Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage by David Reisman, Paula Takahashi, Amanda Polson, Kristy Boggs

“…Numerous studies have demonstrated that p53 transcription is activated before or during early S-phase in cells progressing from G0/G1 into S-phase through the combined action of two DNA-binding factors RBP-Jκ and C/EBPβ-2. Here, we review evidence that this induction occurs to provide available p53 mRNA in order to prepare the cell for DNA damage in S-phase, this ensuring a rapid response to DNA damage before exiting this stage of the cell cycle.…”
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Exposure to triphenyl phosphate during pregnancy: The role of gut-bile acids-liver axis on lipid metabolism in male offspring by Juntong Lin, Fuhui Yan, Longhui Liu, Ganzhong Liao, Yilei Xu, Qian Liu, Miaoliang Wu, Honghui Guo, Bai Zhi, Lianxian Guo, Xiaoshan Liu

“…Measurements of gene expression along the gut-BAs-liver axis showed that the TPhP treatment group had an increase in cholesterol-7alpha-hydroxylase (CYP7A1) and a decrease in apical sodium-dependent bile acid transporter (ASBT), with only the low-dose group exhibiting an increase in carbohydrate response element binding protein (ChREBP). Correlation and mediation analysis highlighted associations of Burkholderiaceae in low-dose treatment group and Erysipelotrichaceae in high dose group with lipid metabolism and BAs metabolites. …”
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Targeted Inhibition of GATA-3 by Pyrrothiogatain: Implications for Adipocyte Biology and Inflammatory Response by Shamma Almuraikhy, Maha Alser, Khaled Naja, Aisha Al-Malki, Nayef A. Mazloum, Mohamed A. Elrayess

“…As expected, GATA-3 knockout cells exhibited enhanced adipogenic capacity, characterized by increased cell and lipid droplet sizes, and upregulated expression of key adipogenic markers including CEBPβ, PPARγ, and PGC-1α. Pyrrothiogatain treatment reduced cell proliferation in both wild-type and GATA-3 knockout 3T3-L1 cells, but did not alter their adipogenic capacity. …”
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Comparison of Platelet-Rich Plasma-Impregnated Suture Material with Low and High Platelet Concentration to Improve Colonic Anastomotic Wound Healing in Rats by Mehmet Akif Aydin, Eray Metin Guler, Ahu Senem Demiroz, Muhammet Fatih Aydin, Gulcan Saglam

“…Rats were sacrificed on the postoperative 7th day for analysis of colonic anastomosis region including macroscopic observation, measurement of anastomotic bursting pressure (ABP), and the hydroxyproline levels and histopathological findings in colon tissue samples. …”
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Comparative Effects of Sulforaphane and Allyl Isothiocyanate on 3T3-L1 Adipogenesis by Satoru Sakuma, Kana Yasuda, Risa Kitahara, Kaho Tsujimoto, Kishiko Yamashita, Naohiro Hoshino, Yohko Fujimoto, Keiichiro Okuhira

“…We found that, at a concentration as low as one-tenth that of allyl isothiocyanate, sulforaphane reduced triacylglycerol levels, lipid-filled adipocyte quantity, and mRNA and protein levels of CCAAT-enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ). …”
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Spontaneous Intracranial Hypotension Treated with a Targeted CT-Guided Epidural Blood Patch by Inês Correia, Inês Brás Marques, Rogério Ferreira, Miguel Cordeiro, Lívia Sousa

“…After failure of conservative treatment, a targeted computer tomography-guided EBP was performed, with complete recovery.…”
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Deep-Learning Prediction Model with Serial Two-Level Decomposition Based on Bayesian Optimization by Xue-Bo Jin, Hong-Xing Wang, Xiao-Yi Wang, Yu-Ting Bai, Ting-Li Su, Jian-Lei Kong

“…The power load data of American Electric Power (AEP) were used to verify the proposed predictor. …”
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Efecto de las estrategias didácticas activas en las actitudes hacia la química y su interacción con el estilo cognitivo by Gladys Elena Hurtado Osorio

“…En este artículo se muestran y analizan los efectos en las actitudes hacia el aprendizaje de la química, con la aplicación de tres estrategias didácticas de enseñanza (aprendizaje basado en problemas — ABP— , aprendizaje por descubrimiento guiado —ADG — y enseñanza para la comprensión —EPC — ) en tres grupos de estudiantes de educación media, diferenciados por su estilo cognitivo en la dimensión dependencia- independencia de campo. …”
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Mechanisms of Chronic State of Inflammation as Mediators That Link Obese Adipose Tissue and Metabolic Syndrome by Eduardo Fuentes, Francisco Fuentes, Gemma Vilahur, Lina Badimon, Iván Palomo

“…Meanwhile, the chronic inflammation in adipose tissue is regulated by a series of transcription factors, mainly PPARs and C/EBPs, that in conjunction regulate the expression of hundreds of proteins that participate in the metabolism and storage of lipids and, as such, the secretion by adipocytes. …”
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MODIFIED LAUTENBACH TECHNIQUE AND EXTERNAL FIXATION AS A TREATMENT FOR INFECTED NON-UNION OF THE SUBTROCHANTER FEMUR: A CASE REPORT by Mouli Edward, Teddy Heri Wardhana, Erfan Nasrullah

