PD-1 cis-targeted IL-2v in combination with radiotherapy inhibits lung cancer growth and remodels the immune microenvironment by Pedro J Romero, Sara Labiano, Gregory Verdeil, Christian Klein, Pablo Umana, Tania Wyss, Christine Trumpfheller, Marie-Catherine Vozenin, Céline Godfroid, Jackeline Romero, Vincent Roh, Genrich V Tolstonog, Chia-Hsien Chuang, Andrea Kelemen, Laura Codarri Deak

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Comparative analysis between abdominal aortic aneurysm and popliteal artery aneurysm by Marcos Vinícius Melo de Oliveira, MD, PhD, Alexandre Malta Brandão, MD, PhD, Gina Camillo Rocha Silvestre, BS, Alexandre Queiroz Silva, BS, Michele Alberto Marques, BS, Marcia Martins Reis, PhD, Maria de Lourdes Higuchi, MD, PhD, Erasmo Simão da Silva, MD, PhD

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Association between adult body shape index and serum levels of the anti-aging protein Klotho in adults: a population-based cross-sectional study of the NHANES from 2007 to 2016 by Li Gong, Jinghan Xu, Yiyang Zhuang, Liwei Zeng, Zhenfei Peng, Yuzhou Liu, Yinluan Huang, Yutian Chen, Fengyi Huang, Chunli Piao

“…Higher ABSI was associated with lower serum Klotho concentrations; however, this association did not seem to be significant in subjects with BMI ≥30 kg/m2.Further study is needed to verify the causality of this association and elucidate the underlying mechanisms.…”
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Direct engulfment of synapses by overactivated microglia due to cadmium exposure and the protective role of Nrf2 by Siyao Li, Mingdan You, Chengjie Chen, Jingqi Fu, Yuanyuan Xu, Jingbo Pi, Yi Wang

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Optimization of the management of pregnant women with new COVID-19 coronavirus infection: An open prospective cross-sectional study by Irina V. Medyannikova, Yuliya Ch. Kuklis, Irina V. Saveljeva, Galina B. Beznoshchenko, Elena G. Galyanskaya, Olga Yu. Tsygankova, Galina V. Krivchik, Elena A. Bukharova, Natalya V. Nosova, Pavel V. Davidov

“…In 32 pregnant women of the main group with a high risk of obstetric complications, the treatment approach included endotheliotropic agent sulodexide and acetylsalicylic acid in addition to the standard of care for the underlying disease. Results. The severe course of COVID-19 in pregnant women is associated with the high rate of placental disorders (odds ratio – OR 6.1; 95% confidence interval – CI 2.6–14.9), fetal growth retardation (OR 5.6; 95% CI 1.2–30.2), preeclampsia (OR 8.5; 95% CI 3.4–22.4), premature birth (OR 14.1; 95% CI 5.8–38.4), surgical delivery (OR 8.5; 95% CI 4.1-18.1), low birth weight of newborns (OR 18.0; 95% CI 6.4–62.2), hospitalization in the neonatal intensive care unit (OR 25.4; 95% CI 6.4–67.0). …”
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BeatProfiler: Multimodal In Vitro Analysis of Cardiac Function Enables Machine Learning Classification of Diseases and Drugs by Youngbin Kim, Kunlun Wang, Roberta I. Lock, Trevor R. Nash, Sharon Fleischer, Bryan Z. Wang, Barry M. Fine, Gordana Vunjak-Novakovic

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The institutionalisation of research and innovation in Swiss sports federations – Analysis of the status quo by Cornel Gübeli, Hippolyt Kempf, Solange Emmenegger, Christelle Ganné-Chedeville

“…Further research is needed to identify the underlying challenges of federations, for them to stay internationally competitive and adaptable to societal changes. …”
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Evaluating choroidal vascular changes in young adults with high myopia utilizing swept source optical coherence tomography angiography by Qing wang, Lin-Bo He, Sha Li, Hong-Ling Liu, Yong Liu

“…Results: SCP and DCP densities in the foveal retina of NHM group were significantly lower than those in HM group(SCP 20.09 ± 4.30 vs. 21.54 ± 4.52, p = 0.043;DCP14.73 ± 3.93 vs. 16.21 ± 4.07, p = 0.024). …”
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Clinical characteristics and risk factors of severe pneumonia caused by human bocavirus in children by Zhuxia Li, Wenjing Gu, Fengming Zhu, Enze Han, Yongdong Yan, Huiquan Sun, Weidong Xu, Xin Zhang, Li Huang, Shan Gao, Yuqing Wang, Chuangli Hao, Xinxing Zhang

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Unraveling Online Mental Health Through the Lens of Early Maladaptive Schemas: AI-Enabled Content Analysis of Online Mental Health Communities by Beng Heng Ang, Sujatha Das Gollapalli, Mingzhe Du, See-Kiong Ng

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Exploring the Dynamics of Brent Crude Oil, S&P500 and Bitcoin Prices Amid Economic Instability by Adela Bara, Irina Alexandra Georgescu, Simona-Vasilica Oprea, Marian Pompiliu Cristescu

