Structure and metabolic function of spatiotemporal pit mud microbiome by Zhihua Li, Chi Zhao, Zhenyu Mao, Fengju Zhang, Ling Dong, Chuan Song, Yao Chen, Xin Fu, Zonghua Ao, Yanfei Xiong, Qin Hui, Weizhi Song, Petri Penttinen, Suyi Zhang

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A family with normal sperm motility carrying a sY86 deletion in AZFa region and partial deletion in AZFc region by Yuhong Zhao, Weiwei Zhi, Weiwei Zhi, Dongsheng Xiong, Dongsheng Xiong, Ningjing Li, Xinrong Du, Jiuzhi Zeng, Jiuzhi Zeng, Guohui Zhang, Guohui Zhang, Weixin Liu, Weixin Liu

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Periodontal pathogens and obesity in the context of cardiovascular risks across age groups by Georgy Leonov, Yurgita Varaeva, Elena Livantsova, Andrey Vasilyev, Andrey Vasilyev, Olga Vladimirskaya, Tatyana Korotkova, Dmitry Nikityuk, Antonina Starodubova, Antonina Starodubova

“…Oral samples were collected for polymerase chain reaction (PCR) analysis to identify periodontal pathogens. …”
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Polydatin retards the progression of osteoarthritis by maintaining bone metabolicbalance and inhibiting macrophage polarization by Qi Sun, Xin-Yu Nan, Hui Wang, Shuo Pan, Gang Ji, Ya-Feng Guo, Ya-Heng Zhao, Gao-Cen Li, Shao-Shi Guo, Lu-Feng Lin, Yu-Jie Jin, Xue Li Zhang, Chang-Cheng Liu, Guo-Bin Liu

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Hyperspectral inversion of heavy metal content in farmland soil under conservation tillage of black soils by Yanan Chen, Wanying Shi, Guzailinuer Aihemaitijiang, Feng Zhang, Jiquan Zhang, Yichen Zhang, Dianqi Pan, Jinying Li

“…Once introduced into the soil, they can bind to soil particles, making them difficult to remove, while potentially entering the food chain through plant uptake or water contamination. …”
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Investigating the potential immunomodulatory effects of commercial oral probiotic supplements on equine gastrointestinal tract barrier function by Agnieszka Żak-Bochenek, Paulina Żebrowska-Różańska, Joanna Bajzert, Łukasz Łaczmański, Bogumiła Szponar, Natalia Siwińska, Klaudia Gładysz, Katarzyna Sikorska, Anna Chełmońska-Soyta

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Expression of lipid metabolism- related genes, body composition and inflammation: Effects of sodium butyrate supplementation in subjects with obesity by Parichehr Amiri, Seyed Ahmad Hosseini, Maryam Saghafi-Asl, Amin Akbari-Naserkiadeh, Seyedeh Asal Jenani Zavieh, Sara Arefhosseini, Samira Asghari, Neda Roshanravan

“…At the end of the trial, the mRNA expression levels of adiponectin receptor-1, adiponectin receptor-2 and uncoupling protein-3, significantly increased in NaBu group to almost two-fold higher levels, compared with placebo group (p = 0.030, p = 0.030 and p = 0.010, respectively). …”
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A Novel Multiplex LAMP Assay for the Rapid and Accurate Diagnosis of Visceral Leishmaniasis Caused by Leishmania infantum from Iran by Sahar Samsami, Sahar Namavari, Saeed Ataei, Abdolmajid Ghasemian, Ava Yazdanpanah, Neda Sepahi, Gholamreza Hatam, Hossein Faramarzi, Hadi Mirzaei, Razie Ranjbar, Ali Ghanbariasad

“…Two separated primers were set and used in a multiplex LAMP assay which was designed based on the ITS2 (internal transcribed spacer II) and were selected on the basis of conserved and high copy number region. …”
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A noninvasive method for the detection of foetal DNA in early pregnancy based on differential methylation pattern of Ras association domain family member 1A by Yulin Sha, Wei Liu, Jiongzhi Hong, Yan Yang, Jian Yu, Xiaodong Fu

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Mitophagy mediated by HIF-1α/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury by Wenjun Zhang, Chao Guo, Yi Li, Hao Wang, Huabing Wang, Yingying Wang, Tingting Wu, Huinan Wang, Gang Cheng, Jiangwei Man, Siyu Chen, Shengjun Fu, Li Yang

“…Additionally, FUNDC1 overexpression reversed the effects of LW6 on the altered expression of light chain 3 (LC3) BII and voltage-dependent anion channels as well as blocked the effects of HIF-1α inhibition in cells. …”
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Polymorphism of Dehydrocholesterol Reductase (DHCR7) Gene and its Effects on Metabolic Components of Polycystic Ovary Syndrome in Women: A Cross-sectional Study from Tertiary Care... by Susmita Banerjee, Shuvankar Mukherjee, Anindya Dasgupta, Palash Kusum Ghosh

“…Results: The mean age was 26.73±7.4 years for PCOS subjects and 27.68±9.2 years for healthy controls. The genotypic frequency between the two groups did not differ significantly (p-value=0.165). …”
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An electrolyte-gated transistor for the monitoring of a CRISPR/Cas activity by Pierre Guermonprez, Le Tu Anh, Louis Renaud, Pierre Nioche, Eric Krejci, Aurélie Alleaume-Butaux, Nicolas Battaglini, Vu Thi Thu, Sébastien Sanaur, Benoît Piro

