Krüppel-like factor 4 modulates the miR-101/COL10A1 axis to inhibit renal fibrosis after AKI by regulating epithelial–mesenchymal transition by Jingying Zhao, Xiuli Wang, Yubin Wu, Chengguang Zhao

Get full text

Oral Fusobacterium nucleatum resists the acidic pH of the stomach due to membrane erucic acid synthesized via enoyl-CoA hydratase-related protein FnFabM by Xiaocong Li, Shipeng Zhang, Huafang Sheng, Yan Zhen, Buling Wu, Zhuang Li, Dingqiang Chen, Hongwei Zhou

Get full text

Biologic Therapies for Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials by Tyler Pitre, Daniel Lupas, Jasmine Mah, Matthew Stanbrook, Alina Blazer, Dena Zeraatkar, Terence Ho

“…Dupilumab may reduce exacerbations more than tezepelumab (RR 0.82 [95% CI 1.14]) (low certainty). For all patients, no treatment improved FEV1 above the pre-specified minimal clinically important difference (MCID) of 0.1 L. …”
Get full text

Tobacco cv. Solaris seed cake as feed for light lambs: growth performance, carcase traits and meat quality by Antonella Fatica, Marisa Palazzo, Siria Tavaniello, Meng Peng, Dereje Birara Teshale, Giuseppe Maiorano, Elisabetta Salimei

“…Fatty acid composition showed lower palmitic acid (C16:0, p < 0.05) and higher stearic acid (C18:0, p < 0.01) content in SSC compared to CTR fed lambs. …”
Get full text

External validation of the prediction model of intradialytic hypotension: a multicenter prospective cohort study by Yuhe Xiang, Guoting Ma, Qin Yang, Min Cao, Wenbin Xu, Lin Li, Qian Yang

“…Decision Curve Analysis (DCA) was employed to evaluate the clinical benefit of updating the model.Results The final cohort comprised 2235 individuals undergoing maintenance hemodialysis, exhibiting a 14.6% occurrence rate of IDH. The externally validated Area Under the Curve (AUC) values for the three original prediction models were 0.746 (95% CI: 0.718 to 0.775), 0.709 (95% CI: 0.679 to 0.739), and 0.735 (95% CI: 0.706 to 0.764) respectively. …”
Get full text

Prenatal genetic detection in foetus with gallbladder size anomalies: cohort study and systematic review of the literature by Yimo Zeng, Rong Hu, Jian Lu, Yiming Qi, Dan Chen, Chaoxiang Yang, Jing Wu

Get full text

Association of frequent intradialytic hypotension with the clinical outcomes of patients on hemodialysis: a prospective cohort study by Yuanhao Wu, Jianda Lu, Tingting Wang, Xiaoye Zhu, Jun Xue, Li You

“…Multivariable Cox regression analysis indicated that frequent IDH was independently associated with a higher risk of all-cause mortality (Model 1: HR = 2.553, 95%CI 1.334–4.886, p = 0.005; Model 2: HR = 2.406, 95%CI 1.253–4.621, p = 0.008). …”
Get full text

Phenological Characteristics and Environmental Factor Associations in Open-Field Cultivation of Pepino on the Qinghai-Tibet Plateau by Zhichao Hou, Cheng Si, Qiwen Zhong, Haiwang Zhang, Ziran Guo, Guangnan Zhang, Dengkui Shao, Shipeng Yang

Get full text

Efficient and Effective Diabetes Care in the Era of Digitalization and Hypercompetitive Research Culture: A Focused Review in the Western Pacific Region with Malaysia as a Case Stu... by Boon-How Chew, Pauline Siew Mei Lai, Dhashani A/P Sivaratnam, Nurul Iftida Basri, Geeta Appannah, Barakatun Nisak Mohd Yusof, Subashini C. Thambiah, Zubaidah Nor Hanipah, Ping-Foo Wong, Li-Cheng Chang

Get full text

General practitioners’ clinical decision-making in patients that could have cancer: a vignette study comparing the Baltic states with four Nordic countries by Alexander Rosendahl, Anet Vanaveski, Liina Pilv-Toom, Jānis Blumfelds, Vija Siliņa, Mette Brekke, Tuomas Koskela, Aurimas Rapalavičius, Hans Thulesius, Peter Vedsted, Michael Harris

Get full text

Adaptation and validation of the Collective Efficacy Questionnaire for Sport (CEQS) in Arabic: enhancing team dynamics assessment by Jaouher Hamaidi, Mohamed Mansour Bouzourraa, Mouna Saidane, Mohamed Ben Aissa, Mohamed Ali Boujelbane, Khaled Trabelsi, Haitham Jahrami, Achraf Ammar, Noomen Guelmami, Makrem Zghibi, Ismail Dergaa

