S-DCNN: prediction of ATP binding residues by deep convolutional neural network based on SMOTE by Sixi Hao, Sixi Hao, Cai-Yan Li, Xiuzhen Hu, Zhenxing Feng, Gaimei Zhang, Caiyun Yang, Huimin Hu

“…Furthermore, when applied to the ATP-221 and ATP-388 datasets for validation, the S-DCNN outperformed existing methods on ATP-221 and performed comparably to other methods on ATP-388 during independent testing.ConclusionOur experimental results underscore the efficacy of the S-DCNN in accurately predicting ATP binding residues, establishing it as a potent tool in the prediction of ATP binding residues.…”
Get full text

The Wilson's disease - etiology, symptoms in various organs, diagnosis, treatment, prognosis by Patryk Graczyk, Paulina Klaudia Kwaśniewska, Anna Wilewska, Kinga Borowiec, Agnieszka Borowiec, Julia Biernikiewicz, Konstanty Alabrudziński, Milena Biernikiewicz, Bartosz Pomirski, Agata Pomirska

“…Introduction: Wilson disease (WD) is a genetic disorder of copper metabolism caused by ATP7B gene mutations, impairing copper excretion and leading to copper accumulation in organs. …”
Get full text

Predicting hepatocellular carcinoma outcomes and immune therapy response with ATP-dependent chromatin remodeling-related genes, highlighting MORF4L1 as a promising target by Chao Xu, Litao Liang, Guoqing Liu, Yanzhi Feng, Bin Xu, Deming Zhu, Wenbo Jia, Jinyi Wang, Wenhu Zhao, Xiangyu Ling, Yongping Zhou, Wenzhou Ding, Lianbao Kong

“…Experimental validation was conducted using quantitative real-time Polymerase Chain Reaction (qRT-PCR), Western blotting, and functional assays in HCC cell lines and xenograft models. Results Our bioinformatics analysis identified four key ACRRGs—MORF4L1, HDAC1, VPS72, and RUVBL2—that serve as prognostic markers for HCC. …”
Get full text

Inhibiting ATP6V0D2 Aggravates Liver Ischemia-Reperfusion Injury by Promoting NLRP3 Activation via Impairing Autophagic Flux Independent of Notch1/Hes1 by Ziyi Wang, Hao Wang, Xuejiao Chen, Sheng Han, Yulin Zhu, Hanhua Wang, Feng Cheng, Liyong Pu

“…Our research fills a gap which has existed in the study of inflammatory stress about the V-ATPase subunit ATP6V0D2 in liver macrophages. …”
Get full text

Pharmacological Characterization of the Mechanisms Involved in Delayed Calcium Deregulation in SH-SY5Y Cells Challenged with Methadone by Sergio Perez-Alvarez, Maria E. Solesio, Maria D. Cuenca-Lopez, Raquel M. Melero-Fernández de Mera, Carlos Villalobos, Hanna Kmita, Maria F. Galindo, Joaquin Jordán

Get full text

Pyrroloquinoline Quinone Improved Boar Sperm Quality via Maintaining Mitochondrial Function During Cryopreservation by Shanpeng Wang, Qi Wang, Lingjiang Min, Hailiang Cao, Adedeji O. Adetunji, Kaifeng Zhou, Zhendong Zhu

“…Due to oxidative damage and mitochondrial dysfunction, boar semen cryopreservation remains a significant challenge. …”
Get full text

Gelatin/Poly (Lactic-Co-Glycolic Acid)/Attapulgite Composite Scaffold Equipped with Teriparatide Microspheres for Osteogenesis in vitro and in vivo by Zhao Z, Feng X, Zhao Y, Song Z, Zhang R, Zhang K, He Y, Chen G, Zhang J, Wang W

“…Four weeks post-implantation, the effectiveness of the scaffolds containing microspheres for repairing skull defects in mice was assessed.Results: Both TPTD microspheres and the GEL/PLGA/ATP scaffold significantly enhanced the proliferation and osteogenic differentiation of BMSCs. …”
Get full text

Elucidation of the Inhibitory Effect of Phytochemicals with Kir6.2 Wild-Type and Mutant Models Associated in Type-1 Diabetes through Molecular Docking Approach by Manaswini Jagadeb, V Badireenath Konkimalla, Surya Narayan Rath, Rohit Pritam Das

“…Among all serious diseases globally, diabetes (type 1 and type 2) still poses a major challenge to the world population. Several target proteins have been identified, and the etiology causing diabetes has been reasonably well studied. …”
Get full text

Management of Neonatal Diabetes due to a KCNJ11 Mutation with Automated Insulin Delivery System and Remote Patient Monitoring by Ming Yeh Lee, Anna L. Gloyn, David M. Maahs, Priya Prahalad

“…Our case highlights the safety and efficacy of these technologies for infants with diabetes, including improvements in glycemia, quality of life, and cost-effectiveness by shortening hospital stay.…”
Get full text

Fine Sieving of Atmospheric Particles in a Collected Air Sample Using Oil Electrophoresis by Xinyue Li, Siyu Xu, Maosheng Yao

“…Furthermore, according to our adenosine triphosphate (ATP) monitoring results, the iSCAPE is capable of separating bacterial particles by size and electrical mobility. …”
Get full text

Platelet-Rich Plasma Improves the Wound Healing Potential of Mesenchymal Stem Cells through Paracrine and Metabolism Alterations by Barbara Hersant, Mounia Sid-Ahmed, Laura Braud, Maud Jourdan, Yasmine Baba-Amer, Jean-Paul Meningaud, Anne-Marie Rodriguez

“…Moreover, PRP treatment ameliorated the survival and activated the proliferation of in vitro cultured MSC and that these effects were accompanied by an alteration of the MSC energetic metabolism including oxygen consumption rate and mitochondrial ATP production. Similar observations were found in vivo following combined administration of PRP and MSC into mouse wounds. …”
Get full text

Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDAC by Yongsheng Li, Zhilong Ding, Tingxin Cheng, Yihuai Hu, Fei Zhong, Shiying Ren, Shiyan Wang

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignant tumor characterized by a complex tumor microenvironment (TME) with significant heterogeneity, posing immense challenges for devising effective therapeutic strategies. …”
Get full text