Genome rearrangements in neurodevelopmental disorders of the central nervous system: origins, genomic mechanisms, functional and clinical consequences. Review article by V. Kučinskas, E. Preikšaitienė, L. Ambrozaitytė, L. Cimbalistienė, A. Utkus

“…In our research, the detection of chromosomal aberrations by molecular karyotyping and whole exome sequencing capable of uncovering pathogenic variants in any of the human genes were the main technologies used to identify the molecular causes of intellectual disability. …”
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Perspectives of Integrative Cancer Genomics in Next Generation Sequencing Era by So Mee Kwon, Hyunwoo Cho, Ji Hye Choi, Byul A Jee, Yuna Jo, Hyun Goo Woo

“…These genome-wide profiles of the genetic aberrations could reveal the candidates for diagnostic and/or prognostic biomarkers as well as mechanistic insights into tumor development and progression. …”
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Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers by Shichen Huang MS, Bowen Li MS, Huanyu Chen MD, Cheng Rong, Zheng Yang MD, Xianqin Zhang PhD

“…In this review, we comprehensively summarize the latest knowledge on the aberrant expression of TRPM2-AS, the relationship between TRPM2-AS and clinical features, and the detailed mechanisms of potential functions of TRPM2-AS in various cancer types. …”
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Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease by Sheetal Verma, Tamisha Vaughan, Kevin D. Bunting

“…In addition, Gabs participate in hematopoiesis and regulation of immune response which can be aberrantly activated in cancer and inflammation. The multifunctionality of Gab adapters might suggest that they would be too difficult to consider as candidates for “targeted” therapy. …”
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Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications by Claudio Campa, Ciro Costagliola, Carlo Incorvaia, Carl Sheridan, Francesco Semeraro, Katia De Nadai, Adolfo Sebastiani, Francesco Parmeggiani

“…Although the term may suggest just a vascular pathological condition, CNV is more properly definable as an aberrant tissue invasion of endothelial and inflammatory cells, in which both angiogenesis and inflammation are involved. …”
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Multitarget CDK inhibitors roscovitine and UCN‑01 induce apoptosis in colorectal cancer cells by inhibiting cell cycle progression and transcription by Sonal Mohan Manohar, Kalpana Sanjay Joshi

“…Abstract Colorectal cancer (CRC) is the third leading cause of cancer death in the world, and its incidence is steadily rising in developing nations. Cell cycle aberrations due to deregulation of cyclin dependent kinases (CDKs) and cyclins are common events during colorectal carcinogenesis. …”
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Digital pathology and artificial intelligence in renal cell carcinoma focusing on feature extraction: a literature review by Ming-Yue Li, Yu Pan, Yang Lv, He Ma, Ping-Li Sun, Hong-Wen Gao

“…Consequently, studies in renal cell carcinoma (RCC) have emerged, highlighting potential in histological subtype classification, molecular aberration identification, and outcome prediction by extracting high-throughput features. …”
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An investigation into the critical ingredients of intensive support teams for adults with intellectual disabilities who display challenging behaviour by Lucretia Thomas, Brynmor Lloyd-Evans, Louise Marston, Angela Hassiotis

“…The primary outcome was mean change in the total score on the Aberrant Behavior Checklist and its subscales. Results A measure of mental illness severity was the only variable associated with our primary outcome of reduction in challenging behaviour. …”
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Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New by Alessia Alunno, Elena Bartoloni, Onelia Bistoni, Giuseppe Nocentini, Simona Ronchetti, Sara Caterbi, Valentina Valentini, Carlo Riccardi, Roberto Gerli

“…However, the pivotal role of T lymphocytes in the induction and perpetuation of aberrant immune response is well established. Among T cells, IL-17 producing T helper (Th17) cells and regulatory T (Treg) cells represent an intriguing issue to be addressed in SLE pathogenesis, since an imbalance between the two subsets has been observed in the course of the disease. …”
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Mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease by Parisa Hassanpour, Fatemeh Sadeghsoltani, Solmaz Saghebasl, Safieh Boroumand, Parisa Khanicheragh, Seyed Hossein Ahmadi Tafti, Reza Rahbarghazi, Mohammad Rahmati