Get full text

Neurohypophysial Receptor Gene Expression by Thymic T Cell Subsets and Thymic T Cell Lymphoma Cell Lines by I. Hansenne, G. Rasier, Ch. Charlet-renard, M.-P. Defresne, R. Greimers, C. Breton, J.-J. Legros, V. Geenen, H. Martens

Get full text

Association between estimated pulse wave velocity and in-hospital mortality of patients with acute kidney injury: a retrospective cohort analysis of the MIMIC-IV database by Xinhai Cui, Yuanlong Hu, Dongxiao Li, Mengkai Lu, Zhiyuan Zhang, Dongfang Kan, Chao Li

Get full text

Strengthening the Resilience of Objective-Oriented Health System Reforms. Analysis of the Left-Turn in the Health Reform Proposals in Mexico (2019) and Colombia (2023) by Laura Flamand, Octavio Gómez-Dantés, Natalia Losada-Trujillo, Diana Pinto, Edson Serván-Mori, Diego Cerecero-García, Thomas Hone, Sumit Mazumdar

Get full text

Shenkang injection for the treatment of acute kidney injury: a systematic review and meta-analysis by Shengchun Liao, Yurou Chen, Shuting Wang, Chen Wang, Chaoyang Ye

“…Secondary outcomes included blood urea nitrogen (BUN), serum cystatin C (CysC), 24-h urine protein (24 h-Upro) levels, APACHE II score and adverse reactions.Results This meta-analysis included eleven studies, and the analysis indicated that, compared with the control group, SKI significantly decreased SCr [WMD = −23.31, 95% CI (-28.06, −18.57); p < 0.001]; BUN [WMD = −2.07, 95% CI (-2.56, −1.57); p < 0.001]; CysC [WMD = −0.55, 95% CI (-0.78, −0.32), p < 0.001]; 24-h urine protein [WMD = −0.43, 95% CI (-0.53, −0.34), p < 0.001]; and the APACHE II score [WMD = −3.07, 95% CI (-3.67, −2.48), p < 0.001]. …”
Get full text

Changes in serum sodium concentration during hemodialysis is a predictor of mortality and cardio-cerebrovascular event by Qixing Liu, Ke Zheng, Haiyun Wang, Dan Song, Xuemei Li

“…Time-averaged ΔSNa also demonstrated an association with all-cause mortality (3-year ΔSNa: HR [95% CI] 1.26 [1.03–1.55], p = 0.026) as well as with CCVE (3-year ΔSNa: HR [95% CI] 1.51 [1.21–1.88], p = <0.001) when fully adjusted. Baseline pre-HD SNa and ΔSNa didn’t exhibit association with both outcomes.Conclusions Lower time-averaged pre-HD SNa and higher time-averaged ΔSNa were associated with a greater risk of all-cause mortality and CCVE in HD patients.…”
Get full text

Impact of pharmacist-led medication review among hemodialysis patients: a systematic review by Ganesh Sritheran Paneerselvam, Chen Kah Yee, Muhammad Junaid Farrukh, Ana Yuda, Andi Hermansyah, Mohd. Fadli Mohd. Asmani, Ibrahim Abdullah, Long Chiau Ming

Get full text

Exploring medicine classification and accessibility: a qualitative study by Awangku Khairi Wazien Pengiran Umar, Hui Poh Goh, Zaidah Rizidah Murang, Andi Hermansyah, Inayat Ur Rehman, Khang Wen Goh, Kwan Foong Chee, Long Chiau Ming

Get full text

High-dose glucocorticoid treatment vs. glucocorticoid replacement in immune checkpoint inhibitor associated hypophysitis (CORTICI): an open, randomised controlled trial by Verena Theiler-Schwetz, Christian Trummer, Lisa Schmitt, Angelika Terbuch, Barbara Obermayer-Pietsch, Erika Richtig, Stefan Pilz

“…The primary outcome was the frequency of hormonal axes recovery.Results Between 17th April 2019 and 16th September 2022, 18 out of the 20 randomised patients finished the trial; eight completed high-dose, 10 glucocorticoid replacement. …”
Get full text

Similar incidence of graft glomerulonephritis in recipients with definitively diagnosed glomerulonephritis and those with unknown etiology: a retrospective observational study by Qianqian Wu, Xuefeng Ni, Jingsong Chen, Dongrui Cheng, Mingchao Zhang, Kenan Xie, Xue Li, Jiqiu Wen

Get full text