Kruppel-family zinc finger proteins as emerging epigenetic biomarkers in head and neck squamous cell carcinoma by Patrick Pearson, Kendra Smith, Nilita Sood, Elizabeth Chia, Alicia Follett, Michael B. Prystowsky, Simon Kirby, Thomas J. Belbin

“…Abstract Background Krüppel-type zinc finger protein genes located on chromosome 19q13 are aberrantly hypermethylated with high frequency in all anatomic sub-sites of head and neck cancers as well as other epithelial tumours resulting in decreased expression. …”
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Developing a new clinical governance framework for chronic diseases in primary care: an umbrella review by Walter Ricciardi, Gianfranco Damiani, Alessandra Buja, Vincenzo Baldo, Mark H Ebell, Roberto Toffanin, Mirko Claus

“…Objectives Our goal is to conceptualise a clinical governance framework for the effective management of chronic diseases in the primary care setting, which will facilitate a reorganisation of healthcare services that systematically improves their performance.Setting Primary care.Participants Chronic Care Model by Wagner et aland Clinical Governance statement by Scally et alwere taken for reference. Each was reviewed, including their various components. …”
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Primary Hyperparathyroidism-Phosphaturic Mesenchymal Tumour: An Unusual Association and a Probable Syndrome by Gwendolyn Fernandes, Avanika, Gloria Khumanthem

“…The exact aetiology for the association of PMT and pHPT is not known, and the hypothesis of aberrant gene expression has been implicated.…”
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The DNMT1/miR-34a Axis Is Involved in the Stemness of Human Osteosarcoma Cells and Derived Stem-Like Cells by Xiao Liang, Chang Xu, Wanchun Wang, Xiang Li

“…Our results revealed that aberrant activation of DNMT1 caused promoter methylation of miR-34a, leading to miR-34a underexpression, and the role of the DNMT1/miR-34a axis in promoting and sustaining the stemness of OSLCs.…”
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Breast Implant Illness May Be Rooted in Mast Cell Activation: A Case-Controlled Retrospective Analysis by Èva S. Nagy, BMedSci(Hons), MBBS, PhD, FRACS, Grad Cert (Breast Surgery), Mark Westaway, MBBS, DCH, Grad Dip Allergy, Suzanne Danieletto, BSc, MBBS (Hons), FRCPA, MIAC, Lawrence B. Afrin, MD

“…Given that neoantigenic/xenobiotic exposures commonly trigger dysfunctional MCs in MCAS to heighten aberrant mediator expression driving inflammatory and other issues, further investigation of whether BII represents an implant-driven escalation of preexisting MCAS and whether an MCAS diagnosis flags risk for BII seems warranted.…”
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Integrated microRNA and mRNA signatures associated with overall survival in epithelial ovarian cancer. by Joanna Lopacinska-Jørgensen, Douglas V N P Oliveira, Guy Wayne Novotny, Claus K Høgdall, Estrid V Høgdall

“…MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression primarily by targeting messenger RNA (mRNA) transcripts. Their aberrant expression patterns have been associated with cancer development, including OC. …”
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Different DNA Loidy Patterns for the Differentiation of Common Subtypes of Renal Tumors by Guorong Li, Michèle Cottier, Odile Sabido, Anne Gentil-Perret, Claude Lambert, Christian Genin, Jacques Tostain

“…DNA ploidy is viewed as a marker of gross genomic aberrations. The aim of this study is to evaluate the DNA ploidy in the common subtypes of renal tumors to increase our understanding of renal tumor biology and to broaden clinical application of DNA ploidy. …”
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Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development. by Rebecca Armstrong, Nikki J Marks, Timothy G Geary, John Harrington, Paul M Selzer, Aaron G Maule

“…Notably, silencing FhCTNNB1, the key effector of the Wnt/β-catenin signal cascade led to aberrant development of the neuromuscular system which ultimately proved lethal - the first report of a lethal RNAi-induced phenotype in F. hepatica. …”
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Lysophosphatidylethanolamine improves diastolic dysfunction by alleviating mitochondrial injury in the aging heart by Guiwen Xu, Wei Xiao, Pengqi Sun, Yuanjun Sun, Xinyu Yang, Xiaomeng Yin, Yang Liu

“…Studies also show that aberrant mitochondrial lipid metabolism impairs mitochondrial function in aging cardiomyocytes. …”
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Susceptibility of different mice species to chemical induction of colorectal cancer by 1,2-dimethylhydrazine by Nourhan M. Abdelmaksoud, Ahmed I. Abulsoud, Tamer M. Abdelghany, Shereen Saeid Elshaer, Ahmed Samaha, Nadine W. Maurice, Sherine Maher Rizk, Mahmoud A. Senousy

