Thyroid Hormone-Induced Cytosol-to-Nuclear Translocation of Rat Liver Nrf2 Is Dependent on Kupffer Cell Functioning by Luis A. Videla, Pamela Cornejo, Pamela Romanque, Catherine Santibáñez, Iván Castillo, Romina Vargas

“…These changes were suppressed by GdCl3 treatment prior to T3, an agent-eliciting Kupffer-cell depletion, inhibition of colloidal carbon phagocytosis, and the associated respiratory burst activity, with enhancement in nuclear inhibitor of Nrf2 kelch-like ECH-associated protein 1 (Keap1)/Nrf2 content ratios suggesting Nrf2 degradation. …”
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Incidence of type 2 diabetes and metabolic syndrome by Occupation – 10-Year follow-up of the Gutenberg Health Study by Juliane Bauer, Janice Hegewald, Karin Rossnagel, Sylvia Jankowiak, Michaela Prigge, Julian Chalabi, Matthias Nübling, Alice Freiberg, Merle Riechmann-Wolf, Pavel Dietz, Philipp S. Wild, Thomas Koeck, Manfred E. Beutel, Norbert Pfeiffer, Karl J. Lackner, Thomas Münzel, Konstantin Strauch, Philipp Lurz, Oliver Tüscher, Julia Weinmann-Menke, Stavros Konstantinides, Andreas Seidler

“…Abstract Background In view of demographic change, rising retirement age, and a growing shortage of skilled workers, it is increasingly important to prevent widespread diseases such as type 2 diabetes or its risk factor metabolic syndrome. …”
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Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice by Ali Yousefian-Jazi, Suhyun Kim, Jiyeon Chu, Seung-Hye Choi, Phuong Thi Thanh Nguyen, Uiyeol Park, Min-gyeong Kim, Hongik Hwang, Kyungeun Lee, Yeyun Kim, Seung Jae Hyeon, Hyewhon Rhim, Hannah L. Ryu, Grewo Lim, Thor D. Stein, Kayeong Lim, Hoon Ryu, Junghee Lee

“…To verify the role of MEF2C-knockdown (MEF2C-KD) in mice, we developed AAV expressing shRNA for MEF2C based on AAV-U6 promoter vector. …”
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Polymorphism of ITS sequences in 35S rRNA genes in Elymus dahuricus aggregate species: two cryptic species? by A. V. Rodionov, K. S. Dobryakova, N. N. Nosov, A. A. Gnutikov, E. O. Punina, A. A. Kriukov, V. S. Shneyer

“…In other words, there are at least two population groups (two races) of the Elymus dahuricus aggregate species that consistently differ in their ITS-sequences in Siberia, the Far East and Northern China. …”
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Soluble CD14 Enhances the Response of Periodontal Ligament Stem Cells to Toll-Like Receptor 2 Agonists by Christian Behm, Alice Blufstein, Johannes Gahn, Nazanin Noroozkhan, Andreas Moritz, Xiaohui Rausch-Fan, Oleh Andrukhov

“…In the present study, we investigated for the first time the potential effect of sCD14 on the hPDLSC response to two different TLR-2 agonists, in vitro. Primary hPDLSCs were stimulated with synthetic lipopeptide Pam3CSK4 or lipoteichoic acid (LTA) in concentrations 1-1000 ng/ml in the presence/absence of sCD14 (250 ng/ml). …”
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Atmospheric Black Carbon Evaluation in Two Sites of San Luis Potosí City During the Years 2018–2020 by Valter Barrera, Cristian Guerrero, Guadalupe Galindo, Dara Salcedo, Andrés Ruiz, Carlos Contreras

“…Nevertheless, there is a lot to know about air pollutants in Mexico’s largest cities, like San Luis Potosi City, which is one of the 12 most crowded cities and is expected to grow in the next years; however, there is little information about air pollutant levels mainly particulate matter in their regulated size fractions (PM₁₀ or PM_2.5), and its main component of the Organic fraction: Black Carbon (BC), which is especially important because of its chemical properties and their effects on human health, air pollution, and climate change. …”
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Comparison of 1D and 3D volume measurement techniques in NF2-associated vestibular schwannoma monitoring by Isabel Gugel, Nuran Aboutaha, Bianca Pfluegler, Ulrike Ernemann, Martin Ulrich Schuhmann, Marcos Tatagiba, Florian Grimm

“…A linear regression model was performed to compare 1D/classification systems to SVA, and the percentage deviation change of MLD3 and OA to SVA was established using a one-way multivariate variance analysis. 2586 SVA and 10344 linear measurements were performed in a cohort of 149 NF2 patients and 292 associated VS. …”
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Genome skimming provides evidence to accept two new genera (Apiaceae) separated from the Peucedanum s.l. by Bo-Ni Song, Chang-Kun Liu, Chang-Kun Liu, Jiao-Jiao Deng, Wei-Yan Tan, Song-Dong Zhou, Xing-Jin He

“…Although previous studies have proved that the genus was not a natural taxonomic unit and taxonomists also conducted several taxonomic revisions for taxa of this genus, classifications of numerous taxa of the genus still have not been satisfactorily resolved, especially for those endemic to China. Therefore, we conducted a comprehensive taxonomic revision of taxa within the polyphyletic Peucedanum s.l. genus in this study.MethodsWe used two molecular datasets (103 plastomes and 43 nrDNA sequences) generated by genome skimming to reconstructed a reliable phylogenetic framework with high support and resolution. …”
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Lifestyle risk behaviours among adolescents: a two-year longitudinal study of the impact of the COVID-19 pandemic by Nicola Clare Newton, Maree Teesson, Jennifer Debenham, Cath Chapman, Bridie Osman, Lauren Anne Gardner, Fiona Elizabeth Wylie, Katrina Elizabeth Champion

