Leptin Receptor Deficiency Protects Mice against Chronic Cerebral Hypoperfusion-Induced Neuroinflammation and White Matter Lesions by Yu Du, Yufei Song, Xiaojie Zhang, Yan Luo, Wenying Zou, Jiawei Zhang, Jianliang Fu

“…Therefore, we performed bilateral common carotid artery stenosis (BCAS) to induce CCH on the leptin receptor- (LepR-) deficient db/db mice, aiming to evaluate the possible involvement of leptin in CCH-induced cognitive impairment, WMLs, and neuroinflammation, and further explore the effect of leptin on chronic hypoxia-induced inflammation using the BV2 microglial cell line. After four weeks of BCAS, wild-type mice showed significant working memory deficits, WMLs, activation of microglia and astrocytes, decrease in the number of oligodendrocytes, downregulation of myelin basic protein expression, and increase in the expression of TNF-α and IL-1β; however, four weeks of BCAS failed to induce significant changes in the LepR-deficient db/db mice but elevated the production of anti-inflammatory cytokines and activated the M2 microglia. …”
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Reusable Tourniquets as Potential Transmitters of Infection: A Microbiological Analysis by Julia Szymczyk, Monika Kurpas, Bartosz Krasiński, Katarzyna Zorena, Wioletta Mędrzycka-Dąbrowska

“…The average number of CFU/cm² across all stages of this study was 545 CFU/cm² for the emergency department and 101 CFU/cm² for the operating theatre. …”
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Technologically-Treated Polyclonal Affinity-Purified Antibodies to the Tumor Necrosis Factor-α, Brain Specific S-100 Protein and Histamine in Treatment of Functional Dyspepsia: Res... by Yu. O. Shulpekova, I. V. Maev, V. B. Grinevich, I. B. Khlynov, Yu. G. Shvarts, V. T. Ivashkin

“…Patients were randomized in two groups receiving Kolofort® or placebo 2 tablets tid for 8 weeks. …”
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Deficit Irrigation Response and Climate Resilience of Mediterranean Tomato Landraces by Yüksel Tüzel, Hüseyin Biyke, Omar S. Harouna, Tunç Durdu, Mahmut Tepecik, Gölgen B. Oztekin, Ulaş Tunalı, Nazim S. Gruda

“…Three irrigation approaches were applied: Full irrigation (Ir-Full), Deficit 1 (Ir-Def1), and Deficit 2 (Ir-Def2) irrigation. Drought stress was simulated via controlled irrigation deficit, reducing the amount of water applied by 35% and 50% in Ir-Def1 and Ir-Def2, respectively. …”
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Towards a Noninvasive Intracranial Tumor Irradiation Using 3D Optical Imaging and Multimodal Data Registration by R. Posada, Ch. Daul, D. Wolf, P. Aletti

“…Tests performed with human data proved that the registration algorithm is accurate (0.1 mm mean distance between homologous points) and robust even for facial expression changes.…”
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Biologic Therapy and Cardiometabolic Risk in Psoriasis: A Retrospective Review by Annika Smith, Aidin Karahasan, Deborah Yi, Sanjay Yapabandara, James Elhindi, Pablo Fernandez-Penas, Clara Chow, Sarah Zaman

“…This study aimed to assess the change in cardiometabolic risk markers in a cohort of patients with psoriasis treated with 1 year of continuous biologic treatment. …”
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The Impact of Bacterial Leaf Blight Disease (<i>Pantoea agglomerans</i>) on Grain Yield and Nutritional Quality of Oat by Ruochen Zhang, Jianjun Wang, Longhai Xue, Malik Kamran, Yue Wang, Xuekai Wei, Guiqin Zhao, Chunjie Li

“…This study was designed to investigate the effects of LBD on grain yield and nutritional quality of two common oat varieties, i.e., <i>Avena nuda</i> “Baiyan 2” (B2) and <i>A. sativa</i> “Baiyan 7” (B7), in greenhouses. …”
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The Golden Afromontane ecosystems at cross-road: Wetland-based upstream-downstream linkage in Genale Dawa River Basin by Habtamu Temesgen, Haile Ketema, Gezahegn Kebede, Fikadu Woldemariyam, Gebremedihin Tesfaye

“…Results showed that: (1) LULC change occurred non-linearly in the GDRB, with agricultural land continuously increasing while forestland, woodland, and grassland decreased between 2005 and 2020; (2) the estimated ecosystem service value (ESV) of the GDRB was approximately US $10,360.28 million in 2005 and US $9033.06 million per year in 2020, indicating a decline of 12.81 %, resulting in a total net loss of US $1327.22 million from the basin. …”
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CONDITION OF HORMONAL STATUS OF THE BODY IN WHITE RATS UNDER THE EXPOSURE TO SODIUM FLUORIDE by I.Yu. Bagmut, I.L. Kolisnyk, S.I. Kryzhna, A.V. Titkova, L.Yu. Svyrydenko

“…Furthermore, in the blood serum of rats, there was an increase in the levels of prostaglandin PGE2, prostacyclin (6 keto-PGF1a), leukotriene B4 and a decrease in the concentrations of prostaglandins PGE1, PGF2a and leukotriene C4. …”
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COVID-19 in the context of pregnancy, infancy and parenting (CoCoPIP) study: protocol for a longitudinal study of parental mental health, social interactions, physical growth and c... by Topun Austin, Jane Barlow, Ezra Aydin, Staci M Weiss, Kevin A Glasgow, Mark H Johnson, Sarah Lloyd-Fox

