Novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models by Shohei Koyama, Yujiro Naito, John D Minna, David E Gerber, Ryan R Kowash, Manoj Sabnani, Laura T Gray, Qing Deng, Nusrat U A Saleh, Luc Girard, Kentaro Masahiro, Zhiqian Lucy Liu, Hemanta Baruah, Esra A Akbay

“…We engineered an antibody-dependent cellular cytotoxicity (ADCC) enhanced MICA/B monoclonal antibody, AHA-1031, which prevents ligand shedding without interfering with binding to natural killer group 2D while targeting cancer cells via superior ADCC. …”
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Oral probiotic extracellular vesicle therapy mitigates Influenza A Virus infection via blunting IL-17 signaling by Hongxia Zhou, Wenbo Huang, Jieting Li, Peier Chen, Lihan Shen, Wenjing Huang, Kailin Mai, Heyan Zou, Xueqin Shi, Yunceng Weng, Yuhua Liu, Zifeng Yang, Caiwen Ou

“…In the present study, we investigated the therapeutic efficacy of Lactobacillus reuteri EHA2-derived EVs (LrEVs) in a mouse model of IAV infection. …”
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Matrine Inhibits Breast Cancer Cell Proliferation and Epithelial-Mesenchymal Transition Through Regulating the LINC01116/miR-9-5p/ITGB1 Axis by Lili Ren, Ziru Fang, Jiaojiao Xu, Xiaoxiao Wu, Yongjun Zhang, Hu Cai, Zhicun Han

“…Methods: The UALCAN and Lnc2Cancer 3.0 databases were used to predict the expression of LINC01116 in BC. …”
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In Vitro Screening and Transfection Concentration Optimization of Cynomolgus Monkey IκBα-siRNA by Zhaoxing Ou, Rui Zeng, Yifan Lin, Si Zhang, Mohammad Alzogool, Peng Zeng, Yuqing Lan

“…The mRNA and protein levels of IκBα were examined by using real-time quantitative polymerase chain reaction (real-time PCR) and western blot to screen a pair of candidate valid sequences with the highest inhibitory rate. …”
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New pneumococcal serotype 20C is a WciG O-acetyltransferase deficient variant of canonical serotype 20B by Jigui Yu, Neil Ravenscroft, Peter Davey, Roshan Liyanage, Oliver Lorenz, Michelle M. Kuttel, Stephanie W. Lo, Feroze A. Ganaie, Moon H. Nahm

“…Previous biochemical studies of serogroup 20 isolates have identified two subtypes—20A and 20B, whose capsule PS differs in the WhaF-mediated glucose side chain. …”
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The Effect of Vascular Endothelial Growth Factor on Bone Marrow Mesenchymal Stem Cell Engraftment in Rat Fibrotic Liver upon Transplantation by Ke Yuan, Chunyou Lai, Lingling Wei, Tianhang Feng, Qinyan Yang, Tianying Zhang, Tao Lan, Yutong Yao, Guangming Xiang, Xiaolun Huang

“…Paraffin section staining, immunofluorescent staining, RT-qPCR (quantitative reverse transcription polymerase chain reaction), and Western blot were used to evaluate hepatic pathological changes and physiology function. …”
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Improving the charge transport of perovskite nanocrystal light-emitting-diodes through Benzylammonium ligand exchange by Minsik Gong, Dong Gyu Lee, Gwang Yong Shin, Yun Seop Shin, Donghwan Yun, Yunhye Jeong, Sang Wook Park, Chan Beom Park, Yung Jin Yoon, Sung Yong Bae, Yun-Hi Kim, Jin Young Kim, Tae Kyung Lee, Gi-Hwan Kim

“…Ligands on the NC surfaces can be substituted using ligand exchange, which significantly influence the properties and performance of LHP light-emitting diodes (LEDs). The alkyl chain in the surface ligands significantly affect external stimuli depending on their length. …”
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4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain by Yu-Zhen Tang, Wan Chen, Bao-Yun Xu, Gang He, Xiu-Cheng Fan, Kang-Lai Tang

“…Purpose: To investigate the pathological changes of the synovium in mice with post-traumatic osteoarthritis (PTOA) treated with 4-octyl itaconate (4-OI) and evaluate the therapeutic effects of 4-OI. …”
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Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer by Xiao Xiao, Fangyi Long, Shaolan Yu, Wengjuan Wu, Dayan Nie, Xiaoyan Ren, Wen Li, Xujuan Wang, Ling Yu, Pinghan Wang, Gang Wang

“…BackgroundsCollagen type I alpha 1 chain (COL1A1) is a key protein encoding fibrillar collagen, playing a crucial role in the tumor microenvironment (TME) due to its complex functions and close association with tumor invasiveness. …”
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Viable but nonculturable state in the zoonotic pathogen Bartonella henselae induced by low-grade fever temperature and antibiotic treatment by Yuze Gou, Yuze Gou, Dongxia Liu, Dongxia Liu, Yuxian Xin, Yuxian Xin, Ting Wang, Jiaxin Li, Yiwen Xi, Xiaoling Zheng, Tuanjie Che, Ying Zhang, Ying Zhang, Tingting Li, Jie Feng, Jie Feng

“…Viability was assessed using SYBR Green I/PI staining and propidium monoazide–quantitative polymerase chain reaction (PMA-qPCR), while culturability was determined through colony-forming unit (CFU) counting on blood agar plates. …”
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Characterization of a WAS splice-site variant in a patient with Wiskott-Aldrich syndrome by Elisabetta Toriello, Rosa Maritato, Antonio De Rosa, Maria Valeria Esposito, Carla Damiano, Carla Damiano, Carmen Rosano, Emilia Cirillo, Antonietta Tarallo, Antonietta Tarallo, Cosimo Abagnale, Francesca Cillo, Roberta Romano, Laura Grilli, Marika Comegna, Marika Comegna, Giancarlo Blasio, Giancarlo Parenti, Giancarlo Parenti, Enrico Maria Surace, Giuseppe Castaldo, Giuseppe Castaldo, Claudio Pignata, Giuliana Giardino

