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A lyophilised formulation of chimpanzee adenovirus vector for long-term stability outside the deep-freeze cold chain
Published 2025-01-01“…This coincides with a 25% increase in the ratio of non-infectious particles/infectious particles. After two years of storage at 5 °C, (i) the loss of infectivity was 0.17 log10; (ii) the vaccine remained immunogenic and effective at clearing RSV from the lungs in a mouse-challenge model; and (iii) the vaccine was not associated with any adverse safety signal in a rabbit toxicology model. …”
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2383
Decision Optimization of Low-Carbon Dual-Channel Supply Chain of Auto Parts Based on Smart City Architecture
Published 2020-01-01“…With the rapid development of the domestic auto parts industry, the number of car ownership has increased dramatically, producing more and more CO2 and waste. Facing the pressure of resources, energy, and environment, the effective and circular operation of the auto parts supply chain under the low-carbon transformation is not only a great challenge, but also a development opportunity. …”
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The Strategy of New Product Introduction in Durable Goods with Secondary Market: Application of the Optimization Method to Supply Chain Problem
Published 2014-01-01“…We also derive the effect of the durability and the degree of quality improvement on the pricing of supply chain partners.…”
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Coordination of New Energy Vehicles Closed-Loop Supply Chain under Government Subsidies and Different Power Structures
Published 2022-01-01“…Finally, when a battery manufacturer is in the dominant position, a revenue sharing contract can incentivize supply chain coordination; when a vehicle manufacturer is in the dominant position, a two-part tariff contract can realize coordination in the supply chain.…”
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Three-Level Supply Chain Coordination under Disruptions Based on Revenue-Sharing Contract with Price Dependent Demand
Published 2014-01-01“…However, the original revenue-sharing contract cannot coordinate the supply chain under disruptions in circumstances of certain incidents leading to significant changes in market demand and causing additional deviation costs. …”
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2395
Single-chain variable fragment affinity tuning can optimize anti-AML CAR-NK cell functionality
Published 2025-02-01“…Here, we study the functional consequences of CAR binding affinity and targeted epitope on CAR-NK cell activation, cytolytic synapse formation, and antitumor activity.Methods We characterized NK-92 and primary NK cell populations expressing variant affinity AML-specific CARs containing single-chain variable fragments (scFvs, 26292 or 7G3) targeting two epitopes on CD123. 26292 affinity variants were discovered through directed evolution of an error-prone mutagenic library, while 7G3 affinity variants were previously reported. …”
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