Gut-Lung Microbiota in Chronic Pulmonary Diseases: Evolution, Pathogenesis, and Therapeutics by Chang Yi Shi, Chen Huan Yu, Wen Ying Yu, Hua Zhong Ying

“…The imbalance of microbiota is usually linked to the aberrant immune responses and inflammation, which eventually promotes the occurrence and development of respiratory diseases. …”
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Hsa_circ_0001304 promotes vascular neointimal hyperplasia accompanied by autophagy activation by Shi-Qing Mu, Jia-Jie Lin, Yu Wang, Li-Yun Yang, Sen Wang, Zhao-Yi Wang, An-Qi Zhao, Wen-Jun Luo, Zi-Qi Dong, Yu-Guang Cao, Ze-An Jiang, Si-Fan Wang, Shan-Hu Cao, Li Meng, Yang Li, Shu-Yan Yang, Shao-Guang Sun

“…Abstract Aberrant autophagy in vascular smooth muscle cells (VSMCs) is associated with the progression of vascular remodeling diseases caused by neointimal hyperplasia. …”
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Distinct Chromosomal Profiles in Metastasizing and Non-Metastasizing Colorectal Carcinomas by B. Michael Ghadimi, Marian Grade, Carsten Mönkemeyer, Bettina Kulle, Jochen Gaedcke, Bastian Gunawan, Claus Langer, Torsten Liersch, Heinz Becker

“…We aimed to detect distinct chromosomal aberrations indicating a metastatic phenotype. Results and discussion: Metastatic tumors exhibited a significantly (P=0.03) higher ANCA value (13.8) if compared with non-metastatic cancers (10.0). …”
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miR-6869-5p Inhibits Glioma Cell Proliferation and Invasion via Targeting PGK1 by Fakai Wang, Huanjun Zhang, Bing Liu, Wei Liu, Zengchao Zhang

“…Accumulating studies have suggested the dysregulated microRNAs (miRNAs) play important roles in brain tumors, including glioma. miR-6869-5p has been documented to be aberrantly expressed in diverse cancers. However, the precise role of miR-6869-5p in glioma remains poorly understood. …”
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Reconstruction of Dynamical Forecasting Model between Western Pacific Subtropical High Area Index and Its Summer Monsoon Impact Factors Based on the Improved Self-Memorization Prin... by Mei Hong, Ren Zhang, Xi Chen, Shanshan Ge, Chengzu Bai, Vijay P. Singh

“…Through 10 experiments of the WPSH abnormal years, forecast results within 25 days are found to be good, with a correlation coefficient of about 0.80 and root mean square error under 8%, showing that the improved model has satisfactory long-term forecasting results. In particular the aberrance of the subtropical high can be drawn and forecast. …”
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The clinicoserological spectrum of inflammatory myopathy in the context of systemic sclerosis and systemic lupus erythematosus by John D Pauling, Sarah Skeoch, Julie J Paik

“…Autoimmune rheumatic diseases (ARDs) are characterized by a pathological triad composed of autoimmunity/inflammation, microangiopathy, and aberrant tissue remodeling. Disease terms such as idiopathic inflammatory myopathy (IIM), scleroderma/systemic sclerosis (SSc), and systemic lupus erythematosus (SLE) are helpful clinically but disguise the considerable overlap that exists within these “distinct” disorders. …”
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Can Well-sampled Phase Curves Be Used to Infer Asteroid Spectral Features? by Zachary Murray

“…However, these efforts often suffer from the inclusion of only a few asteroids, missing phase curve data, uncorrected rotational or apparitional aberrations, and other issues. In this paper, we build upon previous approaches and address these issues. …”
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Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog by Ethan A. Natelson, David Pyatt

“…They are typically considered neoplasms because of frequent genetic aberrations and patient-limited survival with progression to acute myeloid leukemia (AML) or death related to the consequences of bone marrow failure including infection, hemorrhage, and iron overload. …”
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Mutation analysis of SHP2, SOS1, and SOS2 related to dysregulation of Ras/MAPK pathway in Noonan syndrome by Nihayatul Karimah

“…The models demonstrate that the mutations contribute to the aberrant autoinhibitory control and catalytic activity of the proteins.  …”
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Inotersen to Treat Polyneuropathy Associated with Hereditary Transthyretin (hATTR) Amyloidosis by Christopher Robinson, Cynthia Pham, Alec M. Zamarripa, Chase S. Dugay, Christopher A. Lee, Amnon A. Berger, Avi Landman, Elyse M. Cornett, Hisham Kassem, Alan D. Kaye, Ivan Urits, Omar Viswanath, Latha Ganti

