An investigation into cleaning quality of suction-type metal lumen instruments: a cross-sectional study by Yuqi Wu, Li Li

“…Abstract The highest unqualified cleaning rate of suction-type lumen instruments is a major challenge for a central sterile supply department (CSSD). …”
Get full text

Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis by Kakali Ghoshal, Maitree Bhattacharyya

“…Platelet clinical research faces challenges due to the vulnerable nature of platelet structure functions and lack of accurate assay techniques. …”
Get full text

Fine Sieving of Atmospheric Particles in a Collected Air Sample Using Oil Electrophoresis by Xinyue Li, Siyu Xu, Maosheng Yao

“…Furthermore, according to our adenosine triphosphate (ATP) monitoring results, the iSCAPE is capable of separating bacterial particles by size and electrical mobility. …”
Get full text

The Expanding Family of Bone Marrow Homing Factors for Hematopoietic Stem Cells: Stromal Derived Factor 1 Is Not the Only Player in the Game by Mariusz Z. Ratajczak, ChiHwa Kim, Anna Janowska-Wieczorek, Janina Ratajczak

“…However, this unique role of SDF-1 has been recently challenged by several observations supporting SDF-1-CXCR4-independent BM homing. …”
Get full text

Elucidation of the Inhibitory Effect of Phytochemicals with Kir6.2 Wild-Type and Mutant Models Associated in Type-1 Diabetes through Molecular Docking Approach by Manaswini Jagadeb, V Badireenath Konkimalla, Surya Narayan Rath, Rohit Pritam Das

“…Among all serious diseases globally, diabetes (type 1 and type 2) still poses a major challenge to the world population. Several target proteins have been identified, and the etiology causing diabetes has been reasonably well studied. …”
Get full text

Inhibition of hippocampal interleukin-6 receptor-evoked signalling normalises long-term potentiation in dystrophin-deficient mdx mice by Kimberley A. Stephenson, Aaron Barron, Mark G. Rae, Dervla O'Malley

“…Given the importance of mitochondria-generated ATP in synaptic plasticity, reduced maximal respiration in the CA1 region may impact upon this process. …”
Get full text

A new-to-nature photosynthesis system enhances utilization of one-carbon substrates in Escherichia coli by Tian Tong, Xiulai Chen, Kexin Tang, Wanrong Ma, Cong Gao, Wei Song, Jing Wu, Xiaoling Wang, Gao-Qiang Liu, Liming Liu

“…A light reaction is reconstructed using the photosystem of photosynthetic bacteria, increasing ATP and NADH contents by 337.9% and 383.7%, respectively. …”
Get full text

DockCADD: A streamlined in silico pipeline for the identification of potent ribosomal S6 Kinase 2 (RSK2) inhibitors by El Mehdi Karim, Meriem Khedraoui, Abdelkbir Errougui, Yasir S. Raouf, Abdelouahid Samadi, Samir Chtita

“…Ligands L1, L2 and L3 showed stable binding within the ATP-binding pocket, wherein the compounds undergo slight structural distortions with a favorable van der Waal's interaction. …”
Get full text

A Rewired NADPH-Dependent Redox Shuttle for Testing Peroxisomal Compartmentalization of Synthetic Metabolic Pathways in <i>Komagataella phaffii</i> by Albert Fina, Sílvia Àvila-Cabré, Enrique Vázquez-Pereira, Joan Albiol, Pau Ferrer

“…However, measuring subcellular concentrations of these metabolites remains technically challenging. Here, we explored 3-hydroxypropionic acid (3-HP), readily quantifiable and sharing the same precursors—acetyl-CoA, NADPH, and ATP—with the above-mentioned products, as a reporter metabolite for peroxisomal engineering in the yeast <i>Komagataella phaffii</i>. …”
Get full text

Platelet-Rich Plasma Improves the Wound Healing Potential of Mesenchymal Stem Cells through Paracrine and Metabolism Alterations by Barbara Hersant, Mounia Sid-Ahmed, Laura Braud, Maud Jourdan, Yasmine Baba-Amer, Jean-Paul Meningaud, Anne-Marie Rodriguez

“…Chronic and acute nonhealing wounds represent a major public health problem, and replacement of cutaneous lesions by the newly regenerated skin is challenging. Mesenchymal stem cells (MSC) and platelet-rich plasma (PRP) were separately tested in the attempt to regenerate the lost skin. …”
Get full text

Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDAC by Yongsheng Li, Zhilong Ding, Tingxin Cheng, Yihuai Hu, Fei Zhong, Shiying Ren, Shiyan Wang

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignant tumor characterized by a complex tumor microenvironment (TME) with significant heterogeneity, posing immense challenges for devising effective therapeutic strategies. …”
Get full text

Identification of Salvia miltiorrhiza germplasm resources based on metabolomics and DNA barcoding by Gaojie He, Jinhui Man, Ying Chen, Xiaoqin Zhang, Xin Wang, Kelu An, Laha Amu, Wenqin Chen, Baowei Wang, Yue Shi, Yue Shi, Xiaohui Wang, Xiaohui Wang, Shengli Wei, Shengli Wei

“…However, the presence of adulterants and intraspecific variability poses challenges to its clinical safety.MethodsThis study collected samples of S. miltiorrhiza from various regions and commonly encountered adulterants. …”
Get full text

The multifaceted anti-atherosclerotic properties of herbal flavonoids: A comprehensive review by Meiwen Huang, Xuena Xie, Rong Yuan, Qiqi Xin, Shudong Ma, Hongai Guo, Yu Miao, Chunyu Hu, Yizhun Zhu, Weihong Cong

“…Various targets participate in these physiological processes, encompassing acyl-CoA: cholesterol acyltransferase (ACAT), ATP citrate lyase (ACLY), nuclear factor erythroid 2-related factor 2 (Nrf2), krüppel-like factor 2 (KLF2), NOD-like receptor protein 3 (NLRP3), transcription factor EB (TFEB) and so on. …”
Get full text

Transcriptomic, histological and biochemical analyses of Macrobrachium nipponense response to acute heat stress by Xiao Wu, Yaoran Fan, Jianbin Feng, Keyi Ma, Jiale Li

“…These DEGs were significantly involved in the regulation of transcription, proteolysis, nucleus, cytoplasm, metal ion binding, and ATP binding by Gene ontology (GO) enrichment analysis. …”
Get full text

NIR-triggered programmable nanomotor with H2S and NO generation for cascading oncotherapy by three-pronged reinforcing ICD by Jinlong Zhang, Quan Jing, Longlong Yuan, Xianhui Zhou, Duolong Di, Jinyao Li, Dong Pei, Zhongxiong Fan, Jun Hai

“…It is worth noting that the anti-tumor response of mPTT is effectively enhanced by GT by disrupting the mitochondrial respiratory chain, inhibiting ATP production, and promoting tumor cell apoptosis. …”
Get full text

Selected Abstracts of the 20th International Workshop on Neonatology and Pediatrics; Cagliari (Italy); October 23-26, 2024 by --- Various Authors

“…Vendemmia (Naples, Italy) ABS 45. ATP: A POTENTIAL WEAPON AGAINST HCAI IN THE NICU • G. …”
Get full text