Metformin treatment for patients with hand osteoarthritis: protocol for the multicentre, randomised, placebo-controlled METRO trial by David J Hunter, Robin Christensen, Marius Henriksen, Henning Bliddal, Karen Ellegaard, Mikael Boesen, Tue Kragstrup, Filip K Knop, Anna Dossing, Kasper Staberg Madsen, Asbjørn S Poulsen, Rasmus Oscar

“…The primary endpoint is the between-group difference in least squares means for the change in the Visual Analogue Scale (VAS) finger joint pain scores between the metformin and placebo groups at 16 weeks. …”
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Improving Probiotic Strawberry Dairy Beverages with High-Intensity Ultrasound: Syneresis, Fatty Acids, and Sensory Insights by Amanda Gouveia Mizuta, Eloize da Silva Alves, Jaqueline Ferreira Silva, Paula Gimenez Milani Fernandes, Silvio Claudio da Costa, Carlos Eduardo Barão, Tatiana Colombo Pimentel, Andresa Carla Feihrmann, Benício Alves de Abreu Filho, Suelen Siqueira dos Santos, Grasiele Scaramal Madrona

“…Consumer acceptance of milk beverages as probiotic beverages is directly linked to their sensory qualities, such as flavor, consistency, visual appearance, and mouthfeel. Overall, products that exhibit syneresis are often viewed as inferior. …”
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The interdependence of mid-trimester blood pressure and glucose levels in shaping fetal growth and neonatal outcomes: implications for risk–benefit assessment and co-management by Lijuan Lv, Jingbo Yang, Linjie Li, Chuanyi Huang, Huihua Shi, Yiwen Fang, Lushu Zuo, Ting Liu, Hongli Duan, Jiying Wen, Qing Yang, Amanda Henry, Cha Han, Aihua Yin, Xin Zhou

“…Heatmaps were created to visualize the contributions of BP and FPG by categorizing them into ordered groups. …”
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Effectiveness and Safety of Pharmacopuncture Therapy Compared to Standard Physical Therapy in Patients with Chronic Knee Pain: A Pilot Study for a Pragmatic Randomized Controlled T... by Myung In Jeong, Jun Kyu Lim, Yong Jun Kim, Yu Sun Jeon, Suna Kim, Chang Youn Kim, Yeon-Cheol Park, Eun-Jung Kim, Yejin Hong, Dongwoo Nam, Yoon Jae Lee, Doori Kim, In-Hyuk Ha

“…The primary outcome was the NRS score for knee pain, whereas the secondary outcomes were the visual analog scale (VAS), knee range of motion, Korean Western Ontario and McMaster (K-WOMAC), Patient Global Impression of Change, and five-level EuroQol five-dimension scores. …”
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Automated Foveal Avascular Zone Segmentation in Optical Coherence Tomography Angiography Across Multiple Eye Diseases Using Knowledge Distillation by Peter Racioppo, Aya Alhasany, Nhuan Vu Pham, Ziyuan Wang, Giulia Corradetti, Gary Mikaelian, Yannis M. Paulus, SriniVas R. Sadda, Zhihong Hu

“…Optical coherence tomography angiography (OCTA) is a noninvasive imaging technique used to visualize retinal blood flow and identify changes in vascular density and enlargement or distortion of the foveal avascular zone (FAZ), which are indicators of various eye diseases. …”
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Successful implementation of a risk assessment and mitigation program to control bovine digital dermatitis at the herd-level by Jim Weber, Marina Hillen, Torsten Seuberlich, Andreas Fürmann, Corinne Gurtner, Jens Becker, Claudia Syring, Maria Welham Ruiters, Maher Alsaaod, Lina Mazurek, Gertraud Schüpbach, Adrian Steiner

“…Diagnosis of BDD was based on visual inspection (clinical scoring) of the feet. …”
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Neurophysiological findings in Attention Deficit Hyperactivity Disorder, a Pandora’s box with therapeutic implications by Montserrat Gerez-Malo, Armando Tello, Maria Jimena Martin-Salas, Lauro Castanedo, Arturo Mendizábal, Oscar Meneses Luna, Leslie Quintanar, Carlos Acosta

