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    Microbial metabolites and immune modulation by Hassan Ghasemi

    Published 2024-12-01
    “…Propionate, another SCFA, has been linked to the inhibition of histone deacetylases, which are involved in gene regulation, further supporting anti-inflammatory pathways.3,4 These metabolites also modulate macrophage function by promoting a shift toward an anti-inflammatory M2 phenotype, a process essential for resolving inflammation and facilitating tissue repair.5 Additionally, they enhance gut barrier integrity by upregulating proteins involved in epithelial tight junctions, reducing the translocation of harmful microbial components into systemic circulation and thereby mitigating systemic inflammation.6 Secondary bile acids, produced through the microbial biotransformation of primary bile acids synthesized in the liver, exhibit immunomodulatory properties. …”
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    AI-based tumor-infiltrating lymphocyte scoring system for assessing HCC prognosis in patients undergoing liver resection by Zhiyang Chen, Tingting Xie, Shuting Chen, Zhenhui Li, Su Yao, Xuanjun Lu, Wenfeng He, Chao Tang, Dacheng Yang, Shaohua Li, Feng Shi, Huan Lin, Zipei Li, Anant Madabhushi, Xiangtian Zhao, Zaiyi Liu, Cheng Lu

    Published 2025-02-01
    “…Results: In the discovery cohort, the 5-year overall survival (OS) rates were 34.05% for ATLS-8 low-score and 65.03% for ATLS-8 high-score groups (hazard ratio [HR] 2.40; 95% CI, 1.37–4.19; p = 0.015). These findings were confirmed in validation cohort 1, which had 5-year OS rates of 28.57% and 68.73% (HR 3.38; 95% CI, 1.27–9.02; p = 0.0098), and validation cohort 2, which had 59.26% and 81.48% (HR 2.74; 95% CI, 1.05–7.15; p = 0.031). …”
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