NIR-triggered programmable nanomotor with H2S and NO generation for cascading oncotherapy by three-pronged reinforcing ICD by Jinlong Zhang, Quan Jing, Longlong Yuan, Xianhui Zhou, Duolong Di, Jinyao Li, Dong Pei, Zhongxiong Fan, Jun Hai

“…In brief, a gas signal molecule donor NOSH with H2S and NO capable of on-demand H2S and NO release was synthesized and then loaded into hollow mesoporous copper sulfide nanoparticles (termed as HCuSNPs) with an inherent NIR absorption and surface modification activity to obtain the programmable nanomotor (termed as NOSH@PEG-HCuSNPs). …”
Get full text

CISD2-mediated mitochondrial dysfunction and iron redistribution contributes to ferroptosis in arsenic-induced nonalcoholic steatohepatitis by Jingyuan Zhang, Lu Wang, Yang Lu, Fei Zheng, Xiaoqian Ding, Xiaofeng Yao, Jie Bai, Ningning Wang, Guang Yang, Tianming Qiu, Xiance Sun

“…Additionally, administration of NaAsO2 to hepatocytes triggered mitochondrial dysfunction, manifesting as the release of cytochrome c, impairment of the mitochondrial respiratory chain, and reduction in ATP synthesis. …”
Get full text

LRRK2 Mutations and Asian Disease-Associated Variants in the First Parkinson’s Disease Cohort from Kazakhstan by Rauan Kaiyrzhanov, Akbota Aitkulova, Chingiz Shashkin, Nazira Zharkinbekova, Mie Rizig, Elena Zholdybayeva, Zharkyn Jarmukhanov, Vadim Akhmetzhanov, Gulnaz Kaishibayeva, Talgat Khaibullin, Altynay Karimova, Serik Akshulakov, Askhat Bralov, Nurlan Kissamedenov, Zhanar Seidinova, Anjela Taskinbayeva, Aliya Muratbaikyzy, Henry Houlden

“…The cohort was genotyped for five LRRK2 mutations (p.Gly2019Ser, p.Arg1441His, p.Tyr1699Cys, p.Ile2020Thr, and p.Asn1437His) and three East Asian disease-associated variants (p.Gly2385Arg, p.Ala419Val, and p.Arg1628Pro) via Kompetitive allele-specific polymerase chain reaction assay analysis. …”
Get full text

ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2 by Dan Li, Wenjie Zhang, Ruiheng Wang, Shufeng Xie, Yixin Wang, Wanxin Guo, Zixuan Huang, Chaoqun Lu, Liang Shan, Han Liu, Lifang Ma, Xumin Hou, Zhenshu Xu, Jiayi Wang

“…Furthermore, ROR1 CAR-T cells enhanced the production of phosphatidylcholine with diacyl-polyunsaturated fatty acid tails (PC-PUFA2) by working in tandem with IFN-γ. This enhancement promoted the expression of acyl-CoA synthetase long chain family member 4 (ACSL4), which in turn strengthened the overall anti-tumor response. …”
Get full text

A new phase of China-ASEAN health cooperation: the China-ASEAN Beijing Declaration on Cooperation in Innovation of Health Products and Technologies by Jie Qiao, Siyan Zhan, Minghui Ren, Haijun Wang, Yangmu Huang, Zhenyu Zhang, Yanan Luo, Hui Yin, Zhongwei Jia, Wei Huang, Hong Zhou, Jue Liu, Xiaoyun Liu, Qiudan Sun, Xiaojia Li, Jing Bai, Fangjing Liu, Yihong Liu, Yinzi Jin, Ming Xu, on behalf of China-ASEAN Science and Technology Cooperation Center for Public Health

“…The Center held the Second Annual Forum on China-ASEAN Cooperation in Public Health on June 26–28, 2024, and the participants reached consensus on launching the China-ASEAN Beijing Declaration on Cooperation in Innovation of Health Products and Technologies, which calls on China and ASEAN countries to carry out the following actions: (1) Establish a more effective, open, and inclusive cooperation mechanism for health product innovation towards a China-ASEAN innovation ecosystem; (2) Enhance R&D capabilities by targeting new technologies, methods and appropriate and affordable health products for key populations and addressing diseases prevalent in China and ASEAN; (3) Establish a China-ASEAN Collaboration Center for Health Product Innovation, coordinate regional development plans, and enhance equitable access to pharmaceutical products at the regional level; (4) Accelerate regulatory harmonization in the region by optimizing and improving regulatory modalities of China and ASEAN Countries; and (5) Strengthen cross-sectoral cooperation to build resilient health system and achieve sustainable development of innovation cooperation. …”
Get full text

Transient Hemodynamic Changes upon Changing a BCPA into a TCPC in Staged Fontan Operation: A Computational Model Study by Fuyou Liang, Hideaki Senzaki, Zhaofang Yin, Yuqi Fan, Koichi Sughimoto, Hao Liu

“…The purpose of the present study was to identify the cardiovascular factors that dominate the transient hemodynamic changes upon the change of a bidirectional cavopulmonary (Glenn) anastomosis (BCPA) into a total cavopulmonary connection (TCPC). …”
Get full text

Effect of different stocking density on the growth performances of white leg shrimp (Litopenaeus vannamei) and milkfish (Chanos chanos) in polyculture system by Gamal M. Samadan, Muhammad Irfan, Faisal Pitra, Muhammad Nur Findra, Supyan Supyan, Aras Syazili, Rovina Andriani

