Distinct mRNA expression profiles and miRNA regulators of the PI3K/AKT/mTOR pathway in breast cancer: insights into tumor progression and therapeutic targets by Tomasz Sirek, Tomasz Sirek, Katarzyna Król-Jatręga, Katarzyna Król-Jatręga, Przemysław Borawski, Nikola Zmarzły, Dariusz Boroń, Dariusz Boroń, Dariusz Boroń, Dariusz Boroń, Piotr Ossowski, Olga Nowotny-Czupryna, Kacper Boroń, Dominika Janiszewska-Bil, Elżbieta Mitka-Krysiak, Beniamin Oskar Grabarek, Beniamin Oskar Grabarek

“…Microarray and qRT-PCR techniques were employed to profile mRNAs and miRNAs, while bioinformatic tools predicted miRNA-mRNA interactions. …”
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Autoantibodies Targeting Vinculin Reveal Novel Insight into the Mechanisms of Autoimmune Podocytopathies by Hanyan Meng, Dongjie Wang, Chen Zheng, Chao Zhou, Xinrui Mao, Jinglan Gu, Xiaohui Qiao, Fei Liu, Jingjing Wang, Haidong Fu, Jianhua Mao, Qing Ye

“…Methods: Serum anti-vinculin autoantibody levels detected by protein microarray and clinical data were compared among INS patients (n = 147), healthy individuals (n = 84), and patients with other kidney or immune diseases (n = 100 of each disease). …”
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Aldo-keto reductase family 1 member B10 prevents esophageal squamous cell carcinoma from reactive carbonyl species-induced cell death and promotes its progression by Shau-Hsuan Li, Wan-Ting Huang, Yen-Hao Chen, Hung-I Lu, Chien-Ming Lo, Hsin-Ting Tsai, Chang-Han Chen

“…Methods To identify significant gene clusters involved in the metabolism of RCS in ESCC, we used an Agilent SurePrint G3 Human V2 GE 8 × 60 K microarray kit to analyze differentially expressed genes between nine paired ESCC tissues and adjacent normal esophageal tissues taken from areas distant from the tumor site. …”
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Identification of Novel Biomarkers in Huntington’s Disease Based on Differential Gene Expression Meta-Analysis and Machine Learning Approach by Nayan Dash, Md Abul Bashar, Jeonghan Lee, Raju Dash

“…We performed a meta-analysis to identify DEGs using three Gene Expression Omnibus (GEO) microarray datasets from different platforms related to HD-affected brain tissue, applying both relaxed and strict criteria to identify differentially expressed genes. …”
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Altered Expression Profile of Renal α1D-Adrenergic Receptor in Diabetes and Its Modulation by PPAR Agonists by Xueying Zhao, Yuanyuan Zhang, Michelle Leander, Lingyun Li, Guoshen Wang, Nerimiah Emmett

“…The present study was designed to investigate the expression profile of α1D-AR in the diabetic kidneys and its modulation by activation of peroxisome proliferator-activated receptors (PPARs). 12-week-old Zucker lean (ZL) and Zucker diabetic fatty (ZD) rats were treated with fenofibrate or rosiglitazone for 8–10 weeks. Gene microarray, real-time PCR, and confocal immunofluorescence microscopy were performed to assess mRNA and protein expression of α1D-AR in rat kidney tissue. …”
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Transcriptomic Profiling of Virus-Host Cell Interactions following Chicken Anaemia Virus (CAV) Infection in an In Vivo Model. by Efstathios S Giotis, Lisa Rothwell, Alistair Scott, Tuanjun Hu, Richard Talbot, Daniel Todd, David W Burt, Elizabeth J Glass, Pete Kaiser

“…There was little evidence of a Th1 adaptive immune response in any lymphoid tissue, as would normally be expected in response to viral infection. …”
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Expression and prognostic significance of MLH1 and GPRC5C in resectable hepatocellular carcinoma by Jun Lu, Lei Li, Qing Chen, Bingqi Li, Siqian Ren, Meng Yuan, Meng Meng, Jian Lei, Yuntao Bing, Hangyan Wang, Zhaolai Ma, Dianrong Xiu, Chunhui Yuan