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A Community-Based Intervention for Mental Health and Wellbeing in Pregnancy and Postpartum: One Healthy Start Site’s Story by Sampson M, Xu W, York FN, Roberson J

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CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation by Donghua Cai, Chuling Li, Yingyuan Zhang, Sisi He, Yihai Guo, Wangjun Liao, Yulin Liao, Jianping Bin, Xiang He

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Biotechnological Effects of <i>Lactobacillus plantarum</i>, Cellulase, and Xylanase on Nutritional Quality and Microbial Community Structure of Corn Stover Silage by Jianliang Liu, Mingjian Liu, Panjie Sheng, Chaoran Song, Weiqin Ma, Baochao Bai, Jiayu Zhao, Shuai Du, Gentu Ge, Zhijun Wang, Yushan Jia

“…Treatments with <i>Lactobacillus plantarum</i>, cellulase, and xylanase were applied, and silage samples were analyzed after 30 and 60 days of fermentation to assess fermentation quality, nutritional quality, and microbial community structure. …”
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Investigating the impact of microbiome-changing interventions on food decision-making: MIFOOD study protocol by Meghedi Vartanian, Konrad Jakob Endres, Yee Teng Lee, Silke Friedrich, Marie-Theres Meemken, Imke Schamarek, Kerstin Rohde-Zimmermann, Robin Schürfeld, Lina Eisenberg, Anja Hilbert, Frauke Beyer, Michael Stumvoll, Julia Sacher, Arno Villringer, Julia F. Christensen, A. Veronica Witte

“…Previous research indicates that the gut microbiome plays an important role in metabolic, hormonal, and neuronal cross-talk underlying eating behavior. We therefore aim to examine the effects of prebiotic and neurocognitive behavioral interventions on food decision-making and to assay the underlying mechanisms in a Randomized Controlled Trial (RCT). …”
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New Information and Communication Technologies for climate services: Evidence from farmers in Ada East District, Ghana by Rebecca Sarku, Famous Addi, Emmanuel M.N.A.N. Attoh

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Conduction system pacing using electro-anatomical mapping-guided system vs. fluoroscopy: a systematic review, meta-analysis and economic evaluation by Beatriz León-Salas, Beatriz León-Salas, Beatriz León-Salas, Beatriz León-Salas, Diego Infante-Ventura, Diego Infante-Ventura, Diego Infante-Ventura, Aránzazu Hernández-Yumar, Aránzazu Hernández-Yumar, Aránzazu Hernández-Yumar, Renata Linertová, Renata Linertová, Renata Linertová, Renata Linertová, Estefanía Herrera-Ramos, Estefanía Herrera-Ramos, Estefanía Herrera-Ramos, Estefanía Herrera-Ramos, Alezandra Torres-Castaño, Alezandra Torres-Castaño, Alezandra Torres-Castaño, Alezandra Torres-Castaño, Himar González-Pacheco, Himar González-Pacheco, Himar González-Pacheco, Himar González-Pacheco, Analía Abt-Sacks, Analía Abt-Sacks, Analía Abt-Sacks, Analía Abt-Sacks, Javier García-García, Raúl Quirós-López, Raúl Quirós-López, María M. Trujillo-Martín, María M. Trujillo-Martín, María M. Trujillo-Martín, María M. Trujillo-Martín

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Deciphering the effect of exercise timing on glucose metabolism: a randomised controlled trial by Fabienne Bruggisser, Denis Infanger, Henner Hanssen, Raphael Knaier

“…After ingestion of a solution containing 75 g of dextrose, serum glucose was measured at fasting and subsequently after 10, 20, 30, 60, 90, and 120 min. Serum glucose response was quantified over 120 min by calculating the area under the curve (AUC) using the trapezoidal method. …”
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Prediction model for type 2 diabetes mellitus and its association with mortality using machine learning in three independent cohorts from South Korea, Japan, and the UK: a model de... by Hayeon Lee, Seung Ha Hwang, Seoyoung Park, Yunjeong Choi, Sooji Lee, Jaeyu Park, Yejun Son, Hyeon Jin Kim, Soeun Kim, Jiyeon Oh, Lee Smith, Damiano Pizzol, Sang Youl Rhee, Hyunji Sang, Jinseok Lee, Dong Keon Yon

“…Findings: In the discovery cohort, the ensemble model using voting with logistic regression and adaptive boosting achieved a balanced accuracy of 72.6% and an area under the receiver operating characteristics curve (AUROC) of 0.792. …”
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Effects of dietary l-carnosine supplementation on the growth, intestinal microbiota, and serum metabolome of fattening lambs by Yaxuan Meng, Yaxuan Meng, Yaxuan Meng, Tingting Xian, Tingting Xian, Guolei Kang, Hongna Wang, Tao Feng, Tao Feng, Tao Feng

“…However, the mechanisms underlying the effects of l-carnosine on the physiological functions of animals have not been fully elucidated. …”
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