Risk factors for hepatocellular carcinoma: an umbrella review of systematic review and meta-analysis by Jie Wang, Kaijie Qiu, Songsheng Zhou, Yichao Gan, Keting Jiang, Donghuan Wang, Haibiao Wang

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Diversity and functions of fungal VOCs with special reference to the multiple bioactivities of the mushroom alcohol by Guohua Yin, Geromy G. Moore, Joan Wennstrom Bennett

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B-phosphatidylethanol testing to identify hazardous alcohol use in primary health care—a game changer and a challenge for general practitioners: a qualitative study by Åsa Steensland, Anna Segernäs, Mårten Larsson, Andrea Johansson Capusan, Lisa Kastbom

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A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy by Gerhard Frey, Ana Paula G. Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J. Boyle, Jay M. Short

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Exploring Clec9a in dendritic cell-based tumor immunotherapy for molecular insights and therapeutic potentials by Zubair Hussain, Yueteng Zhang, Lu Qiu, Shanshan Gou, Kangdong Liu

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Association between postoperative ibuprofen exposure and acute kidney injury after pediatric cardiac surgery by Sheng Shi, Chao Xiong, Dongyun Bie, Zhongrong Fang, Jianhui Wang

“…A multivariable Cox regression model was used to assess the association between ibuprofen exposure and postoperative AKI by taking ibuprofen as a time-varying covariate.Results Among 1,112 included children, 198 of them (17.8%) experienced AKI. In total, 396 children (35.6%) were exposed to ibuprofen. …”
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‘Piloting a framework for analysing the public contributions to R&D: new antibiotics in focus’ by Louise Schmidt, Ozren Sehic, Ursula Theuretzbacher, Daniel Fabian, Claudia Wild

“…The framework, together with work we have done on identifying sources for funding, can be applied to support pharmaceutical price negotiations that reflect the level of public contribution to product development.Trial registration: EU Clinical Trials Register identifier: 0004-2083-2207.Trial registration: EU Clinical Trials Register identifier: 0003-1754-9422.…”
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Facilitators and barriers of alcohol goals for Latinx men hospitalized with alcohol use disorder seen by an Addiction Consult Team by Mariam S. Carson, Alein Y. Haro-Ramos, Naomi López-Solano, Carla Fernandez, Marcus Cummins, Alicia Fernandez, Triveni DeFries, Marlene Martin

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Targeted modulation of intestinal barrier and mucosal immune-related microbiota attenuates IgA nephropathy progression by Ran Zhang, Yuyan Tang, Xiangru Feng, Xiaoxuan Lu, Mengyao Zhao, Jiayang Jin, Xiaoguo Ji, Haidong He, Liming Zhao

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Perspectives on AI-based recommendations for mask-wearing and COVID-19 vaccination for transplant recipients in the post-COVID-19 era by Oscar A. Garcia Valencia, Charat Thongprayoon, Jing Miao, Jackrapong Bruminhent, Iasmina M. Craici, Wisit Cheungpasitporn

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Fatigue failure mechanisms and life prediction of additive manufactured metallic lattices: a comprehensive review by Hao Xin, Dingcheng Tang, Linwei Dang, Lei Gao, Zhenyu Yang, Bin Wu, Xiaofan He, Zhixin Zhan

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Nonlinear association between proteinuria levels and the risk of cardiovascular disease events and all-cause mortality among chronic kidney disease patients by Haiying Song, Yuheng Liao, Haofei Hu, Qijun Wan

“…Adjusted hazard ratios (HRs) for UPCR in middle and high groups, compared to the low group, were 1.93 (95% CI: 1.28–2.91) and 4.12 (95% CI: 2.87–5.92), respectively, after multivariable adjustment. …”
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The relationship of platelet distribution width with all-cause and cardiovascular mortality in peritoneal dialysis patients by Chunyu Lu, Shuiqin Cheng, Wenjing Fan, Zhihong Zhang, Jinquan Wang

“…After adjusting for confounders, Cox proportional hazards models showed that the PDW value was positively correlated with the risk of all-cause and cardiovascular mortality (HR = 1.162, 95% CI 1.057–1.278, p = 0.002 and HR = 1.200, 95% CI 1.041–1.382, p = 0.012). The adjusted RCS analysis further showed that the relationship of PDW with all-cause and cardiovascular mortality was linear (p for nonlinearly = 0.143 and 0.062).Conclusion Elevated PDW is independently associated with all-cause and cardiovascular mortality in PD patients.…”
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Causes of death among older children and adolescents (5–19 years) in the Magu Health and Demographic Surveillance Study, Tanzania, 1995–2022 by Sophia Kagoye, Milly Marston, Yasson Abha, Eveline T. Konje, Mark Urassa, Jim Todd, Ties Boerma

“…By 2015–2022, 48% of 5–14 and 42% of 15–19-year-olds died in health facilities, up from 25% in 1995–2002. …”
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Evaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry by Jing Xu, John E. Coughlin, Malgorzata Szyjka, Serene Jabary, Sonal Saluja, Zoran Sosic, Yunqiu Chen, Chong-Feng Xu

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Placenta-derived mesenchymal stem cells protect against diabetic kidney disease by upregulating autophagy-mediated SIRT1/FOXO1 pathway by Honghong Liu, Jiao Wang, Guanru Yue, Jixiong Xu

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Safety and efficacy of apixaban versus vitamin K antagonists in patients undergoing dialysis: a systematic review and meta-analysis by Yifang Zhang, Jialiang Wang, Nannan Shen, Jie Jiang, Yanna Xie

“…Meta-analysis also showed that the risk of gastrointestinal bleeding (RR: 0.74, 95% CI: 0.64, 0.85, I2 = 16%) and intracranial bleeding (RR: 0.64, 95% CI: 0.49, 0.84, I2 = 0%) was significantly reduced with apixaban. …”
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Switching to Dolutegravir/lamivudine or Bictegravir/Emtricitabine/Tenofovir alafenamide. A comparative real-world study by Hernando Knobel, Esperanza Cañas-Ruano, Ana Guelar, Pablo Knobel, Judit Villar-García, Alicia González-Mena, Ceclia Canepa, Itziar Arrieta-Aldea, Augustin Marcos, Agustí Abalat-Torrres, Roberto Güerri-Fernández

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Identification of multicohort-based predictive signature for NMIBC recurrence reveals SDCBP as a novel oncogene in bladder cancer by Chen Zhang, Hubin Yin, Tinghao Li, Junrui Chen, Weiyang He, Ke Ren, Bo Li, Xudong Liu

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Blood and body fluids exposure, post-exposure prophylaxis, and HIV self-testing among healthcare workers in northern Nigeria by Zubairu Iliyasu, Musa Babashani, Khadija Dantata, Shaheed A. Zakariyyah, Muktar A. Gadanya, Humayra A. Bashir, Auwalu U. Gajida, Muktar H. Aliyu

“…. <30 years), profession (aOR = 1.88; 95% CI: 1.18-4.66, nurse/midwife vs. physician), work unit (aOR = 0.06; 95% CI: 0.02-0.23, obstetrics/gynecology vs. surgery), and previous HIV testing and counseling (aOR = 0.01; 95% Cl: 0.004-0.03, no vs. yes). …”
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