A headspace-gas chromatography method for isopropanol determination in warfarin sodium products as a measure of drug crystallinity by Rahman Ziyaur, Akhtar Sohail, Siddiqui Akhtar, Ciavarella Anthony B., Nguyenpho Agnes, Faustino Patrick J., Khan Mansoor A.

“…LOD and LOQ were 0.1 and 2 μg mL-1, respectively. Accuracy at low (2 μg mL-1) and high (200 μg mL-1) IPA concentrations of the calibration curve was 103.3-113.3 and 98.9-102.2 % of the nominal value, resp. …”
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Association between short-term exposure to air pollutants and daily stroke incidence among residents in Qingdao city: a time series analysis of disease surveillance, environmental,... by Nan GE, Lu PAN, Xin ZHANG, Dandan LI, Yin WANG, Jingya YIN, Hui ZHOU, Haoyan YU, Xiuqin ZHANG, Chunsheng XU, Yuan FANG, Yan MA, Bingling WANG, Haiping DUAN

“…The RR value for daily stroke incidence at Lag day 6 was 1.431 (95%CI: 1.049 – 1.951) for each 14.93 μg/m3 increase in SO2 concentration. Sensitivity analysis results showed that changing the degrees of freedom of daily mean temperature, barometric pressure, and relative humidity to 4, 5, and 6 had little effect on the effect of ambient PM2.5, O3, CO, PM10, SO2, and NO2 exposure on the risk of daily stroke incidence, indicating that the established models produced relatively stable results. …”
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Evaluation and Correction of the Ambient Particle Spectral Light Absorption Measured Using a Filter-based Aethalometer by Gang Zhao, Yingli Yu, Ping Tian, Jing Li, Guo Song, Chunsheng Zhao

“…A wavelength-independent multiple-scattering compensation factor (2.90), which varies slightly (± 0.04) for eastern China, is recommended for these regions. …”
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Efek Suplementasi Selenium terhadap Marker Darah Pasca Cedera Kontusio by Mariel Daba, Hanna Goenawan, Vita Murniati Tarawan, Aziis Mardanarian Rosdianto, Ronny Lesmana

“…Objectives: To determine the effect of selenium supplementation on changes in blood markers in rats treated with contusion injury. …”
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Correlation between traumatic brain injury, obesity and insulin-resistance – a case report by Laura De Wilde, Charlotte De Ruysscher, Kristine Oostra

“…Her body mass index (BMI) increased from 23 kg/m2 pre-accident to a maximum of 36 kg/m2, despite interventions like medications and lifestyle changes. …”
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Simulation Results of a Thermal Power Dispatch System from a Generic Pressurized Water Reactor in Normal and Abnormal Operating Conditions by Stephen Hancock, Dylan Jurski, Thomas A. Ulrich, Roger Lew, Jisuk Kim, Olugbenga Gideon

“…Normal TPD operating scenarios resulted in minor effects on the existing plant systems: reactor power changes by at most 0.2%, and gross generator output changes by 20.5 MWe from 100 MWt of TPD. …”
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Longitudinal Alterations of Retinal and Choroidal Structure in Patients Recovered from COVID-19 by Mojtaba Abrishami, Kiana Hassanpour, Ghodsieh Zamani, Seyedeh Maryam Hosseini, Nasser Shoeibi, Zahra Emamverdian, Amir Zamani, Nasibeh Amini, Majid Abrishami

“…While the stromal component showed a significant decrease between the baseline and first-month values (1.16 ± 0.29 to 1.01 ± 0.27, P = 0.03), the luminal area mostly changed between months 1 and 3 (2.03 ± 0.28 to 1.91 ± 0.23, P = 0.045). …”
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Yukawa Potential Orbital Energy: Its Relation to Orbital Mean Motion as well to the Graviton Mediating the Interaction in Celestial Bodies by Connor Martz, Sheldon Van Middelkoop, Ioannis Gkigkitzis, Ioannis Haranas, Ilias Kotsireas

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Crystal Structures of <span style="font-variant: small-caps">d</span>-Lyxono-1,4-lactone and Its <i>O</i>-Tosyl Derivative by Anna Sosnowska, Jarosław Chojnacki, Justyna Samaszko-Fiertek, Janusz Madaj, Barbara Dmochowska

