Interplay between Epigenetics and Genetics in Cancer by Jae Duk Choi, Jong-Soo Lee

“…Mechanisms involve both genomic instability and epigenomic aberrations that lose or gain the function of genes that impinge on tumor suppression/prevention or oncogenesis. …”
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Eyes of Aniso-Axial Length Individuals Share Generally Similar Corneal Biometrics with Normal Eyes in Cataract Population by Min Zhang, Tianhui Chen, Michael Deng, Jiahui Chen, Qinghe Jing, Yongxiang Jiang

“…In the longer aniso-axial length group, the posterior corneal aberrations of eyes in the ≥5 mm subgroups were greater than those in the <5 mm subgroups (0.879 ± 0.183 μm vs 0.768 ± 0.178 μm for total aberrations, P<0.001; 0.228 ± 0.086 μm vs 0.196 ± 0.043 μm for high-order aberrations, P=0.036; 0.847 ± 0.173 μm vs 0.741 ± 0.179 μm for low-order aberrations, P=0.001). …”
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The Topographical Effect of Optical Zone Diameter in Orthokeratology Contact Lenses in High Myopes by G. Carracedo, T. M. Espinosa-Vidal, I. Martínez-Alberquilla, L. Batres

“…Contrast sensitivity was decreased in the 5 mm OZ lens design compared with 6 mm OZ design (p-value < 0.05). 5 mm OZ design provoked a greater flattening, more powerful midperipheral ring and 4th-order corneal and total spherical aberration than the 6 mm OZ design, being statistically significant after 7 days, for corneal aberration, and 15 days, for corneal and total, of wearing the lens (p-value < 0.05). …”
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Cone Beam Computed Tomographic Evaluation and Diagnosis of Mandibular First Molar with 6 Canals by Shiraz Pasha, Bathula Vimala Chaitanya, Kusum Valli Somisetty

“…Root canal treatment of tooth with aberrant root canal morphology is very challenging. …”
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COMPARATIVE ANALYSIS OF THE FREQUENCY OF CYTOGENETIC ABNORMALIES IN THE ROOT APICAL MERISTEM OF SPRING BARLEY (<i>HORDEUM VULGARE </i> L.) CULTIVAE SEEDLINGS, CONTRASTING IN THEIR... by A. V. Dikarev, V. G. Dikarev, N. S. Dikareva

“…Comparative analysis of aberration frequencies in cells of most sensitive or tolerant barley cultivars was made. …”
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A Unique Case of Incomplete Bifid Ureter and Associated Arterial Variations by Shivika Ahuja, Hannah Sullivan, Mark Noller, Yun Tan, Daniel Daly

“…Urogenital and vascular anomalies, including a left duplex kidney and a left aberrant renal artery that gave rise to the left ovarian artery, were observed in a 77-year-old female cadaver during a routine dissection. …”
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Wnt/ β-catenin and CTNNB1 gene mutation in hepatocellular carcinoma, a case study in Egyptian patients by Ramy A. Abdelsalam, Ibrahim M. El-Shawaf, Azza Abdel-Aziz, Tarek A. Bismar, Shaimaa M. Yussif

“…The relation between aberrant β-Catenin, Wnt2 IHC staining and CTNNB1 mRNA expression and different clinicopathological characteristics was studied. …”
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DNA Methylation Profiles of Blood Cells Are Distinct between Early-Onset Obese and Control Individuals by Je-Keun Rhee, Jin-Hee Lee, Hae Kyung Yang, Tae-Min Kim, Kun-Ho Yoon

“…Both epigenetic and genetic aberrations may play a role in the pathogenesis of obesity. …”
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STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromes by Zoe King, Sudhamsh Reddy Desai, David A. Frank, Aditi Shastri

“…Aberrant activation of STAT proteins has been implicated as a mediator of oncogenesis in several malignancies. …”
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(Pro)renin Receptor in Kidney Development and Disease by Renfang Song, Ihor V. Yosypiv

“…These forms of CAKUT include renal papillary hypoplasia, hydronephrosis, duplicated collecting system, renal tubular dysgenesis, renal vascular abnormalities, and aberrant glomerulogenesis. Emerging evidence indicates that (pro)renin receptor (PRR), a novel component of the RAS, is essential for proper kidney development and that aberrant PRR signaling is causally linked to cardiovascular and renal disease. …”
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Chromatin remodeling (SWI/SNF) complexes, cancer, and response to immunotherapy by Razelle Kurzrock, Shumei Kato, Nithya Krishnamurthy, Scott Lippman

