In Vitro Activity of Nisin A Against Staphylococci Isolated from Periprosthetic Joint Infection by Melissa J. Karau, Christina A. Koscianski, Andrew D. Badley, Nicholas A. Bedard, John W. Zinckgraf, Robin Patel

“…The results were determined as the lowest concentrations with no visual growth. Two-dimensional MICs with nisin A and vancomycin were assessed for 20 isolates. …”
Get full text

In Silico Approach for Identification of PI3K/mTOR Dual Inhibitors for Multiple Myeloma Treatment by İlke Maşalacı, Yaren Akdoğan, Özge Mutlu, Hande Eyvaz, Yağmur Kiraz

“…Protein-dual inhibitor complexes and the amino acids and bond types were visualized to identify molecular interactions. The absorption, distribution, metabolism, and excretion properties of dual inhibitors were analyzed and evaluated. …”
Get full text

Age-related differences in eye blink-related neural activity and functional connectivity during driving by Emad Alyan, Stefan Arnau, Stephan Getzmann, Julian Elias Reiser, Melanie Karthaus, Edmund Wascher

“…Furthermore, functional connectivity analysis revealed that aging most significantly affects the visual network in the beta band. More specifically, younger participants showed an increase in the clustering coefficient and degrees of the networks, reflecting more robust neural network integration. …”
Get full text

Safety and cost analysis of selective histopathological examination following appendicectomy and cholecystectomy (FANCY study): protocol and statistical analysis plan of a prospect... by Willem A Bemelman, Pieter J Tanis, Lianne Koens, Vivian P Bastiaenen, Bartholomeus JGA Corten, Elise AJ de Savornin Lohman, Joske de Jonge, Anne C Kraima, Hilko A Swank, Jaap LP van Vliet, Gijs JD van Acker, Anna AW van Geloven, Klaas H in 't Hof, Philip R de Reuver, Charles C van Rossem, Gerrit D Slooter, Valeska Terpstra, Marcel GW Dijkgraaf

“…The aim of the selective histopathological examination Following AppeNdicectomy and CholecystectomY (FANCY) study is to investigate the oncological safety and potential cost savings of selective histopathological examination based on macroscopic assessment performed by the surgeon.Methods and analysis This is a Dutch multicentre prospective observational study, in which removed appendices and gallbladders will be systematically assessed by the operating surgeon for macroscopic abnormalities suspicious for malignant neoplasms. After visual inspection and digital palpation of the removed specimen, the operating surgeon will report whether macroscopic abnormalities suspicious for a malignant neoplasm are present, and if he or she believes additional microscopic examination by the pathologist is indicated. …”
Get full text

LIVER EXPLANATION TECHNOLOGY OPTIMIZATION by Александр Сергеевич Разумов, Григорий Валерьевич Вавин, Алексей Владимирович Будаев, Игорь Александрович Радионов, Ольга Дмитриевна Сидорова, Е. Е. Ставицкий, Дарья Александровна Раева, Ф. А. Будаев, Вадим Гельевич Мозес

“…During explantation, the vascular bed of the liver was washed from the blood with a 0.9 % sodium chloride solution with the addition of heparin (500 ME/kg) under a pressure of 20-35 mmHg antegrade along an open circuit through a catheter in the portal vein with an outflow through the catheter in the inferior vena cava until a perfusate appears in which blood was not visually detected. The animals were divided into 2 series: 1st series (n = 6), which were washed using normothermic perfusion (solution at 37 ± 1°C); 2nd series (n = 8) with which washing was carried out using hypothermic perfusion (solution with a temperature of 3 ± 1°C). …”
Get full text

Effects of High-intensity Training and Electrical Stimulation on Pain, Disability, Knee Kinematic and Performance in Patellofemoral Pain: A Randomized Controlled Trial by Hadi Mohammadi Nia Samakosh, Rafael Oliveira, Shahriar Shahabi, Behrooz Sarvarifar, Sahar Moddares Gorji, Amirreza Amirkhanloo, Georgian Badicu, Fatma Hilal Yagin, Abdullah F. Alghannam

“…The exercise performed was 8 weeks of a high-intensity strength program for 45-60 minutes, plus cooling and a warm-up phase. Visual analogue scale (VAS), disability (Kujala patellofemoral score), knee valgus angle (KVA) and single-leg hop (SLH) were tested before (pre-test) and after training (post-test at 8 weeks) using a within-between group analysis (ANOVA 2×2). …”
Get full text

