A novel biochemical analysis for ApoE4 quantification in plasma and discrimination of homozygous and heterozygous APOE ε4 carriers by Andrés Rodríguez, Olga Calero, Sergio Veiga, Miriam Menacho-Román, Ignacio Arribas, Lluís Cano, Guillermo García-Ribas, Miguel Calero

“…Conclusion The e4Quant assay is a novel alternative for genotyping to determine APOE ε4 carrier status, while also providing quantitative measurements of ApoE4 levels. …”
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Development of a postoperative recurrence prediction model for stage Ⅰ non-small cell lung cancer patients using multimodal data based on machine learning by ZHANG Di, WU Yi, XU Yu

“…Radiomic models were established based on extracted features from tumor-dominant regions of interest (ROI) on CT images, while clinical models were developed using demographic characteristics and preoperative laboratory examinations. …”
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Explainable machine learning for predicting distant metastases in renal cell carcinoma patients: a population-based retrospective study by Zhao Hou, Zhao Hou, Peipei Wang, Peipei Wang, Dingyang Lv, Dingyang Lv, Huiyu Zhou, Huiyu Zhou, Zhiwei Guo, Zhiwei Guo, Jinshuai Li, Jinshuai Li, Mohan Jia, Mohan Jia, Hongyang Du, Hongyang Du, Weibing Shuang, Weibing Shuang

“…Hyperparameters were optimized using grid search and tenfold cross-validation. …”
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Developing a Machine Learning Model for Predicting 30-Day Major Adverse Cardiac and Cerebrovascular Events in Patients Undergoing Noncardiac Surgery: Retrospective Study by Ju-Seung Kwun, Houng-Beom Ahn, Si-Hyuck Kang, Sooyoung Yoo, Seok Kim, Wongeun Song, Junho Hyun, Ji Seon Oh, Gakyoung Baek, Jung-Won Suh

“…Among 46,225 patients of the Seoul National University Bundang Hospital, MACCE occurred in 4.9% (2256/46,225), including myocardial infarction (907/46,225, 2%) and stroke (799/46,225, 1.7%), while in-hospital mortality was 0.9% (419/46,225). …”
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Artificial intelligence-based prediction of second stage duration in labor: a multicenter retrospective cohort analysisResearch in context by Xiaoqing Huang, Xiaodan Di, Suiwen Lin, Minrong Yao, Suijin Zheng, Shuyi Liu, Wayan Lau, Zhixin Ye, Zilian Wang, Bin Liu

“…Since durations beyond 3 h were rare, we developed binary classification models with thresholds at 1 h and 2 h. After the optimal features selected by recursive feature elimination (RFE) method, four ML algorithms were employed to build the models. …”
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An IoT-enabled AI system for real-time crop prediction using soil and weather data in precision agriculture by MD Shaifullah Sharafat, Nilavro Das Kabya, Rahimul Islam Emu, Mehrab Uddin Ahmed, Jakaria Chowdhury Onik, Mohammad Aminul Islam, Riasat Khan

“…Several machine learning algorithms, including Random Forest, Gradient Boosting, and Stacking ensembles, as well as deep learning models such as TabNet, were evaluated for crop prediction. …”
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Cellular hierarchy framework based on single-cell and bulk RNA sequencing reveals fatty acid metabolic biomarker MYDGF as a therapeutic target for ccRCC by Ning Wang, Ziyu Xu, Lina Zhang, Lina Zhang, Yanfang Lu, Yanfang Lu, Yanliang Wang, Yanliang Wang, Lei Yan, Lei Yan, Huixia Cao, Huixia Cao, Limeng Wang, Limeng Wang, Fengmin Shao, Fengmin Shao

“…Functional enrichment algorithms, including AUCell, UCell, singscore, ssGSEA, and AddModuleScore, along with hdWGCNA analysis, were used to identify hub genes influencing high FAM of ccRCC. …”
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Comparison of Random Survival Forest Based‐Overall Survival With Deep Learning and Cox Proportional Hazard Models in HER‐2‐Positive HR‐Negative Breast Cancer by Wenqi Cai, Yan Qi, Linhui Zheng, Huachao Wu, Chunqian Yang, Runze Zhang, Chaoyan Wu, Haijun Yu

“…Predictive models were developed using five feature sets and three algorithms (Cox PH, RSF, DeepSurv), with feature selection optimized via Concordance index (C‐index). …”
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Burden of chronic spontaneous urticaria in Italy through healthcare resource utilization and direct costs: a retrospective analysis of real-world using administrative healthcare da... by Giulia Ronconi, Letizia Dondi, Silvia Calabria, Leonardo Dondi, Irene Dell’Anno, Lucia Casoli, Diletta Valsecchi, Ornella Bonavita, Eustachio Nettis, Nello Martini, Carlo Piccinni

“…Conclusions During the first year following the new CSU diagnosis, a lower than recommended antihistamines dispensation while an elevated use of OCS and a low and delayed omalizumab initiation after CSU exacerbation were observed, suggesting the urgent need to optimize treatment management to limit the burden on patients and healthcare systems.…”
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Identification and validation of diagnostic biomarkers and immune cell abundance characteristics in Staphylococcus aureus bloodstream infection by integrative bioinformatics analys... by Junhong Shi, Li Shen, Yanghua Xiao, Cailing Wan, Bingjie Wang, Peiyao Zhou, Jiao Zhang, Weihua Han, Rongrong Hu, Fangyou Yu, Hongxiu Wang