“…Objective To examine changes in the prevalence of six key chronic disease risk factors (the “Big 6”), from before (2019) to during (2021) the COVID-19 pandemic, among a large and geographically diverse sample of adolescents, and whether differences over time are associated with lockdown status and gender.Design Prospective cohort study.Setting Three Australian states (New South Wales, Queensland and Western Australia) spanning over 3000 km.Participants 983 adolescents (baseline Mage=12.6, SD=0.5, 54.8% girl) drawn from the control group of the Health4Life Study.Primary outcomes The prevalence of physical inactivity, poor diet (insufficient fruit and vegetable intake, high sugar-sweetened beverage intake, high discretionary food intake), poor sleep, excessive recreational screen time, alcohol use and tobacco use.Results The prevalence of excessive recreational screen time (prevalence ratios (PR)=1.06, 95% CI=1.03 to 1.11), insufficient fruit intake (PR=1.50, 95% CI=1.26 to 1.79), and alcohol (PR=4.34, 95% CI=2.82 to 6.67) and tobacco use (PR=4.05 95% CI=1.86 to 8.84) increased over the 2-year period, with alcohol use increasing more among girls (PR=2.34, 95% CI=1.19 to 4.62). …”
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Association of baseline and trajectory of triglyceride-glucose index with the incidence of cardiovascular autonomic neuropathy in type 2 diabetes mellitus by Qiong Huang, Wenbin Nan, Baimei He, Zhenhua Xing, Zhenyu Peng

“…Intensive glycemic therapy might influence the association between the trajectory of TyG index and the chance of developing CAN.…”
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Seq2scFv: a toolkit for the comprehensive analysis of display libraries from long-read sequencing platforms by Marianne Bachmann Salvy, Luca Santuari, Emanuel Schmid-Siegert, Nikolaos Lykoskoufis, Ioannis Xenarios, Bulak Arpat

“…In addition to providing annotated scFvs, translated sequences and numbered chains, Seq2scFv enables linker inference and characterization, sequence encoding with unique identifiers and quantification of identical sequences across selection rounds, thereby simplifying enrichment identification. …”
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Analysis of some error-causing factors in two-dimensional geoelectrical studies and providing a solution to minimize them by Hosein Moghaddasi, Mohsen Moghaddasi, Ahmad Neyamadpour

“…In this article, we will discuss error-causing factors and will provide a solution to minimize them Discussion Pole-dipole and dipole-dipole arrays are two of the most used arrays for 2d geoelectrical studies. …”
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Sex differences of molecular mechanisms of insulin sensitivity in young and adult C57BL/6J mice by T. V. Yakovleva, A. Yu. Kazantseva, E. N.  Makarova, N. M. Bazhan

“…In females, the levels of mRNA Irs1 in muscle and mRNA Pik3cd and Slc2a4 in adipose tissue decreased with age. Thus the molecular basis of sex differences and age-related changes in insulin sensitivity may be a change in expressions of insulin signal transduction genes in the target tissues.…”
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Des « craintes légitimes » aux « craintes irrationnelles » : analyse argumentative de l’inscription des modalités appréciatives dans les textes du débat public sur les nanotechnolo... by Assimakis Tseronis

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Thrombolysis, time-to-treatment and in-hospital outcomes among young adults with ischaemic stroke in China: findings from a nationwide registry study in China by Yong-Jun Wang, Xin Yang, Qi Zhou, Hao Li, Xia Meng, Yong Jiang, Li-Ping Liu, Yi-long Wang, Hong-Qiu Gu, Zi-Xiao Li, Xing-Quan Zhao, Chun-Juan Wang, Chelsea Liu, Hai-yan Wang, Ying-Yu Jiang

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The Change in HbA1c Associated with Initial Adherence and Subsequent Change in Adherence among Diabetes Patients Newly Initiating Metformin Therapy by Gregory A. Nichols, A. Gabriela Rosales, Teresa M. Kimes, Kaan Tunceli, Karen Kurtyka, Panagiotis Mavros

“…Introduction. Whether changes in adherence are associated with changes in HbA1c is assumed but not known. …”
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Examining the impact of implementing routine rotavirus vaccination on the number of paediatric admissions due to diarrhoea and dehydration in Kenyan hospitals: A study using interr... by Samuel Akech, Lucas Malla, Daisy Chelangat, Reuben C. Langat

“…Routinely collected data for children aged 2-36 months were examined. We used a segmented mixed effects model to assess changes in the burden of diarrhoea and dehydration after introduction of rotavirus vaccine. …”
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Does the household clean energy transition benefit the mental health of the elderly in rural China? Evidence from China health and retirement longitudinal study by Hengxing Yin, Ling Han, Li Yan, Chenhao Liu

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Properties of Actinobacillus pleuropneumoniae isolates by V. А. Evgrafova, О. V. Pruntova, N. B. Shadrova, А. М. Timina

“…All isolates were confirmed to belong to Actinobacillus pleuropneumoniae species and to 2, 5 and 9 serotypes by real-time polymerase chain reaction using species-specific and serotype-specific primers. …”
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PHYTOSTEROLS, A TRITERPENOID, AND A LONG CHAIN ALCOHOL ISOLATED FROM THE LEAVES OF Camellia dalatensis Luong, Tran & Hakoda by Nguyễn Thị Tố Uyên, Trần Thị Thanh Phúc, Lương Văn Dũng, Trịnh Thị Điệp

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