshwaran Venkatesan, Wendy Magis, Kirti Prasad, Sevanthy Suresh, Aswin Anand Pai, Srujan Marepally, Alok Srivastava, Kumarasamypet Murugesan Mohankumar, David I. K. Martin, Saravanabhavan Thangavel

“…By editing more than one regulatory sequence in the HBG promoter, the production of fetal hemoglobin (HbF) can be significantly increased. However, achieving this goal requires precise nucleotide conversions in hematopoietic stem and progenitor cells (HSPCs) at therapeutic efficiency, which remains a challenge. …”
Get full text

Using causal diagrams and superpopulation models to correct geographic biases in biodiversity monitoring data by Robin J. Boyd, Marc Botham, Emily Dennis, Richard Fox, Collin Harrower, Ian Middlebrook, David B. Roy, Oliver L. Pescott

“…Estimating a time trend in the variable of interest is achieved by fitting models for multiple time‐periods and, if the drivers of bias are suspected to change over time, by constructing per period causal diagrams. …”
Get full text

Predicting breast cancer prognosis using PR and PIK3CA biomarkers: a comparative analysis of diagnostic groups by Yuting Feng, Qingzhen Song, Lei Yan, Ruoqi Li, Mengqin Yang, Peng Bu, Jing Lian

“…Moreover, ROC analysis revealed that models incorporating both PR expression and PIK3CA mutation status achieved the highest level of diagnostic precision (AUC = 0.82). …”
Get full text

Prospects for the use of deep brain stimulation in the treatment of Parkinson's disease in Ukraine by K.R. Kostiuk, A.O. Lisianyi, Yu.M. Medvediev, A.O. Popov, V.V. Cheburakhin, V.M. Buniakin, D.A. Tevzadze

“…After unilateral and staged bilateral pallidotomy, tremor and rigidity regression were achieved in more than two-thirds of operated patients, and levodopa-induced dyskinesias (LID) stopped in over 80% of cases. …”
Get full text

Canadian Rhinology Working Group consensus statement: biologic therapies for chronic rhinosinusitis by Andrew Thamboo, S. Kilty, I. Witterick, Y. Chan, C. J. Chin, A. Janjua, A. Javer, J. Lee, E. Monterio, B. Rotenberg, J. Scott, K. Smith, D. D. Sommer, L. Sowerby, M. Tewfik, E. Wright, M. Desrosiers

“…Results After three rounds, a total of 11 statements achieved consensus. This white paper only contains the final agreed upon statements and clear rationale and support for the statements regarding the use of biologics in patients with CRS. …”
Get full text

Reinforcement learning based route optimization model to enhance energy efficiency in internet of vehicles by Quadeer Hussain, Ahmad Shukri Mohd Noor, Muhammad Mukhtar Qureshi, Jianqiang Li, Atta-ur Rahman, Aghiad Bakry, Tariq Mahmood, Amjad Rehman

“…The simulation results highlight the effectiveness of our model in achieving energy-efficient routing while maintaining network performance under different scenarios. …”
Get full text

Level of Physical Activity and its Correlation with Mental Health in Community-dwelling Older Individuals: A Cross-sectional Study by Vipra Paragkumar Dalal, Subhash Khatri

“…Hence, the promotion of healthy living and active ageing is essential for achieving an active and healthy life during this phase. …”
Get full text

The Russian-Indian Scientific and Technological Cooperation in the First Decade of the 21st Century by Konstantin P. Kurylev, Larisa A. Chereshneva, Mariia N. Starikova, Liudmila A. Belousova

“…It analyses the main directions, goals and already achieved results of this partnership, as well as prospects for its future. …”
Get full text

Mapping integral cell-type-specific interferon-induced gene regulatory networks (GRNs) involved in systemic lupus erythematosus using systems and computational analysis by Blessy Kiruba, Akshayata Naidu, Vino Sundararajan, Sajitha Lulu S

“…Although extensive research has been conducted on SLE pathogenesis, a comprehensive understanding of its molecular landscape in different cell types has not been achieved. This study uncovers the molecular mechanisms of the disease by thoroughly examining gene regulatory networks within neutrophils, dendritic cells, T cells, and B cells. …”
Get full text

Food Insecurity Resilience Capacity of Rural Households in the Face of Induced-Weather Extremities in Bauchi State of Nigeria by Mohammed Sadiq, Muhammad Ahmad, Mahmood Bala, Invinder Singh

“…Nevertheless, income and consumption smoothening were the commonest short-term food coping strategies adopted in the study area. To achieve the sustainable development goals of zero hunger by 2030, it becomes imperative on policymakers to sensitize rural households on the need to adopt safe and eco-friendly improved indigenous food technologies so as to address the poor states of food utilization and stability affecting food security of the study area.…”
Get full text

A systematic review and mapping exercise to assess the content validity of patient-reported outcome measures for adults having reconstructive surgery of the lower limb by Jennie Lister, Sophie James, Hemant K. Sharma, Catherine Hewitt, Helen Fulbright, Heather Leggett, Catriona McDaid

“…There is an urgent need for improved outcome measurement in this population. This can be achieved through development of a new PROM, or through validation of existing measures in representative samples. …”
Get full text

Study on Intelligent Classing of Public Welfare Forestland in Kunyu City by Meng Sha, Hua Yang, Jianwei Wu, Jianning Qi

