Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis by Yan Lin, Yu Dong, Yanfeng Gao, Ranran Shi, Yubing Li, Xiuman Zhou, Wenwen Liu, Guodong Li, Yuanming Qi, Yahong Wu

“…In this study, we identified cytotoxic T lymphocyte epitopes on drug resistance-associated membrane protein efflux pumps of MTB, the ATP-binding cassette and the major facilitator superfamilies. …”
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Inhibiting ATP6V0D2 Aggravates Liver Ischemia-Reperfusion Injury by Promoting NLRP3 Activation via Impairing Autophagic Flux Independent of Notch1/Hes1 by Ziyi Wang, Hao Wang, Xuejiao Chen, Sheng Han, Yulin Zhu, Hanhua Wang, Feng Cheng, Liyong Pu

“…At present, liver ischemia-reperfusion (IR) injury is still a great challenge for clinical liver partial resection and liver transplantation. …”
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Pharmacological Characterization of the Mechanisms Involved in Delayed Calcium Deregulation in SH-SY5Y Cells Challenged with Methadone by Sergio Perez-Alvarez, Maria E. Solesio, Maria D. Cuenca-Lopez, Raquel M. Melero-Fernández de Mera, Carlos Villalobos, Hanna Kmita, Maria F. Galindo, Joaquin Jordán

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On Typical Flaws of the Transformer Models for Inrush Current Evaluation by Serhii Zirka, Yurii Moroz

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Exploring the Prevalence and Components of Metabolic Syndrome in Sub-Saharan African Type 2 Diabetes Mellitus Patients: A Systematic Review and Meta-Analysis by Nelson Musilanga, Hussein Nasib, Given Jackson, Frank Shayo, Clarkson Nhanga, Saleh Girukwigomba, Ambokile Mwakibolwa, Samson Henry, Keneth Kijusya, Edgar Msonge

“…Central obesity was the most prevalent component of metabolic syndrome, with a pooled prevalence of 55.9% and 61.6% using NCEP-ATP III 2004 and IDF criteria, respectively. There was no statistical evidence of publication bias in both the NCEP-ATP III 2004 and IDF pooled estimates. …”
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Resveratrol-loaded metal-organic framework for mitochondria-targeted amplified CO gas therapy by Fengqin Wang, Yinfang Jiang, Yang Wang

“…However, the primary challenge in gas therapy is the effective delivery of gas prodrug to targeted sites, as well as achieving precise spatial-temporal control over their release behavior. …”
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Resveratrol Alleviates NEFA-Induced Oxidative Damage in Bovine Mammary Epithelial Cells by Restoring Mitochondrial Function by Longwei Sun, Junpeng Huang, Xiangyang Dou, Zhenyu Dong, Yuan Li, Shujing Tan, Ran Yu, Chengmin Li, Weiguo Zhao

“…RES treatment restored mitochondrial function in NEFA-stressed BMECs, as evidenced by the increase in MMP, ATP generation and NAD⁺/NADH ratio accompanying the decline in mitochondrial structural abnormalities and cell apoptosis. …”
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Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation by Adam Aguirre, Carola J. Maturana, Paloma A. Harcha, Juan C. Sáez

“…Consequently, activated microglia and astrocytes release ATP and glutamate, affecting myelinization, neuronal development, and survival. …”
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Endothelial Cells Potentially Participate in the Metastasis of Triple-Negative Breast Cancer by Yanfei Ma, Yanghong Li, Pengwei Guo, Jingjie Zhao, Qiang Qin, Jiajia Wang, Zhengfang Liang, Dalong Wei, Zechen Wang, Jiajia Shen, Siyuan He, Qianli Tang, Guanming Lu, Guiling Shi, Lingzhang Meng

“…Inhibition of triple-negative breast cancer metastasis has long been a challenge, mainly due to the difficulty in identifying factors that contribute to this process. …”
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Pyrroloquinoline Quinone Improved Boar Sperm Quality via Maintaining Mitochondrial Function During Cryopreservation by Shanpeng Wang, Qi Wang, Lingjiang Min, Hailiang Cao, Adedeji O. Adetunji, Kaifeng Zhou, Zhendong Zhu

