Next generation sequencing of multiple SARS-CoV-2 infections in the Omicron Era by Marzia Cavalli, Giulia Campoli, Anna Anselmo, Rossella Brandi, Antonella Fortunato, Maria Di Spirito, Anella Monte, Martina Lipari, Manfredo Bortone, Vanessa Vera Fain, Raffaele D’Amelio, Florigio Lista, Silvia Fillo

“…We conducted a retrospective descriptive study using data collected during the SARS-CoV-2 pandemic. This analysis involved Reverse Transcriptase Quantitative Polymerase Chain Reaction (RT-qPCR) and Next Generation Sequencing (NGS). …”
Get full text

Inflammation and ER Stress Downregulate BDH2 Expression and Dysregulate Intracellular Iron in Macrophages by Susu M. Zughaier, Brandon B. Stauffer, Nael A. McCarty

“…Upon infection macrophages retain iron to limit its bioavailability which limits bacterial growth. Recently, a short chain butyrate dehydrogenase type 2 (BDH2) protein was reported to contain an iron responsive element and to mediate cellular iron trafficking by catalyzing the synthesis of the mammalian siderophore that binds labile iron; therefore, BDH2 plays a crucial role in intracellular iron homeostasis. …”
Get full text

SARS-CoV-2 S-protein expression drives syncytia formation in endothelial cells by Katie V. Tieu, Madaline Espey, Aarthi Narayanan, Rebecca L. Heise, Farhang Alem, Daniel E. Conway

“…Abstract SARS-CoV-2 is a viral infection, best studied in the context of epithelial cell infection. …”
Get full text

Novel Pt (II) Complexes With Anticancer Activity Against Pancreatic Ductal Adenocarcinoma Cells by Erika Stefàno, Gianluca Rovito, Luca G. Cossa, Federica De Castro, Viviana Vergaro, Asjad Ali, Giulia My, Danilo Migoni, Antonella Muscella, Santo Marsigliante, Michele Benedetti, Francesco Paolo Fanizzi

“…In this study, we examined the ability of two Pt (II) cationic complexes, [Pt(η1-C2H4OR) (DMSO) (phen)]+ (in short Pt-EtORSOphen; R = Me, 1; Et, 2), to inhibit the growth and spread of BxPC-3 PDAC cells, in comparison to CDDP. …”
Get full text

1990—2021年中国和全球归因于高BMI的缺血性卒中疾病负担变化趋势分析 Analysis of the Trend in the Burden of Ischemic Stroke Attributable to High BMI in China and Globally from 1990 to 2021... by 刘乾坤1，李鹏鹞1，马丽1，戴婧佼2，徐洋1，庞佳雪1，黄菊菊1，谢晖1 (LIU Qiankun1, LI Pengyao1, MA Li1, DAI Jingjiao2, XU Yang1, PANG Jiaxue1, HUANG Juju1, XIE Hui1 )

“…Globally, the corresponding increases were 0.95 times and 1.08 times. The annual percent change for China’s age-standardized mortality rate and age-standardized disability-adjusted life years was 2.67% and 2.69%, respectively, showing a significant upward trend. …”
Get full text

Gene Polymorphism of Antigen B Subunit 2 and Pathogenesis of Cystic Echinococcosis in Murine Model by Hadi M. Alsakee, Hussein M. Abdulla, Reshna K. Albarzanji

“…This study aims to investigate the role of antigen B subunit 2 (AgB2) gene polymorphism in the pathogenesis of cystic echinococcosis (CE) in murine model. …”
Get full text

The Effect of Chromium Picolinate Supplementation on the Pancreas and Macroangiopathy in Type II Diabetes Mellitus Rats by Shan Huang, Wenfang Peng, Xiaohong Jiang, Kan Shao, Lili Xia, Yubin Tang, Jiayin Qiu

“…The aim was to explore the effect of the chromium picolinate (CrPic) administration on the pancreas and macroangiopathy of type II diabetes mellitus rats. Methods. The type II diabetes mellitus (T2DM) rat model was induced by low-dose streptozotocin (STZ). …”
Get full text

Enhanced effect of the immunosuppressive soluble HLA-G2 homodimer by site-specific PEGylation by Chisato Yamada, Kimiko Kuroki, Naoyoshi Maeda, Hiroshi Watanabe, Ami Takahashi, Katsumi Maenaka

