A novel nanocarrier based on natural polyphenols enhancing gemcitabine sensitization ability for improved pancreatic cancer therapy efficiency by Yuman Dong, Jieru Li, Yiwei Dai, Xinyu Zhang, Xiangyan Jiang, Tao Wang, Bin Zhao, Wenbo Liu, Haonan Sun, Pengcheng Du, Long Qin, Zuoyi Jiao

“…Despite the widespread use of gemcitabine (Gem)-based chemotherapy as the first-line treatment for PC, its efficacy is often compromised by significant drug resistance. 1,2,3,4,6-Pentagaloyl glucose (PGG), a natural polyphenol, has demonstrated potential in sensitizing PC cells to Gem. …”
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Synthesis and Antimicrobial Activity of Some Novel Chalcones of 2-Hydroxy -1-Acetonapthone and 3-Acetyl Coumarin by Y. Rajendra Prasad, P. Ravi Kumar, Ch. Asha Deepti, M. Venkata Ramana

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Synthesis and Anti-Inflammatory Activity of a Novel Series of Diphenyl-1,2,4-triazoles and Related Derivatives by Swapna Cherala, Harikiran Lingabathula, Rama Ganta, Srinivas Ampati, Sarangapani Manda

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Design, synthesis, and in vitro, in vivo, and in silico evaluation of novel substituted 1,3,4-thiadiazole derivatives as anticonvulsant agents by Tulika Anthwal, Swati Pant, Preeti Rana, Sumitra Nain

“…In the present study, a library of ten novel substituted 1,3,4‐thiadiazole derivatives were designed and synthesized using an appropriate synthetic route. …”
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Reverse-Phase Chromatographic Determination and Intrinsic Stability Behavior of 5-[(4-Chlorophenoxy)Methyl]-1,3,4-Oxadiazole-2-Thiol by Shehzadi Naureen, Hussain Khalid, Islam Muhammad, Bukhari Nadeem Irfan, Khan Muhammad Tanveer, Salman Muhammad, Siddiqui Sabahat Zahra, Rehman Aziz-Ur, Abbasi Muhammad Athar

“…The study describes the development and preliminary validation of a simple reverse-phase chromatographic method for determination of a novel drug candidate, 5-[(4-chlorophenoxy) methyl]-1,3,4-oxadiazole-2-thiol (OXCPM), in bulk and stressed solution, in order to find out the intrinsic stability behavior of the compound. …”
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A Novel 2.3 Mb Microduplication of 9q34.3 Inserted into 19q13.4 in a Patient with Learning Disabilities by Shalinder Singh, Fern Ashton, Renate Marquis-Nicholson, Jennifer M. Love, Chuan-Ching Lan, Salim Aftimos, Alice M. George, Donald R. Love

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Electrochemical Corrosion Performance of N80 steel in Acidized 10% HCl medium using 4-methyl-1-Phenyl-3-(p-tolyldiazenyl) −2,3-dihydro-1H-pyrrol-2-ol by Reham H. Wahba, Adel Z. El-Sonbati, Mostafa A. Diab, Esam A. Gomaa, Marwa N. El-Nahass, Y.M. Abdallah

“…Background: In this study, the azo dye, 4-methyl-1-phenyl-3-(p-tolyldiazenyl)-2,3-dihydro-1H-pyrrol-2-ol (MPTHP) was synthesized and estimated as a novel inhibitor for protecting N80 steel from corrosion in a 10 % HCl acidic environment. …”
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Synthesis of Some Metal Complexes with New Heterocyclic Ligand (5-(((2-(3-(1<i>H</i>-indol-3-yl)acryloyl)phenyl)amino)methylene)-2-thiooxodihydropyrimidine-4,6(1<i>H</i>,5<i>H</i>)... by Thanaa Abdul Ameer Hilal, Ibtihal Kadhim Kareem

“…A novel ligand 5-(((2-(3-(1H-indol-3-yl)acryloyl)phenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione) (L1) which contains two groups of carbonyl synthesized in one pot and three-component reaction with thiobarbituric acid as starting material, and its complexes with Co(II), Ni(II), Cu(II), Zn(II) and Au(III) have been synthesized. …”
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Synthesis of Novel Iono- and Photochromic Spiropyrans Derived from 6,7-Dihydroxy-8-Formyl-4-Methyl-2H-Chromene-2-One by Olga G. Nikolaeva, Alexey V. Tsukanov, Evgenii N. Shepelenko, Boris S. Lukyanov, Anatoly V. Metelitsa, Olga Yu. Kostyrina, Alexander D. Dubonosov, Vladimir A. Bren, Vladimir I. Minkin

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Synthesis of bioactive quinazolin-4(3H)-one derivatives via microwave activation tailored by phase-transfer catalysis by El-Badry Yaser A., El-Hashash Mahr A., Al-Ali Khalil