“…This study (CoCoPIP) will investigate: (1) how parent’s experiences of the social, medical and financial changes during the pandemic have impacted prenatal and postnatal parental mental health and parent–infant social interaction; and (2) the extent to which these COVID-19-related changes in parental prenatal and postnatal mental health and social interaction are associated with fetal and infant development.Methods and analysis The CoCoPIP study is a national online survey initiated in July 2020. …”
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Mapping global annual urban land cover fractions (2001–2020) derived with multi-objective deep learning by Haoyu Wang, Qian Wang, Xiuyuan Zhang, Shihong Du, Lubin Bai, Shuping Xiong

“…The GAULCF dataset reveals significant global ULC changes over the past 20 years: the impervious surface area nearly doubled, while building areas increased from 124,589 km2 to 206,603 km2; and vegetation and cropland were the predominant land cover types lost to urban expansion. …”
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Vegetation height estimation based on machine learning model driven by multi-source data in Eurasian temperate grassland by Wuhua Wang, Jiakui Tang, Na Zhang, Xuefeng Xu, Anan Zhang, Yanjiao Wang, Kaihui Li, Yidan Wang

“…Significance tests indicated that approximately 4.40 % of the surveyed regions, primarily concentrated in northern Central Asia, experiencing a noteworthy increase in grassland height dynamics. Conversely, about 2.10 % of the areas, predominantly located in Inner Mongolia, China, and southern Central Asia, have witnessed a reduction in grassland height. …”
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Spoofing detection on adaptive authentication System‐A survey by Hind Baaqeel, Sunday Olusanya Olatunji

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The amount of DNA and RNA in primary cancer cells and their metastases by Oleksandr Herasymenko, Kostyantyn Gerasymenko, Olha Herasymenko

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Computer Axial Tomography and evoked potentials as predictors of clinical improvement in cranioencephalic trauma. by José Ramón Tejera del Valle, Florencio Pons Moscoso, Joaquín Aguilar Trujillo, Yarima López Puig, José Arteaga Bermúdez

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UNEXPECTED FINDINGS DURING LAPAROTOMY SURGERY AND URGENT SURGICAL INDICATIONS ARE ASSOCIATED WITH POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH CROHN’S DISEASE by Guilherme Zupo TEIXEIRA, Magaly Gemio TEIXEIRA, Marina Carla GIMENEZ, Silvia Caroline Neves RIBEIRO, Nathacia Bernardo CHIMELLO, Vania Aparecida LEANDRO-MERHI

“…RESULTS: There was an association regarding the history of adalimumab use (p=0.04, OR 2.8, 95%CI 1.03-7.65), previous use of prednisone (p<0.01, OR 2.03, 95%CI 2.00-2.05), urgent surgery indications (p<0.01, OR=4.32, 95% CI=1.58-11.82), mechanical anastomosis (p=0.02, OR=0.22, 95%CI 0.06-0.80), unexpected intraoperative findings (p=0.02, OR 10.46, 95%CI 1.50-72.99), length of hospital stay greater than 10 days (p<0.01, OR 16.86, 95%CI 2.99-94.96), unplanned intensive care unit (ICU) admission (p=0.01, OR 15.06, 95%CI 1.96-115.70), and planned ICU admission (p<0.01, OR 18.46, 95%CI 3.60-94.51). …”
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Carbon Footprint of Beef Cattle in a Conventional Production System: a Case Study of a Large-Area Farming Enterprise in the Wielkopolska Region by Jerzy Bieńkowski, Radosław Dąbrowicz, Małgorzata Holka, Janusz Jankowiak

“…The average CF in the entire beef cattle production system was 25.43 kg of CO2 kg-1 of live weight of marketed cattle, while in the individual subsystems of basic breeding herd, breeding heifers, breeding bulls and fattening bulls, the CF (after GHG allocation) was: 11.0 kg CO2 eq., 34.30 kg CO2 eq., 27.32 and 25.40 kg CO2 eq., respectively. …”
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Study Comparison between Alcoholic Extract of Broccoli, Folic Acid and Ferrous Sulfate Against Damage of the Cardiovascular System Induced by Lead-acetate in Rabbits by Dina S Dheyab, Jawad K Arrak, Majida A J Al-Qayim

“…Heart tissue obtained to examine the histopathological changes. The results after the 4th week in the 2nd,3rd, 4th and 5th groups demonstrated a significant elevation (p≤0.05) in Troponin I, and platelets count while at the 8th week of the treatments, the mean values of Troponin I and platelets count reduced significantly(p≤0.05) .On the contrary, prothrombin time significantly (p≤0.05) decreased in the 4th week of exposed lead acetate  and significantly(p≤0.05) increased in T1F,T2FS,T3B at the 8th week of the treatments. …”
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Interactive effects of atmospheric oxidising pollutants and heat waves on the risk of residential mortality by Nan Ren, Huimin Huang, Baoying Liu, Chuancheng Wu, Jianjun Xiang, Quan Zhou, Shuling Kang, Xiaoyang Zhang, Yu Jiang

“…Results Atmospheric oxidising pollutants increased the risk of residential mortality at lower concentrations, and O3 and Ox were positively associated with a maximum risk of 2.19% (95% CI: 0.74–3.66) and 1.29% (95% CI: 0.51–2.08). …”
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Three-Year Outcomes of Patients with Neovascular Age-Related Macular Degeneration Treated with Aflibercept under the National Health Insurance Program in Taiwan by Kang-Jung Lo, Jin-Yu Chang, Hsin-Yi Chang, Shih-Hwa Chiou, De-Kuang Hwang, Shih-Jen Chen

“…Compared with initial visual acuity, 5 (5.1%) of our patients improved their vision for 3 or more lines after 3 years of follow-up, 11 (11.1%) of our patients improved for 1 to 3 lines, 62 (62.6%) patients remained their vision with 1 line or less changes, 15 (15.2%) patients lost their vision for 1 to 3 lines, and 6 (6%) patients lost their vision for 3 or more lines. …”
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