Teachers’ perception of the implementation of project-based learning in early childhood education in Indonesia<subtitle>Project-Based Learning: a perspective from Indonesian early... by Siti Aisyah, Dian Novita

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Evaluating the implementation of person-centred care and simulation-based learning in a midwifery education programme in the Democratic Republic of Congo: a study protocol by Frida Temple, Ewa Carlsson Lalloo, Marie Berg, Urban Berg, Alumeti Munyali Désiré, Olivier Nyakio, Aline Mulunda, Malin Bogren

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The Modulation of Meteorological Parameters on Surface PM2.5 and O3 Concentrations in Guangzhou, China by Qiaoli Bu, Yingying Hong, Haobo Tan, Li Liu, Chunlin Wang, Jianjun Zhu, Pakwai Chan, Chen Chen

“…Calculating each factor’s critical values for these concentrations, we found that the hourly PM2.5 concentration tended to increase when the relative humidity was > 50%, the hourly rainfall intensity was ≤ 0.6 mm hour−1, or the wind speed was ≤ 1.8 m s−1 but otherwise decreased, whereas the MDA8 O3 concentration tended to increase when the sunshine duration was > 4 hours, the maximum temperature was > 29°C, or the average daily wind speed was ≤ 1.8 m s−1 but otherwise decreased. …”
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Accuracy of an articulated head-and-neck motion model using deep learning-based instance segmentation of skeletal bones in CT scans for image registration in radiotherapy by Alexandra Walter, Cornelius J. Bauer, Ama Katseena Yawson, Philipp Hoegen-Saßmannshausen, Sebastian Adeberg, Jürgen Debus, Oliver Jäkel, Martin Frank, Kristina Giske

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“Arming half-baked people with weapons!” Information enclaving among professionals and the need for a care-centred model for antibiotic use information in Uganda, Tanzania and Mala... by Susan Nayiga, Eleanor E MacPherson, John Mankhomwa, Fortunata Nasuwa, Raymond Pongolani, Rita Kabuleta, Mike Kesby, Russell Dacombe, Shona Hilton, Delia Grace, Nicholas Feasey, Clare I.R. Chandler

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Perception and adaptation to climate change of the K'Ho people related to coffee production in Lâm Đồng province, Vietnam by Nguyen Dinh Nghiep, Le Minh Chien, Nguyen Van Hoang, Pham Hong Hai, Dao Thi Hieu, Nguyen Thi Thanh Thuan, Do Van Toan, Le Quang Ngoc, Ho Dieu Huyen

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Discussion on the mechanism of HER2 resistance in esophagogastric junction and gastric cancer in the era of immunotherapy by Yan Zhang, Wenxuan Fan, Fei Su, Xiaoling Zhang, Yunyi Du, Weiling Li, Yangjun Gao, Wenqing Hu, Jun Zhao

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Exploring RNA modifications in infectious non-coding circular RNAs by Pavel Vopalensky, Anton Škríba, Michela Chiumenti, Lucia Ďuričeková, Anna Šimonová, Ondřej Lukšan, Francesco di Serio, Beatriz Navarro, Hana Cahova

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Impact of Lonicera hypoglauca leaf inclusion on immune and antioxidant responses in geese by Zonghao Lv, Zhen Li, Zhizhong Zhang, Gao Li, Qinghua Chen, Qian Lin

“…The parent study explored the effects of LHLs as a partial feed substitute on the growth performance, serum biochemistry, antioxidant capacity and immune function of geese. For this study, 180 one-day-old male Xiang goslings were randomly assigned to control and 4 treatment groups (6 replicates per group; 6 goslings per replicate). …”
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Abnormal directed migration of blood polymorphonuclear leukocytes in rheumatoid arthritis. Potential role in increased susceptibility to bacterial infections by F. Aglas, J. Hermann, G. Egger