“…Histopathology of distal colon revealed aberrant crypt foci and loss of goblet cells in DMH-exposed C57BL/6 mice. …”
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Burnout among Nurses Working in Ethiopia by Abrha Hailay, Woldu Aberhe, Guesh Mebrahtom, Kidane Zereabruk, Guesh Gebreayezgi, Teklehaimanot Haile

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Impact of central corneal astigmatism on postoperative visual outcomes in patients undergoing trifocal intraocular lens implantation by Lan Wang, Jiaqi Meng, Jiao Qi, Dongling Guo, Yi Lu, Xiangjia Zhu

“…Moreover, the high astigmatism group showed significantly poorer CS, greater higher-order aberrations, and more symptoms of blurred vision and diplopia. …”
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Long-Term Environmental Enrichment Relieves Dysfunctional Cognition and Synaptic Protein Levels Induced by Prenatal Inflammation in Older CD-1 Mice by Zhe-Zhe Zhang, Li-Ping Zeng, Jing Chen, Yong-Fang Wu, Ya-Tao Wang, Lan Xia, Qi-Gang Yang, Fang Wang, Gui-Hai Chen

“…A mounting body of evidence suggests that prenatal inflammation may enhance the rate of age-associated cognitive decline and may involve aberrant amounts of synaptic proteins in the hippocampus, including synaptotagmin-1 (Syt1) and activity-regulated cytoskeleton-associated protein (Arc). …”
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Effects of Particulate Matter Exhaust on Functional Parameters of Organ Systems and Reactive Oxygen Species: A Cross-Sectional Study by Manjula Shivanagappa, SS Malini, Thanmayi Mahadeshwara Prasad, D. R. Mahadeshwara Prasad

“…Serum oxidative stress markers, hemogram, renal and liver functional parameters were analysed.Results: A significant variation was observed among the oxidative stress markers among the exposures with surge in malondialdehyde and reduction in superoxide dismutase and catalase with variation in cell count, renal and liver functional parameters (p ≤ 0.05).Conclusion: Diesel combustion nanoparticles induces oxidative stress which reflects hepato-renal aberration.…”
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Peripheral nerve injury induces dystonia-like movements and dysregulation in the energy metabolism: A multi-omics descriptive study in Thap1+/− mice by Colette Reinhold, Susanne Knorr, Rhonda L. McFleder, Lisa Harder-Rauschenberger, Tom Gräfenhan, Andreas Schlosser, Michael Sendtner, Jens Volkmann, Chi Wang Ip

“…These findings suggest that aberrant energy metabolism in brain regions relevant to dystonia may underlie the dystonic phenotype observed in nerve injured Thap1+/− mice.…”
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Linking altered neuronal and synaptic properties to nicotinic receptor Alpha5 subunit gene dysfunction: a translational investigation in rat mPFC and human cortical layer 6 by Danqing Yang, Guanxiao Qi, Daniel Delev, Uwe Maskos, Dirk Feldmeyer

“…Our findings suggest that dysfunction in the α5 subunit gene leads to aberrant neuronal and synaptic properties, shedding light on the underlying mechanisms of cognitive deficits observed in human populations carrying α5SNPs. …”
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Management of Cataract in Patients with Irregular Astigmatism with Regular Central Component by Phacoemulsification Combined with Toric Intraocular Lens Implantation by Yi Gao, Zi Ye, Wenqian Chen, Jinglan Li, Xinlin Yan, Zhaohui Li

“…Postoperative visual acuity, residual astigmatism, toric IOL rotation, higher-order aberration, and objective and subjective visual quality were measured 3 months after surgery. …”
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Extraction of a low grade zinc ore using gravity and froth flotation methods by Alabi Oladunni Oyelola, Dalhatu Aboki Abdu, Abere Dare Victor, Magnus T Igonwelundu, Bala Meshack Bosan, Araoye Babatunde Oyebode

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PAX6 enhances Nanog expression by inhibiting NOTCH signaling to promote malignant properties in small cell lung cancer cells by Xiao-Fang Guo, Ling-Ling Wang, Fei-Meng Zheng, He-Ping Li

“…Small cell lung cancer (SCLC) is a highly aggressive form of lung cancer. The aberrant regulation of Paired box 6 (PAX6) expression has been proposed to play an important oncogenic role in several cancer types. …”
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Alcohol promotes CPT1A-induced lipid metabolism disorder to sentinel-regulate acute pancreatitis by Zenghui Li, Xinghui Li, Hui Jiang, Jingdong Li, Bin Xiao, Yong Chen, Shunhai Jian, Mei Zeng, Xiaoming Zhang

“…Etomoxir treatment mitigates the influence of alcohol stimulation on the aberrant expression of proteins associated with oxidative stress, increased ROS production, mitochondrial ultrastructural alterations and mitochondrial dysfunction in AR42J cells. …”
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