“…The most active, even more active than the reference 5-fluorouracil, were found to be ethyl 4-[(4-oxo-2-propylquinazolin-3(4H)-yl)methyl]benzoate (3c), 3-{2-[6-(pyrrolidin-1-yl-sulfonyl)-1,2,3,4-tetrahydroquinoline]-2-oxoethyl}-2-propylquinazolin--4(3H)-one (3e), N’-[(E)-(2H-1,3-benzodioxo-5-yl)methylidene]-2-(4-oxo-2-propylquinazolin-3(4H)-yl)acetohydrazide (10a), N’-[(E)-(4-hydroxyphenyl)methylidene]-2-(4-oxo-2-propylquinazo-lin-3(4H) -yl)acetohydrazide (10b) and N’-[(E)-(4-nitrophenyl)methyl idene]-2-(4-oxo-2-propylquinazolin-3(4H)-yl)acetohydrazide (10c).…”
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Synthesis of novel benzo fused bridged azaheterocycles through the reaction of chalcone with hydrazone by Congyang Li, Ruochen Pang, Weiwu Ren

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Synthesis of Novel 1,2,4-Triazole Derivatives as Antimicrobial Agents via the Japp-Klingemann Reaction: Investigation of Antimicrobial Activities by Tasneem Taj, Ravindra R. Kamble, Atukuri Dorababu, Gangadhar Y. Meti

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Novel MOF-based vanadium and 2,2 -bipyridine-4,4 -dicarboxylic acid as phenomenal dye adsorbent and antimicrobial agent by Baraa Mohammed Yaseen, Farag M. A. Altalbawy, Farag M. A. Altalbawy, Rafid Jihad Albadr, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Hiba Mushtaq, Khursheed Muzammil, Ahmed Hussein Zwamel, Ahmed Hussein Zwamel, Ahmed Hussein Zwamel

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Studies on Novel N4-[4,6-Diaryl-2-pyrimidinyl]-7-chloro-4-quinolinamine and their Microbicidal Efficacy by Arvind G. Mehta, Avnish A. Patel

“…Novel pyrimidine quinoline clubbed molecules 3a-h have been prepared by reaction of 2a-h with 4,7-dichloroquinoline. …”
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Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses by Valentina Stock, Rebecca Hofer, Franziska Lochmann, Vera Spanke, Klaus R. Liedl, Jakob Troppmair, Thierry Langer, Hubert Gstach, Christian Dank, Chris A. Mayhew, Sarah Kammerer, Veronika Ruzsanyi

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Syntheses, structures and anticancer activities of CuII and ZnII complexes containing 1,1′-[(3-fluorophenyl)methylene]bis[3-(3-fluorophenyl)imidazo[1,5-a]pyridine] by Hai Le Thi Hong, Hau Nguyen Van, Duong Hoang Tuan, Hung Tran Quang, Tuan Dang Thanh, Luc Van Meervelt

“…Two novel complexes, [Cu(T4)Cl2] and [Zn(T4)Cl2], were synthesized from 1,1′-[(3-fluorophenyl)methylene]bis[3-(3-fluorophenyl)imidazo[1,5-a]pyridine] (T4), and copper(II) and zinc(II) chloride, respectively. …”
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Synthesis of Some Novel Fluorinated/Nonfluorinated α-Amino Acids, Bearing 3-Thioxo-5-oxo-1,2,4-triazin-6-yl and Steroidal Moieties, and Evaluation of Their Amylolytic Effects against Some Fungi, Part-II by Reda M. Abdel-Rahman, Wafa A. Bawazir

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Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway by Su Qing, Xu Baolin, Tian Zhoubin, Gong Ziling

“…The entire set of compounds showed significant to moderate inhibition of both kinases in the nanomolar range. The three most active compounds: 4e (N-(4-(3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)acryloyl)phenyl)-4-nitrobenzamide), 4f (N-(4-(3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)acryloyl)phenyl)-4-chlorobenzamide) and 4g (4-bromo-N-(4-(3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)acryloyl)phenyl)benzamide), were evaluated for anticancer activity against human OS cancer cell line (MG-63), liver cancer cell line (HepG2), lung cancer cell line (A549) and cervical cancer (HeLa), using MTT assay. …”
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3-bromo-4-(2-hydroxyethyl)-7-methoxy-2H-chromen-2-one inhibits allergic reactions in IgE-mediated RBL-2H3 cells and a passive cutaneous anaphylaxis mouse model by Moonsu Kim, Huiji Kim, Sun Young Moon, Seong-Ah Shin, Minji Kim, Seyeon Choi, Sugeun Gwon, Jun Hyuck Lee, Hyun Ho Park, Chang Sup Lee

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Improved Photocatalytic Performance of a Novel Fe3O4@SiO2/Bi2SiO5 Hierarchical Nanostructure with Magnetic Recoverability by Xinxin Zhang, Xiaoli Dong, Baiyu Leng, Hongchao Ma, Xiufang Zhang

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