“…Abstract Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule that has an immunosuppressive effect mediated by binding to immune inhibitory leukocyte immunoglobulin-like receptors (LILR) B1 and LILRB2. A conventional HLA-G isoform, HLA-G1, forms a heterotrimeric complex composed of a heavy chain (α1-α3 domains), β2-microglobulin (β2m) and a cognate peptide. …”
Get full text

数字健康技术在卒中一级预防中的应用与挑战 The Application and Challenges of Digital Health Technology in Primary Prevention of Stroke by 熊维清1，赵一霖2，邱月3 (XIONG Weiqing1, ZHAO Yilin2, QIU Yue3 )

Get full text

La crise de la covid-19, un levier de changement pour le système alimentaire français ? by Adeline Alonso Ugaglia, Ornella Boutry, Marie Ferru, Jacques Mathé, Benoît Prévost, Audrey Rivaud

Get full text

Microplastics contamination in two peripheral fish species harvested from a downstream river by M.R. Maulana, S. Saiful, Z.A. Muchlisin

“…Microplastics in the rivers potentially contaminate the fish through the food chains, and are then transferred to humans once consumed. …”
Get full text

ERK1/2 Inhibition Alleviates Diabetic Cardiomyopathy by Suppressing Fatty Acid Metabolism by Erin McLean, Caroline De Roo, Annabel Maag, Megan Coble, Jefferson Cano, Ruijie Liu

“…Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) have been implicated in the metabolism of fatty acids in the liver and skeletal muscles. …”
Get full text

African agri-entrepreneurship in the face of the COVID-19 pandemic by Mariam A. T. J. Kadzamira, Adewale Ogunmodede, Solomon Duah, Dannie Romney, Victor Attuquaye Clottey, Frances Williams

Get full text

Monitoring Interannual Variability in Spatial Distribution of Plastic-Mulched Farmland in Black Soil Areas Using Google Earth Engine by Jingfa Zhong, Dongmei Ji, Lei Chang, Yuefen Li

Get full text

Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation by L. Caccialupi Da Prato, A. Rezzag Lebza, A. Consumi, M. Tessier, A. Srinivasan, C. Rivera, C. Rivera, J. Laurin, C. Pellegrino

“…This effect was correlated with the recovery of KCC2 expression in the blood exosomes, the prevention of extensive neuronal loss among the interneurons, and changes in secondary neurogenesis.…”
Get full text

Antifungal activity and mechanism of Phoebe bournei wood essential oil against two dermatophytes by Yan Yang, Qinglin Sun, Yuting Zhang, Junhua Huang, Wenjun Ma, Qi Yang, Zaikang Tong, Junhong Zhang

“…Five hub genes were identified by weighted gene co-expression network analysis (WGCNA), of which Long chain fatty acid CoA ligase 1 (ACSL1) was significantly up-regulated expressed. …”
Get full text

Discussion on the mechanism of HER2 resistance in esophagogastric junction and gastric cancer in the era of immunotherapy by Yan Zhang, Wenxuan Fan, Fei Su, Xiaoling Zhang, Yunyi Du, Weiling Li, Yangjun Gao, Wenqing Hu, Jun Zhao

“…This review examines the mechanisms of drug resistance in HER2-positive G/GEJ cancer, the primary mechanisms of resistance explored include alterations in the HER2 receptor itself, such as mutations and changes in expression levels, as well as downstream signaling pathways, and interactions with the tumor microenvironment (TME). …”
Get full text

Functioning performance trajectory and its associated factors for people with disability—A 4-year national study by Tzu-Ying Chiu, Tsan-Hon Liou, Chia-Feng Yen

“…However, previous studies are mainly cross-sectional ones, and fewer studies focus on the long-term effect of changes in functioning for people with disabilities. …”
Get full text

Rapid identification of high-temperature Daqu Baijiu with the same aroma type by UV-VIS sensor of HBT combined with Zn2+ by Yanmei Zhu, Yuanyuan Su, Yipeng Cang, Hengye Chen, Wanjun Long, Wei Lan, Xue Jiang, Haiyan Fu

“…The specific mechanism of light signal change was mainly based on the competitive coordination effect of pyrazines and other nitrogen-containing compounds in high-temperature Daqu Baijiu and small molecular probe HBT on Zn2+ and the excited state intramolecular proton transfer (ESIPT) mechanism of HBT itself. …”
Get full text