“…How and by which mechanisms, mitochondria can reduce aberrant myocardial tissue remodeling via different pathways such as angiogenesis and de novo blood formation was discussed in detail. …”
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Superior Thyroid Cornu Anatomical Variation Causing Globus Pharyngeous and Dysphagia by Jiannis K. Hajiioannou, Vasiliki Florou, Panagiotis Kousoulis

“…Clinical examination and diagnostic procedures revealed a rare anatomic aberrance of the thyroid cartilage. Surgical treatment was declined by the patient who accepted a yearly followup. …”
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Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis by Koichi Tsuneyama, Yen-Chen Chen, Makoto Fujimoto, Yoshiyuki Sasaki, Wataru Suzuki, Tsutomu Shimada, Seiichi Iizuka, Mitsunobu Nagata, Masaki Aburada, Shao-Yuan Chen

“…As for the effects of increasing oxidative stress, the liver histology of the HBOT group showed severer cellular damage and aberrant TNF-α expression. HBOT has the advantage of improving obesity in patients with metabolic syndrome, but the fault of causing organ damage by increasing oxidative stress.…”
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Histone demethylases in autophagy and inflammation by Yaoyao Ma, Wenting Lv, Yi Guo, Tong Yin, Yujie Bai, Ziqi Liu, Chao Chen, WenjuanYang, Jiayi Feng, Wenbin Qian, Ruiling Tang, Yanting Su, Shigang Shan, Huifen Dong, Yongfen Bao, Lihua Qu

“…Epigenetic changes, such as aberrant expression of histone demethylase, are actively associated not only with oncogenesis but also with inflammatory responses. …”
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Exploring the role of ubiquitination modifications in migraine headaches by Qian Zhu, Qian Zhu, Jin Yang, Jin Yang, Lei Shi, Lei Shi, Jieying Zhang, Jieying Zhang, Peng Zhang, Peng Zhang, Junlong Li, Junlong Li, Xiaoli Song, Xiaoli Song

“…Calcitonin gene-related peptide (CGRP) plays a dominant role and activation of MAPK and NF-κB signaling pathways regulates neuropeptide release, glial cell activation, and amplification of nociceptive signals. Aberrant activation of these pathways drives migraine onset and chronicity. …”
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Autophagy: More Than a Nonselective Pathway by Fulvio Reggiori, Masaaki Komatsu, Kim Finley, Anne Simonsen

“…Autophagy is a catabolic pathway conserved among eukaryotes that allows cells to rapidly eliminate large unwanted structures such as aberrant protein aggregates, superfluous or damaged organelles, and invading pathogens. …”
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Rescue of common and rare exon 2 skipping variants of the GAA gene using modified U1 snRNA by Paolo Peruzzo, Natascha Bergamin, Martina Bon, Sara Cappelli, Alessandra Longo, Elisa Goina, Cristiana Stuani, Emanuele Buratti, Andrea Dardis

“…In this study, we used modified, GAA-tailored U1 snRNAs to correct the aberrant splicing determined by the c.-32-13T>G and other GAA exon 2-skipping mutations. …”
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Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma by Malcolm K Brenner, Challice Bonifant, Norihiro Watanabe, Mary K McKenna, Daniel Brenner, Ada Ozcan, Maureen Legendre, Dafydd G Thomas, Christopher Ashwood, Richard D Cummings, David M Markovitz

“…We address both limitations with a novel class of chimeric antigen receptors based on plant lectins, which recognize the aberrant sugar residues that are a ‘hallmark’ of both malignant and associated stromal cells. …”
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Autoridade prática e ambivalência das instituições de justiça no crime-desastre da Barragem de Fundão by José Szwako, Poema Euristenes Portela

“…We argue that the concept of practical authority (Abers & Keck 2016) sheds light on both the dynamics of correcting injustices suffered in the context of Samarco’s crime-disaster (Mariana, MG, 2015), and on the ambivalence of institutional representatives. …”
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Feline Neural Progenitor Cells I: Long-Term Expansion under Defined Culture Conditions by Jing Yang, Jinmei Wang, Ping Gu, X. Joann You, Henry Klassen

“…Importantly, later passage cNPCs did not develop chromosomal aberrations.…”
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Molecular Pathogenesis of MALT Lymphoma by Katharina Troppan, Kerstin Wenzl, Peter Neumeister, Alexander Deutsch

“…This review mainly discusses MALT lymphomas in terms of their genetic aberration and association with chronic infections and summarizes recent advances in their molecular pathogenesis.…”
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