Engineering and Evaluation of a Live-Attenuated Vaccine Candidate with Enhanced Type 1 Fimbriae Expression to Optimize Protection Against <i>Salmonella</i> Typhimurium by Patricia García, Arianna Rodríguez-Coello, Andrea García-Pose, María Del Carmen Fernández-López, Andrea Muras, Miriam Moscoso, Alejandro Beceiro, Germán Bou

“…<i>fimA</i> expression was quantified by qRT-PCR, and fimbriation visualized by transmission electron microscopy. Adhesive properties were evaluated through FimH sequence analysis, yeast agglutination, mannose-binding/inhibition assays, and HT-29 cell adherence. …”
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Socio‐economic status and adherence to HIV preventive and therapeutic interventions: exploring the mediating role of food insecurity among men who have sex with men and transgender... by Paula M. Luz, Thiago S. Torres, Victor C. Matos, Giovanna G. Costa, Brenda Hoagland, Cristina Pimenta, Marcos Benedetti, Beatriz Grinsztejn, Valdilea G. Veloso

“…Self‐report of ART adherence was measured by the WebAd‐Q instrument (3‐items/past week) plus a visual analogue scale. Self‐report of PrEP adherence was measured by the number of days the person took PrEP in the past week. …”
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Assessment of grain production levels and analysis of obstacle factors in China: a sustainable, stable and green perspective by Caixia Shangguan, Ruijundi Ma, Yan Lu, Hui Zhang, Mingjin Tian, Yongzhong Teng, Li Jing, Xia Zhang, Hongbin Liu, Ke Li, Xingxing Mei

“…The entropy-weighted TOPSIS method and the obstacle degree model were employed to assess production levels and determine critical constraints, while ArcGIS was used to visualize the spatial distribution across China’s nine major agricultural regions.ResultsThe results reveal that Grain production followed a development trend of initial decline, slow recovery, and rapid growth, with significant differences in the subsystems. …”
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Effect of acupoint application combined with moxibustion in the treatment of postoperative constipation in patients with thoracolumbar compression fracture (艾灸联合穴位贴敷治疗胸腰椎压缩性骨折患者术后便... by WANG Tingting (王亭亭), LIU Fei (柳菲), NIE Shanshan (聂珊珊), YANG Qiujing (杨秋景), YANG Yang (杨杨)

“…The clinical efficacy and anxiety status by Visual Analogue Scale (VAS) of the two groups were compared. …”
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Perceived barriers of dairy producers to the adoption of selective antimicrobial therapies for nonsevere clinical mastitis and at dry-off in dairy cattle: A focus group study in On... by M.W. Brunt, T.F. Ehigbor, C. Ritter, D.L. Renaud, S.J. LeBlanc, D.F. Kelton

“…Individual cow data from automatic milking systems and record keeping were viewed as instrumental to the success of selective AMU but human elements (e.g., visual assessment of animals) continued to be used in the decision-making process. …”
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Multidisciplinary, Clinical Assessment of Accelerated Deep-Learning MRI Protocols at 1.5 T and 3 T After Intracranial Tumor Surgery and Their Influence on Residual Tumor Perception by Christer Ruff, Till-Karsten Hauser, Constantin Roder, Daniel Feucht, Paula Bombach, Leonie Zerweck, Deborah Staber, Frank Paulsen, Ulrike Ernemann, Georg Gohla

“…The image quality metrics NQM, SNR, and PSNR showed better results for DLR. Visual assessment of residual tumor was similar at 3 T but differed at 1.5 T, with more residual tumor detected with DLR, especially by the neurosurgeon (<i>n</i> = 4). …”
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Investigating the profile of patients with idiopathic inflammatory myopathies in the post-COVID-19 period by Lu Cheng, Yan-hong Li, Yin-lan Wu, Yu-bin Luo, Yu Zhou, Tong Ye, Xiu-ping Liang, Tong Wu, De-ying Huang, Jing Zhao, Yi Liu, Zong-an Liang, Chun-yu Tan

“…The PC group exhibited a greater incidence of cardiac damage, including a greater proportion of cardiac injury (P = 0.016), clinical diagnosis of myocarditis (P = 0.02), palpitation (P = 0.031), and Myositis Activity Assessment Visual Analog Scale/Myositis Intention-to-Treat Activity Index cardiovascular involvement scores (all P < 0.001), and elevated levels of myoglobin (P = 0.03), creatinine kinase MB (P = 0.015), cardiac troponin T (P = 0.011), N-terminal pro-B-type natriuretic peptide (P = 0.028), lactate dehydrogenase (P = 0.033), and hydroxybutyrate dehydrogenase (P = 0.019). …”
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Computational analysis of reproducibility and image quality of 2011 and 2017 models of Heidelberg Spectralis SD-OCT machines by Kyoung A Viola Lee, Corey Tesdahl, Keith Zimmerman, Kimberly Jun, Sabrina Khalil, Alexander Shahin, Abdullah Abou-Samra, Ramesh Ayyala, Radouil Tzekov

