An IS element-driven antisense RNA attenuates the expression of serotype 2 fimbriae and the cytotoxicity of Bordetella pertussis by Alexandre D’Halluin, Denisa Petráčková, Ivana Čurnová, Jakub Držmíšek, Jan Čapek, Peggy Bouquet, Loïc Henin, Rudy Antoine, Loïc Coutte, Camille Locht, Branislav Večerek, David Hot

Get full text

Association of albumin to non-high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients by Yongjie Xie, Xiaoran Feng, Youqun Gao, Xiaojiang Zhan, Fenfen Peng, Qian Zhou, Xianfeng Wu, Xiaoyang Wang, Na Tian, Qingdong Xu, Ning Su, Xingming Tang, Jianbo Liang, Jiao Li, Yueqiang Wen

“…Combining albumin and non-HDL-C with mortality may be more plausible in clinical practice.Methods This retrospective cohort study included 1954 Chinese PD patients from 1 January 2009 to 31 December 2016. …”
Get full text

Hubungan antara Indeks Massa Tubuh dengan Kadar Nitrit Oksid pada Masyarakat Etnik Minangkabau di Kota Padang by Nidia Purwadianti, Fadil Oenzil, Delmi Sulastri

“…Mean NO level of obese group was 28.37±17.45 μmol/L and 23.91±11.55 μmol/L for non-obese group, p-value=0.084. It indicates that there is no significant correlation between obesity and NO level on Minangkabau ethnic group in Padang. …”
Get full text

Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo by Zheng Wang, Yu Liu, Yunxia Xu, Lin Lu, Zhen Zhu, Baojie Lv, Xin Fang, Yao Tang, Jinhua Wang, Yu Cheng, Ying Hu, Junwen Lou, Peican Wu, Chendan Liu, Yanjun Liu, Xin Zeng, Qing Xu

Get full text

Association of socioeconomic status with diabetic microvascular complications: a UK Biobank prospective cohort study by Yikeng Huang, Zhi Zheng, Haibing Chen, Chufeng Gu

“…Results The median follow-ups of the DR, DN and DPN cohorts were 12.95, 12.89 and 13.02 years, respectively. In total, 3,177 (11.2%) participants developed DR, 4,418 (14.8%) developed DN and 1,604 (5.4%) developed DPN. …”
Get full text

Hubungan Usia dan Paritas dengan Kejadian Preeklampsia Berat di Rumah Sakit Achmad Mochtar Bukittinggi Tahun 2012 - 2013 by Siqbal Karta Asmana, Syahredi Syahredi, Noza Hilbertina

“…Analisis <em>ratio prevalence</em> menyimpulkan bahwa usia ekstrem merupakan faktor risiko preeklampsia berat (RP= 1,476; CI= 1,094 – 1,922), dan nuliparitas belum dapat ditentukan apakah merupakan faktor risiko atau faktor protektif (RP= 0,765; CI= 0,565 – 1,034). …”
Get full text

Characteristic TARC/CCL17 expression in the salivary gland of IgG4-related disease: potential diagnostic utility and insights into pathogenesis by Nanako Kikuchi, Sae Hatanaka, Terufumi Kubo, Ryuta Kamekura, Masatoshi Kanda, Takuya Kakuki, Takashi Sasaya, Kengo Mita, Hiroki Kobayashi, Hajime Ikai, Kenta Sasaki, Naoki Shijubou, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Tadashi Hasegawa, Akihiro Miyazaki, Hiroki Takahashi, Ken-ichi Takano, Toshihiko Torigoe

“…Immunohistochemical analysis revealed TARC/CCL17 positivity in 87.2% of histologically confirmed IgG4-RD cases and negativity in 84.6% of histologically unconfirmed but clinically suspected IgG4-RD cases. …”
Get full text

Multisectoral interventions for urban health in Africa: a mixed-methods systematic review by Meelan Thondoo, Ebele R. I. Mogo, Lambed Tatah, Monica Muti, Kim R. van Daalen, Trish Muzenda, Rachel Boscott, Omar Uwais, George Farmer, Adelaide Yue, Sarah Dalzell, Gudani Mukoma, Divya Bhagtani, Sostina Matina, Philip M. Dambisya, Kufre Okop, Charles Ebikeme, Lisa Micklesfield, Tolu Oni

“…We searched four academic databases (PubMed, Scopus, Web of Science, Global Health) for evidence dated 1989–2019 and identified grey literature from expert input. …”
Get full text

Predatory Functional Response of Harmonia sedecimnotata to Aphis craccivora by Jiaru DENG, Zhiwei LIU, Lizhi HUO, Longhua SUN

“…When the predator density reached 5 individuals per plate, the predation rates of female and male adults was the lowest, which were 0.198 and 0.172, and the intensity of scramble competition was the highest, which were 0.548 and 0.558, respectively.…”
Get full text

A rare deleterious missense mutation in the AXIN2 gene in Chinese women with polycystic ovary syndrome by Ying Zhang, Yu Chen, Fa-Ying Liu, Jing-Wen Fu, Xian-Xian Liu, Jun Tan, Ou-Ping Huang, Yang Zou

Get full text

CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody by Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang

