Ligilactobacillus salivarius LZZAY01 accelerated autophagy and apoptosis in colon cancer cells and improved gut microbiota in CAC mice by Wenhong Yang, Tao Li, Shixiang An, Rong Chen, Yuxin Zhao, Jiaxian Cui, Mingyu Zhang, Jingkun Lu, Yunpeng Tian, Lili Bao, Pengwei Zhao

“…A model of colitis-associated cancer (CAC) was established in C57BL/6j mice following induction with AOM/DSS. The levels of autophagy and apoptosis proteins, tight junction proteins, and inflammatory factors were detected by western blotting, immunofluorescence assay, and enzyme-linked immunosorbent assay. …”
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Adaptation for Staphylococcus aureus to hosts via insertion mutation in the accessory gene regulator agrC gene: decreased virulence and enhanced persistence capacity by Jiawei Chen, Yun Wu, Ying Zhu, Li Zhang, Yingchun Xu, Yali Liu

“…ABSTRACT Staphylococcus aureus is an important human pathogen due to its vast array of virulence factors regulated by multiple regulatory mechanisms, including the accessory gene regulator. …”
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Comparison of the STANDARD M10 C. difficile, Xpert C. difficile, and BD MAX Cdiff assays as confirmatory tests in a two-step algorithm for diagnosing Clostridioides difficile infec... by Hyunseul Choi, Minhee Kang, Sun Ae Yun, Hui-Jin Yu, Eunsang Suh, Tae Yeul Kim, Hee Jae Huh, Nam Yong Lee

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Antimicrobial peptide Hs02 with rapid bactericidal, anti-biofilm, and anti-inflammatory activity against carbapenem-resistant Klebsiella pneumoniae and Escherichia coli by Deyi Zhao, Miran Tang, Panjie Hu, Xiaowei Hu, Weijun Chen, Zhexiao Ma, Huanchang Chen, Haifeng Liu, Jianming Cao, Tieli Zhou

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From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes by Ana Luisa Reis, Anusyah Rathakrishnan, Vlad Petrovan, Muneeb Islam, Lynnette Goatley, Katy Moffat, Mai Tuyet Vuong, Yuan Lui, Simon J. Davis, Shinji Ikemizu, Linda K. Dixon

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An inner membrane complex protein IMC1g in Plasmodium berghei is involved in asexual stage schizogony and parasite transmission by Yinjie Liu, Shitong Cheng, Gang He, Dawei He, Duo Wang, Sicong Wang, Lumeng Chen, Liying Zhu, Yonghui Feng, Liwang Cui, Yaming Cao, Xiaotong Zhu

“…Additionally, PbIMC1g was also important for male gametogenesis and ookinete development. …”
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Catabolic pathway acquisition by rhizosphere bacteria readily enables growth with a root exudate component but does not affect root colonization by Stephan Christel, Alyssa A. Carrell, Leah H. Hochanadel, Manuel I. Villalobos Solis, Paul E. Abraham, Sara S. Jawdy, Julie E. Chaves, Nancy L. Engle, Timkhite-Kulu Berhane, Tao Yao, Jin-Gui Chen, Wellington Muchero, Timothy J. Tschaplinski, Melissa A. Cregger, Joshua K. Michener

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Are we serologically prepared against an avian influenza pandemic and could seasonal flu vaccines help us? by Iván Sanz-Muñoz, Javier Sánchez-Martínez, Carla Rodríguez-Crespo, Corina S. Concha-Santos, Marta Hernández, Silvia Rojo-Rello, Marta Domínguez-Gil, Ahmed Mostafa, Luis Martinez-Sobrido, Jose M. Eiros, Aitor Nogales

“…Due to the lack of population immunity in humans and ongoing evolution of AIV, there is a continuing risk that new IAV could emerge and rapidly spread worldwide, causing a pandemic, if the ability to transmit efficiently among humans was gained. The aim of this study is to analyze the basal protection and presence of antibodies against IAV H5N1 and H7N9 subtypes in the population from different ages. …”
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m6A demethylase CpALKBH regulates CpZap1 mRNA stability to modulate the development and virulence of chestnut blight fungus by Lijiu Zhao, Xiangyu Wei, Fengyue Chen, Baoshan Chen, Ru Li

“…Collectively, our findings highlight the essential role of CpALKBH as an m6A demethylase in the development and virulence of C. parasitica, while also elucidating the molecular mechanisms through which m6A modification impacts CpZap1 mRNA stability.IMPORTANCEN6-methyladenosine (m6A) is the most abundant eukaryotic mRNA modification and is involved in various biological processes. …”
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Appearance of green tea compounds in plasma following acute green tea consumption is modulated by the gut microbiome in mice by John D. Sterrett, Kevin D. Quinn, Katrina A. Doenges, Nichole M. Nusbacher, Cassandra L. Levens, Mike L. Armstrong, Richard M. Reisdorph, Harry Smith, Laura M. Saba, Kristine A. Kuhn, Catherine A. Lozupone, Nichole A. Reisdorph