“…Methods: 230 children with ADHD diagnosis studied with hypothesis-related variables from electroencephalogram (EEG) visual inspection and quantitative z-scored power, coherence and ratios, and from event-related brain potentials (ERPs) z-sored P50, N100, N200, P300 latencies amplitudes and ratios. …”
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Efficacy of repetitive transcranial magnetic stimulation for smoking cessation: a systematic review and meta-analysis by Youssef A. Ismail, Omar K. Habib, Yahya El-Banan, Raneem Ramadan, Mohamed O. Henidak, Mohamed E. El-Badry, Ahmed R. Rabea, Amira A. Fouad, Salsapeel I. El-Tahlawy, Rahma M. El-Shawa, Mohamed Atef, Rahma A. Abd El-Kader, Abdullah El-Lawendy, Mariam El-Morsy, Mariam S. El-Rayes, Hanem El-Hasanen, Moaz Abouelmagd

“…However, no significant effects were observed for self-reported cigarette consumption (MD = -2.74, 95% CI [-7.26 to 1.79], P = 0.24) or the Visual Analog Scale for craving (SMD = -0.29, 95% CI [-0.67 to 0.10], P = 0.14). …”
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Evidence of functional connectivity disruptions between auditory and non-auditory regions in adolescents living with HIV by Joanah Madzime, Joanah Madzime, Marcin Jankiewicz, Marcin Jankiewicz, Marcin Jankiewicz, Ernesta M. Meintjes, Ernesta M. Meintjes, Ernesta M. Meintjes, Peter Torre, Barbara Laughton, Martha J. Holmes, Martha J. Holmes, Martha J. Holmes, Martha J. Holmes

“…We also report associations between the nodal efficiency of middle temporal and superior frontal regions and delayed recall, a neurocognitive marker of working memory, present in CHUU but not in CPHIV.DiscussionOur results demonstrate FC alterations in the PAC and between CAS regions and non-auditory regions involved in limbic, visual and motor processing, as well as disruptions to the regional properties of the CAS regions in the functional brain network. …”
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Anterior lumbar interbody fusion with a novel osteoinductive allograft – Mid-term clinical and radiographic outcomes by Charlie R. Faulks, Dean T. Biddau, Michael D. Selby, Ralph J. Mobbs, Gregory M. Malham

“…Patient reported outcome measures included visual analog scale (VAS) back pain, Oswestry disability index (ODI) and 12-Item Short Form Survey (SF-12) measured at preoperative, 6-week, 6-month, 12-month, and 24-month time points. …”
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Developing epidemiological preparedness for a plant disease invasion: Modelling citrus huánglóngbìng in the European Union by John Ellis, Elena Lázaro, Beatriz Duarte, Tomás Magalhães, Amílcar Duarte, Jacinto Benhadi‐Marín, José Alberto Pereira, Antonio Vicent, Stephen Parnell, Nik J. Cunniffe

“…Even with significant visual surveillance, any epidemic will be widespread on first detection, making eradication unlikely. …”
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Anterior cervical discectomy and fusion in treating acute myelopathy caused by Brucella cervical spondylitis: a case series by Long Chen, Tao Zhang, Xing-yu Chen, Yi-zhe Wang, Xing-guo Tan, Da-shuai Huang, Yan-peng Lu, Song-kai Li

“…Clinical data such as age, gender, surgery duration, follow-up period, medication duration, time to bone fusion, ASIA classification, Visual Analog Scale (VAS) score, Japanese Orthopaedic Association (JOA) score, and Neck Disability Index (NDI) score were collected both preoperatively and postoperatively. …”
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In-vitro and in-vivo assessment of biocompatibility and efficacy of ostrich eggshell membrane combined with platelet-rich plasma in Achilles tendon regeneration by Omid Koohi-Hosseinabadi, Reza Shahriarirad, Amireza Dehghanian, Laleh Amini, Sajjad Barzegar, Afrooz Daneshparvar, Omid Alavi, Seyedeh-Parvin Khazraei, Saba Hosseini, Ali Arabi Monfared, Roya Khorram, Nader Tanideh, Soheil Ashkani-Esfahani

“…High-resolution scanning electron microscopy (HRSEM) was utilized to visualize the sample morphology and fiber bonding. …”
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Deep learning feature-based model for predicting lymphovascular invasion in urothelial carcinoma of bladder using CT images by Bangxin Xiao, Yang Lv, Canjie Peng, Zongjie Wei, Qiao Xv, Fajin Lv, Qing Jiang, Huayun Liu, Feng Li, Yingjie Xv, Quanhao He, Mingzhao Xiao

