Phase I study of intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or ade... by Lucie Heinzerling, Michael Fluck, Caroline Robert, Celeste Lebbe, Erika Richtig, Sven D Koch, Ulrike Gnad-Vogt, Tobias Seibel, Thomas Eigentler, Juan Martin-Liberal, Sebastian Ochsenreither, Peter Mohr, Patrick Terheyden, Carsten Weishaupt, Michael Erdmann, Lukas Koch, Ainara Soria, Igor Samoylenko, Jürgen Krauß, Peter Brossart, Franz Georg Bauernfeind, Marina Gonzalez, Peter Wengenmayer, Ioannis Thomas, Artem Poltoratskiy, Marina Sekacheva, Beate Schmitt-Bormann, Gianluca Quintini, Martin Falk, Paula Codó, Arjun Oberoi, Jana Hess, Yulia Semiletova, Casilda Llacer Perez, Oliver Schönborn-Kellenberger

“…In the expansion cohorts in patients with anti-PD-1 therapy-refractory melanoma, 0/10 patients treated with CV8102 as monotherapy and 5/30 patients (17%) treated in combination with a PD-1 inhibitor experienced objective responses.Conclusions IT CV8102 was generally well tolerated with preliminary signs of efficacy as monotherapy and in combination with a PD-1 inhibitor.Trial registration number NCT03291002.…”
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The JWST-SUSPENSE Ultradeep Spectroscopic Program: Survey Overview and Star Formation Histories of Quiescent Galaxies at 1 < z < 3 by Martje Slob, Mariska Kriek, Aliza G. Beverage, Katherine A. Suess, Guillermo Barro, Rachel Bezanson, Gabriel Brammer, Chloe M. Cheng, Charlie Conroy, Anna de Graaff, Natascha M. Förster Schreiber, Marijn Franx, Brian Lorenz, Pavel E. Mancera Piña, Danilo Marchesini, Adam Muzzin, Andrew B. Newman, Sedona H. Price, Alice E. Shapley, Mauro Stefanon, Pieter van Dokkum, Daniel R. Weisz

“…These galaxies show a variety of mass-weighted ages (0.8–3.3 Gyr) and star formation timescales (∼0.5–4 Gyr), and four out of 20 galaxies were already quiescent by z = 3. …”
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Improving the experience of health services for trans and gender-diverse young people and their families: an exploratory qualitative study by Melissa Stepney, Samantha Martin, Magdalena Mikulak, Sara Ryan, Jay Stewart, Richard Ma, Adam Barnett

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Peer support for adult social care in prisons in England and Wales: a mixed-methods rapid evaluation by Holly Walton, Efthalia Massou, Chris Sherlaw-Johnson, Donna Gipson, Lucy Wainwright, Paula Harriott, Pei Li Ng, Stephen Riley, Stephen Morris, Naomi J Fulop

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Meta-Analysis of the Effect of Different Amounts of Cow Manure, Chemical (Nitrogen), and Biological Fertilizers on Some Quantitative and Qualitative Traits of Thyme (Thymus vulgari... by Havva Mahnoudi asl, Mahmoud Mokhtari, Reza Sadrabadi Haghighi, مهدی الهی ترشیزی

“…Studies on the effect of chemical fertilizers only on the increase in dry weight yield with the effect size (g = 0.614) have been positive and significant (p≤0.01). …”
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Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trialsResearch in context by Sabri Soussi, Tuukka Tarvasmäki, Antoine Kimmoun, Mojtaba Ahmadiankalati, Feriel Azibani, Claudia C. dos Santos, Kevin Duarte, Etienne Gayat, Jacob C. Jentzer, Veli-Pekka Harjola, Benjamin Hibbert, Christian Jung, Lassus Johan, Bruno Levy, Zihang Lu, Patrick R. Lawler, John C. Marshall, Janine Pöss, Malha Sadoune, Alexis Nguyen, Alexandre Raynor, Katell Peoc'h, Holger Thiele, Rebecca Mathew, Alexandre Mebazaa

“…Patients in the inflammatory and cardiopathic subphenotypes had the highest 28-day mortality (p (log-rank test) = 0.0099 and 0.0055 in the CardShock and FROG-ICU cohorts, respectively). …”
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Investigating the effect of learning and motivational strategies on the self-efficacy of physical education and sports science students with the mediating role of academic progress... by Ahmad Sabihabdollah Alharishavi, Hasan ghalavandi, Mohammad hassani

“…The reliability of the tool was confirmed using Cronbach's alpha coefficient in a preliminary study for the learning strategies questionnaire 0.88, motivational strategies 0.91, academic achievement goals 0.87, academic enthusiasm 0.91, and academic self-efficacy 0.86. …”
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Implementing a nurse-enabled, integrated, shared-care model involving specialists and general practitioners in early breast cancer post-treatment follow-up (EMINENT): a single-cent... by Raymond J. Chan, Fiona Crawford-Williams, Chad Yixian Han, Lee Jones, Alexandre Chan, Daniel McKavanagh, Marissa Ryan, Christine Carrington, Rebecca L. Packer, Megan Crichton, Nicolas H. Hart, Emma McKinnell, Melissa Gosper, Juanita Ryan, Bethany Crowe, Ria Joseph, Carolyn Ee, Jane Lee, Steven M. McPhail, Katharine Cuff, Laisa Teleni, Jon Emery

