HVEM as a tumor-intrinsic regulator in non-small cell lung cancer: Suppression of metastasis via glycolysis inhibition and modulation of macrophage polarization by Yuanshan Yao, Bin Li, Chunji Chen, Jing Wang, Feng Yao, Zhigang Li

“…In this study, We demonstrated that CK+HVEM+ tumor correlates with better survival using Multiplex immuno histochemistry (mIHC) in Human Lung Adenocarcinoma Tissue microarray. Next, we showed that HVEM knockdown promoted NSCLC cell invasion and metastasis in vitro whereas exhibited no effect on proliferation. …”
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Bioinformatic analyses reveal lysosomal-associated protein transmembrane 5 as a potential therapeutic target in lipotoxicity-induced injury in diabetic kidney disease by Xin Chen, Shenglong Zhu, Ciyou Huang, Jiayi Liu, Jinbang Wang, Siyuan Cui

“…Here, we analyzed the GSE 30529 microarray datasets of human tubulointerstitial tissue samples from the Gene Expression Omnibus database (GEO). …”
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VPS25 Promotes an Immunosuppressive Microenvironment in Head and Neck Squamous Cell Carcinoma by Li-Guo Chen, Yu-Han Fang, Kui-Ming Wang, Wei Zhang, Gang Chen

“…Bulk RNA-sequencing data and HNSCC tissue microarrays (TMAs) were used to evaluate VPS25 expression and its clinical significance. …”
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RETRACTED: Modern Subtype Classification and Outlier Detection Using the Attention Embedder to Transform Ovarian Cancer Diagnosis by S. M. Nuruzzaman Nobel, S M Masfequier Rahman Swapno, Md. Ashraful Hossain, Mejdl Safran, Sultan Alfarhood, Md. Mohsin Kabir, M. F. Mridha

“…The dataset includes a wide range of images, such as tissue microarray (TMA) images at 40× magnification and whole-slide images (WSI) at 20× magnification. …”
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Developing the new diagnostic model by integrating bioinformatics and machine learning for osteoarthritis by Jian Du, Tian Zhou, Wei Zhang, Wei Peng

“…Methods From the Gene Expression Omnibus (GEO) database, we first obtained OA synovial tissue microarray datasets. Differentially expressed genes (DEGs) associated with OA were identified through utilization of the Limma package and weighted gene co-expression network analysis (WGCNA). …”
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Myogenic IGFBP5 levels in rhabdomyosarcoma are nourished by mesenchymal stromal cells and regulate growth arrest and apoptosis by Yue Zhang, Karim Katkhada, Liu Zhen Meng, Binbin Zhao, Shanlin Tong, Wiem Chaabane, Aditi Kallai, Nicholas P. Tobin, Arne Östman, Alessandro Mega, Monika Ehnman

“…Abstract Background Mesenchymal stromal cells belong to a diverse collection of cells in different states that are poorly characterized in soft-tissue sarcomas. In this study, we explored tumor growth-regulatory signaling between differentially educated non-malignant mesenchymal stromal cells and malignant cells in pediatric rhabdomyosarcoma (RMS). …”
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Bioinformatics Identification and Validation of Ferroptosis-Related Key Genes and Therapeutic Compounds in Septic Lung Injury by Li Z, Gan H, Li S, Xue Y, Luo K, Huang K, Zhang Y, Wang Y, Jiang L, Zhang H

“…This study aimed to elucidate and validate key ferroptosis-related genes involved in the pathogenesis of SLI through bioinformatics analysis and experimental validation.Methods: Microarray data related to SLI from the GSE130936 dataset were downloaded from the Gene Expression Omnibus (GEO) database. …”
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Prognostic effect of immunohistochemically determined molecular subtypes in gastric cancer by Jefim Brodkin, Tuomas Kaprio, Jaana Hagström, Alli Leppä, Arto Kokkola, Caj Haglund, Camilla Böckelman

“…We constructed a tumour tissue microarray immunostained for the following markers: microsatellite instability (MSI) markers MSH2, MSH6, MLH1, and PMS2; p53; E-cadherin; and EBERISH. …”
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The preoperative neutrophil‐to‐lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving r... by Zhi Cao, Jin Ji, Chao Zhang, Fubo Wang, Huan Xu, Yongwei Yu, Yinghao Sun

“…A total of 994 subjects were retrospectively enrolled, and the histological specimens of 210 patients were retrieved for constructing a tissue microarray. Immunohistochemistry was then performed to assess the expression of AR, ERG, PTEN, p‐AKT, Bcl‐2, Beclin‐1, Ki‐67, CD3, CD4, CD8, IFN‐γ and TNF‐α. …”
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Effects of long-term pioglitazone treatment on peripheral and central markers of aging. by Eric M Blalock, Jeremiah T Phelps, Tristano Pancani, James L Searcy, Katie L Anderson, John C Gant, Jelena Popovic, Margarita G Avdiushko, Don A Cohen, Kuey-Chu Chen, Nada M Porter, Olivier Thibault