“…Methods We detected MLH1 and GPRC5C expression using the tissue microarray-based immunohistochemical staining in tumor and matched adjacent non-tumor liver (ANL) specimens from 230 patients who underwent radical resection for HCC. …”
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Pericytes in castration-resistant prostate cancer associated with disease progression and immunotherapy response: insights from single-cell analysis by Yifeng Qiu, Yuhan Wang, Jiahe Liu, Kai Sun, Shigeo Horie, Zhitong Bing, Qi Hou

“…The clinical and prognostic significance of CRPC-pericytes was assessed by employing several bulk RNA-seq and microarray datasets. Additionally, we examined the association between the abundance of CRPC-pericytes and immunological features in the PCa microenvironment. …”
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Identifying shared hub genes in LIRI and MASLD through bioinformatics analysis and machine learning by Yongzhi Zhou, Bing Yin, Yang Yang, Zhongyu Li, Zhanzhi Meng, Shounan Lu, Baolin Qian, Xinglong Li, Yongliang Hua, Hongjun Yu, Yao Fu, Yong Ma

“…Using liver transplantation and MASLD datasets from the Gene Expression Omnibus, we applied Linear Models for Microarray Data and weighted gene co-expression analysis to identify differentially expressed genes and key module genes. …”
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Involvement of WNT Signaling in the Regulation of Gestational Age-Dependent Umbilical Cord-Derived Mesenchymal Stem Cell Proliferation by Sota Iwatani, Akemi Shono, Makiko Yoshida, Keiji Yamana, Khin Kyae Mon Thwin, Jumpei Kuroda, Daisuke Kurokawa, Tsubasa Koda, Kosuke Nishida, Toshihiko Ikuta, Kazumichi Fujioka, Masami Mizobuchi, Mariko Taniguchi-Ikeda, Ichiro Morioka, Kazumoto Iijima, Noriyuki Nishimura

“…In the present study, we isolated UC-MSCs from 23 infants delivered at 22–40 weeks of gestation and analyzed their gene expression and cell proliferation. Microarray analysis revealed that global gene expression in preterm UC-MSCs was distinct from term UC-MSCs. …”
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Targeting PRDX2 to inhibit tumor growth and metastasis in triple-negative breast cancer: the role of FN1 and the PI3K/AKT/SP1 pathway by Jiawei Zhou, Anqi Cheng, Jianqiang Guo, Yafeng Liu, Xuan Li, Maoqian Chen, Dong Hu, Jing Wu

“…Methods This study utilized TNBC tissue microarrays to detect Peroxiredoxin 2 (PRDX2) expression levels and analyzed the correlation between PRDX2 and tumor invasion as well as invasion-related gene expression through the TCGA database. …”
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PRMT3 drives PD-L1-mediated immune escape through activating PDHK1-regulated glycolysis in hepatocellular carcinoma by Chen-Hong Ding, Fang-Zhi Yan, Bo-Nan Xu, Hui Qian, Xia-Lu Hong, Shu-Qing Liu, Yuan-Yuan Luo, Si-Han Wu, Ling-Yan Cai, Xin Zhang, Wei-Fen Xie

“…Tissue microarray analysis showed a positive correlation between PRMT3 and PD-L1 expression in HCC patients. …”
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Expression of apoptotic protease activating factor-1 in adenoid cystic carcinoma of the salivary glands and its clinicopathological relevance by Dožić Branko, Aničić Boban, Sinobad Vladimir, Miković Nikola, Milanović Srđan, Dožić Ivan

“…We used the technique of tissue microarray (TMA blocks). Sections from the TMA mold, 5 μm thick, were stained with the streptavidin-biotin immunohistochemical technique using primary antibodies specific for Apaf-1 (Leica Biosystems, Newcastle, UK). …”
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Screening of endoplasmic reticulum stress characteristic genes and immune infiltration manifestations in chronic obstructive pulmonary disease by ZHANG Shuang, LUO Chenyang, HE Zhiyi