“…Remarkable, although anecdotal, responses to ICB have been reported in both SMARCA4-aberrant and SMARCB1-aberrant advanced cancers. This review focuses on the role that SWI/SNF chromatin remodeling subunits play in carcinogenesis, the immune microenvironment, and in immunotherapy responsiveness.…”
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A Case Report of Leptomeningeal Myelomatosis and Rapid Improvement with Regimen Consisting of Daratumumab, Pomalidomide, Vincristine, Procarbazine, and Dexamethasone by Jew Win Kuan, Sing Ling Chai, Pathmanathan Rajadurai, Lee Gong Lau, Joseph Uchang, Sharifah Noor Akmal Syed Husain

“…A 61-year-old man was diagnosed with MM with left paravertebral plasmacytoma, R-ISS II with high suspicion of double-hit MM, either biallelic aberrancy of TP53 or del(17p) and IGH aberrancy depending on the definition chosen, treated with lenalidomide-bortezomib-dexamethasone and local radiotherapy, later developed systemic relapse and progression to MM-CNS in the form of leptomeningeal myelomatosis. …”
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The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour by Lynne Sykes, David A. MacIntyre, Xiao J. Yap, Tiong Ghee Teoh, Phillip R. Bennett

“…The majority of publications that report on aberrant Th1:Th2 balance focus on early pregnancy loss and preeclampsia. …”
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The Homogeneous Multiplexed System-a New Method for Autoantibody Profile in Systemic Lupus Erythematosus by Gisele Zandman-Goddard, Boris Gilburd, Ora Shovman, Miri Blank, Svetlana Berdichevski, Pnina Langevitz, Yehuda Shoenfeld

“…Systemic lupus erythematosus (SLE) is a multi-systemic autoimmune disease leading to immunological aberrations and excessive multiple autoantibody production. …”
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Co-Occurrence of Rarest Type of Dysphagia Lusoria (Type N-1) and Eosinophilic Esophagitis in a Cognitively Disabled Individual by Kishore Kumar, Jasbir Makker, Hassan Tariq, Ariyo Ihimoyan, Chime Chukwunonso, Masooma Niazi, Michael Lombino, Muhammad Kamal, Harish K. Patel

“…Dysphagia due to esophageal compression from an aberrant right subclavian artery is rare, and it is termed as “dysphagia lusoria.” …”
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COMPETE BY «HIRCH’S»? by Dmitry A. Novikov

“…The paper analyzes in a polemical form the typical aberrations and myths (common as for officials from science governance, and, often, for the scientists) about the possibility and expediency of using formal bibliometric indicators to assess the working efficiency of individual and collective research activities.…”
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Ectopic Pancreas in Duodenal Wall Putatively Causal for Gastrointestinal Bleeding by O. V. Khlynova, L. G. Girfanova, A. A. Cheremin

“…Aim: Clinical description of an ectopic pancreas (EP) in the duodenal wall.Key points: Aberrant or ectopic pancreas is a congenital abnormality of pancreatic heterotopy into unrelated organs with no connection to the true pancreas. …”
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Comparative Analysis of Visual Performance and Optical Quality with a Rotationally Asymmetric Multifocal Intraocular Lens and an Apodized Diffractive Multifocal Intraocular Lens by Xiao Wang, Haixia Tu, Yong Wang

“…For intraocular optical quality outcomes, statistically significant differences between groups were observed in RMS of intraocular total aberrations, coma, and trefoil high-order aberrations, presenting significantly higher values of these parameters in the eyes of the SBL-3 group (p < 0.01). …”
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HIV-Related Immune Activation and Inflammation: Current Understanding and Strategies by Tingxia Lv, Wei Cao, Taisheng Li

“…Of note, a more profound understanding of the specific mechanisms for aberrant inflammation is still imperative for identifying an effective clinical intervention strategy.…”
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Preimplantation aneuploidy screening using embryonic cell-free DNA isolated from spent culture medium: a case report by Lama Khudari, Marwan Halabi, Sahar Al Fahoum

“…Abstract Background Chromosomal aberrations are frequent in human embryos and can be identified during IVF by performing preimplantation genetic testing for aneuploidies (PGT-A). …”
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