“…Reverse transcriptase-polymerase chain reaction (RT-PCR) remains the gold standard, but clustered regularly interspaced short palindromic repeats linked to a Cas endoribonuclease particle (CRISPR/Cas) have recently revolutionized the recognition step of two RNAs, i.e. the CRISPR-RNA (crRNA) and the target, providing a much better selectivity compared to the naked hybridization on which RT-PCR is based. …”
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Detection and characterization of multidrug resistant Escherichia coli carrying virulence gene isolated from broilers in Bangladesh by Md. Sirazul Islam, Chandan Nath, F. M. Yasir Hasib, Tahia Ahmed Logno, Md. Helal Uddin, Mohammad Mahmudul Hassan, Sharmin Chowdhury

“…The prevalence of VAGs was astA (56.50%), iucD (31.07%), iss (21.47%), irp2 (15.82%) and cva/cvi (3.39%), respectively. Conclusions This study highlights the presence of ARGs contributing to the development of MDR in E. coli carrying VAGs in broilers. …”
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Machine learning-based plasma metabolomics for improved cirrhosis risk stratification by Jingru Song, Ziwei Gao, Liqun Lai, Jie Zhang, Binbin Liu, Yi Sang, Siqi Chen, Jiachen Qi, Yujun Zhang, Huang Kai, Wei Ye

“…The model performance was assessed in both the derivation and validation cohorts. Results A total of 2,738 eligible patients were included in the analysis. …”
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Systemic Resolvin E1 (RvE1) Treatment Does Not Ameliorate the Severity of Collagen-Induced Arthritis (CIA) in Mice: A Randomized, Prospective, and Controlled Proof of Concept Study by Rafael Scaf de Molon, Rogier M. Thurlings, Birgitte Walgreen, Monique M. Helsen, Peter M. van der Kraan, Joni Augusto Cirelli, Marije I. Koenders

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Early health technology assessment of tongue swab for non-sputum based pulmonary tuberculosis diagnosis in ThailandResearch in context by Langming Mou, Teerawat Wiwatpanit, Apiwat Piriyapol, Puwadol Chawengkul, Janjira Thaipadungpanit, Puttarin Kulchaitanaroaj, Yot Teerawattananon, Yi Wang

“…An early health economic model evaluated the cost-effectiveness of two innovative strategies: tongue swab with Loop-Mediated Isothermal Amplification (LAMP) and tongue swab with real-time polymerase chain reaction (RTPCR). …”
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Interleukin-12 Inhibits Tumor Growth and Metastasis Promoted by Tumor-Associated Mesenchymal Stem Cells in Triple-Negative Breast Cancer by Babak Jahangiri, Zahra-Soheila Soheili, Elahe Asadollahi, Mehdi Shamsara, Vahid Shariati, Alireza Zomorodipour

“…RNA-seq data analysis identified upregulated oncogenes in TA-MSCs,among which MMP3, CXCL2, CXCL5, and ICAM1 were selected as the most relevant to metastasis. …”
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Yunvjian decoction attenuates lipopolysaccharide-induced acute lung injury by inhibiting NF-κB/NLRP3 pathway and pyroptosis by Fanxuan Zhang, Fang Wang, Lisha Zhao, Leqian Wang, Wenjing Li, Feihua Huang, Feihua Huang, Nani Wang, Nani Wang

“…YNJ-containing serum also decreased the secretion of tumor necrosis factor-α, IL-6, and IL-1β in LPS-stimulated RAW264.7 macrophages, and promoted macrophage polarization toward an M2 phenotype. A total of 23 absorbed components were identified in YNJ-containing serum. …”
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LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis by Yasuka Matsunaga, Yusuke Nakatsu, Toshiaki Fukushima, Hirofumi Okubo, Misaki Iwashita, Hideyuki Sakoda, Midori Fujishiro, Takeshi Yamamotoya, Akifumi Kushiyama, Shin-ichiro Takahashi, Yoshihiro Tsuchiya, Hideaki Kamata, Fuminori Tokunaga, Kazuhiro Iwai, Tomoichiro Asano

“…Recently, it was reported that the new ubiquitin ligase complex termed linear ubiquitin chain assembly complex (LUBAC), composed of SHARPIN (SHANK-associated RH domain-interacting protein), HOIL-1L (longer isoform of heme-oxidized iron-regulatory protein 2 ubiquitin ligase-1), and HOIP (HOIL-1L interacting protein), forms linear ubiquitin on NF-κB essential modulator (NEMO) and thereby induces NF-κB pathway activation. …”
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Beta 3 adrenoreceptors protect from hypertrophic remodelling through AMP‐activated protein kinase and autophagy by Emilie Dubois‐Deruy, Roselle Gelinas, Christophe Beauloye, Hrag Esfahani, Lauriane Y.M. Michel, Chantal Dessy, Luc Bertrand, Jean‐Luc Balligand

“…Concomitant with hypertrophy, autophagy was decreased by PE, as measured by microtubule‐associated protein 1 light chain 3 (LC3)‐II/LC3‐I ratio (/2.6, P = 0.0010) and p62 abundance (×3, P = 0.0016) in NRVM or by TAC in WT mice (LC3‐II/LC3‐I ratio: /5.4, P = 0.0159), but preserved in human β3‐AR expressing cells and mice, together with reduced hypertrophy. …”
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