“…Finally the lncRNA-miRNA-mRNA ceRNA network of key genes was constructed and the mRNA expression levels of lung tissue in the mouse emphysema model were verified. …”
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FABP4 suppresses proliferation and invasion of hepatocellular carcinoma cells and predicts a poor prognosis for hepatocellular carcinoma by Cheng‐Qian Zhong, Xiu‐Ping Zhang, Ning Ma, Er‐Bin Zhang, Jing‐Jing Li, Ya‐Bo Jiang, Yu‐Zhen Gao, Yan‐Mei Yuan, Shi‐Qian Lan, Dong Xie, Shu‐Qun Cheng

“…In our study, we investigated the expression of FABP4 at both mRNA and protein levels, and by examining 175 cases of patients with cancer of the liver tissue microarray, the significance between the expression of FABP4 and clinical characteristics had been discussed. …”
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CCNY-mediated phosphorylation and TET2-BACH1-driven DNA demethylation activate PRC1 to augment NSCLC progression by Dayu Huang, Xianglin Chu, Chunxiao Wu, Xuan Wang, Mengkun Shi, Xiaofeng Chen, Yubao Lyu, Dapeng Li, Xuyu Gu

“…Subcutaneous xenograft and orthotopic isograft tumor models were generated for in vivo verification. Tissue microarray (TMA) and bioinformatics analyses were employed to evaluate the clinical prognostic value of CCNY, TET2, and PRC1 in NSCLC. …”
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Identification of differentially expressed immune-related genes in patients with systemic lupus erythematosus and the development of a hub gene-based diagnostic model by Quangang Fang, Weili Kong, Huaping Zhou, Yilin Pang, Haiyun Liu

“…Methods This study analyzed gene expression data from three GEO microarray datasets to explore immunity-related differentially expressed genes (DEGs) in SLE. …”
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FAM111B knockdown attenuates tumorigenesis of ovarian cancer via the downregulation of MYC by Guoyu Yu, Fang Wei, Wanying Li, Qiuyun Guo, Lihong Zhang

“…Immunohistochemical analyses conducted on tissue-microarray samples obtained from patients with serous ovarian cancer indicated that elevated levels of FAM111B expression were associated with unfavorable prognostic outcomes. …”
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Restriction of YWHAB-mediated YAP cytoplasmic retention is a novel mechanism underlying stemness maintenance and chemoresistance in ovarian cancer peritoneal metastasis by Chang Liu, Lei Shi, Zijun Meng, Manlin Zhang, Zhiqi Zhang, Yunzhe Li, Kaiwen Du, Muyao Yang, Lin Qiu, Jing Feng, Yuchen He, Jiayun Liu, Hua Zhang, Hongbin Zhang, Tingyuan Lang, Zhuo Yang

“…Combined tandem mass tag- and tissue microarray-based proteomic studies revealed YWHAB down-regulation in post-neoadjuvant chemotherapy OCPM tissues, which was confirmed in no-neoadjuvant-chemotherapy-response tissues, isolated OCPM stem cells, and induced cisplatin-resistant cells. …”
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SFB flagellin mediates cell adhesion, endocytosis and immune regulation in germ-free mice by Huahai Chen, Huahai Chen, Huahai Chen, Huahai Chen, Huahai Chen, Liu Wu, Liu Wu, Xiongyu Cao, Xiongyu Cao, Zongyan Li, Zongyan Li, Renjun Zhu, Renjun Zhu, Xiaojing Wang, Jun Li, Jun Li, Jun Li, Zuzhang Wei, Zuzhang Wei, Dengfeng Yang, Dengfeng Yang, Dengfeng Yang, Yeshi Yin, Yeshi Yin

“…Immunohistochemical analysis of ileal tissues showed co-localization of recombinant bacteria with the lysosomal-associated membrane protein 2 (Lamp2), confirming cellular internalization. …”
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