“…Additionally, 1000 nM PQQ increased mitochondrial membrane potential (MMP) and ATP levels, while decreasing MDA and mitochondrial ROS levels, and reducing DNA damage (<i>p</i> < 0.05). …”
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Management of Neonatal Diabetes due to a KCNJ11 Mutation with Automated Insulin Delivery System and Remote Patient Monitoring by Ming Yeh Lee, Anna L. Gloyn, David M. Maahs, Priya Prahalad

“…Management of hyperglycemia in neonates with subcutaneous insulin is challenging because of frequent feeding, variable quantity of milk intake with each feed, low insulin dose requirements, and high risk for hypoglycemia and associated complications in this population. …”
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An investigation into cleaning quality of suction-type metal lumen instruments: a cross-sectional study by Yuqi Wu, Li Li

“…Abstract The highest unqualified cleaning rate of suction-type lumen instruments is a major challenge for a central sterile supply department (CSSD). …”
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Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis by Kakali Ghoshal, Maitree Bhattacharyya

“…Platelet clinical research faces challenges due to the vulnerable nature of platelet structure functions and lack of accurate assay techniques. …”
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Fine Sieving of Atmospheric Particles in a Collected Air Sample Using Oil Electrophoresis by Xinyue Li, Siyu Xu, Maosheng Yao

“…Furthermore, according to our adenosine triphosphate (ATP) monitoring results, the iSCAPE is capable of separating bacterial particles by size and electrical mobility. …”
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The Expanding Family of Bone Marrow Homing Factors for Hematopoietic Stem Cells: Stromal Derived Factor 1 Is Not the Only Player in the Game by Mariusz Z. Ratajczak, ChiHwa Kim, Anna Janowska-Wieczorek, Janina Ratajczak

“…However, this unique role of SDF-1 has been recently challenged by several observations supporting SDF-1-CXCR4-independent BM homing. …”
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Elucidation of the Inhibitory Effect of Phytochemicals with Kir6.2 Wild-Type and Mutant Models Associated in Type-1 Diabetes through Molecular Docking Approach by Manaswini Jagadeb, V Badireenath Konkimalla, Surya Narayan Rath, Rohit Pritam Das

“…Among all serious diseases globally, diabetes (type 1 and type 2) still poses a major challenge to the world population. Several target proteins have been identified, and the etiology causing diabetes has been reasonably well studied. …”
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Inhibition of hippocampal interleukin-6 receptor-evoked signalling normalises long-term potentiation in dystrophin-deficient mdx mice by Kimberley A. Stephenson, Aaron Barron, Mark G. Rae, Dervla O'Malley

“…Given the importance of mitochondria-generated ATP in synaptic plasticity, reduced maximal respiration in the CA1 region may impact upon this process. …”
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DockCADD: A streamlined in silico pipeline for the identification of potent ribosomal S6 Kinase 2 (RSK2) inhibitors by El Mehdi Karim, Meriem Khedraoui, Abdelkbir Errougui, Yasir S. Raouf, Abdelouahid Samadi, Samir Chtita

“…Ligands L1, L2 and L3 showed stable binding within the ATP-binding pocket, wherein the compounds undergo slight structural distortions with a favorable van der Waal's interaction. …”
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A Rewired NADPH-Dependent Redox Shuttle for Testing Peroxisomal Compartmentalization of Synthetic Metabolic Pathways in <i>Komagataella phaffii</i> by Albert Fina, Sílvia Àvila-Cabré, Enrique Vázquez-Pereira, Joan Albiol, Pau Ferrer

“…However, measuring subcellular concentrations of these metabolites remains technically challenging. Here, we explored 3-hydroxypropionic acid (3-HP), readily quantifiable and sharing the same precursors—acetyl-CoA, NADPH, and ATP—with the above-mentioned products, as a reporter metabolite for peroxisomal engineering in the yeast <i>Komagataella phaffii</i>. …”
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Platelet-Rich Plasma Improves the Wound Healing Potential of Mesenchymal Stem Cells through Paracrine and Metabolism Alterations by Barbara Hersant, Mounia Sid-Ahmed, Laura Braud, Maud Jourdan, Yasmine Baba-Amer, Jean-Paul Meningaud, Anne-Marie Rodriguez

“…Chronic and acute nonhealing wounds represent a major public health problem, and replacement of cutaneous lesions by the newly regenerated skin is challenging. Mesenchymal stem cells (MSC) and platelet-rich plasma (PRP) were separately tested in the attempt to regenerate the lost skin. …”
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