PROTON RADIATION THERAPY: CLINICAL APPLICATION OPPORTUNITIES AND RESEARCH PROSPECTS by M. V. Zabelin, V. A. Klimanov, J. J. Galyautdinova, A. S. Samoilov, A. O. Lebedev, E. V. Shelyhina

“…Physical properties of a fascicle of protons allow to achieve the maximum dose conformality, having lowered, thereby, a radial load on the next crucial anatomical structures. …”
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The peak efficiency of initial antihypertensive therapy of primary open-angle glaucoma considering the factors that reduce adherence to the ther by N.G. Glazko, T.M. Volobueva, E.A. Egorov

“…Egorov </p> <p> Pirogov Russian National Research Medical University, Moscow, Russian Federation </p> <p> Glaucoma treatment is a combined approach including selection of antihypertensive drugs to achieve the target pressure and their regular use by a patient as per the prescribed regimen. …”
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Evaluating Meaningful Changes in Patient‐Reported Outcome Measurement Information System–Fatigue Scores from Three Phase 3 Clinical Trials of Sarilumab for Patients With Rheumatoid... by Clifton O. Bingham, Emily Molina, Amy Praestgaard, Stefano Fiore, David Cella

“…Objective The aim of this study was to evaluate changes in fatigue measured by Patient‐Reported Outcome Measurement Information System (PROMIS)‐Fatigue scores in patients with rheumatoid arthritis (RA) who received sarilumab and to assess the proportion of patients achieving clinically meaningful change. Methods Data from three phase 3 randomized controlled trials of patients with RA who received sarilumab—MOBILITY, TARGET, and MONARCH—were evaluated. …”
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Treating common mental disorder including psychotic experiences in the primary care improving access to psychological therapies programme (the TYPPEX study): protocol for a stepped... by David Fowler, Jesus Perez, Peter B Jones, Debra Russo, Clare Knight, Mary Dixon-Woods, Allan B Clark, Margaret Heslin, Sarah Byford, Paul French, Thomas Kabir, Jan Stochl, Mona Kanaan, James Clarke, Nick Grey, Ann Marie Swart, Polly-Anna Ashford, Ushma Patel, Freya Stuart, Hannah Murray, J Hodgekins, Nesta Reeve, Nicola Marshall, Michelle Painter, Maria Leathersich, Martin Pond

“…These individuals are less likely to achieve recovery. IAPT services do not routinely screen for nor offer specific treatments for CMD including PE. …”
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Development of a Novel Clinical Classification for Radiation-induced Cystitis: The Portuguese Navy Radiation-induced Cystitis (PNRC) Scale by Tiago Ribeiro de Oliveira, Carla D’Espiney Amaro, Sérgio Henriques Pereira, Afonso Sousa Castro, Pedro Gomes Monteiro, João Cardoso Felício, Guilherme Bernardo, João Chambino, José Palma dos Reis, Chandra Shekhar Biyani

“…Phase 3 involved assessment of the applicability, relevance, inter-rater reliability, and usability of the scale using numerical and graphical methods to achieve consensus among international experts. Key findings and limitations: In phase 1, the panel analysed 13 existing classification systems and developed the PNRC scale, a comprehensive system encompassing five clinical domains: haematuria, other lower urinary tract symptoms, functional impairment, endoscopic findings, and therapeutic interventions. …”
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Distal Femur Type III Open Fractures: Functional Outcome Analysis by Arul R Bhagyaraj, Anand Ashok, Manisha J Kumar, Krupakaran Ganesan, Anand Kurian, Dan B Inja, Manasseh Nithyananth, Vinoo M Cherian, Jeremy Bliss

“…Conclusion: Type III open distal femur fractures are a challenging group to manage; however, with early debridement, primary definitive fixation, and aggressive follow-up, it is possible to achieve predictable and optimum outcomes.…”
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A two‐stage reactive power optimization method for distribution networks based on a hybrid model and data‐driven approach by Ghulam Abbas, Wu Zhi, Aamir Ali

“…The case study results demonstrate that the proposed hybrid model‐data‐driven algorithm effectively coordinates day‐ahead and real‐time controls of various devices, achieving real‐time model‐free optimization throughout the day. …”
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Adding chitosan nanoparticles of green tea extract in diluent and thawing temperatures ameliorate the post-thawed quality of Boer buck semen by Suherni Susilowati, Imam Mustofa, Tri Wahyu Suparyogi, Adeyinka Oye Akintunde, Djoko Agus Purwanto, Wurlina Wurlina, Suzanita Utama, Sri Mulyati

“…Conclusions: Higher quality post-thawing Boer buck semen is achieved by adding 1 μg/mL of chitosan nanoparticles of green tea extract to the skimmed egg yolk diluent and thawing at 39 °C.…”
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The effects of eccentric phase tempo in squats on hypertrophy, strength, and contractile properties of the quadriceps femoris muscle by Filip Kojic, Danimir Mandic, Sasa Duric

“…An ANCOVA model with baseline values as covariates was used to examine between-group differences.ResultsResults showed significant strength gains in both groups, with the SE group achieving greater 1RM increases (effect size [ES] = 1.60 vs 0.99, p &lt; 0.05). …”
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Exclusive Breastfeeding and Normative Belief among Rural Mothers in Ethiopia, 2019: A Cross-Sectional Survey Embedded with Qualitative Design by Wolde Melese Ayele

