Varying pixel resolution significantly improves deep learning-based carotid plaque histology segmentation by Yurim Lee, Rashid Al Mukaddim, Tenzin Ngawang, Shahriar Salamat, Carol C. Mitchell, Jenna Maybock, Stephanie M. Wilbrand, Robert J. Dempsey, Tomy Varghese

“…We were able to train Mask R-CNN using regions of interests with varied pixel resolution, with a $$7\%$$ increase in pixel accuracy versus training with patches. The model achieved F1 scores of $$0.70\pm 0.29$$ for calcified regions, $$0.68\pm 0.12$$ for lipid core with fibrinous material and cholesterol crystals, and $$0.38\pm 0.12$$ for fibrous regions, as well as a pixel accuracy of $$90\%\pm 2\%$$ . …”
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Calpain 2 promotes Lenvatinib resistance and cancer stem cell traits via both proteolysis-dependent and independent approach in hepatocellular carcinoma by Xiaolu Ma, Kaixia Zhou, Tianqing Yan, Ling Hu, Suhong Xie, Hui Zheng, Ying Tong, Heng Zhang, Yanchun Wang, Zhiyun Gong, Cuncun Chen, Yanan Tian, Lin Guo, Renquan Lu

“…Further in vitro and in vivo experiments indicated that knocking down CAPN2 greatly sensitized HCC cells to Lenvatinib treatment, while overexpression of CAPN2 achieved opposite effects in a Lenvatinib-sensitive HCC cell line. …”
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The effect of thioredoxin and prochymosin coexpression on the refolding of recombinant alpaca chymosin by S. V. Belenkaya, D. N. Shcherbakov, A. I. Chapoval, T. I. Esina, V. V. Elchaninov

“…The purpose of this work is to study the effect of coexpression of thioredoxin and prochymosin on the refolding of the recombinant zymogen and the activity of alpaca chymosin. To achieve this goal, on the basis of the pET32a plasmid, an expression vector was constructed containing the thioredoxin A gene fused to the N-terminal sequence of the marker enzyme zymogen, alpaca prochymosin. …”
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A Resource-Efficient Multi-Entropy Fusion Method and Its Application for EEG-Based Emotion Recognition by Jiawen Li, Guanyuan Feng, Chen Ling, Ximing Ren, Xin Liu, Shuang Zhang, Leijun Wang, Yanmei Chen, Xianxian Zeng, Rongjun Chen

“…The proposed method achieves 84.62% and 82.48% accuracy in arousal and valence classification tasks, respectively, indicating its effectiveness in reducing data dimensionality and computational complexity while maintaining an accuracy of over 80%. …”
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Modern approaches to digital product development in the conditions of market variability by E. V. Vasilieva, E. A. Morev

“…Currently, the interest in design thinking in the world has made it possible to add many techniques and visual schemes that can solve various kinds of problems, including for building a strategy to achieve the company’s goals, its corporate spirit and the development of creative skills of its employees. …”
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Combination of Hotspot Mutations With Methylation and Fragmentomic Profiles to Enhance Multi‐Cancer Early Detection by Thi Hue Hanh Nguyen, Giang Hoang Vu, Tu Thi Nguyen, Tuan Anh Nguyen, Vu Uyen Tran, Luyen Thi Vu, Giang Thi Huong Nguyen, Nhat Duy Nguyen, Trung Hieu Tran, Van Thien Chi Nguyen, Thanh Dat Nguyen, Trong Hieu Nguyen, Dac Ho Vo, Thi Tuong Vi Van, Thanh Thi Do, Minh Phong Le, Le Anh Khoa Huynh, Duy Sinh Nguyen, Hung Sang Tang, Hoai‐Nghia Nguyen, Minh‐Duy Phan, Hoa Giang, Lan N. Tu, Le Son Tran

“…The combination of hotspot mutations with SPOT‐MAS predictions improved early‐stage cancer detection, achieving an overall sensitivity of 78.5% at a specificity of 97.7%. …”
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Person-based design and evaluation of MIA, a digital medical interview assistant for radiology by Kerstin Denecke, Daniel Reichenpfader, Dominic Willi, Karin Kennel, Harald Bonel, Harald Bonel, Knud Nairz, Nikola Cihoric, Damien Papaux, Hendrik von Tengg-Kobligk

“…However, there is room for improvement in the perceived quality of the conversation, the information provided, and the protection of privacy. The Q&A module achieved a precision of 0.51, a recall of 0.87 and an F-Score of 0.64 based on 114 questions asked by the participants. …”
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Quantification of Mineral Oil Aromatic Hydrocarbons (MOAH) in Anhydrous Cosmetics Using 1H NMR by Sandra Weber, Tamina Schmidt, Paul Schumacher, Thomas Kuballa, Gerd Mildau, Stephan G. Walch, Andrea Hartwig, Dirk W. Lachenmeier

“…The SPE cleanup was successfully achieved for all tested potentially interfering aromatic cosmetic ingredients except for butylated hydroxytoluene. …”
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Comparison of Two Wavefront Autorefractors: Binocular Open-Field versus Monocular Closed-Field by Gonzalo Carracedo, Carlos Carpena-Torres, Laura Batres, Maria Serramito, Anahí Gonzalez-Bergaz

