Synergistic activity of Pitstop-2 and 1,6-hexanediol in aggressive human lung cancer cells by Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Luca Matteo Todesca, Félix Alexandre Antunes Soares, Victor Shahin

“…We have previously demonstrated the ability of two different types of compounds to interfere with linchpins of metabolic reprogramming, Pitstop-2 and 1,6-hexanediol (1,6-HD). 1,6-HD disrupts glycolysis enzymes and mitochondrial function, enhancing reactive oxygen species production and reducing cellular ATP levels, while Pitstop-2 impedes clathrin-mediated endocytosis and small GTPases activity. …”
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Mutation Analysis of HTRA2 Gene in Chinese Familial Essential Tremor and Familial Parkinson’s Disease by Ya-Chao He, Pei Huang, Qiong-Qiong Li, Qian Sun, Dun-Hui Li, Tian Wang, Jun-Yi Shen, Juan-Juan Du, Shi-Shuang Cui, Chao Gao, Rao Fu, Sheng-Di Chen

“…There was no difference in allele, genotype, and haplotype between groups. Conclusions. HTRA2 exonic variant might be rare among Chinese Parkinson’s disease and essential tremor patients with family history, and HTRA2 may not be the cause of familial Parkinson’s disease and essential tremor in China.…”
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A Role of Fluoride on Free Radical Generation and Oxidative Stress in BV-2 Microglia Cells by Xi Shuhua, Liu Ziyou, Yan Ling, Wang Fei, Guifan Sun

“…Our study found that NaF of concentration from 5 to 20 mg/L can stimuli BV-2 cells to change into activated microglia displaying upregulated OX-42 expression. …”
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Physicochemical Differences in the Leaves of the Two <i>Agave salmiana</i> Subspecies Grown in Different Regions by Oscar Campos-Herrera, Leopoldo González-Cruz, Guillermo Antonio Silva-Martínez, Norma Leticia Flores-Martínez, Rosa Isela Ortíz-Basurto, Aurea Bernardino-Nicanor

“…Although both regions have clay soils, some differences in cation exchange capacity (CEC) and nutrient concentration were found, which may have induced changes in leaf size in <i>Agave</i> during the adaptation process. …”
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Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion. by Harriet V Mears, George R Young, Theo Sanderson, Ruth Harvey, Jamie Barrett-Rodger, Rebecca Penn, Vanessa Cowton, Wilhelm Furnon, Giuditta De Lorenzo, Margaret Crawford, Daniel M Snell, Ashley S Fowler, Anob M Chakrabarti, Saira Hussain, Ciarán Gilbride, Edward Emmott, Katja Finsterbusch, Jakub Luptak, Thomas P Peacock, Jérôme Nicod, Arvind H Patel, Massimo Palmarini, Emma Wall, Bryan Williams, Sonia Gandhi, Charles Swanton, David L V Bauer

“…Our findings demonstrate that SARS-CoV-2 is undergoing evolutionary changes at the functional RNA level in addition to the amino acid level.…”
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Benthic algal community dynamics on Palmyra Atoll throughout a decade with two thermal anomalies by Adi Khen, Maggie D. Johnson, Michael D. Fox, Jennifer E. Smith

“…Long-term monitoring of coral reef algal communities is critical for understanding their differential responses to thermal stress and can improve projections of ecosystem functioning in the context of global change.…”
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Shear-Dependent Yield Stress of Iron Ore Fine Tailings in Two-Step Flocculation Process by Ying Yang, Hongjiang Wang, Bern Klein, Aixiang Wu

“…In order to explore the change rule of the yield stress and its internal causes, a two-step flocculation process of the iron ore fine tailings with different shear conditions in the four different phases was designed. …”
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Anti-SARS-CoV-2 Biotherapeutics and Chemotherapeutics: An Insight into Product Specifications and Marketing Dynamics by Vijay Kotra, Dinakar Mallem, Anil Kumar Kanuri, Mahesh Reddy Burra, Shaik Nyamathullah, Looi Shu Ying, Khairul Anwar Husain, Ravi Varala, Madhadevi Sudhakar, Khang Wen Goh, Toong Hai Sam, Long Chiau Ming

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HEAT DISSIPATION ON THE LATERAL SURFACE OF CYCLONE CHAMBER WITH ASYMMETRICAL TWO-WAY GAS INPUT AND OUTPUT by E. N. Saburov, N. V. Smolina

“…In the experiences on the camera with the bilateral asymmetrical conditions for the introduction of gases the asymmetry of the introduction of flow was created due to a change in the relative entrance area whoo remained constant. …”
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Fission yeast cells deficient in siderophore biosynthesis require Str2 for ferrichrome-dependent growth by Berthy Mbuya, Samuel Plante, Tobias Vahsen, Ariane Brault, Simon Labbé

