Mitochondrial apoptosis in response to cardiac ischemia-reperfusion injury by Kaixin Wang, Qing Zhu, Wen Liu, Linyuan Wang, Xinxin Li, Cuiting Zhao, Nan Wu, Chunyan Ma

“…Abnormal opening of the mitochondrial permeability transition pore, aberrant mitochondrial membrane potential, Ca2+ overload, mitochondrial fission, and mitophagy can lead to mitochondrial dysfunction, thereby inducing mitochondrial apoptosis. …”
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A Possible Role of HMGB1 in DNA Demethylation in CD4+ T Cells from Patients with Systemic Lupus Erythematosus by Yaping Li, Chenghui Huang, Ming Zhao, Gongping Liang, Rong Xiao, Susan Yung, Tak Mao Chan, Qianjin Lu

“…The aberrant activity of CD4+ T cells in patients with systemic lupus erythematosus (SLE) is associated with DNA hypomethylation of the regulatory regions in CD11a and CD70 genes. …”
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Targeting TLR/IL-1R Signalling in Human Diseases by Maria Loiarro, Vito Ruggiero, Claudio Sette

“…On the other hand, an aberrant activation of TLR/IL-1R signalling can promote the onset of inflammatory and autoimmune diseases, raising the interest in the development of therapeutic strategies for the control of their function. …”
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Tumor cells escape immunosurveillance by hampering LFA-1 by Shishir Upadhyay, Lewis Murugu, Lena Svensson, Lena Svensson

“…During tumor immunosurveillance, leukocytes play a crucial role in the cellular defense system, working collaboratively with other immune components to recognize and eliminate aberrant cells. Integral to this process is the integrin Lymphocyte Function-Associated Antigen 1 (LFA-1). …”
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HCV and Lymphoproliferation by Anna Linda Zignego, Carlo Giannini, Laura Gragnani

“…These hypotheses have variously emphasized the important role played by sustained stimulation of the immune system by HCV, infection of the lymphatic cells, viral proteins, chromosomal aberrations, cytokines, or microRNA molecules. In this paper we describe the main hypotheses that have been proposed with the corresponding principal supporting data.…”
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A Rare 46,X,t(Y;10)(q12;p14) Balanced Translocation in Non-Obstructive Azoospermic Patient with Elevated FSH and LH Levels by Kousar Jahan Syeeda Khursheed, Mohammed Rahman Kaleemullah, Annu Joseph, Mohammed Hasan Al Durazi, Moiz Bakhiet

“…Structural chromosomal aberrations like translocations have been shown to cause spermatogenic failure. …”
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RUNX2 enhances bladder cancer progression by promoting glutamine metabolism by Zhigang Huang, Bin Liu, Xiaoju Li, Chenghua Jin, Quansen Hu, Zhiwei Zhao, Yimin Sun, Qian Wang

“…Targeting RUNX2 could represent a promising therapeutic approach for addressing aberrant glutamine metabolism in bladder cancer.…”
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Beware of diffusion models for synthesizing medical images—a comparison with GANs in terms of memorizing brain MRI and chest x-ray images by Muhammad Usman Akbar, Wuhao Wang, Anders Eklund

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Pulse2AI: An Adaptive Framework to Standardize and Process Pulsatile Wearable Sensor Data for Clinical Applications by Sicong Huang, Roozbeh Jafari, Bobak J. Mortazavi

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D-Amino Acids in the Nervous and Endocrine Systems by Yoshimitsu Kiriyama, Hiromi Nochi

“…H2S generated from D-cysteine reduces disulfide bonds in receptors and potentiates their activity. Aberrant receptor activity is related to diseases of the central nervous system (CNS), such as Alzheimer’s disease, amyotrophic lateral sclerosis, and schizophrenia. …”
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Physiological Roles of DNA Double-Strand Breaks by Farhaan A. Khan, Syed O. Ali

“…Growing evidence points to a role of aberrant DSB physiology in human disease and an understanding of these processes may both inform the design of new therapeutic strategies and reduce off-target effects of existing drugs. …”
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Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson’s Disease by Katharina E. Rosenbusch, Arjan Kortholt

“…Here, we review the recent progress in elucidating the complex LRRK2 activation mechanism, describe the accumulating evidence that link LRRK2-mediated PD to mitochondrial dysfunction and aberrant autophagy, and discuss possible ways for therapeutically targeting LRRK2.…”
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Photochemical and photobiological properties of furocoumarins and homologues drugs by F. Bordin

“…Both compounds are very active; however while FQ produced many chromosomal aberrations and strong skin erythemas, HFQ practically did not induce such side effects. …”
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“A glass half full” or “a breastless dwarf”: Metaphorical talk in women’s accounts of Turner syndrome by Kamila Ciepiela

“…Turner syndrome is a genetic aberration that affects females, and results in short stature, ovarian failure and a number of less typical body deformations; it often takes a long time to be appropriately diagnosed. …”
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A scoping review on self-regulation and reward processing measured with gambling tasks: Evidence from the general youth population. by Francesca Bentivegna, Efstathios Papachristou, Eirini Flouri

“…Aberrant reward processing and poor self-regulation have a crucial role in the development of several adverse outcomes in youth, including mental health disorders and risky behaviours. …”
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Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance? by Gloria Lopez-Castejon, Mariola J. Edelmann

“…This response is tightly regulated since any aberrant activation of immune responses would have severe pathological consequences such as sepsis or chronic inflammatory and autoimmune diseases. …”
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Analysis of the IFN-γ-induced signal transduction pathway in fetal rejection by Irene Athanassakis

“…The data presented here point to novel directions not only as to the intracellular signalling, but also to the use of pathway inhibitors in vivo to treat aberrant antigen expression associated with fetal loss.…”
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Association between Probiotics and Modulation of Gut Microbial Community Composition in Colorectal Cancer Animal Models: A Systematic Review (2010–2021) by Shabnam Zeighamy Alamdary, Shahnaz Halimi, Akram Rezaei, Roghayeh Afifirad

“…According to the current findings, probiotics/synbiotics could significantly attenuate aberrant crypt foci (ACF) formation, restore beneficial bacteria in the microbiota population, increase short-chain fatty acids (SCFAs), and change inflammatory marker expression. …”
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Cytokines and Myelination in the Central Nervous System by Thomas Schmitz, Li-Jin Chew

“…Many cytokines are virtually undetectable in the uninflamed central nervous system (CNS), so that their rapid induction and sustained elevation in immune and glial cells contributes to dysregulation of the inflammatory response and neural cell homeostasis. This results in aberrant neural cell development, cytotoxicity, and loss of the primary myelin-producing cells of the CNS, the oligodendrocytes. …”
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Adrenal Incidentalomas with Supraphysiologic Response to ACTH Stimulus: A Case Report by Marianna Antonopoulou, Asya Perelstein

“…Our differential diagnosis includes subclinical CS with aberrant receptors versus a functioning extramedullary plasmacytoma.…”
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