“…Agreement between the devices was analyzed through Bland-Altman plots, and spatial variability was visualized using heatmaps. The dimensionality reduction techniques Principal Component Analysis (PCA) and Multidimensional Scaling (MDS) were employed to explore data patterns. …”
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Transitional and CD21− PD-1+ B cells are associated with remission in early rheumatoid arthritis by Sarah McGrath, Boel Sundbeck, Katrin Thorarinsdottir, Charlotte A. Jonsson, Alessandro Camponeschi, Monica Leu Agelii, Anna-Karin H. Ekwall, Merete Lund Hetland, Mikkel Østergaard, Till Uhlig, Michael Nurmohamed, Jon Lampa, Dan Nordström, Kim Hørslev-Petersen, Bjorn Gudbjornsson, Gerdur Gröndal, Ronald van Vollenhoven, Anna Rudin, Inga-Lill Mårtensson, Inger Gjertsson

“…The logistic regression model was also used to simultaneously visualize the sensitivity and specificity of the model for all possible values of the exposure (B-cell subpopulations) in predicting the outcome. …”
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Combining transcranial direct current stimulation with music therapy improves cognitive function in schizophrenia: study protocol for a randomized, double-blind, sham-controlled cl... by Yange Wei, Yange Wei, Shanyuan He, Peng Luo, Hanshuo Su, Yuanle Chen, Shisen Qin, Zhongguo Zhang, Rongxun Liu, Dongshuai Wei, Juan Wang, Fei Wang, Fei Wang, Chuansheng Wang

“…The anodal electrode of tDCS will be positioned over the medial prefrontal cortex (mPFC), while the cathodal electrode will be placed over the visual cortex. MT will incorporate both Western Mozart and traditional Chinese classical music. …”
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Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisation by Linamara Rizzo Battistella, Felipe Fregni, Marta Imamura, Vinicius Delgado Ramos, Lucas Ramos De Pretto, Simon K H A A Van Cauwenbergh, Sabrina Saemy Tome Uchiyama, Denise Matheus, Flavia Kuhn, Ana Alice Amaral de Oliveira, Gabriella Souza Naves, Aline Rossetti Mirisola, Fernando de Quadros Ribeiro, Andre Tadeu Sugawara, Mauricio Cantarino, Rafael Andrade Santos Antunes Cavalca, Vanessa Pagano, Melina Valentim Marques, Elizabeth Mendes da Silva, Alessandra Pereira Gomes

“…It analyses participants' sociodemographic background, COVID-19 clinical manifestations, and clinical and functional evaluations.Setting Tertiary-level university hospital in São Paulo, Brazil.Participants Study participants are COVID-19 survivors admitted to hospital care for at least 24 hours to treat acute SARS-CoV-2 infection.Outcome measures Epworth Sleepiness Scale, EuroQoL-5 Dimensions-5 Levels, Functional Assessment of Chronic Illness Therapy–Fatigue, Functional Independence Measure, Functional Oral Intake Scale, Handgrip Strength, Insomnia Severity Index, Medical Research Council (MRC) Dyspnea Scale, MRC sum score, Modified Borg Dyspnea Scale, pain Visual Analogue Scale, Post-COVID-19 Functional Status, Timed Up and Go, WHO Disability Assessment Schedule 2.0, 1-Minute Sit to Stand Test.Results Many participants required invasive mechanical ventilation (41.57%, 333 of 801). …”
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Comprehensive coronary CT angiography in people living with HIV: a systematic review and meta-analysis by Binh T Nguyen, Edward Hulten, Venkatesh L Murthy, Tarin Phillips, Gregory M Blake, Jonathan A Aun, Lisa M Conte, Ritika Gadodia, Aakash Tuli, Sara L Robinson, Travis E Harrell

“…Publication bias was assessed by visual inspection of funnel plots and formal testing by Egger’s and Begg’s tests. …”
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Follow-up rescreening uptake and persistent positive rates among women after positive cervical cancer screening results in Ethiopia: a longitudinal cross-sectional study by Adamu Addissie, Eva Johanna Kantelhardt, Eric Sven Kroeber, Sefonias Getachew, Muluken Gizaw, Abel Shita, Alemnew Destaw, Eyerusalem Getachew, Miresa Midaksa, Sophie Sarah Rossner

“…Among those re-screened, the persistent visual inspection with acetic acid (VIA) positivity rate was 16.1% (95% CI: 11.0% to 21.7%). …”
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Analysis of the short-to-intermediate-term efficacy of autologous costochondral transplantation in treatment for Hepple V osteochondral lesion of talus by Jiazheng Wang, Jieyuan Zhang, Shaolin Fu, Xueqian Li, Cheng Wang, Chenglin Wu, Shutao Zhang, Xin Ma, Zhongmin Shi