“…Like Str1, Str2 expression is transcriptionally regulated in response to changes in iron concentrations. …”
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Evaluation of Coal Pore Connectivity Using N2 Sorption Isotherm and Spontaneous Imbibition Tests by Tong-qiang Xia, Jiao-fei He, Shi-xing Fan, Qiang-qiang Zhang, Zi-long Li, Dun-shuai Sun

“…In order to investigate them, six typical coal samples from different collieries in China (Yangcun, Changcun, Gengcun, Yanbei, Dongxia, and Yuwu coal) are selected to carry out N2 sorption isotherm and spontaneous imbibition tests. …”
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Iterative Analytical Solutions for Nonlinear Two-Phase Flow with Gas Solubility in Shale Gas Reservoirs by Xiaoji Shang, J. G. Wang, Zhizhen Zhang

“…Thirdly, the convergence and accuracy of the solutions are checked through history matching of two sets of gas production data: a China shale gas reservoir and a horizontal Barnett shale well. …”
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SEM-2/SoxC regulates multiple aspects of C. elegans postembryonic mesoderm development. by Marissa Baccas, Vanathi Ganesan, Amy Leung, Lucas R Pineiro, Alexandra N McKillop, Jun Liu

“…We have identified a novel partial loss-of-function sem-2 allele that has a proline to serine change in the C-terminal tail of the highly conserved DNA-binding domain. …”
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Electronic and photophysical properties of copper (II) Complexes: Insights into solvatochromic Effects, Photoreduction, and fluorescence behavior by Haja Tar, Lama M. Alhomaidan, Lotfi Beji, Abrar S. Alnafisah, Noura Kouki, Sabri Messaoudi, Fahad M. Alminderej, Azizah A. Algreiby, Lotfi M. Aroua

“…While HL1 exhibits a single peak, HL2 displays two peaks, findings supported by calculated transition energies and oscillator strengths.Moreover, the oxidation processes of copper complexes with iodide salt and triethylamine unveil favorable electron transfer mechanisms, as corroborated by cyclic voltammograms and free energy change values. …”
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First Basic Problem of Elasticity Theory for a Composite Layer with Two Thick-Walled Tubes by Oleksandr Yu. Denshchykov, Valentyn P. Pelykh, Yaroslav V. Hrebeniuk, Vitalii Yu. Miroshnikov

“…In addition to the absolute value of stresses, changes in the character of the diagrams and the sign are possible. …”

The Effect of CaCl₂ on the Gelling Properties of Pea Protein–Pectin Dispersions by Dan Zhang, Da Chen, Osvaldo H. Campanella

“…In PostCa gels, their elasticity increased with the CaCl₂ content, a rheological change associated with the formation of denser microstructures. …”
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Quantitative and O2 Enhanced MRI of the Pathologic Lung: Findings in Emphysema, Fibrosis, and Cystic Fibrosis by Alfred Stadler, Leopold Stiebellehner, Peter M. Jakob, Johannes F. T. Arnold, Edith Eisenhuber, Isabella von Katzler, Alexander A. Bankier

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Inadequate Lymph Node Yield: An Inadequate Indication for Adjuvant Chemotherapy in Stage II Colon Cancer by Alan Zambeli-Ljepović, MD, MHS, Daniel Hoffman, MD, Katherine E. Barnes, BS, Fernanda Romero-Hernandez, MD, Amir Ashraf Ganjouei, MD, MPH, Mohamed A. Adam, MD, Ankit Sarin, MD, MHA

“…This study aims to determine whether the survival benefit of ACT in stage II disease varies based on the adequacy of LNY. …”
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AMEND 2.0: module identification and multi-omic data integration with multiplex-heterogeneous graphs by Samuel S. Boyd, Chad Slawson, Jeffrey A. Thompson

“…Results We present AMEND 2.0, an updated active module identification method which can analyze multiplex and/or heterogeneous networks integrated with multi-omic data in a highly generalizable framework, in contrast to existing methods, which are mostly appropriate for at most two specific omic types. …”
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Continuously relapsing (for two years) course of diarrheal variant of IBS (<i>Clinical case</i>) by Ye. A. Poluektova, S. Yu. Kuchumova, A. A. Kurbatova, A. A. Sheptulin, O. S. Shifrin, V. T. Ivashkin

“…The patient was repeatedly examined, but according to carried out investigation no significant changes were revealed. Antispasmodics of various groups, enzyme and antisecretory agents in this relation were prescribed to him without any noteworthy effect for two years prior to admission to Vasilenko Clinic of internal diseases propedeutics, gastroenterology and hepatology. …”
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