“…Unstimulated PMN migration of RA patients was increased compared with healthy controls as measured by the following parameters: (a) absolute number of migrant PMNs (1954 ± 87 vs. 1238 ± 58 PMN/mm2), (b) percentage of PMNs migrated into the filter (total migration index, TMI) (28.6 ± 0.9 vs. 24.0 ± 0.8 %), (c) the distance half the migrating PMNs had covered (distribution characteristic, DC) (22.6 ± 1.1 vs. 16.1 ± 0.6 mm) and (d) the product of TMI and DC (neutrophil migratory activity, NMA) (669.0 ± 45.0 vs. 389.0 ± 18.9). fMLP stimulated PMNs of RA patients showed defective migration compared to unstimulated samples as shown by (a) a reduced number of migrant PMNs (1799 ± 93 PMN/mm2), (b) lower TMI (26.1 ± 0.9 %), (c) unremarkable altered distribution characteristic (22.9 ± 0.8 mm) and (d) significant reduced migratory activity (600.0 ± 30.0). …”
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Variable domain mutational analysis to probe the molecular mechanisms of high viscosity of an IgG1 antibody by Jing Dai, Saeed Izadi, Jonathan Zarzar, Patrick Wu, Angela Oh, Paul J. Carter

“…A negative correlation was found between the viscosity determined at high concentration (180 mg/mL) and the DLS interaction parameter measured at low concentration (2–10 mg/mL). …”
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The validity of the renal Doppler resistivity index in renal allograft infections by Moataz Fatthy, Karim M. Soliman, Éva Csongrádi, Abd El Rahman Marzouk, Ahmed Fathy, Ahmed Fayed

“…Based on laboratory and histopathological findings, 64 renal-allograft recipients were recruited for the infected group, and 45 were recruited for the non-infected group.Results The causes of allograft infection were Cytomegalovirus (CMV) infection (30.3%), urinary tract infections (UTI) (18.3%), and polyomavirus 1 (BK virus) infections (10.1%). …”
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Prognostic significance of pathological response and lymph node status in neoadjuvant immunotherapy for potentially resectable non-small cell lung cancer by Yuan Xu, Dongjie Ma, Yingzhi Qin, Hongsheng Liu

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Interprofessional teaching rounds in medical education: improving clinical problem-solving ability and interprofessional collaboration skills by Peiwen Yang, Ting Xiong, Xiyuan Dong, Shulin Yang, Jing Yue

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Synthesis of antifungal imines as inhibitors of ergosterol biosynthesis by Joydeep Karan, Aditi Kundu, Robin Gogoi, Kanchikeri Math Manjaiah, Ashutosh Kumar Singh, Koyel Mondal, Rajesh Kumar, Parshant Kaushik, Priya Saini, Virendra Singh Rana, Najam Akhtar Shakil

“…The most effective antifungal compounds displayed >80% inhibition of the lanosterol-14α-demethylase enzyme.…”
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Co-creation of a toolkit to assist risk communication and clinical decision-making in severe preeclampsia: SPOT-Impact study design by Hannah Brown Amoakoh, Bregje C. De Kok, Linda Lucy Yevoo, Klaartje M. Olde Loohuis, Emmanuel K. Srofenyoh, Daniel K. Arhinful, Koiwah Koi-Larbi, Kwame Adu-Bonsaffoh, Mary Amoakoh-Coleman, Joyce L. Browne

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Clinical course and potential associated factors of progressive calcinosis cutis in early systemic sclerosis: a cohort study by Vassana Kanjanajarurat, Prathana Chowchuen, Chingching Foocharoen, Punthip Thammaroj

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Role of macrophage migration inhibitory factor (MIF) in allergic and endotoxin-induced airway inflammation in mice by M. Korsgren, L. Källström, L. Uller, T. Bjerke, F. Sundler, C. G. A. Persson, O. Korsgren

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Sustainable cultivation of phytopharmaceuticals in Baden-Wuerttemberg, Germany: a SWOT analysis and future directions by Peter W. Heger, Ilka Meinert, Peter Nick, Peter Riedl, Michael Heinrich, Michael Straub

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Can deep freezing maintain the quality of two different Iberian pork products over a long storage period? by Ainhoa Sarmiento-García, Beatriz Martínez, Begoña Rubio, Juan-José García-García, Ceferina Vieira

“…To assess whether prolonged frozen storage preserves the properties of two deep-frozen Iberian pork products (sirloin and ‘picadillo’), the technological, microbiological, and sensory characteristics of both products (n = 32) were evaluated at zero time in the fresh product, and after 12, 18 and 24 months of storage at −20 °C after deep-freezing at −80 °C for 50 min after thawing. …”
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