Effect of Xingbi Gel Nasal Drops on Rats with Allergic Rhinitis Based on the Nasal Mucosa-Hippocampus Neuroimmune Mechanism by FAN Xueqi, QIU Caixia, YAN Shuiping, ZHUANG Xiangli, AI Si, GUO Lihua, ZHENG Jian

“…The AR rat behavioral scoring criteria was used to evaluate rhinitis behavior of rats; Morris water maze test was used to evaluate learning and memory function of rats; enzyme-linked immunosorbent assay (ELISA) was used to detect serum levels of immunoglobulin E (IgE) and transforming growth factor-β1 (TGF-β1); hematoxylin-eosin (HE) staining was used to observe pathological changes of nasal mucosa and eosinophil (EOS) count; immunohistochemistry method was used to detect expression levels of non-receptor tyrosine kinases Fyn, substance P (SP), vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) in the hippocampus; and real-time polymerase chain reaction (RT-PCR) was used to detect mRNA transcription levels of Fyn, SP, VIP and NPY in the hippocampus.Results(1) Behavioral scores of rhinitis: compared with the normal group, behavioral scores of rhinitis were significantly higher in the model group, the traditional Chinese medicine group and the western medicine group before treatment (<italic>P</italic>&lt;0.05). …”
Get full text

Labeling tumor-associated extracellular vesicles with antibody-DNA conjugates for quantitative analysis by Xiao Du, Xiao Du, Xiao Du, Hongxiu Li, Hongxiu Li, Hongxiu Li, Shiyi Shen, Shiyi Shen, Shiyi Shen, Chao Tian, Chao Tian, Chao Tian, Xiaohuan Cao, Xiaohuan Cao, Xiaohuan Cao, Xingang Xu, Nan Xu, Shuling Wang, Shuling Wang, Shuling Wang, Qingchang Tian, Qingchang Tian, Qingchang Tian

Get full text

Serum metabolome associated with novel and legacy per- and polyfluoroalkyl substances exposure and thyroid cancer risk: A multi-module integrated analysis based on machine learning by Fei Wang, Yuanxin Lin, Lian Qin, Xiangtai Zeng, Hancheng Jiang, Yanlan Liang, Shifeng Wen, Xiangzhi Li, Shiping Huang, Chunxiang Li, Xiaoyu Luo, Xiaobo Yang

Get full text

Lactobacillus reuteri LR1 Improved Expression of Genes of Tight Junction Proteins via the MLCK Pathway in IPEC-1 Cells during Infection with Enterotoxigenic Escherichia coli K88 by Hongbo Yi, Li Wang, Yunxia Xiong, Zhilin Wang, Yueqin Qiu, Xiaolu Wen, Zongyong Jiang, Xuefen Yang, Xianyong Ma

Get full text

Best evidence summary for nutritional management of cancer patients with chyle leaks following surgery by Jie Zhou, Wentao Huang, Ya Hu, Fen Liu, Man Xu, Xiaoping Chen, Mingzhu Xin, Huiming Lu, Xia Zheng

“…Quality assessment of the literature was completed independently by two researchers with professional evidence-based training and expert advice, and evidence was extracted and summarized for those that met the quality criteria.ResultsA total of 13 articles were included in the analysis, comprising two expert consensus, one guideline, one class of experimental studies, seven systematic evaluations, and two clinical decisions. …”
Get full text

Towards a high-quality in situ observation network for oxygenated volatile organic compounds (OVOCs) in Europe: transferring metrological traceability to the field by M. Iturrate-Garcia, T. Salameh, P. Schlauri, A. Baldan, M. K. Vollmer, E. Stratigou, S. Dusanter, J. Li, S. Persijn, A. Claude, R. Holzinger, C. Sutour, T. Macé, Y. Elshorbany, A. Ackermann, C. Pascale, S. Reimann

“…Accurate, stable and SI-traceable reference gas mixtures (RGMs) and working standards are needed to achieve SI traceability through an unbroken chain of calibrations of the analytical instruments used to monitor VOCs. …”
Get full text

Dual α-globin-truncated erythropoietin receptor knockin restores hemoglobin production in α-thalassemia-derived erythroid cells by Simon N. Chu, Eric Soupene, Devesh Sharma, Roshani Sinha, Travis McCreary, Britney Hernandez, Huifeng Shen, Beeke Wienert, Chance Bowman, Han Yin, Benjamin J. Lesch, Kun Jia, Kathleen A. Romero, Zachary Kostamo, Yankai Zhang, Tammy Tran, Marco Cordero, Shota Homma, Jessica P. Hampton, James M. Gardner, Bruce R. Conklin, Tippi C. MacKenzie, Vivien A. Sheehan, Matthew H. Porteus, M. Kyle Cromer

Get full text

Comprehensive epidemiological evaluation of ruminant brucellosis and associated risk factors in some Egyptian Governorates by Nesreen Allam Tantawy Allam, Mahinour Ezzeldin Abdelsalam, Hend I. Elsharkawy, Mai Mohamed Kandil, Amany Mohamed Mohamed Mohamed, Fatma Ali, Mohamed A. Gebely, Safaa Y. Nour, Doaa Sedky, Mona Ebrahim Hussien Abd El-Gawad, Hoda M. Zaki, Nazek Al-Gallas, Amal M. Aboelmaaty, Mona Mohamed Sobhy, Nagwa Sayed Ata, Marwa Salah Abdel-Hamid, Ghada A. Badawy