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Lack of activity of HIV-1 integrase strand-transfer inhibitors on recombinase activating gene (RAG) activity at clinically relevant concentrations by Sally Demirdjian, Vincent N. Duong, Jennifer N. Byrum, Arabinda Nayak, Cooper B. McKinney, Jason K. Perry, Christian Callebaut, Karla K. Rodgers, Brie Falkard, Joy Y. Feng

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Emerging carbapenem-resistant Klebsiella pneumoniae in a tertiary care hospital in Lima, Peru by Fiorella Krapp, Diego Cuicapuza, Guillermo Salvatierra, Jean P. Buteau, Catherine Amaro, Lizeth Astocondor, Noemí Hinostroza, Jan Jacobs, Coralith García, Pablo Tsukayama

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Dietary supplementation with compound microecological preparations: effects on the production performance and gut microbiota of lactating female rabbits and their litters by Chengcheng Zhao, Youhao Li, Hui Wang, Ahamba Ifeanyi Solomon, Shuhui Wang, Xianggui Dong, Bing Song, Zhanjun Ren

“…Although antibiotics can reduce pathogenic bacteria, they also harm beneficial microorganisms and disrupt the normal intestinal microbiota balance. …”
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Laboratory evaluation of oral fluid for syphilis screening among clinic users from Lima, Peru by Jazmin Qquellon, Silver K. Vargas, Francesca Vasquez, E. Michael Reyes-Diaz, Kelika A. Konda, Carlos F. Caceres, Jeffrey D. Klausner

“…Oral fluid and serum were analyzed using the SD Bioline Syphilis 3.0 rapid test (Standard Diagnostics Inc., Korea). Serum was also tested using RPR (RPR slide test, Wiener Laboratorios SAIC, Argentina) and TPPA (Serodia, Fujirebio Diagnostics Inc., Japan). …”
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Optogenetic control of horizontally acquired genes prevent stuck fermentations in yeast by David Figueroa, Diego Ruiz, Nicolò Tellini, Matteo De Chiara, Eduardo I. Kessi-Pérez, Claudio Martínez, Gianni Liti, Amparo Querol, José M. Guillamón, Francisco Salinas

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Protein kinases MpkA and SepH transduce crosstalk between CWI and SIN pathways to activate protective hyphal septation under echinocandin cell wall stress by Alexander G. Doan, Jessica E. Schafer, Casey M. Douglas, Matthew S. Quintanilla, Meredith E. Morse, Harley Edwards, Walker D. Huso, Kelsey J. Gray, JungHun Lee, Joshua K. Dayie, Steven D. Harris, Mark R. Marten

“…To better understand this crosstalk, we used a microscopy-based assay to measure septum density, aiming to understand the septation response to cell wall stress. …”
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Engineering a live-attenuated porcine reproductive and respiratory syndrome virus vaccine to prevent RNA recombination by rewiring transcriptional regulatory sequences by Liwei Li, Jinxia Chen, Zhengda Cao, Ziqiang Guo, Jiachen Liu, Yanjun Zhou, Guangzhi Tong, Fei Gao

“…However, owing to the wide variety of live vaccines, non-standard use, and the wild viruses prevalent on pig farms, new strains, generated via RNA recombination, are continuously emerging. Vaccine strains are also involved in PRRSV recombination, which leads to the emergence of new variants and alterations in virulence and pathogenesis. …”
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Preliminary clinical performance of a Cas13a-based lateral flow assay for detecting Neisseria gonorrhoeae in urine specimens by Lao-Tzu Allan-Blitz, Gordon Adams, Gabriela Sanders, Palak Shah, Krithik Ramesh, Jana Jarolimova, Kevin L. Ard, John A. Branda, Jeffrey D. Klausner, Pardis C. Sabeti, Jacob E. Lemieux

“…We previously developed a CRISPR-based lateral flow assay for detecting N. gonorrhoeae. We aimed to pair that assay with point-of-care DNA extraction, assess performance in clinical urine specimens, and optimize assay kinetics. …”
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A novel Alteromonas phage with tail fiber containing six potential iron-binding domains by Chen Yu, Meishun Yu, Ruijie Ma, Shuzhen Wei, Min Jin, Nianzhi Jiao, Qiang Zheng, Rui Zhang, Xuejin Feng

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A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation by Vladimir Majerciak, Beatriz Alvarado-Hernandez, Yanping Ma, Shivalee Duduskar, Alexei Lobanov, Maggie Cam, Zhi-Ming Zheng

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