Persistent lipoprotein(a) exposure and its association with clinical outcomes after acute myocardial infarction: a longitudinal cohort study by Zhenwei Wang, Junnan Tang, Qian Shi, Lijuan Fang, Naifeng Liu, Jinying Zhang

“…The group with persistent high Lp(a) faced increased risk of MACCE (HRadjusted, 1.871; 95% CI: 1.474–2.374), non-fatal stroke (HRadjusted, 1.647; 95% CI: 1.031–2.632), unplanned revascularization (HRadjusted, 1.571; 95% CI: 1.008–2.449), and both all-cause (HRadjusted, 1.546; 95% CI: 1.134–2.108) and cardiovascular death (HRadjusted, 2.163; 95% CI: 1.405–3.331), compared to the persistent low Lp(a) group.Conclusions In AMI patients, sustained high Lp(a) levels were significantly associated with increased risk of MACCE, non-fatal stroke, unplanned revascularization, and both all-cause and cardiovascular death.…”
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Corticosterone rapidly modulates dorsomedial hypothalamus serotonin and behavior in an estrogen- and progesterone-dependent manner in adult female rats: potential role of organic c... by Jamie L. Scholl, Joshua T. Rogers, Na Feng, Gina L. Forster, Michael J. Watt, Jazmine D. W. Yaeger, Michael W. Buchanan, Christopher A. Lowry, Kenneth J. Renner

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Bushen Huoxue formula protects against renal fibrosis and pyroptosis in chronic kidney disease by inhibiting ROS/NLRP3-mediated inflammasome activation by Lin Liao, Pengyu Tao, Qiming Xu, Jie Chen, Weiwei Liu, Jing Hu, Jianrao Lu

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Long-term mortality in patients with end-stage renal disease undergoing hemodialysis and peritoneal dialysis: a propensity score matching retrospective study by Pengjie Zhang, Liru Xun, Nan Bao, Ding Tong, Bin Duan, Du Peng

“…However, the 5- and 10-year mortality rates of the matched patients were 15.8%. 17.6% in the HD group and 21.0%. 27.3% in the PD group, respectively. …”
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Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy by Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber

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Comprehensive characterization of higher order structure changes in methionine oxidized monoclonal antibodies via NMR chemometric analysis and biophysical approaches by Mingyue Li, Victor A. Beaumont, Shahajahan Akbar, Hannah Duncan, Arch Creasy, Wenge Wang, Kelly Sackett, Lisa Marzilli, Jason C. Rouse, Hai-Young Kim

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Clinicopathological characteristics and outcomes of PLA2R related idiopathic membranous nephropathy in patients with seronegative PLA2R antibodies by Xue Li, Yang Shen, Yanchun Li, Lijie Ma, Qianmei Sun

“…Multivariate logistic analyses indicated that low albumin (0.79 [95%CI: 0.66–0.95], p = .01) and high cholesterol (1.81 [95%CI: 1.02–3.19], p = .04) were correlated with seropositivity of PLA2R antibody. …”
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Prevalence and influencing factors of non-suicidal self-injurious behaviour among Chinese college students: a Meta-analysis by TAO Silu, MAO Guoju, XIONG Yi, GUO Mengjia, WU Dongmei

“…Freshman year [OR=1.55, 95%CI(1.22, 1.97)], sophomore year [OR=1.74, 95%CI(1.36, 2.23)], bornin urban or town [OR=1.44, 95%CI(1.26, 1.64)], non-medical colleges or majors [OR=1.50, 95%CI(1.39, 1.61)], negative life events [OR=1.02, 95%CI(1.01, 1.04)], sexual abuse in primary school or earlier [OR=3.14, 95%CI(1.97, 5.02)], depression [OR=1.47, 95%CI(1.33, 1.63)], anxiety [OR=2.20, 95%CI(1.25, 3.87)], fantasies [OR=1.18, 95%CI(1.03, 1.35)], alcohol consumption [OR=1.60, 95%CI(1.40, 1.83)], and feelings of sadness and despair [OR=6.32, 95%CI(2.96, 13.51)] were the risk factors for prevalence of NSSI in Chinese college students.Conclusion The prevalence of NSSI among Chinese college students is high and closely related to a variety of factors. …”
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The gut microbiota predicts and time-restricted feeding delays experimental colitis by Hannah K. Ruple, Eva Haasis, Anna Bettenburg, Carina Maier, Carolin Fritz, Laura Schüle, Sarah Löcker, Yvonne Soltow, Lynn Schintgen, Nina S. Schmidt, Celine Schneider, Axel Lorentz, W. Florian Fricke