“…Due to steric reasons, 3,5-<i>O</i>-isopropylidene-<span style="font-variant: small-caps;">d</span>-lyxono-1,4-lactone was formed, which in a further step led to the formation of a 2-<i>O</i>-tosyl derivative. Its structure was confirmed by X-ray diffraction analysis. …”
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Joubert Syndrome Presenting with Motor Delay and Oculomotor Apraxia by Harjinder Gill, Brinda Muthusamy, Denize Atan, Cathy Williams, Matthew Ellis

“…We describe two sisters who presented in early childhood with motor delay and unusual eye movements. …”
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Numerical Analysis of Microcracks of Fly Ash/Slag Concrete with Cobble as Coarse Aggregate by Songfang Xie, Mingxing Gao, Hangtian Li

“…Through the numerical loading test of the two-dimensional model for fly ash/slag concrete with cobble as coarse aggregate, it can be concluded that the change of the concrete follows the law of macromechanical properties.…”
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Disentangling effects of droughts and heatwaves on alpine periphyton communities: A mesocosm experiment by Tamika Nagao, Rolf Vinebrooke

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PROBLEMS AND PROSPECTS OF REFORMING STATE CONTROL IN THE RUSSIAN FEDERATION by Anna V. Lipuntsova

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Defending Deep Neural Networks Against Backdoor Attack by Using De-Trigger Autoencoder by Hyun Kwon

“…For MNIST, Fashion-MNIST, and CIFAR-10, respectively, the proposed method detected 91.5%, 82.3%, and 90.9% of the backdoor samples and had 96.1%, 89.6%, and 91.2% accuracy on legitimate samples.…”
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Entropic Entanglement: Information Prison Break by Alexander Y. Yosifov, Lachezar G. Filipov

“…The source of the modification is (i) smooth at r=2M and (ii) rapidly vanishing at r≫2M. Furthermore, we restore the unitary evolution by introducing extra quanta which departs slightly from the generic Hawking emission without changing the experience of an infalling observer (no drama). …”
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Cloud radiative effect dominates variabilities of surface energy budget in the dark Arctic by Cheng Tao, Minghua Zhang, Shaocheng Xie

“…Here we investigate one of the main drivers of changes in surface temperature: the net surface heat flux in the models. …”
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A metalens for detecting fractional-order optical vortices by A.G. Nalimov, V.V. Kotlyar, Y.V. Khanenko, S.D. Poletaev

“…A change in the topological charge of the incident beam is numerically shown to lead to an off-axis shift of the focal spot from the center, with the intensity maximum value also changing. …”
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Association of expedited review programmes with postmarketing safety events of new drugs approved by the US food and drug administration between 2007 and 2017 by Bao Liu, Xingyue Zhu

“…Objective To explore the associations between the risks of postmarketing safety events of new drugs and the four expedited programmes of priority review, accelerated approval, fast track and breakthrough therapy established by the US Food and Drug Administration (FDA); and to investigate whether multiple uses of expedited programmes, and the combinations of expedited programmes with orphan designation, were relevant to different safety profiles.Design Cohort study.Setting USA.Participants All new drugs approved by the FDA between 1 January 2007 and 31 December 2017, followed up until 10 April 2021.Outcome measures Safety events included safety-related withdrawal, new boxed warning, drug safety communication, postapproval risk evaluation mitigation strategy and safety-related labelling changes. The duration from marketing approval to the occurrence of a safety event was measured.Method Cox models were performed to determine the factors related to the time-to-safety event.Results The FDA approved 338 new drugs between 2007 and 2017, among which 53.6% (181) were under expedited review and 32.2% (109) received two or more expedited programmes. …”
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Evidence of Negative Effects of Defect Size and Older Patient Age by Quantitative CT-Based 3D Image Analysis in Ultraporous Beta-Tricalcium Phosphate Grafted Extremity Bone Defects... by Timothy A. Damron, Kenneth A. Mann

“…The purpose was to analyze volumetric CT-based changes in defects grafted with TCP with/without BMA in a completed prospective RCT to objectively determine (1) relationship between size and age versus TCP incorporation and (2) whether there is an advantage to addition of BMA. …”
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Comparative Efficacy of Antihypertensive Agents in Flow-Mediated Vasodilation of Patients with Hypertension: Network Meta-Analysis of Randomized Controlled Trial by Hong Ding, Shu Liu, Ke-Xin Zhao, Jie Pu, Ya-Fei Xie, Xiao-Wei Zhang

“…Hypertension induces both structural and functional changes in blood vessels, thereby increasing endothelial dysfunction, which in turn, contributes to an increase in blood pressure. …”
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