A Systematic Review of the Prevalence and Diagnostic Workup of PIK3CA Mutations in HR+/HER2– Metastatic Breast Cancer by Elizabeth J. Anderson, Lea E. Mollon, Joni L. Dean, Terri L. Warholak, Ayal Aizer, Emma A. Platt, Derek H. Tang, Lisa E. Davis

“…A comprehensive search of PubMed/MEDLINE, EMBASE, Cochrane Central, and select conference abstracts (i.e., AACR, ASCO, SABCS, ECCO, and ESMO conferences between 2014 and 2017) identified 39 studies of patients with HR+, HER2– mBC. The median prevalence of PIK3CA mutation was 36% (range: 13.3% to 61.5%); identified testing approaches more commonly used tissue over liquid biopsies and primarily utilized next-generation sequencing (NGS), polymerase chain reaction (PCR), or Sanger sequencing. …”
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Identification and Characterization of the Diverse Stress-Responsive R2R3-RMYB Transcription Factor from Hibiscus sabdariffa L. by Bahaeldeen Babikar Mohamed, Beenish Aftab, Muhammad Bilal Sarwar, Bushra Rashid, Zarnab Ahmad, Sameera Hassan, Tayyab Husnain

“…We identified and characterized the salt stress-responsive R2R3 type RMYB transcription factor from Hibiscus sabdariffa which has an open reading frame of 690 bp, encoding 229 long chain amino acids. …”
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Transcriptomics-based analysis of neurotoxic and reproductive effects in turbot (Scophthalmus maximus) after exposure to tris (2-chloroethyl) phosphate (TCEP) by Xiaoqian Zhou, Weifeng Liu, Bailin Cong, Aifang Deng, Jing Lin, Linlin Zhao, Shenghao Liu

“…Abstract Background Tris (2-chloroethyl) phosphate (TCEP), a widely used flame retardant, is widespread in the environment and potentially harmful to organisms. …”
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Aggregation control of anionic pentamethine cyanine enabling excitation wavelength selective NIR-II fluorescence imaging-guided photodynamic therapy by Yibin Li, Fei Qu, Fang Wan, Cheng Zhong, Jingyi Rao, Yijing Liu, Zhen Li, Jintao Zhu, Zhong’an Li

“…Herein, we report an example of an anionic pentamethine cyanine (C5T) photosensitizer for high-performance NIR-II fluorescence imaging-guided PDT. Through the counterion engineering approach, a triphenylphosphine cation (Pco) modified with oligoethylene glycol chain is synthesized and adopted as the counterion of C5T, which can effectively suppress the excessive and disordered aggregation of the resulting C5T-Pco by optimizing the dye amphipathicity and enhancing the cyanine-counterion interactions. …”
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RETRACTED: Long non‐coding RNA Sox2OT promotes coronary microembolization‐induced myocardial injury by mediating pyroptosis by Liying Xuan, Danni Fu, Dong Zhen, Dongsong Bai, Lijun Yu, Guohua Gong

“…Herein, this study intended to evaluate the role of lncRNA Sox2 overlapping transcript (Sox2OT) in CME‐induced MI. …”
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Interaction of dietary protein and energy-protein ratio on growth performance of snakehead Channa striata by Hani Wijianti, Muhammad Agus Suprayudi, Nur Bambang Priyo Utomo, Dedi Jusadi

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Global biogeography of N₂-fixing microbes: <i>nifH</i> amplicon database and analytics workflow by M. Morando, J. D. Magasin, S. Cheung, S. Cheung, M. M. Mills, J. P. Zehr, K. A. Turk-Kubo

“…One widely used approach for understanding diazotroph diversity and biogeography is polymerase chain reaction (PCR) amplification of a portion of the <i>nifH</i> gene, which encodes a structural component of the <span class="inline-formula">N₂</span>-fixing enzyme complex, nitrogenase. …”
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Comparative Analysis of the Enzymatic, Coagulant, and Neuromuscular Activities of Two Variants of <i>Crotalus durissus ruruima</i> Venom and Antivenom Efficacy by Poliana J. Demico, Isabele N. Oliveira, Vitória S. Proença-Hirata, Samuel R. Dias, Hugo A. Ghirotti, Elisangela O. Silva, Inês C. Giometti, Francis L. Pacagnelli, Kristian A. Torres-Bonilla, Stephen Hyslop, Nathália C. Galizio, Karen de Morais-Zani, Manuela B. Pucca, Anderson M. Rocha, Jéssica B. Maciel, Marco A. Sartim, Wuelton M. Monteiro, Rafael S. Floriano

“…<b>Results:</b> SDS-PAGE showed that the venoms had similar electrophoretic profiles, with the main bands being phospholipase A₂ (PLA₂), serine proteinases, L-amino acid oxidase (LAAO), and phosphodiesterase. …”
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Quintana Samayoa Oscar y Wolfgang W. Wurster, Ciudades mayas del Noreste del Petén, Guatemala. Un estudio urbanístico comparativo, Materialen zur Allgemeinen und Vergleichenden Archäologie, Band 59, Verlag Philipp von Zabern, Mainz am Rhein, 2001, vi + 194 p., 271 ill., 2 cartes by Eric Taladoire

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Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study by Heinz Wiendl, Frederik Barkhof, Frederik Barkhof, Xavier Montalban, Anat Achiron, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Letizia Leocani, Letizia Leocani, Klaus Schmierer, Klaus Schmierer, Finn Sellebjerg, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Anita Chudecka, Andreas Kloetgen, Dongdong Lin, Lidia Gardner, Nicola De Stefano