“…The experimental results demonstrated that the GA-SVM model achieved classification accuracies of 98.83% (test set) and 99.65% (overall sample), with MCC values of 0.9796 and 0.990, respectively, outpacing other optimization algorithms, including Grid Search (GS) and Particle Swarm Optimization (PSO). …”
Get full text

The role of resilience in explaining hotel growth: A fuzzy-set QCA approach by Diana Dryglas, Anna Lis, Marcin Suder

“…A fuzzy-set qualitative comparative analysis (fsQCA) was chosen to achieve the goal, which belongs to the group of configurational analysis methods. …”
Get full text

Larvicidal activity of Bacillus thuringiensis strains against Aedes aegypti and Culex quinquefasciatus mosquitoes by Prakai Rajchanuwong, Sawaporn Peaboon, Ratchadawan Ngoen-Klan, Atsalek Rattanawannee, Atirat Noosidum, Boonhiang Promdonkoy, Jariya Chanpaisaeng, Theeraphap Chareonviriyaphap

“…Preliminary bioassays conducted on 434 strains demonstrated that 41 strains (11.64%) and 14 strains (3.97%) achieved 100% mortality against Ae. aegypti and Cx. quinquefasciatus larvae, respectively. …”
Get full text

Efficacy of Amflow®, a Real-Time-Portable Feedback Device for Delivering Appropriate Ventilation in Critically Ill Patients: A Randomised, Controlled, Cross-Over Simulation Study by Jong Won Kim, Sang O Park, Kyeong Ryong Lee, Dae Young Hong, Kwang Je Baek

“…In all three scenarios, a higher percentage of target RR delivered was achieved in the feedback group (88.3%, 99.2%, and 96.3%, respectively) compared with the no-feedback group (5.8%, 12.5%, and 10.0%, respectively) (all p<0.05). …”
Get full text

Prediction of long-term drug-free outcomes in ACPA-positive and ACPA-negative rheumatoid arthritis by combined clinical and ultrasound assessment of residual disease: a 5-year pros... by Carlomaurizio Montecucco, Garifallia Sakellariou, Claudia Alpini, Catherine Klersy, Serena Bugatti, Ludovico De Stefano, Emanuele Bozzalla Cassione, Antonio Manzo, Blerina Xoxi, Terenzj Luvaro, Ylenia Sammali

“…Objective To delineate, within the framework of current clinical practice and criteria, the sustainability of first-line immuno-suppressive treatment discontinuation in rheumatoid arthritis (RA) and the impact of residual disease in remission on long-term drug-free (DF) outcomes.Methods RA patients, referring to the Pavia early arthritis clinic (EAC) between 2009 and 2021 and achieving remission after Disease Activity Score-driven methotrexate (MTX) monotherapy, were recruited. …”
Get full text

Shorter versus longer durations of antibiotic treatment for patients with community-acquired pneumonia: a protocol for a systematic review and meta-analysis by Gordon Guyatt, Arnav Agarwal, Mark Loeb, John Basmaji, Ya Gao, Maryam Ghadimi, Layla Bakaa, Luis Enrique Colunga Lozano, Saad Asif, Aninditee Das

“…While equipoise regarding the optimal duration of antimicrobial therapy to treat CAP remains, recent studies suggest shorter durations of therapy may achieve optimal outcomes. We have therefore planned a systematic review and meta-analysis evaluating the impact of shorter versus longer durations of antibiotic therapy for patients with CAP.Methods and analysis We searched Ovid MEDLINE, Embase, CINAHL and Cochrane Central Register of Controlled Trials from inception to September 2021 for randomised controlled trials evaluating shorter versus longer duration of antibiotics. …”
Get full text

Effects of Immediate or Delayed Estradiol on Behavior in Old Menopausal Macaques on Obesogenic Diet by Kristine Coleman, Nicola D. Robertson, Adriane Maier, Cynthia L. Bethea

“…All animals gained weight, but ImE delayed the time to maximum weight achieved at 18 months. Over the course of the study, ImE-treated monkeys spent more time “alone” and less time in “close social” contact than placebo-controls. …”
Get full text

Liquid crystal template-assisted electrodeposition of nanoporous nickel microspheres: A sensitive electrochemical sensing platform for electrocatalytic oxidation and quantitative d... by R. Dehdari Vais, M. Negahdary, S.R. Rasouli Nasrabadi, A. Rahi, S.A. Dastgheib, H. Heli

“…Based on these measurements, an LC diffusion coefficient of 4.1 × 10−6 cm2 s−1, a catalytic rate constant of 4.0 × 104 cm3 mol−1 s−1, and an electron transfer coefficient of 0.41 were achieved. The proposed sensor was then employed as a sensitive amperometric sensor for determination of LC with a linear dynamic range of 25 to 217 μmol L−1, a calibration sensitivity of 67.85 mA L mol−1, and a detection limit of 3.2 μmol L−1. …”
Get full text

Lentinan Attenuates Damage of the Small Intestinal Mucosa, Liver, and Lung in Mice with Gut-Origin Sepsis by Zhongshen Kuang, Tingting Jin, ChangYi Wu, Yanan Zong, Panpan Yin, WangYu Dong, Xue Lin, WeiYan You, Chenlong Zhang, Lijie Wang, Yongying Liu, Shan Ren, Jiangwen Yin, Hang Xu

“…In vitro assessment of bacterial translocation was achieved through inoculated culture media. Western blot and RT-qPCR were used to detect the expression of molecules related to the NF-κB signaling pathway in the small intestine tissues of mice. …”
Get full text