Get full text

Development and validation of an integrated model for the diagnosis of liver cirrhosis with portal vein thrombosis combined with endoscopic characters and blood biochemistry data:... by Jie Yang, Xu Zhang, Jia Chen, Xianghong Hou, Minghong Shi, Longlong Yin, Longchun Hua, Cheng Wang, Xiaolong Han, Shuyan Zhao, Guolan Kang, Ping Mai, Rui Jiang, Hongwei Tian

Get full text

The development and implementation of an innovative community-based intervention to strengthen community capacity for HIV prevention and care among Canadians of African Caribbean a... by Josephine Etowa, Notisha Massaquoi, Francisca Omorodion, Danielle Brown-Shreves, Ilene Hyman, Akalewold Gebremeskel, Hugues Loemba, Bishwajit Ghose, Egbe Etowa, Jennifer Rayner, Charles Dabone, Lounanjio Brown O’Sullivan, Azeeza Sule, Joseph Kiirya, Sanni Yaya, Wangari Tharao, Haoua Inoua, Angela Kaida, Apondi Odhiambo, Clinton Beckford

Get full text

Gut microbiota modulation via fecal microbiota transplantation mitigates hyperoxaluria and calcium oxalate crystal depositions induced by high oxalate diet by Lingyue An, Shujue Li, Zhenglin Chang, Min Lei, Zhican He, Peng Xu, Shike Zhang, Zheng Jiang, Muhammad Sarfaraz Iqbal, Xinyuan Sun, Hongxing Liu, Xiaolu Duan, Wenqi Wu

Get full text

The rationale, design of the Assisted reproductive technology cohort nested in a pre-pregnancy family cohort (APP-Cohort) by Wei Xiong, Qinghan Liang, Xiaojie Han, Qiaolu Cheng, Qihang Liu, Xifang Zuo, Huiyu Wang, Huijing He, Guangliang Shan

Get full text

Coactivation of Tie2 and Wnt signaling using an antibody–R-spondin fusion potentiates therapeutic angiogenesis and vessel stabilization in hindlimb ischemia by Byungtae Hwang, Min-Young Jeon, Ju-Hong Jang, Young-Lai Cho, Dong Gwang Lee, Jeong-Ki Min, Jangwook Lee, Jong-Gil Park, Ji-Hun Noh, Wonjun Yang, Nam-Kyung Lee

Get full text

Overexpression of multiple cytochrome P450 genes with and without knockdown resistance mutations confers high resistance to deltamethrin in Culex quinquefasciatus by Saowanee Chamnanya, Benyapa Kiddela, Jassada Saingamsook, Woottichai Nachaiwieng, Nongkran Lumjuan, Pradya Somboon, Jintana Yanola

“…The cDNA of mosquitoes was amplified and sequenced for four fragments of vgsc gene. The kdr L1014F mutation and the haplotype of the CYP9M10 gene were detected in survivor and dead mosquitoes after exposure to the deltamethrin WHO test paper. …”
Get full text

Effect of Acarbose on High Carohydrate Diet Induced Liver Injury in Largemouth Bass (Micropterus salmoides) by Yanhao CAO, Xiaolong BO, Hongli LIU, Xiaoli HUANG

“…The results of flow cytometry showed that the total apoptosis rate of liver cells in the high carbohydrate group was the highest at 4.64% among the three groups, while that of the acarbose group significantly decreased to 1.24% (P < 0.05). In addition, compared with the control group, the ROS content in the liver tissue of largemouth bass in the high carbohydrate group increased to 30.94%, while that decreased to 22.35% in the acarbose group, showing a trend of returning to normal levels. …”
Get full text

The association between systemic inflammatory response index and contrast-associated acute kidney injury in patients undergoing elective percutaneous coronary intervention by Jun-Han Chen, Li-Wei Zhang, Wen-Jia Liang, Wei-ze Lin, Xiao-Fang Chen, Zhi-Jie Lin, Chang-Xi Wang, Kai-Yang Lin, Yan-Song Guo

“…[Hazard ratio (HR)=1.448, 95%CI: 1.188–1.765; p < 0.001]. Besides, Kaplan–Meier survival curve also indicated that the cumulative rate of mortality was considerably higher in the high SIRI group.Conclusions High levels of SIRI are independent predictors of CA-AKI and long-term mortality in patients undergoing elective PCI.…”
Get full text

Alternative splicing for tuneable expression of protein subunits at desired ratios by Christel Aebischer-Gumy, Pierre Moretti, Timothee Brunstein Laplace, Jana Frank, Ysaline Grand, Farid Mosbaoui, Emilie Hily, Anna Galea, Megane Peltret, Carole Estoppey, Daniel Ayoub, Roberto Giovannini, Martin Bertschinger

“…To illustrate this approach, we developed constructs expressing varying ratios of GFP and dsRED and extended their application to multimeric proteins such as monoclonal antibodies, achieving industrially relevant expression levels (>1 g/L) in a 14-day fed-batch process. The stability of the splice ratio was confirmed by droplet digital PCR in a stable pool cultivated over a 28-day period, while product quality was assessed via intact mass analysis, demonstrating absence of product-related impurities resulting from undesired splice events. …”
Get full text