“…No differences were observed between groups for health-related quality of life and the other effectiveness outcomes measures listed above at all timepoints (P > 0.05 for all). There were significantly fewer average post-treatment radiation oncology appointments per patient in the intervention group compared to the control group (0.69 versus 1.27, P = 0.013) at 24-months. …”
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Evaluación del rol del equipo de coordinación de nefrología en la consulta externa específica de acceso vascular. ¿Qué podemos aportar de nuevo? by Néstor Fontseré, Gaspar Mestres, Xavi Yugueros, Daniel Gil, Carla Blanco, Valentín Lozano, Lidia María Rodas, Arantxa Gelabert, Paula Escarcena, Rosa Ramos, Francisco Maduell

“…Primary (PP) and secondary (PS) patencies at 6, 12 and 24 months were PP: 76.2%, 64.9%, 57.5% and PS: 86.4%, 81.2%, 74.7%, respectively. Of the total number of procedures, nephrology obtained an adequate degree of agreement in 93.6% of the cases (kappa index: 0.886). …”
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PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO): protocol for a multicentre, open-label,... by David Taylor-Robinson, Steve Goodacre, Neil French, Richard Body, Kerenza Hood, Emma Thomas-Jones, Jane Daniels, Sarah Walker, Ingeborg Welters, Mike Bradburn, Paul Schmidt, Enitan Carrol, Lucy Brookes-Howell, Sarah Milosevic, Andrew Tabner, Philip Pallmann, Stephen Aston, Gavin Barlow, Emma Richards, Emmanuel Nsutebu, Philip Howard, Matthew Inada-Kim, Stacy Todd, Fiona McGill, Martin Llewelyn, Louis Wihelmus Niessen, Joanne Euden, Julie Carman, Stephanie Gilbert, Sam Clarkstone, Jacqui Hughes, Lena Meister, Angela Brain, Matthew Scarborough, Sian O'Shea, Claire James

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Dynamic retinal vessel analysis: flickering a light into the brain by Anna Peterfi, Anna Peterfi, Anna Peterfi, Ana Clara da C. Pinaffi-Langley, Ana Clara da C. Pinaffi-Langley, Zsofia Szarvas, Zsofia Szarvas, Zsofia Szarvas, Mihaly Muranyi, Mihaly Muranyi, Mihaly Muranyi, Zalan Kaposzta, Zalan Kaposzta, Zalan Kaposzta, Cheryl Adams, Camila Bonin Pinto, Camila Bonin Pinto, Peter Mukli, Peter Mukli, Peter Mukli, Konstantin Kotliar, Andriy Yabluchanskiy, Andriy Yabluchanskiy, Andriy Yabluchanskiy, Andriy Yabluchanskiy

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The Eczema Bathing Study: Weekly versus daily bathing for people with eczema? Protocol of an online, randomised controlled trial [version 2; peer review: 1 approved, 2 approved wit... by Paul Leighton, Wei Chern Gavin Fong, Ingrid Muller, Laura Howells, Arabella Baker, Eleanor J Mitchell, Eleanor Harrison, Leila Thuma, Yimin Jiang, Lucy Bradshaw, Alan Montgomery, Fiona Cowdel, Matthew J Ridd, Jane Ravenscroft, Reiko J Tanaka, Miriam Santer, Richard Swinden, Nicholas Hilken, Carron Layfield, Richard Dooley, Sophia Collins, Clare Upton, Tracy Owen, Firoza Davies, Devin Patel, Mars Eddis-Finbow, Hywel C Williams, Goldie Putrym, Kim S Thomas, Amanda Roberts

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Solar Energetic Particle Events Detected in the Housekeeping Data of the European Space Agency's Spacecraft Flotilla in the Solar System by Beatriz Sánchez‐Cano, Olivier Witasse, Elise W. Knutsen, Dikshita Meggi, Shayla Viet, Mark Lester, Robert F. Wimmer‐Schweingruber, Marco Pinto, Richard Moissl, Johannes Benkhoff, Hermann Opgenoorth, Uli Auster, Jos deBrujine, Peter Collins, Guido DeMarchi, David Fischer, Yoshifumi Futaana, James Godfrey, Daniel Heyner, Mats Holmstrom, Andrew Johnstone, Simon Joyce, Daniel Lakey, Santa Martinez, David Milligan, Elsa Montagnon, Daniel Müller, Stefano A. Livi, Timo Prusti, Jim Raines, Ingo Richter, Daniel Schmid, Peter Schmitz, Håkan Svedhem, Matt G. G. T. Taylor, Elena Tremolizzo, Dimitri Titov, Colin Wilson, Simon Wood, Joe Zender

