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501
The Association between Deoxyribonucleic Acid Hypermethylation in Intron VII and Human Leukocyte Antigen-C∗07 Expression in Patients with Endometriosis
Published 2023-01-01“…There is an increasing amount of evidence that suggests that epigenetic aberrations, including deoxyribonucleic acid (DNA) methylation, play a definite role in the pathogenesis of endometriosis. …”
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502
Glutamine-glutamate centered metabolism as the potential therapeutic target against Japanese encephalitis virus-induced encephalitis
Published 2025-01-01“…Conclusion Altogether, our study highlights an aberrant glutamine-glutamate metabolism during JEV infection and unveils how this facilitates viral replication and promotes JE progression. …”
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503
Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma
Published 2025-02-01“…Genomic studies have identified common driver aberrations in high-risk NB, such as MYCN amplification. …”
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504
Effect of crystalline lens decentration and tilt on visual performance in eyes implanted with bifocal or extended depth of focus intraocular lenses
Published 2025-02-01“…Beyond these points, internal aberrations such as coma increased significantly (all P < 0.01). …”
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505
Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria
Published 2016-01-01“…Aberrant autophagy played an important role in the pathogenesis of autoimmune diseases, especially in systemic lupus erythematosus (SLE). …”
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506
Multimodal Imaging Analysis in a Case with Congenital Fovea-Involving Retinal Macrovessel and Excellent Visual Acuity
Published 2017-01-01“…Congenital retinal macrovessels (CRM) represent rare aberrant vasculature of the retinal vessels that can supply or drain the macula. …”
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507
Neuroinflammatory Mechanisms of Mitochondrial Dysfunction and Neurodegeneration in Glaucoma
Published 2021-01-01“…Mitochondrial damage has been linked to the accumulation of age-related mitochondrial DNA mutations and mitochondrial dysfunction, possibly through aberrant reactive oxygen species production and defective mitophagy. …”
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508
CANDLE syndrome – a narrative review
Published 2024-09-01“…The syndrome is associated with gene mutations encoding proteasome or immunoproteasome subunits, particularly PSMB8, contributing to disrupted proteostasis and aberrant type 1 interferon production. The diagnostic criteria remain undefined, necessitating a multidisciplinary approach for accurate diagnosis and management. …”
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509
Breast mass - An uncommon clinical manifestation of ovarian carcinoma: A case report and brief literature review
Published 2023-07-01“…In cytology the breast lesion was initially misdiagnosed as primary breast carcinoma and subsequently diagnosed as metastatic ovarian carcinoma based on core needle biopsy findings, aberrant immuno-profile and clinical findings; thus making the complex case worthy of discussion.…”
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510
Alternative Splicing: Emerging Roles in Anti-Aging Strategies
Published 2025-01-01“…Alternative splicing plays a fundamental role in gene expression and protein complexity. Aberrant splicing impairs cell homeostasis and is closely associated with aging and cellular senescence. …”
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511
Une « Laine d’Albâtre » : Quelques cas de surexposition dans la photographie américaine
Published 2013-12-01“…Originally considered a technical aberration, overexposure tends to mythify the American land (Timothy O’Sullivan), leading to forms of divinizing and mystical illumination in 19th century landscape photography. …”
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512
Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-α Production in PBMC of Patients with Behçet’s Disease
Published 2016-01-01“…The pathogenesis of BD is still unknown. Aberrant production of some cytokines/chemokines plays an important role in the pathogenesis of various inflammatory diseases. …”
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513
Color imaging using a system based on 3 diffractive lenses
Published 2023-10-01“…This approach allows us to significantly narrow the spectral range of each lens, thus significantly reducing the image distortion caused by chromatic aberration inherent in diffractive optics. It shows that this scheme allows us to perform the neural network-aided image reconstruction, providing a significantly improved resulting image quality. …”
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514
EZH2 inhibition induces pyroptosis via RHA-mediated S100A9 overexpression in myelodysplastic syndromes
Published 2025-01-01“…Abstract Myelodysplastic Syndromes (MDS) represent a group of heterogeneous myeloid clonal diseases derived from aberrant hematopoietic stem/progenitor cells. Enhancer of zeste homolog 2 (EZH2) is an important regulator in gene expression through methyltransferase-dependent or methyltransferase-independent mechanisms. …”
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515
Potential Role of Meiosis Proteins in Melanoma Chromosomal Instability
Published 2013-01-01“…Here, we review pathways unique to meiosis with a focus on how the aberrant expression of meiosis proteins in normal mitotic cells “meiomitosis” could impact chromosomal instability in melanoma and other cancers.…”
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516
Multi-frame blind deconvolution using X-ray microscope images of an in-plane rotating sample
Published 2024-11-01“…From demonstration experiments using full-field X-ray microscopy with advanced Kirkpatrick–Baez mirror optics at SPring-8, a spatial resolution of 34 nm (half period) was successfully achieved by removing the wavefront aberration and improving the apparent numerical aperture. …”
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517
Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases
Published 2020-01-01“…As aberrant Notch signaling has been linked to cancerous growth, Notch inhibitors represent a novel category of targeted oncological therapy. …”
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518
Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease
Published 2014-01-01“…Excess nutrient intake resulting in adipose tissue expansion triggers lipid release and aberrant adipokine, cytokine and chemokine production, and signaling that ultimately lead to adipose tissue inflammation, a hallmark of obesity. …”
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519
Anatomic Variation of Subclavian Artery Visualized on Ultrasound-Guided Supraclavicular Brachial Plexus Block
Published 2014-01-01“…Hence, a thorough knowledge of the ultrasound anatomy is important in order to identify various aberrations and variations. It is also prudent to perform a preliminary scan, prior to performance of the block to localize the target area and avoid any inadvertent complications.…”
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520
IDH Mutant Cholangiocarcinoma: Pathogenesis, Management, and Future Therapies
Published 2025-01-01“…These neomorphic point mutations endow mutant IDH (mIDH) with the ability to generate an R-enantiomer of 2-hydroxyglutarate (R2HG), a metabolite that drives malignant transformation through aberrant epigenetic signaling. As a result, pharmacologic inhibition of mIDH has become an attractive therapeutic strategy in CCAs harboring this mutation. …”
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