Optimisation of the cultured ELISpot/Fluorospot technique for the selective investigation of SARS-CoV-2 reactive central memory T cells by Jack R. Jerome, Jack R. Jerome, Kirsty L. Wilson, Kirsty L. Wilson, Joshuah Fialho, Joshuah Fialho, Georgia Goodchild, Georgia Goodchild, Monica D. Prakash, Monica D. Prakash, Charlie McLeod, Charlie McLeod, Charlie McLeod, Charlie McLeod, Peter C. Richmond, Peter C. Richmond, Peter C. Richmond, Peter C. Richmond, Vasso Apostolopoulos, Katie L. Flanagan, Katie L. Flanagan, Katie L. Flanagan, Magdalena Plebanski, Magdalena Plebanski

“…Fluorospot enabled a higher cell density while minimising the generation of visual artefacts, meanwhile immediate cell washing was critical for improving endpoint assay sensitivity. …”
Get full text

Safety and feasibility of deep brain stimulation of the anterior cingulate and thalamus in chronic refractory neuropathic pain: a pilot and randomized study by Denys Fontaine, Aurélie Leplus, Anne Donnet, Nelly Darmon, Anne Balossier, Bruno Giordana, Benoit Simonet, Petru Isan, Jean Regis, Michel Lanteri-Minet

“…Changes on pain intensity (Visual Analogic Scale) and quality of life (EQ-5D scale) were used to evaluate DBS efficacy. …”
Get full text

Serum Interleukin-17 and Its Association with Inflammation and Bone Remodeling in Rheumatoid Arthritis and Hand Osteoarthritis: Insights from Musculoskeletal Ultrasound by Amany M. Ebaid, Essam Atwa, Mohamed A. Mortada, Hibah Abdulrahim Bahri, Noura Almadani, Noha M. Hammad

“…Both RA and OA patients completed a Visual Analog Scale (VAS) to evaluate pain intensity. …”
Get full text

Acetyl-L-Carnitine as an Add-On Treatment in Fibromyalgia Syndrome: A Retrospective Analysis on 183 Patients, According to the Generalized Linear Mixed Model for Longitudinal Data by Vittorio Schweiger, Libera Villagrossi, Francesco Taus, Leonardo Gottin, Eleonora Bonora, Marco Anderloni, Giustino Varrassi, Luca Polati, Marta Nizzero, Alvise Martini, Enrico Polati

“…Regarding efficacy, in the 137 analyzed patients, the change from baseline to the end of observation in Visual Analogue Scale score (VAS) was statistically significant, ranging from 75.9 ± 1.56 to 51.9 ± 1.99 (<i>p</i> < 0.001). …”
Get full text

Long-term Quality of Life After Intensive Care Unit Admission (a Single-Center Observational Study) by C. Leggieri, L. Dezza, B. Oltolini, R. Lembo, B. Noto, S. M. Villa, A. Belletti, G. Lombardi, A. Battaini, E. Pedrini, C. F. Zuccato, A. Zangrillo

“…All EQ-5D-5L parameters improved significantly in the IT group, while only Visual Analog Scale Health Perception improved in the IM group.Conclusion. …”
Get full text

The Effect of Short-Term Kinesiology Taping on Neuromuscular Controls in Hallux Valgus During Gait: A Study of Muscle and Kinematic Synergy by Yanyan Liu, Ruiping Liu, Xinzhu Wan, Chunyan Chen, Yining Wang, Wanqi Yu, Jun OuYang, Lei Qian, Gang Liu

“…During gait, the HV group tended to activate more muscles around foot joints to maintain body stability. The visual analogue scale (VAS) scores, hallux valgus angle (HVA), and COP were significantly decreased after the intervention (<inline-formula> <tex-math notation="LaTeX">${P}\lt 0.05$ </tex-math></inline-formula>). …”
Get full text

iTBS on RDLPFC improves performance of motor imagery: a brain-computer interface study combining EEG and fNIRS by Jialin Chen, Quan Liu, Gengbin Chen, Guiyuan Cai, Junbo Jiang, Xueru Yang, Chunqiu Tan, Cailin Zhang, Guangqing Xu, Yue Lan

“…Corticospinal excitability and motor imagery vividness were assessed using single-pulse transcranial magnetic stimulation (spTMS) and the Kinesthetic and Visual Imagery Questionnaire-20 (KVIQ-20) before and following the trial. …”
Get full text