“…# Background Amyloidosis is a group of diseases with the common pathophysiology of protein misfolding and aberrant deposition in tissue. There are both acquired and hereditary forms of this disease, and this review focuses on the latter hereditary transthyretin-mediated (hATTR). hATTR affects about 50,000 individuals globally and mostly appears as one of three syndromes - cardiac, polyneuropathy, and oculoleptomeningeal. …”
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Assessment of Cytotoxicity and Genotoxicity Potential of Effluents from Bahir Dar Tannery Using Allium cepa by Tayachew Admas, Bizuayehu Kerisew

“…The results showed that cytotoxicity, genotoxicity, and chromosomal aberrations were induced by the tannery effluent. Industries shall think of biological waste treatment methods.…”
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Goldenhar Syndrome Associated with Extensive Arterial Malformations by Renee Frances Modica, L. Daphna Yasova Barbeau, Jennifer Co-Vu, Richard D. Beegle, Charles A. Williams

“…Cardiac CT angiogram confirmed a right arch and aberrant, stenotic left subclavian artery, dilation of the main pulmonary artery, and agenesis of the left thyroid lobe. …”
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Interstitial Mycosis Fungoides: An Unusual Mimic of Interstitial Granuloma Annulare Not to Miss by Neha Singh, Kiley K. Fagan, Douglas J. Grider

“…Immunohistochemistry staining revealed the atypical lymphocytes to be positive for CD3 and CD8 and negative for CD4 and CD7, an aberrant immunoprofile. Mixed in the dermis with the atypical lymphoid cells were a few CD68 positive histiocytes and S100 protein positive dermal dendritic cells. …”
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Brain lesion MRI and co-related MRS spectroscopy datasetMendeley Data by Sura Riyadh Saleh, Suhad A. Yousif, Israa Qader Ahmed

“…Analysing brain lesions of various aetiologies necessitates imaging data with subsequent diagnostic techniques that may enable concomitant visualization of spatial anatomical entities, and aberrant molecular behaviour. To fulfil this necessity, several image types and modalities should be collected. …”
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PTEN Gene: A Model for Genetic Diseases in Dermatology by Corrado Romano, Carmelo Schepis

“…A recent model sees PTEN function as a stepwise gradation, which can be impaired not only by heterozygous mutations and homozygous losses, but also by other molecular mechanisms, such as transcriptional regression, epigenetic silencing, regulation by microRNAs, posttranslational modification, and aberrant localization. The involvement of PTEN function in melanoma and multistage skin carcinogenesis, with its implication in cancer treatment, and the role of front office in diagnosing PHTS are the main reasons why the dermatologist should know about PTEN.…”
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Recent advances in oblique plane microscopy by Kim Jeongmin

“…This unconventional widefield imaging approach is made possible by using a remote focusing principle that eliminates optical aberrations for object points beyond the focal plane. …”
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Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation by Shahida A. Khan, Ashraf Ali, Sarah A. Khan, Solafa A. Zahran, Ghazi Damanhouri, Esam Azhar, Ishtiaq Qadri

“…Obesity today stands at the intersection between inflammation and metabolic disorders causing an aberration of immune activity, and resulting in increased risk for diabetes, atherosclerosis, fatty liver, and pulmonary inflammation to name a few. …”
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Metalloprotease Dependent Release of Placenta Derived Fractalkine by Monika Siwetz, Astrid Blaschitz, Julia Kremshofer, Jelena Bilic, Gernot Desoye, Berthold Huppertz, Martin Gauster

“…Increased expression and release of placental fractalkine may contribute to low grade systemic inflammatory responses in third trimester of normal pregnancy. Aberrant placental metalloprotease activity may not only affect the release of placenta derived fractalkine but may at the same time affect the abundance of the membrane-bound form of the chemokine.…”
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Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein by Ioannis Papaioannou, J. Paul Simons, James S. Owen

“…In particular, we discuss the possibility and potential benefit of applying in combination two technical advances to repair aberrant APOE genes: (i) an engineered endonuclease to introduce a double-strand break (DSB) in exon 4, which contains the common, but dysfunctional, ε2 and ε4 alleles; (ii) an efficient and selectable template for homologous recombination (HR) repair, namely, an adeno-associated viral (AAV) vector, which harbours wild-type APOE sequence. …”
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Deafferentation-Induced Plasticity of Visual Callosal Connections: Predicting Critical Periods and Analyzing Cortical Abnormalities Using Diffusion Tensor Imaging by Jaime F. Olavarria, Andrew S. Bock, Lindsey A. Leigland, Christopher D. Kroenke

“…Last, we discuss the potential of utilizing DTI to distinguish normal from abnormal cerebral cortical development, both within the context of aberrant connectivity induced by early retinal deafferentation, and more generally as a potential tool for detecting abnormalities associated with neurodevelopmental disorders.…”
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