“…According to the foot and ankle ability measurement (FAAM)–activities of daily living subscale (FAAM–ADL) and sports subscale (FAAM-Sp), the EuroQol-Visual Analogue Scale (EQ VAS) and the Magnetic Resonance Observation of Cartilage Repair Tissue 2.0 ankle score (MOCART 2.0), surgical efficacy and of the patients’ function were evaluated, to verify the clinical satisfaction of ACT. …”
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Development and validation of a multimodal automatic interictal epileptiform discharge detection model: a prospective multi-center study by Nan Lin, Lian Li, Weifang Gao, Peng Hu, Gonglin Yuan, Heyang Sun, Fang Qi, Lin Wang, Shengsong Wang, Zi Liang, Haibo He, Yisu Dong, Zaifen Gao, Xiaoqiu Shao, Liying Cui, Qiang Lu

“…Abstract Background Visual identification of interictal epileptiform discharge (IED) is expert-biased and time-consuming. …”
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Hypometabolism and atrophy patterns associated with Niemann-Pick type C by Jesús Silva-Rodríguez, Cristina Castro, Julia Cortés, Manuel Arias, Virginia Pubul, Alexis Moscoso, Michel J. Grothe, Gabriel Reynes-Llompart, Laura Rodríguez-Bel, Jordi Gascon-Bayarri, María Jesús Sobrido, Pablo Aguiar

“…Conversely, [18F]FDG PET imaging revealed extensive hypometabolism in the cerebellum, thalamus, and cingulate cortex (d = 1.42, p < 0.0001), and moderate hypometabolism in broad frontotemporal areas. [18F]FDG PET provided higher effect sizes across all brain regions, including regions without apparent atrophy, which suggests that it may be more sensitive than MRI for detecting NP-C neurodegenerative changes. Single-subject visual assessment of individual PET images further validated the clinical utility of [18F]FDG PET, with significant hypometabolism observed in the cerebellum, thalamus and anterior and posterior cingulate reported by physicians in 17/22 patients. …”
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Exploration of the molecular mechanism of melatonin against polycystic ovary syndrome based on a network pharmacology approach and experimental validation by Ran Cheng, Ran Cheng, Ran Cheng, Ying Zhu, Sheng-kai Wang, Chun-Xiao Zong, Hong-Li Zhao, Hong-Li Zhao, Hong-Li Zhao, Qin Zhang, Qin Zhang, Qin Zhang

“…Targets related to PCOS were extracted from three databases: DisGeNET, GeneCards, and the National Center for Biotechnology Information gene. To visualize the relationships between proteins, a protein-protein interaction network was generated using the STRING database. …”
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Evaluation of timed dexamethasone eye drops to prevent proliferative retinopathy of prematurity: a study protocol for a randomized intervention, multi-centre, double-blinded trial... by Ann Hellström, Mariya Petrishka-Lozenska, Aldina Pivodic, Anders K. Nilsson, Ulrika Sjöbom, Ingrid Hansen Pupp, David Ley, Lotta Gränse, Hanna Maria Öhnell, Gunnar Jakobsson, Karin Sävman, Lois E. H. Smith, Pia Lundgren, the DROPROP collaboration group

“…An ophthalmological follow-up will be initiated at 2 and 5.5 years of age, evaluating visual acuity, refractive errors, strabismus, retinal morphology and ophthalmological complications. …”
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Development and validation of a clinical-friendly model for predicting 180-day mortality in the older with community-acquired pneumonia by Bingxuan Weng, Lixue Huang, Wenshu Jiao, Yuanqi Wang, Mengyuan Wang, Xuefeng Zhong, Xunliang Tong, Jin Jin, Yanming Li

“…Internal validation was performed using both bootstrap resampling and 10-fold cross-validation. The model was visualized by a nomogram and a questionnaire. The optimal cutoff value of the nomogram was determined based on the maximum Youden index for the 180-day mortality prediction, dividing patients into high- and low-risk groups. …”
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Fatal risk factors and the efficacy of glucocorticoid therapy in severe fever with thrombocytopenia syndrome: a multicenter retrospective cohort study by Fang Zhong, Shiyu Zhang, Chengxi Zheng, Dilihumaer Zhayier, Shuting Liu, Qinyu You, Hongming Huang, Bin Zhu, Jin Tian, Zhiliang Hu, Zhiliang Hu, Zhiliang Hu, Xin Zheng, Baoju Wang, Zhihang Peng, Zhihang Peng, Zhihang Peng

“…A nomogram was used to visualize the predictive model. ROC curves, calibration curves, and DCA curves were conducted to assess model accuracy and clinical applicability. …”
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