“…By sequencing the polymerase chain reaction product, we identified a premature stop at codon 269; thus, consequently, no Wiskott-Aldrich syndrome protein (WASp) was detectable in peripheral blood mononuclear cells from the patient. …”
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Green Tea Extract (<i>Theaceae</i>; <i>Camellia sinensis</i> L.): A Promising Antimicrobial, Anti-Quorum Sensing and Antibiofilm Candidate Against Multidrug-Resistant <i>Campylobac... by Mona S. Emara, Ahmed M. Ammar, Ashraf M.O. Abdelwahab, Attia A. Elgdawy, Adel Abdelkhalek, Elena Pet, Gabi Dumitrescu, Mirela Ahmadi, Norhan K. Abd El-Aziz

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Diversity and distribution of nitrifying bacteria play an important role in the nitrogen cycle in mangrove sediments by A. Mubaraq, M. Sembiring, E. Widiastuti, E. Fachrial, B. Utomo, M. Turjaman, F. Sidik, Y.I. Ulumuddin, V.B. Arifanti, E.S. Siregar, T. Kajita, S. Proches, M. Basyuni

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Fusarium Head Blight in Argentina, a Profile of Produced Mycotoxins and a Biocontrol Strategy in Barley During Micro-Malting Process by María Silvina Alaniz-Zanon, Marianela Bossa, Lorenzo Antonio Rosales Cavaglieri, Juan Manuel Palazzini, Michael Sulyok, Sofía Noemí Chulze, María Laura Chiotta

“…Both species produced several mycotoxins, including NX-2 and NX-3, which is the first report of their production by strains isolated from barley in Argentina. …”
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First microscopic and molecular identification of Cryptosporidium spp. in fat sand rats (Psammomys obesus) in Egypt and their potential zoonotic implications by Sara Abdel-Aal Mohamed, Fatma A. S. Anwar, Ahmed Gareh, Marwa M. I. Ghallab, Remigio Martínez, Asmaa Aboelabbas Gouda, Fatemah Enad Alajmi, Hind Alzaylaee, Ignacio García-Bocanegra, Ignacio García-Bocanegra, Ehab Kotb Elmahallawy, Ehab Kotb Elmahallawy

“…Furthermore, molecular identification and characterization of the parasite were carried out on selected microscopy-positive samples (n = 30) using conventional polymerase chain reaction (PCR) targeting the Cryptosporidium oocyst wall protein (COWP) gene. …”
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Confocal Microscopy for Detection of Intracellular Bacteria in Urine Samples of patients Suspected with Urinary Tract Infection: A Cross-sectional Observational Study by Bhagyashri Patil-Takbhate, Nilam Memane, Srikanth Tripathy, Nageswari Gandham, Shahzad Mirza

“…Mean age of women was 36.2±9.5 years and 74 (80.4%) had fever, 19 (20.7%) had burning sensation and 16 (17.4%) had frequent micturition. …”
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Genetic investigations of autosomal recessive inherited ichthyosis impressed by fetal ultrasound: Exome sequencing and haplotype linkage analysis by Ting-Yu Chang, Zhu Wei Lim, Yi-Tzu Chu, Wan-Ju Wu, Mei-Hui Lee, Shun-Ping Chang, Dong-Jay Lee, Wen-Hsiang Lin, Ming Ho, Jin-Chung Shih, Gwo-Chin Ma, Ming Chen

“…Genome Analysis ToolKit (GATK 4 version 4.2.1.0) was merged using a setting of the trio model for exome variation analysis. …”
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Measuring serious violence perpetration: comparison of police-recorded and self-reported data in a UK cohort by Rosie Cornish, Alison Teyhan, Kate Tilling, John Macleod, Iain Brennan

“…Multiple imputation using chained equations was used to impute self-reported violence data to examine the likely impact of missing data on estimates of prevalence. …”
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Clinical Significance of Perioperative Minimal Residual Disease Detected by Circulating Tumor DNA in Patients With Lung Cancer With a Long Follow-up Data: An Exploratory Study by Shuta Ohara, MD, PhD, Kenichi Suda, MD, PhD, Sumedha Sudhaman, PhD, Akira Hamada, MD, PhD, Masato Chiba, MD, PhD, Masaki Shimoji, MD, PhD, Toshiki Takemoto, MD, PhD, Ekaterina Kalashnikova, PhD, Samantha K. Cheung, PhD, Michael Krainock, MD, PhD, Jordan Feeney, BS, Himanshu Sethi, MPH, Minetta C. Liu, MD, Junichi Soh, MD, PhD, Yasuhiro Tsutani, MD, PhD, Tetsuya Mitsudomi, MD, PhD

“…Method: Plasma samples were collected from 46 patients with clinical stage II-III NSCLC before surgery (n = 46), after surgery (n = 45), and every six months until two years thereafter (n = 78). …”
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Identification of Genetic Markers of <i>APOM</i> and <i>CYP7A1</i> Genes Affecting Milk Production Traits in Chinese Holstein by Yanan Liu, Zijiao Guo, Junqing Ni, Chendong Yang, Bo Han, Yabin Ma, Jianming Li, Guie Jiang, Weijie Zheng, Dongxiao Sun

“…With Haploview 4.2, we further found that six SNPs in <i>APOM</i> and thee SNPs in <i>CYP7A1</i> formed one haplotype, respectively. …”
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