“…The difference between species was significant for BCS; 14.2% in low-BCS cattle and camels and 8.4% in high-BCS buffaloes. …”
Get full text

Dépôts et pratiques symboliques dans l’établissement aristocratique gaulois de Varennes-sur-Seine, la Justice (Seine-et-Marne) by Jean-Marc Séguier, Ginette Auxiette, Fabien Pilon

“…Building on an enclosure that was occupied from the end of the 3rd to the middle of the 2nd c. BC and then dismantled, the settlement consists of a main enclosure of 3,500 m2 delimited by ditches and an embankment, within which were grouped various constructions dedicated to housing and storage. …”
Get full text

XCL1-secreting CEA CAR-T cells enhance endogenous CD8+ T cell responses to tumor neoantigens to confer a long-term antitumor immunity by Kun Chen, Fei Zhao, Hong Zhao, Dongmei Wang, Chunfeng Qu, Zhiyuan Wu, Feifei Wang, Xing-Ning Li, Ruochan Zhang, Chentong Xiao, Yuliang Ran

“…However, in co-culture with CT26.CEAhigh and CT26.CEAint cells, 7XCL1-CAR T cells displayed higher cytotoxicity than that reg-CAR T cells after 60 hours. …”
Get full text

Identification and leveling of factors affecting the acceptance of excellence model in Islamic Azad University by Seyedeh Somayeh Mousavi Siah Deleh, Samad Jabbari Asl, Musa Rezvani Chaman Zamin

“…From this point of view, the message of excellence model is the answer to the following two questions: 1) how this model is identified as a suitable management structure and 2) who should play a central role in this chain of communication and interactions. …”
Get full text

Presenting the fintech market development model with an emphasis on existing challenges and strategies by Seyed Mani Sadraee, Farideh Haghshenaskashani, Mehdi Karimizand

Get full text

Sodium butyrate restored TRESK current controlling neuronal hyperexcitability in a mouse model of oxaliplatin-induced peripheral neuropathic pain by Idy H.T. Ho, Yidan Zou, Kele Luo, Fenfen Qin, Yanjun Jiang, Qian Li, Tingting Jin, Xinyi Zhang, Huarong Chen, Likai Tan, Lin Zhang, Tony Gin, William K.K. Wu, Matthew T.V. Chan, Changyu Jiang, Xiaodong Liu

Get full text

Multilevel plasticity and altered glycosylation drive aggressiveness in hypoxic and glucose-deprived bladder cancer cells by Andreia Peixoto, Dylan Ferreira, Andreia Miranda, Marta Relvas-Santos, Rui Freitas, Tim S. Veth, Andreia Brandão, Eduardo Ferreira, Paula Paulo, Marta Cardoso, Cristiana Gaiteiro, Sofia Cotton, Janine Soares, Luís Lima, Filipe Teixeira, Rita Ferreira, Carlos Palmeira, Albert J.R. Heck, Maria José Oliveira, André M.N. Silva, Lúcio Lara Santos, José Alexandre Ferreira

Get full text

An interlaboratory comparison to quantify oxidative potential measurement in aerosol particles: challenges and recommendations for harmonisation by P. A. Dominutti, J.-L. Jaffrezo, A. Marsal, T. Mhadhbi, R. Elazzouzi, C. Rak, F. Cavalli, J.-P. Putaud, A. Bougiatioti, N. Mihalopoulos, N. Mihalopoulos, D. Paraskevopoulou, I. Mudway, I. Mudway, A. Nenes, A. Nenes, K. R. Daellenbach, C. Banach, S. J. Campbell, H. Cigánková, D. Contini, G. Evans, M. Georgopoulou, M. Ghanem, D. A. Glencross, D. A. Glencross, M. R. Guascito, M. R. Guascito, H. Herrmann, S. Iram, M. Jovanović, M. Jovašević-Stojanović, M. Kalberer, I. M. Kooter, S. E. Paulson, A. Patel, A. Patel, A. Patel, E. Perdrix, M. C. Pietrogrande, P. Mikuška, J.-J. Sauvain, K. Seitanidi, P. Shahpoury, E. J. d. S. Souza, S. Steimer, S. Steimer, S. Stevanovic, G. Suarez, P. S. G. Subramanian, B. Utinger, M. F. van Os, V. Verma, X. Wang, R. J. Weber, Y. Yang, X. Querol, G. Hoek, R. M. Harrison, R. M. Harrison, G. Uzu

Get full text

Identifying and Evaluating the Components of Human Resource Competence in the Era of Digital Transformation by Mahdieh Abidi, Rashid Zolfaghari Zafarani, Masoud Haghighi

Get full text

First Aid Guidelines for Allergic Reaction, Seizure and Diabetic Emergency: Educational Approach and Adaptation

Get full text

Applying the metacombination approach in order to design the native model of new product development by seyed Rohollah faraji, Hoseain Adab, jalal HaghighatMonfared

Get full text

Designing and explaining the improvement model of women's employability capacity with emphasis on the 7th development plan by Mahsa Vahidpour, Akbar Etebarian Khorasgani, Mehrban Hadi Peykani, Saeed Daei-Karimzadeh

“…Employability skills are important because they make easier the people's recruitment for employers and increase their chances of getting and keeping a job (Chang, 2016; Abelha et al, 2020). …”
Get full text