“…Finally, a combination of microarray analyses on hippocampal tissue and serum-based multiplex cytokine assays revealed that age-dependent inflammatory increases were not reversed by PIO.…”
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Immunohistochemical profile of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) versus other thyroid follicular lesions by Rehab Monir Samaka, Aiat Shaban Hemida, Hagar Alfouly, Mona A. Kora

“…Methods one hundred and nine thyroidectomy specimens including 31 NIFTP, 34 non-neoplastic, 34 papillary thyroid carcinoma (PTC) and 10 invasive encapsulated follicular variant papillary thyroid carcinoma (IEFVPTC) cases, were acquired between 2019 and 2022 from the Menoufia University’s Faculty of Medicine’s Pathology Department. Tissue microarray construction (TMA) blocks were prepared and CD56, HBME-1, RRM2 and APLP2 immunostaining were performed. …”
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B7-H3 and B7-H4 expression in phyllodes tumors of the breast detected by RNA in situ hybridization and immunohistochemistry: Association with clinicopathological features and T-cel... by Ga-Eon Kim, Nah Ihm Kim, Min Ho Park, Ji Shin Lee

“…The messenger RNA and protein expression of B7-H3/B7-H4 were determined by RNAscope in situ hybridization and immunohistochemistry, respectively, in 101 phyllodes tumors (60 benign, 26 borderline, and 15 malignant) using a tissue microarray. Immunohistochemistry for CD3 and CD8 was also performed. …”
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HIF-2α not HIF-1α overexpression confers poor prognosis in non–small cell lung cancer by Zhao-Jia Gao, Yong Wang, Wei-dong Yuan, Jun-qiang Yuan, Kai Yuan

“…In present study, immunohistologic expression of HIF-1α/ HIF-2α was studied in a tissue microarray of 140 Stage I-III NSCLCs and correlated with clinicopathologic parameters and clinical outcome. …”
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Expression patterns of MCM8 in lung adenocarcinoma and its correlation with key biological processes by Xu-Sheng Liu, Jin Xie, Rui-Min Wu, Gao-Chun Xiao, Yu Zhang, Zhi-Jun Pei

“…MCM8 expression was assessed by immunohistochemistry (IHC) using tissue microarrays. The diagnostic value of MCM8 was assessed by Receiver Operating Characteristic curve analysis, and its prognostic significance was determined by Kaplan–Meier analysis. …”
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The Expression Profile of MicroRNAs in Small and Large Abdominal Aortic Aneurysms by Václava Černá, Pavel Ostašov, Pavel Pitule, Jiří Moláček, Vladislav Třeška, Martin Pešta

“…Methods. Tissue samples of AAA patients and healthy controls were collected, from which miRNA was isolated. …”
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Global Trends and Emerging Frontiers on Ovarian Endometriosis: A Bibliometric and Visualization Analysis by Wu X, Yu X, Yang L, Xie A, Su Y, Zhang L, Lin Y, Gan X

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Long Noncoding RNA and mRNA m6A Modification Analyses of Periodontal Ligament Stem Cells from the Periodontitis Microenvironment Exposed to Static Mechanical Strain by Weifu Sun, Jia Liu, Xu Zhang, Xiaochen Zhang, Jie Gao, Xin Chen, Xian Wang, Wen Qin, Zuolin Jin

“…Our previous study demonstrated that periodontal ligament stem cells derived from periodontitis tissue (pPDLSCs) are more sensitive to static mechanical strain (SMS) than those derived from healthy tissue (hPDLSCs) and reported the long noncoding RNA (lncRNA) expression profiles of pPDLSCs exposed to SMS. …”
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Dysfunction in mitochondrial electron transport chain drives the pathogenesis of pulmonary arterial hypertension: insights from a multi-omics investigation by Xin Zhang, Jieling Li, Minyi Fu, Xijie Geng, Junjie Hu, Ke-Jing Tang, Pan Chen, Jianyong Zou, Xiaoman Liu, Bo Zeng

“…PAH and control lung tissue samples were collected, and transcriptomic and metabolomic profiling were performed. …”
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Clinicopathologic implications of Myb and Beta-catenin expression in adenoid cystic carcinoma by Susan Park, Manali Vora, Annemieke van Zante, Joseph Humtsoe, Hyun-Su Kim, Sue Yom, Shweta Agarwal, Patrick Ha

“…In this study, we aim to analyze the impact of Myb and β-catenin expression on prognosis in ACC. Methods A tissue microarray constructed from archival tissue from 64 patients with ACC was stained for Myb and β-catenin; both localization and intensity were evaluated. …”
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Spatially resolved analysis of TGF/BMP signalling in pancreatic ductal adenocarcinoma by digital pathology identifies patient subgroups with adverse outcome by Konstantin Bräutigam, Philipp Zens, Stefan Reinhard, Jessica L. Rohrbach, Simon J. Leedham, Anna S. Wenning, Beat Gloor, Viktor H. Koelzer, Martin Wartenberg

“…Methods We performed a spatially resolved analysis of PDAC on a multi-region tissue microarray cohort of 117 curatively resected PDAC specimens consisting of tumour centre (TC), tumour front (TF), and stromal(-predominant) tissue cores each. …”
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