“…The Eye Refract provided enough accuracy and reliability to estimate refractive errors in different age groups, achieving better results than the VX110. Therefore, the Eye Refract proved to be a useful autorefractor to be incorporated into clinical practice.…”
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Conceptual foundations of a REFRAME-based approach to discriminate across total knee implant designs based on the positions of functional centres of rotation by Adrian Sauer, Ariana Ortigas-Vásquez, Christoph Thorwaechter, Peter E. Müller, Henning Windhagen, Allan Maas, Thomas M. Grupp, William R. Taylor, Matthias Woiczinski

“…The goal of this study was to achieve a first step towards identifying easily accessible and intuitive features that allow for discrimination between implant designs based on kinematic data. …”
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A machine learning model and identification of immune infiltration for chronic obstructive pulmonary disease based on disulfidptosis-related genes by Sijun Li, Qingdong Zhu, Aichun Huang, Yanqun Lan, Xiaoying Wei, Huawei He, Xiayan Meng, Weiwen Li, Yanrong Lin, Shixiong Yang

“…Besides, significant differences in DRGs, immune cells, biological functions, and pathway activities were observed between the two clusters.A nomogram was created to aid in the practical application of clinical procedures. The SVM model achieved the best results in differentiating COPD patients across various clusters. …”
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Women’s experiences of living with adenomyosis and perceptions of the diagnostic journey: a scoping review by Tim J Croudace, Margaret A Taylor, Margot McBride, Fiona E Muir

“…Education with improved multidisciplinary collaboration and further qualitative and case study research will be crucial to achieve this goal.Registration A priori protocol was registered (https://doi.org/10.17605/OSF.IO/2UDYN) and published (https://doi.org/10.1136/bmjopen-2023-075316).…”
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Economic evaluation of integrated services for non-communicable diseases and HIV: costs and client outcomes in rural Malawi by Luckson Dullie, Emily B Wroe, Elizabeth L Dunbar, Noel Kalanga, Lawrence Nazimera, Adarsh Shah, Bright Mailosi, Chiyembekezo Kachimanga, Ryan K McBain, Natalie Price, Mahlet Gizaw, Chantelle Boudreaux, Liberty Neba

“…Among clients with HIV, 81% achieved an undetectable viral load within their first year of enrolment. …”
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Predicting Subsurface Layer Thickness and Seismic Wave Velocity Using Deep Learning: Knowledge Distillation Approach by Amir Moslemi, Anna Briskina, Jason Li, Zubeka Dang, Peyman Moghaddam

“…Self-distillation significantly enhanced the performance of simpler architectures like VGG19, achieving over 95% accuracy in several depth and velocity prediction tasks. …”
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The impact of neuroscience education therapy, behavioral economics, and digital navigators on patient migraine treatment adherence to a mobile health application: a prospective pil... by Mia T. Minen, Erin K. Waire, John Torous, Jessica Fishman, Richard B. Lipton, Scott W. Powers

“…With use of NET, behavioral economics, and digital navigators, participants achieved higher levels of adherence to both self-management programs compared to prior remote migraine self-management studies. …”
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Integrated Serosurveillance of Infectious Diseases Using Multiplex Bead Assays: A Systematic Review by Selina Ward, Harriet L. S. Lawford, Benn Sartorius, Colleen L. Lau

“…Integrated serological surveillance (serosurveillance) involves testing for antibodies to multiple pathogens (or species) simultaneously and can be achieved using multiplex bead assays (MBAs). This systematic review aims to describe pathogens studied using MBAs, the operational implementation of MBAs, and how the data generated were synthesised. …”
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Critical Analysis and Application of Net-Metering Practice in MEPCO by Hassan Zahid, Farhana Umer, Zeeshan Rashid, Abdur Raheem, Rabia Shakoor, G. Amjad Hussain

“…The aim behind this research work is to promote renewable energy utilization through net-metering mechanism in order to achieve maximum power. The export of units from consumer side to utility grid and vice versa can be made through bidirectional energy meter. …”
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Impact of Peracetic Acid on the Dynamic Cyclic Fatigue of Heat-Treated Nickel-Titanium Rotary Endodontic Instrument by Suhad Jabbar Hamed Al-Nasrawi, Zuha Ayad Jaber, Nibrass Talib Al-Quraine, Abtesam Imhemed Aljdaimi, Sattar Jabbar Abdul-Zahra Al-Hmedat, Saleh Zidan, Julfikar Haider

“…It has been used at different concentrations to achieve various functions. However, endodontic instruments in contact with PAA of a certain concentration may affect their fatigue resistance. …”
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Ginger protects against vein graft remodeling by precisely modulating ferroptotic stress in vascular smooth muscle cell dedifferentiation by Xiaoyu Yu, Weiwei Wu, Jingjun Hao, Yuxin Zhou, Deyang Yu, Wei Ding, Xuejuan Zhang, Gaoli Liu, Jianxun Wang

“…Ginger significantly inhibited neointimal hyperplasia and promoted lumen (L) opening in a 3-month VG, which was primarily achieved by reducing ferroptotic stress. Ferroptotic stress is a pro-ferroptotic state. …”
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Common themes in architecture and interactions of prokaryotic PolB2 and Pol V mutasomes inferred from in silico studies by Kęstutis Timinskas, Albertas Timinskas, Česlovas Venclovas

“…One of the most intriguing such cases in B-family is represented by archaeal PolB2 and its bacterial homologs. Previously thought to be catalytically inactive, PolB2 was recently shown to be absolutely required for targeted mutagenesis in Sulfolobus islandicus. …”
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