Toward enhancement of antibody thermostability and affinity by computational design in the absence of antigen by Mark Hutchinson, Jeffrey A. Ruffolo, Nantaporn Haskins, Michael Iannotti, Giuliana Vozza, Tony Pham, Nurjahan Mehzabeen, Harini Shandilya, Keith Rickert, Rebecca Croasdale-Wood, Melissa Damschroder, Ying Fu, Andrew Dippel, Jeffrey J. Gray, Gilad Kaplan

“…The 200 variants were produced through a robust high-throughput method and tested for thermal and colloidal stability (Tonset, Tm, Tagg), affinity (KD) relative to the parental antibody, and for developability parameters (nonspecific binding, aggregation propensity, self-association). Of the designed clones, 91% and 94% exhibited increased thermal and colloidal stability and affinity, respectively. …”
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Analgesic Effect of Passive Range-of-Motion Exercise on the Healthy Side for Pain after Total Knee Arthroplasty: A Prospective Randomized Trial by Shuichi Eto, Motoki Sonohata, Yasuo Takei, Masaya Ueno, Norio Fukumori, Masaaki Mawatari

“…In this prospective randomized controlled trial, participants were randomly assigned to two groups: a bilateral group that received bilateral exercise on the operated and healthy sides and a unilateral group that received exercise therapy only on the affected side. …”
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Türkiye’de Gaspıralı Gündemi Üzerine Bir Değerlendirme by Volkan Marttin

“…Gaspıralı fikir ve faaliyetleriyle Rusya sınırlarını aşmış, Türk ve Müslümanların yaşadığı yerlere ulaşabilmiştir. …”
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Les pratiques culturelles juvéniles en ligne en Algérie by Farid Ladjouzi, Aïssa Merah

“…This text examines one aspect of youth cultural practices and digital culture in Algeria. …”
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Psoriatic arthritis: An up to date overview by Simon Hackett, Laura Coates

“…The classification of disease has been refined over recent years following the development of criteria such as ClASsification of PsA criteria. In addition to classification, treatment options for PsA have continued to expand over recent years, with the development of monoclonal antibody therapies targeting the underlying immunological mediators involved in PsA such as interleukin (IL)-17, tumor necrosis factor-alpha, and IL-23. …”
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Brain‐Derived Neurotrophic Factor (BDNF) as a Potential Biomarker in Brain Glioma: A Systematic Review and Meta‐Analysis by Fatemeh Hasani, Mahdi Masrour, Sina Khamaki, Kimia Jazi, Erfan Ghoodjani, Antonio L. Teixeira

“…After screening and data extraction, we conducted quality assessment, meta‐analysis, and meta‐regression. Results Eight studies were included. …”
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Armand Mattelard et Erik Neveu. Introduction aux Cultural Studies. by Michel Imbert

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Changes to Intermediary Metabolites in Sporadic and LRRK2 Parkinson’s Disease Demonstrated by Proton Magnetic Resonance Spectroscopy by Jan O. Aasly, Oddbjørn Sæther, Krisztina K. Johansen, Tone F. Bathen, Guro F. Giskeødegård, Linda R. White

“…Results from patients with sporadic PD or LRRK2-PD were compared with asymptomatic LRRK2 mutation carriers and healthy control individuals. …”
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Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies by Lucile Musset, Makoto Miyara, Olivier Benveniste, Jean-Luc Charuel, Alexander Shikhman, Olivier Boyer, Richard Fowler, Andrew Mammen, Joe Phillips, Michael Mahler

“…Anti-HMGCR antibodies are not always associated with the use of statin and appear to be the exclusive autoantibody specificity in patients with statin associated myopathies.…”
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High Reliable Relay Selection Approach for QoS Provisioning in Wireless Distributed Sensor Networks by Yong Jin

“…To address this problem, we focus on the reliable adaptive relay selection approach and adaptive QoS supported algorithm, based on which we present a Markov chain model, in consideration of different packet states and error control algorithm assignment. The mathematical analyses and NS-2 simulation results show that the proposed relay selection approach could perform better in terms of saturation throughput, reliability, and energy efficiency, compared with the traditional approaches. …”
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Role of world financial insitutions in de-shadowing of global economy by Оlena Baula, Olena Liutak