Get full text

¿POR QUÉ LAS REFORMAS ECONÓMICASDE MÉXICO NO HAN GENERADO CRECIMIENTO? by Timothy J. Kehoe, Kim J. Ruhl

Get full text

Effects of Chinese Herbal Medicines on Growth Performance, Antioxidant Capacity, and Liver and Intestinal Health of Hybrid Snakehead (<i>Channa maculata</i> ♀ × <i>Channa. argus</i... by Jiamin Kang, Shuzhan Fei, Junhao Zhang, Haiyang Liu, Qing Luo, Mi Ou, Langjun Cui, Tao Li, Jian Zhao

Get full text

CO2 geological storage in sedimentary basins: An update on the potential and suitability evaluation and a field test by Yujie Diao, Xin Ma, Chenglong Zhang, Xiaolin Jin, Xufeng Li, Chao Zhang

“…China has pledged to peak carbon dioxide (CO2) emissions by 2030 and achieve carbon neutrality by 2060. …”
Get full text

A novel system for markerless intra-operative bone and bone fragment tracking by Marcus Tatum, Andrew Kern, Jessica E. Goetz, Geb Thomas, Donald D. Anderson

“…This approach enables robust and expedient 3D object registration from only two semi-orthogonal 2D fluoroscopic images.…”
Get full text

The rise in incidence of pediatric type 2 diabetes during the COVID-19 pandemic and the virus as a potential causative factor by Andrew Kanouse, Joanna S. Fishbein, Parissa Salemi

“…Our aim was to determine if an association exists between the COVID-19 virus and new diagnoses of pediatric type 2 diabetes. Methods: We examined 130 new patients in our pediatric endocrinology practice diagnosed with type 2 diabetes immediately before and just after the emergence of the pandemic to determine if there was a change in presenting characteristics between these two periods. …”
Get full text

Tensile force promotes osteogenic differentiation via ephrinB2-EphB4 signaling pathway in orthodontic tooth movement by Hang Yu, Xiaoxi Wei, Huan Jiang, Huichuan Qi, Yi Zhang, Min Hu

“…Changes of MAPK pathways were detected to investigate whether they were downstream of ephrinB2-EphB4 signaling in mediating TF promote osteogenic differentiation. …”
Get full text

Haploinsufficiency of PDE2A causes in mice increased exploratory behavior associated with upregulation of neural nitric oxide synthase in the striatum by Ana Gabriela de Oliveira do Rêgo, Francesca D'Amico, Vincenza D’Angelo, Silvia Cardarelli, Debora Cutuli, Davide Decandia, Eugenia Landolfo, Laura Petrosini, Manuela Pellegrini, Marcello D’Amelio, Nicola Biagio Mercuri, Mauro Giorgi, Giuseppe Sancesario

“…However, neurological and neurochemical effects of PDE2A deficiency are poorly understood. To address this gap, we studied behavioral characteristics and cerebral morpho-chemical changes of adult male heterozygous C57BL/6-PDE2A+/− (HET), and wild type C57BL/6-PDE2A+/+ (WT) mice.Behavioral functions of mice were evaluated by a wide test battery. …”
Get full text

Relationship between Myopia Progression and School Entrance Age: A 2.5-Year Longitudinal Study by Linjie Liu, Dandan Jiang, Chunchun Li, Yaoyao Lin, Wenzhe Zhou, Haishao Xiao, Yanyan Chen

“…Methods. 1,463 children aged six to nine years from Wenzhou, China, were examined and followed up for two and a half consecutive years. …”
Get full text

Developing Targeted Health Service Interventions Using the PRECEDE-PROCEED Model: Two Australian Case Studies by Jane L. Phillips, John X. Rolley, Patricia M. Davidson

“…This paper provides an overview of the applicability of the PRECEDE-PROCEED Model to the development of targeted nursing led chronic illness interventions. Background. Changing health care practice is a complex and dynamic process that requires consideration of social, political, economic, and organisational factors. …”
Get full text

Correction: Strategic entrepreneurship in the future: Theoretical views (2016, vol.4, no.2, str. 35-42) by Martinović Milan, Martinović Saša

Get full text

Factors Correlated to the Renoprotective Effect of Sitagliptin in Patients with Type 2 Diabetes Mellitus: Retrospective Observational Study by Pirawan Khunkit, Konkanok Wattana

“…Diabetic kidney disease (DKD) is a kidney complication that increases the mortality rate in type 2 diabetes mellitus (T2DM) patients. The important parameters that predict appropriate sitagliptin treatment are known as factors. …”
Get full text

Continuous Loss of Global Lake Ice Across Two Centuries Revealed by Satellite Observations and Numerical Modeling by Xinchi Wang, Lian Feng, Wei Qi, Xiaobin Cai, Yi Zheng, Luke Gibson, Jing Tang, Xiao‐peng Song, Junguo Liu, Chunmiao Zheng, Brett A. Bryan

“…Abstract Lake ice loss has been detected worldwide due to recent climate warming, yet spatially and temporally detailed information on the changes in global ice phenology does not exist. Here, we build a global lake ice phenology database comprising three lake ice phenologies—freeze‐up, break‐up, and ice duration—for each year across two centuries (1900–2099). …”
Get full text

Effect of Electric Fields on the Mechanical Mechanism of Regorafenib–VEGFR2 Interaction to Enhance Inhibition of Hepatocellular Carcinoma by Yichen Tian, Fenghui Liao, Heng Sun, Yongrong Lei, Yuna Fu, Feng Xia, Jianhua Wang

“…The morphological changes in VEGFR2 prove that electric fields regulate protein conformation. …”
Get full text