“…In this report, we present a 20-yo woman with infected subtrochanter femur following open reduction internal fixation (ORIF)with angle blade plate (ABP) 95o. One stage surgery was performed involving implant removal, debridement, definite external fixation, and antibiotic delivery using modified Lautenbach technique. …”
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Aprendizaje basado en proyectos con enfoque STEAM; una experiencia de integración entre matemáticas, ciencias naturales y artes by Ramiro Adolfo Jimenez Leal

“…Integrando con los saberes de ciencias naturales y artes aplicando la metodología del aprendizaje basado en proyectos (ABP) con enfoque STEAM (sus siglas hacen referencia a la integración de las ciencias, tecnología, ingeniería, artes y matemáticas). …”
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Effects of Different Types of Pinching in Growth and Yield of Two Varieties of Okra (Abelmoschus esculentus L.) in Pokhara, Kaski, Nepal by Prajjwal Koirala, Rijwan Sai, Pratikshya Subedi, Chiranjibi Khadka

“…The treatments includes two okra varieties (Arka Anamika and Parbati) and 4 pinching types (apical bud pinching (P1), ABP along with 1 leaf pinching (P2), and ABP along with 2 leaf pinching (P3) and control (P4)). …”
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Safety analysis in the era of large language models: A case study of STPA using ChatGPT by Yi Qi, Xingyu Zhao, Siddartha Khastgir, Xiaowei Huang

“…This study examines the application of Systems Theoretic Process Analysis (STPA) to Automatic Emergency Brake (AEB) and Electricity Demand Side Management (DSM) systems, utilising Chat Generative Pre-Trained Transformer (ChatGPT). …”
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Customized Allogeneic Bone Augmentation Improves Esthetic Outcome in Anteromaxillary Dental Implantation by Manfred Nilius, Minou Hélène Nilius, Charlotte Mueller, Bernhard Weiland, Dominik Haim, Anna Krahe, Guenter Lauer

“…It allows predictable advanced backward planning (ABP) even in the maxillary esthetic zone. Diameter-reduced implants show long-term stability of a minimum of three years after loading and excellent results of prosthetic fixtures. …”
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Obesity-Induced Methylation of Osteopontin Contributes to Adipogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells by Min Tang, Rui Chen, Hao Wang, Guowei Sun, Fan Yin, Beibei Liang, Yang Yang, Gaowa Sharen, Huafeng Wei, Xuyu Zhou, Gang Huang, Jian Zhao

“…Additionally, OPN suppresses adipogenic differentiation in ASCs through the C/EBP pathways. Consistent with these in vitro results, by intravenous injection of OPN-expressing adenovirus to the mice, we found OPN can delay the development of obesity and improve insulin sensitivity. …”
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The Specific Dermatoses of Pregnancy by Paulina Polańska

“…They encompass four primary conditions: atopic eruption of pregnancy (AEP), polymorphic eruption of pregnancy (PEP), intrahepatic cholestasis of pregnancy (ICP), and pemphigoid gestationis (PG). …”
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Discriminative training of spiking neural networks organised in columns for stream‐based biometric authentication by Enrique Argones Rúa, Tim Vanhamme, Davy Preuveneers, Wouter Joosen

“…One of the challenges when using SNNs is the discriminative training of the network since it is not straightforward to apply the well‐known error backpropagation (EBP), massively used in traditional artificial neural networks (ANNs). …”
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Tangshenning Attenuates High Glucose-Induced Podocyte Injury via Restoring Autophagy Activity through Inhibiting mTORC1 Activation by Jiayi Xu, Xiaomeng Shan, Chunwei Chen, Yanbin Gao, Dawei Zou, Xiaolei Wang, Tao Wang, Yimin Shi

“…Results showed that TSN treatment enhanced the weakened nephrin expression and autophagic activity of podocytes and inhibited the mTORC1 pathway (p-mTOR, mTOR, p-p70S6K, p70S6K, ULK1, and 4EBP1) under high glucose conditions. Furthermore, the mTORC1 activator (siRNA-TSC2) partially inhibited the above beneficial effects of TSN, suggesting that mTORC1 was the target of TSN to regulate autophagy. …”
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Energy and Wake effects Optimization of Offshore Wind Farm using PSO algorithm by Ouhdan Mahmoud, Ait Madi Abdessalam, Hassoine Mohammed Amine

“…To tackle this problem, the research has developed a multi-objective optimization framework in Python that shows the Pareto front, which illustrates the trade-off between wake effects and (AEP) by using a particle swarming optimization (PSO) algorithm. …”
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Mealworm-Derived Protein Hydrolysates Enhance Adipogenic Differentiation via Mitotic Clonal Expansion in 3T3-L1 Cells by Hee-Jeong Ryu, Syng-Ook Lee

“…Fh-T facilitated adipogenesis by promoting mitotic clonal expansion (MCE) during the early stage of differentiation, which was associated with the upregulation of C/EBPδ and the downregulation of p27. These findings underscore the potential of mealworm-derived protein hydrolysates, particularly Fh-T, as sustainable and functional ingredients for use in glycemic control, skin health, and tissue regeneration. …”
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