“…The article examines the practical aspects of the influence of world financial institutions on preventing the spread of shadowing processes in the global economy. …”
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XXVIII. Kütüphane Haftası Açılış Töreni Konuşmaları (30 Mart 1992) by Necmeddin Sefercioğlu

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Economic Impact of Postoperative Urinary Retention in the US Hospital Setting by Weijia Wang, Arielle Marks-Anglin, Vladimir Turzhitsky, Robert J. Mark, Aurelio Otero Rosales, Nathaniel W. Bailey, Yiling Jiang, Joseph Abueg, Ira S. Hofer, Toby N. Weingarten

“…These findings support the use of NMB reversal agents associated with a lower incidence of POUR.…”
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Chinese and western medicine treatment of myocardial fibrosis drugs by Yuxi Zhu, Yuxi Zhu, Fangmei Zhang, Zhongcheng Li, Yu Zhou, Yi Shu, Jian Ruan, Guo Chen

“…Traditional Chinese medicines, such as Salvia miltiorrhiza, Astragalus, and Angelica extracts, and patent Chinese medicines, such as Qiliqiangxin capsules, Shenqi Yiqi dropping pills, and Tongxinluo capsules, can improve myocardial fibrosis. …”
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Gaps in Capacity in Primary Care in Low-Resource Settings for Implementation of Essential Noncommunicable Disease Interventions by S. Mendis, Igbal Al Bashir, Lanka Dissanayake, Cherian Varghese, Ibtihal Fadhil, Esha Marhe, Boureima Sambo, Firdosi Mehta, Hind Elsayad, Idrisa Sow, Maltie Algoe, Herbert Tennakoon, Lai Die Truong, Le Thi Tuyet Lan, Dismond Huiuinato, Neelamni Hewageegana, Naiema A. W. Fahal, Goitom Mebrhatu, Gado Tshering, Oleg Chestnov

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Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome by Kenneth A. Iczkowski, Kathleen C. Torkko, Gregory R. Kotnis, R. Storey Wilson, Wei Huang, Thomas M. Wheeler, Andrea M. Abeyta, M. Scott Lucia

“…In conclusion, digitally measured pseudolumen size and shape may associate with outcome.…”
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Numerical Simulation and Optimization of Outdoor Wind Environment in High-Rise Buildings Zone of Xuzhou City by Huanhuan Fang, Xiang Ji, Jiuxin Wang, Jijun Lu, Mengcheng Yang, Jiajun Li, Zhongcheng Duan

“…Utilizing Computational Fluid Dynamics (CFD) simulations, the research identifies key wind-related challenges associated with high-rise buildings in representative settlements. …”
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Effect of carbonation curing and sodium content on geopolymer subjected to sodium and magnesium sulfate attack by Amanda Venancio Trisotto, Tassiane Apolinário de Oliveira, Maytê Dionísio Marçon, Neusa Aparecida Munhak Beltrame, Ronaldo Alves de Medeiros-Junior

“… Abstract Geopolymer cement stands as an alternative to Portland cement to reduce the impacts associated with its production. This material is also affected by ions that can damage its mechanical properties and reduce its durability. …”
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Liver-specific gene PGRMC1 blocks c-Myc-induced hepatocarcinogenesis through ER stress-independent PERK activation by Fubo Ji, Jianjuan Zhang, Liping Mao, Yaqi Tan, Meihua Ye, Xianglei He, Yongzhi Zhao, Jiaxin Liu, Yan Zhang, Nachuan Zhang, Jiong Shi, Jianing Yan, Xiujun Cai, Bin Zhao, Jianping Jin, Pinglong Xu, Stephanie Roessler, Xin Zheng, Junfang Ji

“…Among the c-Myc- and patient prognosis-associated LSGs, PGRMC1 significantly blocks c-Myc-induced orthotopic HCC formation. …”
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Modeling feasibility and prediction of minimum and maximum temperature in Iran by bettitt and Holt-Winters methods by Ahmad reza ghasemi

“…Air temperature is one of the most frequently used parameters in the assessment of climate change at global and regional scale. …”
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