“…Background and objectivesCladribine tablets (CladT) represent an effective immune reconstitution therapy, administered in short treatment courses over two consecutive years. To better understand the amplitude of immune changes, we performed a comprehensive analysis during the 2-year study period for the entire MAGNIFY-MS population (N=270). …”
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La classification de la diversité de maïs des Mixtèques et des Chatines de la Sierra Sur, Oaxaca Mexique by Quetzalcóatl Orozco-Ramírez, Stephen Brush

“…We work in two neighboring municipalities located in the Sierra Sur, Oaxaca, one Mixtec and the other Chatino. …”
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Encapsulation of albumin from snakehead fish (Channa striata) with porous starch from arrowroot (Maranta arundinacea) by Nastitia Dian Pratiwi, Arima Diah Setiowati, Lucia Dhiantika Witasari

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Effects of Different Vegetation Zones on CH4 and N2O Emissions in Coastal Wetlands: A Model Case Study by Yuhong Liu, Lixin Wang, Shumei Bao, Huamin Liu, Junbao Yu, Yu Wang, Hongbo Shao, Yan Ouyang, Shuqing An

“…This study used a DNDC model to simulate current and future CH4 and N2O emissions of coastal wetlands in four sites along the latitude in China. …”
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Genetic Insights Into Lipid Traits and Lipid-Modifying Drug Targets in Pregnancy Complications: A Two-Sample Mendelian Randomization Study by Shao H, Xu C, Zhang C, Li L, Wu P, Chen Z, Guan R

“…Huijing Shao,1,&ast; Chang Xu,2,&ast; Caihong Zhang,2 Lirong Li,3 Pengfei Wu,4 Zixi Chen,5 Rui Guan2 1Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, People’s Republic of China; 2Department of Obstetrics and Gynecology, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People’s Republic of China; 3Department of Traditional Chinese Gynecology, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China; 4Department of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, 200080, People’s Republic of China; 5Department of Laboratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Rui Guan, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Naval Medical University, No. 168 Changhai Road, Yangpu District, Shanghai, 200433, People’s Republic of China, Email cngreen785@163.comBackground: Dyslipidemia is linked to pregnancy complications, but its causal role remains uncertain. …”
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Rapid Verbal Persuasion to increase influenza vaccine uptake: protocol for a randomized hybrid type 2 effectiveness -implementation trial by Siyuan Liu, Lan Gao, Yingying Jin, Jiangyun Chen, Dadong Wu, Yiyuan Cai, Tao Wang, Sanhao Huang, Ciling Yan, Run Wang, Dong Roman Xu

“…Abstract Background While influenza vaccines are the most effective measure for preventing influenza, uptake rates in China remain relatively low. Rapid Verbal Persuasion (RVP), with highly rapid fashion, has a strong evidence base in promoting behavior change. …”
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Predictions of State and County Top Civil Servants Regarding the Abolition of County State Administration Offices: Two Sides of the Same Coin? by Iva Lopižić, Romea Manojlović Toman

“…The statistical analysis of the data (response rate 52%) shows a statistically significant difference between the predictions of the two groups in relation to all four categories of effects of this organizational change (inputs, processes, outputs, and outcomes). …”
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Paying attention to the SARS-CoV-2 dialect : a deep neural network approach to predicting novel protein mutations by Magdalyn E. Elkin, Xingquan Zhu

“…Because mutations introduce changing context to the underlying sequence, DNMS models three aspects of the protein sequences: semantic changes, grammatical changes, and attention changes, each modeling protein sequence aspects from shifting of semantics, grammar coherence, and amino-acid interactions in latent space. …”
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Long-term monitoring of plant diversity data in the “Montagna di Torricchio” Strict Nature Reserve, Italyb2share - EUDAT by Marco Cervellini, Leonardo Salvatori, Stefano Chelli, Federico Maria Tardella, Alessandro Chiarucci, James L. Tsakalos, Giandiego Campetella, Maura Francioni, Luciano Ludovico Maria De Benedictis, Roberto Canullo

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Polyphonic discourses in the Hong Kong press: a diachronic analysis of media attitudes towards the One Country, Two Systems policy by Qingyu Gao, Dezheng Feng William

“…Abstract The One Country, Two Systems policy (OCTS), which is the cornerstone for the establishment of the Hong Kong SAR in 1997, has been subjected to varying and changing interpretations and opinions in Hong Kong society. …”
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Role of Psychological Distress in the Assessment of Chronic Illness Care and Self-Management Behaviors of Elderly Patients with T2DM Chronic Complications by Sun X, Wang X, Zhou R, Deng W, Jiang J, Shi Y

“…Xiao Sun,1 Xue Wang,2 Rongrong Zhou,3 Wei Deng,4 Jinxia Jiang,2 Yan Shi5 1Department of Nursing, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China; 2Department of Emergency, Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China; 3School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China; 4Department of Colorectal Disease, Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China; 5Department of Nursing, Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of ChinaCorrespondence: Jinxia Jiang; Yan Shi, Email jiangjinxia99@163.com; 2080153@tongji.edu.cnBackground: This study sought to explore the interrelationship between diabetes-related distress, patient evaluations of chronic illness management, and self-management practices among older adults diagnosed with T2DM and associated chronic complications.Methods: This was a cross-sectional study including 264 older adults with T2DM in Shanghai, China. …”
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