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Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals by Bowen Zhu, Fang Li, Weidong Zhang, Shuan Zhao, Nana Song, Shi Jin, Ziyan Shen, Yufei Lu, Yang Li, Hong Liu

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Identification of novel anti-CD16a antibody clones for the development of effective natural killer cell engagers by Bill Liao, Christine Tumanut, Lin Li, Adam Corper, Dilip Challa, Alex Chang, Hydari Begum, Elinaz Farokhi, Catherine Woods, Xiaomin Fan

“…Epitope mapping studies revealed that they bind to an epitope dependent on residue Y158 of CD16a, since mutation of Y158 to the corresponding CD16b residue H158 completely abolishes binding to CD16a. …”
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Utilizing vaginal natural orifice to facilitate bowel manipulation during totally intracorporeal ileal conduit construction: a retrospective cohort study by Kaipeng Jia, Shiwang Huang, Zhun Wang, Yuda Lin, Yiduo Bai, Chong Shen, Zhe Zhang, Zhouliang Wu, Yunkai Qie, Hailong Hu

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Preliminary efficacy of eye movement desensitization and reprocessing for children aged 1.5–8 years with PTSD: a multiple baseline experimental design (N = 19) by Carlijn de Roos, Julia Offermans, Samantha Bouwmeester, Ramón Lindauer, Frederike Scheper

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USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation by Ranran Xu, Fei Huang, Qingquan Liu, Yongman Lv, Liu Hu, Qian Zhang

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Novel immune cross-talk between inflammatory bowel disease and IgA nephropathy by Qianqian Yan, Zihao Zhao, Dongwei Liu, Jia Li, Shaokang Pan, Jiayu Duan, Zhangsuo Liu

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Demographics and outcomes of acute type A aortic dissection in young adults in southeastern China: impact of syndromic heritable thoracic aortic disease by Xin-fan Lin, Hang-qi Gao, Qing-song Wu, Yu-ling Xie, Liang-wan Chen, Lin-feng Xie

“…Most patients underwent extensive arch procedures and in-hospital mortality rate of patients was 14.2%, which was higher in the HTAD group than in the non-HTAD group (20.0% vs. 11.0%, p = .142). …”
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The complexities of elexacaftor/tezacaftor/ivacaftor therapeutic drug monitoring in a person with cystic fibrosis and Mycobacterium abscessus pulmonary disease by Claire Y Mou, Daniel J Henderson, Angela G Matson, Karen M Herd, David W Reid, Timothy Riddles, Ellie Johnson, Brett McWhinney, Rebecca Swenson, Andrew Burke, Ieuan E S Evans

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Immune checkpoint inhibitors in cancer patients with autoimmune disease: Safety and efficacy by Jiayuan Le, Yuming Sun, Guangtong Deng, Yating Dian, Yanli Xie, Furong Zeng

“…When cancer patients with preexisting autoimmune diseases received ICIs treatment, the overall incidence was 0.610 (95% CI: 0.531–0.686) for any grade irAEs, 0.295 (95% CI: 0.248–0.343) for flares, 0.325 (95% CI: 0.258–0.396) for de novo irAEs, 0.238 (95% CI: 0.174–0.309) for grade ≥3 irAEs, and 0.143 (95% CI: 0.109–0.180) for discontinuation due to immunotoxicity. …”
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The family medicine accelerated track at Texas Tech University Health Sciences Center: results from a 10-year program to bend the primary care curve by Betsy Goebel Jones, Ronald C. Cook, Felix Morales, Keeley Hobart, Steven L. Berk

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A Collision-Free Path-Planning Method for an Articulated Mobile Robot by P. Quintero-Alvarez, G. Ramirez, S. Zeghloul

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