Network pharmacology-based approach to research the effects and mechanisms of Salvia Miltiorrhiza injection against idiopathic pulmonary fibrosis by Liangyu Chen, Liangyu Chen, Haobo Lin, Haobo Lin, Haobo Lin, Linmang Qin, Linmang Qin, Linmang Qin, Guangfeng Zhang, Guangfeng Zhang, Guangfeng Zhang, Peisheng Chen, Zebo Jiang, Pan Xu, Donghui Huang, Xiao Zhang, Xiao Zhang

“…A protein–protein interaction (PPI) network of these targets was constructed using the STRING database and visualized with Cytoscape software, where the CytoHubba plug-in was utilized to determine core therapeutic targets. …”
Get full text

Low-Frequency Ultrasound Assisted in Improvement in Cell Development and Production of Parasporal Crystals from <i>Bacillus thuringiensis</i> HD1 by Sufen Cui, Kaihui Shen, Shiqi Xiong, Xiao Li, Yue Wang, Xueqing Geng, Yujie Lu

“…FESEM/CLSM and TEM analyses visually displayed the changes in cell morphology. …”
Get full text

Clinic and diagnosis of encephalopathy of critical conditions in children with infectious diseases by E. S. Egorova, A. V. Klimkin, A. A. Vilnits, N. V. Skripchenko, V. B. Voitenkov, Yu. P. Vasilyeva, M. A. Bedova

“…By the time of discharge, 47% of patients had an increase NSE and S100 protein. Visual evoked potentials in 84% of the children of the main group in the acute period, had a decrease the amplitude of the N2-P2 cortical response was revealed without significant dynamics in the future, which was accompanied by pronounced clinical manifestations, which made it possible to substantiate the expediency of dispensary observation of children who underwent a critical condition against the background of severe infectious pathology.Conclusion: in infectious diseases in children that are not accompanied by inflammatory processes in the nervous system, but proceed with the development of a critical condition, there is a neuropsychiatric deficit in the outcomes, which necessitates follow-up follow-up of such patients in the future.…”
Get full text

Effectiveness of segmental stabilization and general lumber stabilization exercises in chronic low back pain: A randomized controlled trial by Amnah Anum, Summaiya Malik Zaman, Muhammad Ahmad, Humaira Aftab, Fozia Malik Zaman

“…The experimental group received Segmental Stabilization Exercises (SSE) while the control group received General Lumbar Stabilization (GLS). Visual Analogue Scale (VAS) was used to determine the severity or level of pain, a goniometer was used to measure the Range of Motion (ROM), Oswestry Disability Scale (ODI), was used to determine the severity or level of disability. …”
Get full text

Understanding the association between skin involvement and joint activity in patients with psoriatic arthritis: experience from the Corrona Registry by Philip J Mease, Jeffrey D Greenberg, Carol J Etzel, William J Huster, Talia M Muram, April W Armstrong, Jeffrey R Lisse, Sabrina Rebello, Rhiannon Dodge, Mwangi James Murage, William N Malatestinic

“…Effect modification showed this linear relationship was modified by age, gender, insurance, work status, current therapy, Health Assessment Questionnaire, Nail visual analogue scale, minimal disease activity, dactylitis count, patient-reported pain and fatigue.Conclusion Skin severity is modestly correlated with joint activity, and patients with higher skin severity are two times more likely to have increased joint involvement. …”
Get full text

Distribution and Neurochemical Characterization of Dorsal Root Ganglia (DRG) Neurons Containing Phoenixin (PNX) and Supplying the Porcine Urinary Bladder by Paweł Janikiewicz, Urszula Mazur, Piotr Holak, Nastassia Karakina, Kamil Węglarz, Mariusz Krzysztof Majewski, Agnieszka Bossowska

“…The sensory neurons investigated were visualized with a retrograde tracing method using Fast Blue (FB), while their chemical profile(s) were identified using double-labelling immunohistochemistry with antibodies against PNX, calcitonin gene-related peptide (CGRP), calretinin (CRT), galanin (GAL), neuronal nitric oxide synthase (nNOS), pituitary adenylate cyclase-activating polypeptide (PACAP), somatostatin (SOM) and substance P (SP). …”
Get full text

Impact on Body Composition and Physical Fitness of an Exercise Program Based on Immersive Virtual Reality: A Case Report by Andrés Godoy-Cumillaf, Paola Fuentes-Merino, Frano Giakoni-Ramírez, Marcelo Maldonado-Sandoval, José Bruneau-Chávez, Eugenio Merellano-Navarro

“…Immersive virtual reality is a tool that allows individuals to immerse themselves in a simulated world and perceive visual, auditory, and tactile sensations. Its use in physical activity interventions favors exercise in situations that, due to time and space, could be limited in real life. …”
Get full text