“…Deep learning features were extracted and visualized using Grad-CAM. Principal Component Analysis reduced features to 64. …”
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Effect of simultaneous intravitreal ranibizumab and extended-release dexamethasone injection on patients with naïve versus refractory retinal vein occlusion macular edema: a prospe... by Yao-Yao Sun, Jie Meng, Shan-Shan Li, Qin Xiao, Tian-Zi Zhang, Heng Miao, Ming-Wei Zhao, Hui-Jun Qi

“…The mean changes in best-corrected visual acuity (BCVA) and central macular thickness (CMT) were measured as main outcomes. …”
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Enhanced transdermal delivery of lidocaine cream via ultrasound and microneedle rollers by Jiaxiao Sun, Yang Yang, Yang Yang, Juanjuan Zheng, Hao Liang, Feng Yan, Wensheng Zhang, Wensheng Zhang, Wenqin Xie

“…ObjectiveThe aim of this study is to determine the most effective physical parameters for optimizing the transdermal delivery of lidocaine cream.MethodsPreliminary experiments were conducted to optimize ultrasound settings while ensuring safety, guided by visual and histopathological evaluations following observations of skin burns in rats. …”
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16 weeks of moderate intensity resistance exercise improves strength but is insufficient to alter brain structure in Gulf War Veterans with chronic musculoskeletal pain: a randomiz... by Stephanie M. Van Riper, Jacob V. Ninneman, Jacob V. Ninneman, Aaron J. Stegner, Aaron J. Stegner, Brady A. Riedner, Brady A. Riedner, Laura D. Ellingson, Ryan J. Dougherty, Patrick J. O’Connor, Gunnar A. Roberge, Gunnar A. Roberge, Andrew L. Alexander, Andrew L. Alexander, Andrew L. Alexander, Doug C. Dean, Doug C. Dean, Doug C. Dean, Jill N. Barnes, Dane B. Cook, Dane B. Cook

“…Outcomes assessed at baseline, 6, 11 and 17 weeks and 6- and 12-months post-intervention included GM volume (voxel-based morphometry), WM microstructure (diffusion tensor imaging), pain [short form McGill Pain Questionnaire (SF-MPQ) and 0–100 visual analog scale (VAS)], fatigue (0–100 VAS), and mood (Profile of Mood States). …”
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Pathogenicity and Metabolomic Characterization of <i>Fusarium graminearum</i> and <i>Fusarium poae</i> Challenge in Barley under Controlled Conditions by Raja Khanal, Kerin Hudson, Adam Foster, Xiben Wang, Elizabeth K. Brauer, Thomas E. Witte, David P. Overy

“…No significant effect on visual FHB disease ratings or fungal DNA detection was observed between the cultivars tested. …”
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Modified double-row suture bridge technique for anterior colliculus fractures combined with deltoid ligament injury: a retrospective study by Jianlong Ni, Zhihao Chen, Wang Wei, Ruiying Li, Dazhi Wang, Dongjian Wang, Zenan Tian, Zhikun Jia, Qichun Song, Meng Feng, Zhibin Shi

“…For clinical outcome evaluation, objective data are presented through clinical examination findings; radiographic assessments, including X-rays and computed tomography (CT); and follow-up analysis utilizing American Orthopaedic Foot & Ankle Society ankle‒hindfoot (AOFAS) scores, Olerud Molander Ankle Scores (OMAS), and visual analogue scale (VAS) scores. Preoperative and follow-up scores were compared with Student’s t test. …”
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Can bioelectrical impedance analysis be used to identify water loading in patients with anorexia nervosa?– Implications from experimental measurements in young, healthy, and normal... by Nadja Knoll-Pientka, Dorina Schils, Katrin Pasternak, Sandra Czarnetzky, Christoph Jansen, Gertraud Gradl-Dietsch, Jochen Seitz, Eva-Maria Skoda, Lars Libuda, Adam Schweda, Martin Teufel

“…Biological impedance analysis (BIA) is a helpful tool in routinely visualizing changes in body composition during the refeeding process. …”
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