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From ex vivo to in vivo chimeric antigen T cells manufacturing: new horizons for CAR T-cell based therapy
Published 2025-01-01“…Abstract In the past decades, Chimeric Antigen Receptor (CAR)-T cell therapy has achieved remarkable success, leading to the approval of six therapeutic products for haematological malignancies. …”
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82
POLITIK ISLAM MAHATHIR MOHAMMAD DI MALAYSIA DAN SOEHARTO DI INDONESIA
Published 2018-06-01“…Due to the monetary crisis and democratic reforms in 1998 affected the Soeharto regime to step down and make an end to all of the political projects he has designed. …”
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83
Temporal and Spatial Characteristics of Precipitation in West River Basin Based on Remote Sensing Precipitation
Published 2023-01-01“…To accurately analyze the spatial and temporal characteristics of precipitation in the West River Basin,this paper evaluates the applicability of GPM precipitation data in the West River Basin from 2001 to 2019 by the measured precipitation data from 34 meteorological stations in the basin and quantitatively analyzes the spatiotemporal variation characteristics of precipitation in the West River Basin based on the GPM data.The results show that the GPM data are consistent with the measured precipitation data with reasonable errors,and have applicability in the West River Basin.The annual precipitation in the basin shows an overall upward trend,and the characteristics of alternate stages of drought and flood periods.The precipitation from April to September accounts for 78.39% of the whole year.The spatial distribution of annual and monthly precipitation shows a gradually increasing trend from west to east step by step.The precipitation has increased in the past 19 years,but 72.39% of the areas do not reach the confidence level of 90%.The degree of precipitation variation is mainly moderate,accounting for 66.24%.In the past 19 years,78.50% of the areas have shown reverse continuous precipitation,and 61.16% of the areas where precipitation increased in the past 19 years do not reach the confidence level of 90%.The future precipitation is likely to reverse to a decreasing trend.The research results can provide theoretical support for scientific planning of West River Basin water resources and promoting the high-quality development of river basin water conservancy in the new stage.…”
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84
Proper Orthogonal Decomposition as Surrogate Model for Aerodynamic Optimization
Published 2016-01-01“…In the first case, the boundary shape of the problem is deformed and the flow past a backward facing step with variable step slope is studied. …”
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85
L’historien et le jeu-vidéo
Published 2018-10-01“…Leaving this postulate, this article has two objectives. Offer a historical step of analysis of the object-game to grab in what the historian can use this medium to understand stakes of the representations of past in popular culture. …”
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86
Clinical Holistic Medicine (Mindful, Short-Term Psychodynamic Psychotherapy Complemented with Bodywork) Improves Quality of Life, Health, and Ability by Induction of Antonovsky-Sal...
Published 2007-01-01“…The treatment responders radically improved their self-assessed physical health (0.6 step), self-assessed mental health (1.6 step), their relation to self (1.2 step), friends (0.3 step), and partner (2.1 step on a 6-step scale), and their ability to love (1.2 step) and work (0.8 step), and to function socially (1.0 step) and sexually (0.8 step). …”
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87
From Eastern European Rooted Immigrant Circle to the Mainstream of American Culture an Alfred Kazin's Transition
Published 2021-10-01“…Many of the immigrant children regarded this type of attitude as another logical step in their development. But although this incorporation into the mainstream of the American culture was fruitful, some of them experienced a deep sense of irreversible loss over their past.…”
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88
The snow avalanches risk on Alpine roads network
Published 2014-10-01“…These indicators were modeled using the graph theory in a GIS framework, integrating avalanche activity indicators derived from the past activity with the road network. …”
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89
Weathering products in glacial silt and clay: Using automated mineralogy to probe size distribution and source
Published 2025-12-01“…Characterizing the mineral alterations that occur subglacially is a step toward identifying the chemical weathering reactions that control the balance of dissolved species in glacial meltwaters and a step toward understanding the source of clay minerals from present and past glacial environments.…”
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90
Systematic coarse-graining of sequence-dependent structure and elasticity of double-stranded DNA
Published 2025-01-01“…For scenarios where the local stretch modulus is inconsequential, this range can be significantly increased by only considering the rotational degrees of freedom, which permits faithful coarse-grained representation up to several helical repeats. Rather than providing a fully parametrized model, we present the methodology and software necessary for mapping any base pair-step model to the desired level of coarse-graining. …”
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91
Digital Twins and Enabling Technology Applications in Mining: Research Trends, Opportunities, and Challenges
Published 2025-01-01“…Although the mining industry has not undergone revolutionary digital change, numerous technologies have been applied and improved during the past two decades. Through a systematic literature survey, this study presents research trends, opportunities, and challenges in the context of digital twinning in the mining industry. …”
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92
Investigating Factors Affecting Location by Meta-Analysis
Published 2022-06-01“…In the second step, the coefficient of effect size was evaluated using the second version of CMA software. …”
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93
Research on Comprehensive Evaluation of Food Governance Sustainable Development Based on Entropy Weight Method
Published 2025-01-01“…Based on the availability of data, entropy weight method is used to carry out empirical evaluation on the index data of the past three years. Variability in the index data provide suggestions for the sustainable development path of food governance in the next step.…”
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94
Numerical simulation of dynamic brittle fracture of pipeline steel subjected to DWTT using XFEM-based cohesive segment technique
Published 2016-03-01“…In the past several numerical studies have addressed the ductile mode of fracture propagation. …”
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95
Covoiturage au Grand-Nokoué et plateformes numériques de mobilité partagée en Afrique de l'Ouest
Published 2024-04-01“…Shared mobilities, particularly carpooling, foster a paradox in Africa. While bush taxis have experienced historic success for the past 50 years due to traditional sharing practices transposed into public transport, modernization through digital platforms is struggling to take root in a sustainable way. …”
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96
Efficient Strategy to Identify Gene-Gene Interactions and Its Application to Type 2 Diabetes
Published 2016-12-01“…Over the past decade, the detection of gene-gene interactions has become more and more popular in the field of genome-wide association studies (GWASs). …”
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97
Quantum many-body physics calculations with large language models
Published 2025-01-01“…We evaluate GPT-4’s performance in executing the calculation for 15 papers from the past decade, demonstrating that, with the correction of intermediate steps, it can correctly derive the final Hartree-Fock Hamiltonian in 13 cases. …”
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98
How Large Is the Risk of Stagflation in the Eurozone?
Published 2022-02-01“…Abstract The rapid recovery of demand combined with supply constraints has led to rising prices during the past months. This is evident in oil and gas markets, but also in international trade, which has been thrown out of step by bottlenecks at Asian ports. …”
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Geografia dos campeões: migração, força de trabalho e nacionalidade de argentinos e franceses na Copa do Mundo do Catar 2022
Published 2023-12-01“…The aim of this article is to promote a debate around this sport as a face of the current stage of globalization, breaking with the borders of the past and interlinking migratory flows of the workforce with the question of the nationality (or dual nationality) of the players. …”
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