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Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent by Timothy R. Rebbeck, Susan S. Devesa, Bao-Li Chang, Clareann H. Bunker, Iona Cheng, Kathleen Cooney, Rosalind Eeles, Pedro Fernandez, Veda N. Giri, Serigne M. Gueye, Christopher A. Haiman, Brian E. Henderson, Chris F. Heyns, Jennifer J. Hu, Sue Ann Ingles, William Isaacs, Mohamed Jalloh, Esther M. John, Adam S. Kibel, LaCreis R. Kidd, Penelope Layne, Robin J. Leach, Christine Neslund-Dudas, Michael N. Okobia, Elaine A. Ostrander, Jong Y. Park, Alan L. Patrick, Catherine M. Phelan, Camille Ragin, Robin A. Roberts, Benjamin A. Rybicki, Janet L. Stanford, Sara Strom, Ian M. Thompson, John Witte, Jianfeng Xu, Edward Yeboah, Ann W. Hsing, Charnita M. Zeigler-Johnson

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Protocol for Home-Based Solution for Remote Atrial Fibrillation Screening to Prevent Recurrence Stroke (HUA-TUO AF Trial): a randomised controlled trial by Jing Tan, Yan Liang, Yong Liu, Wei Jiang, Duo Huang, Ning Tan, Chung-Wah Siu, Jo Jo Hai, Xiaoyu Huang, Jianfeng Ye, Ji-yan Chen, Chun Ka Wong, Mi Zhou, Li-Xue Yin, Ming-Liang Zuo, Kui Kai Lau, Zhen Lei, Yingqing Feng, Bryan P Yan, Wen-Sheng Yue, Wen-Jun Zhang, Yuk-Ming Lau, Hin-Wai LUI, Koon-Ho Chan, Toi Meng Mok, Weng-Chio Tam, Kun-Chong Tam, Xiuhua Feng, Xiaofei Jiang, Guanming Tan, Mario Alberto Evora

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Multiomics analysis reveals the involvement of NET1 in tumour immune regulation and malignant progression by Jian Pang, Xiaoyan Huang, Ya Gao, Xinyu Guan, Lejia Xiong, Lun Li, Nana Yin, Mei Dai, Tong Han, Wenjun Yi

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A systematic review of the cost-effectiveness of anti-VEGF drugs for the treatment of diabetic retinopathy by Robert Hodgson, Matthew Walton, Helen Fulbright, Laura Bojke, Ruth Walker, Alexis Llewellyn, Sofia Dias, Lesley Stewart, David Steel, John Lawrenson, Tunde Peto, Mark Simmonds

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A hepatocellular carcinoma model with and without parenchymal liver damage that integrates technical and pathophysiological advantages for therapy testing by Karina Benderski, Paul Schneider, Panayiotis Kordeves, Michael Fichter, Jenny Schunke, Federica De Lorenzi, Feyza Durak, Barbara Schrörs, Özlem Akilli, Fabian Kiessling, Matthias Bros, Mustafa Diken, Stephan Grabbe, Jörn M. Schattenberg, Twan Lammers, Alexandros Marios Sofias, Leonard Kaps

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Distinct clinical outcomes based on multiple serum cytokine and chemokine profiles rather than autoantibody profiles and ultrasound findings in rheumatoid arthritis: a prospective... by Yukitaka Ueki, Tom W J Huizinga, René E M Toes, Shoichi Fukui, Tomoki Origuchi, Takahiro Maeda, Atsushi Kawakami, Tomohiro Koga, Naoki Matsuoka, Toshihiko Hidaka, Naoki Iwamoto, Mami Tamai, Shin-ya Kawashiri, Akitomo Okada, Ayako Nishino, Tamami Yoshitama, Takahisa Suzuki, Toshimasa Shimizu, Shimpei Morimoto, Tomomi Tsuru, Karin A J van Schie, Masahiro Ayano, Remi Sumiyoshi, Yushiro Endo, Tohru Michitsuji, Kaori Furukawa, Masataka Umeda, Nobutaka Eiraku, Hiroaki Hamada

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Effectiveness of a physiotherapist-led triage and treatment service on WAITing time for adults with musculoskeletal pain referred to Australian public hospital physiotherapy clinic... by Ian A Harris, Andrew Lawson, Bethan Richards, Chris G Maher, Laurent Billot, David Roberts, Chris Needs, David Anderson, Nadine E Foster, Danielle Coombs, Marnee McKay, Joshua R Zadro, Tarcisio F de Campos, Michael Swain, Daniel Treacy, Lisa A Harvey, Gustavo Machado, Jackie Chu, Christopher S Han, Andrew R Gamble, Timothy Shaw, Mark Halliday, Joshua M Hutton, Tom Lung, Lisa Gridley, Joshua Wakefield

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