“…Although the prevalence of exclusive breastfeeding was good when compared with other studies, rigorous interventions are needed to achieve the WHO recommendation of all infants should exclusively be breastfed. …”
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REPEATED THERAPEUTIC LEUKAPHERESIS - A SOLE TREATMENT DURING PREGNANCY AS A BRIDGE BEFORE TYROSINE KINASE INHIBITORS FOR A PREGNANT WOMAN WITH CHRONIC MYELOGENOUS LEUKEMIA – A CASE... by Ivan Tonev, Chavdar Botev, Georgui Balatzenko, Milcho Mincheff

“…Results:The patient's WBC count was kept between 170 and 270 x 109/L until childbirth, and immediately after delivery, imatinib mesylate therapy was initiated.A healthy male child with a weight of 2250 kg and height of 46 сm was born. The mother achieved hematologic, cytogenetic and molecular remission within the next 6-9 months after initiation of tyrosine kinase inhibitor therapy. …”
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Trends in the levels, causes, and risk factors of maternal mortality in Pakistan: A comparative analysis of national surveys of 2007 and 2019. by Farid Midhet, Samina Naeem Khalid, Shehla Baqai, Shahzad Ali Khan

“…<h4>Background</h4>Maternal mortality ratio (MMR) has decreased worldwide but Pakistan is still striving towards achieving the SDG targets for maternal health. This study highlights the trends in maternal mortality levels and risk factors in Pakistan between 2007 and 2019.…”
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Parodontgel® on Wound Healing and Patient-Reported Outcome Measures (PROMs) after Tunneled Coronally Advanced Flap (TCAF) by Leonardo Mancini, Vincenzo Mancini

“…Subsequently, after 8 weeks, a tunneled coronally advanced flap (TCAF) was executed to further refine the gum contours and achieve root coverage. Postoperative Healing Protocol. …”
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Synthesis of bioactive quinazolin-4(3H)-one derivatives via microwave activation tailored by phase-transfer catalysis by El-Badry Yaser A., El-Hashash Mahr A., Al-Ali Khalil

“…In vitro antimicrobial activity of the compounds was investigated against four bacterial and two fungal strains; very modest activity was achieved. Some of the synthesized compounds were screened for their antitumor activity against different human tumor cell lines. …”
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An investigation of machine learning methods applied to genomic prediction in yellow-feathered broilers by Bogong Liu, Huichao Liu, Junhao Tu, Jian Xiao, Jie Yang, Xi He, Haihan Zhang

“…The results indicated that classic methods, such as GBLUP and Bayesian, achieved superior prediction accuracy compared to ML methods in five of the eight traits. …”
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Bridging Research and Practice: Swiss Olympic’s Approach to Sports Science and Innovation by Sarah Geboltsberger

“…The aim of the ‘Sports Science’ funding programme is to promote practice-oriented (sports) science in the federations. This is to be achieved on the one hand by subsidising scientific staff and on the other by promoting scientific measures and projects. …”
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Uncertainty-aware diabetic retinopathy detection using deep learning enhanced by Bayesian approaches by Mohsin Akram, Muhammad Adnan, Syed Farooq Ali, Jameel Ahmad, Amr Yousef, Tagrid Abdullah N. Alshalali, Zaffar Ahmed Shaikh

“…Our experiments on a combined dataset (APTOS 2019 + DDR) with pre-processed images showed that the Bayesian-augmented DenseNet-121 outperforms state-of-the-art models in test accuracy, achieving 97.68% for the Monte Carlo Dropout model, 94.23% for Mean Field Variational Inference, and 91.44% for the Deterministic model. …”
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Machine-Learning Parsimonious Prediction Model for Diagnostic Screening of Severe Hematological Adverse Events in Cancer Patients Treated with PD-1/PD-L1 Inhibitors: Retrospective... by Seok Jun Park, Seungwon Yang, Suhyun Lee, Sung Hwan Joo, Taemin Park, Dong Hyun Kim, Hyeonji Kim, Soyun Park, Jung-Tae Kim, Won Gun Kwack, Sung Wook Kang, Yun-Kyoung Song, Jae Myung Cha, Sang Youl Rhee, Eun Kyoung Chung

“…Among the tested ML algorithms, random forest achieved the highest accuracy (area under the receiver operating characteristic curve [AUROC] 0.88 for both cohorts). …”
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Exploring the relationship between Total Athleticism score and CrossFit® Open Performance in amateur athletes: single measure involving body fat percentage, aerobic capacity, muscl... by Ramires Alsamir Tibana, Fábio Hech Dominski, Alexandro Andrade, Nuno Manuel Frade de Sousa, Fabricio Azevedo Voltarelli, Ivo Vieira de Sousa Neto

“…Interestingly, the top five athletes with the highest scores also achieved the highest z-scores in the CrossFit® Open 2021. …”
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Evidence for direct dopaminergic connections between substantia nigra pars compacta and thalamus in young healthy humans by Giovanni Cirillo, Giuseppina Caiazzo, Federica Franza, Mario Cirillo, Michele Papa, Fabrizio Esposito

“…While histological validation and concurrent PET-MRI remains needed for ultimate proofing of existence, given the potential role of this pathway, the possibility to achieve a good reproducibility of these measurements in humans might enable the monitoring of dopaminergic-related disorders, towards targeted personalized therapies.…”
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