“…Gene expression dataset GSE33341 was optimized as the discovery dataset, which contained samples from human and mice. …”
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Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease by Mingming Wang, Liping Liang, Zibo Tang, Jimin Han, Lele Wu, Le Liu, Le Liu, Ye Chen, Ye Chen

“…Current precision medicine approaches lack robust molecular tools integrating transcriptomic signatures with immune dynamics for personalized treatment guidance.MethodsWe performed multi-omics analyses of GEO datasets using machine learning algorithms (LASSO/Random Forest) to derive a four-gene signature. …”
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Application of machine learning for the analysis of peripheral blood biomarkers in oral mucosal diseases: a cross-sectional study by Huiyu Yao, Zixin Cao, Liangfu Huang, Haojie Pan, Xiaomin Xu, Fucai Sun, Xi Ding, Wan Wu

“…Future research should focus on validating these findings in larger cohorts and exploring alternative machine-learning algorithms to improve diagnostic accuracy further.…”
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Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling by Bisha Ding, Jie Li, Jia-Lin Yan, Chun-Yan Jiang, Ling-Bo Qian, Jie Pan

“…Resveratrol (RES) is known for its multiple health benefits, while current understanding of its role in regulating cancer immunogenicity remains limited. …”
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PhA-MOE: Enhancing Hyperspectral Retrievals for Phytoplankton Absorption Using Mixture-of-Experts by Weiwei Wang, Bingqing Liu, Song Gao, Jiang Li, Yueling Zhou, Songyang Zhang, Zhi Ding

“…Traditional methods often fail under these circumstances, while improved machine-learning approaches are hindered by data scarcity, heterogeneity, and noise from data collection. …”
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A novel method for soil organic carbon prediction using integrated ‘ground-air-space’ multimodal remote sensing data by Yilin Bao, Xiangtian Meng, Huanjun Liu, Mengyuan Xu, Mingchang Wang

“…Regarding model performance in SOC content prediction, GNN is more suitable for Model (i) and Model (iii), while CNN is more appropriate for Model (ii). In conclusion, ResoCroS-Net achieved collaborative optimization of spatial-spectral features across scales, provided a significant advantage in improving the accuracy of quantitative remote sensing, offers an efficient and accurate SOC monitoring tool, providing a practical basis for the integrated remote sensing theory of ‘ground-air-space’.…”
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Generation of Spatial Structure of Urban Parks Based on Spatial Analysis of Agent-Based Models by Huizi KONG, Tianming LIU, Jiajie LIAO, Liu CUI

“…Additionally, the simulation results show that the slime mold agent model can rapidly generate foraging networks in complex environments due to its efficient organization and structural resilience, as well as optimize path selection according to behavioral objectives.ConclusionABM analysis, supported by advanced algorithms, considers the basic spatial information of the site and simulates individual behavior patterns using distributed computation rules, thereby providing a new paradigm for landscape design thinking. …”
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Knowledge Distillation in Object Detection for Resource-Constrained Edge Computing by Arief Setyanto, Theopilus Bayu Sasongko, Muhammad Ainul Fikri, Dhani Ariatmanto, I. Made Artha Agastya, Rakandhiya Daanii Rachmanto, Affan Ardana, In Kee Kim

“…We compare various KD algorithms to identify the technique that produces a smaller model with the modest accuracy drop. …”
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Molecular subtype of recurrent implantation failure reveals distinct endometrial etiology of female infertility by Jing Yang, Lingtao Yang, Ying Zhou, Fengyang Cao, Hongkun Fang, Huan Ma, Jun Ren, Chunyu Huang, Lianghui Diao, Qiyuan Li, Qionghua Chen

“…A molecular classifier (MetaRIF) was developed using the optimal F-score from 64 combinations of machine learning algorithms. …”
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Artificial intelligence in hospital infection prevention: an integrative review by Rabie Adel El Arab, Zainab Almoosa, May Alkhunaizi, May Alkhunaizi, Fuad H. Abuadas, Joel Somerville, Joel Somerville

“…Comparative data suggest that while both machine learning and deep learning approaches perform well, some deep learning models may offer slight advantages in complex data environments. …”
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Design and Implementation of a Deep Learning-Based Hand Gesture Recognition System for Rehabilitation Internet-of-Things (RIoT) Environments Using MediaPipe by Nurul Hanis Mohd Dhuzuki, Ahmad Anwar Zainuddin, Nur Anis Sofea Kamarul Zaman, Alin Nur Maisarah Ahmad Razmi, Wonderful Shammah Kaitane, Asmarani Ahmad Puzi, Mohd Naqiuddin Johar, Maslina Yazid, Nor Azlin Mohd Nordin, Shahrul Naim Sidek, Hasan Firdaus Mohd Zaki

“…The system's objective is to provide precise, real-time tracking of hand movements, enabling patients to perform exercises at home by maintaining an optimal distance between the camera and hand placement, ensuring ideal room lighting conditions across IoT devices such as mobile phones' front cameras and webcams, while healthcare professionals remotely monitor their progress. …”
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