Experimental study on the role and biomarker potential of CX3CR1 in osteoarthritis by Junpu Huang, Xifan Zheng, Jinzhi Meng, Hongtao Wang, Lingyun Chen, Jun Yao

“…This study aimed to identify OA-associated genes and elucidate the molecular pathways implicated, with the goal of discovering reliable diagnostic biomarkers.Methods The microarray dataset was retrieved from the Gene Expression Omnibus (GEO) and analyzed using R software to identify the signature gene, CX3CR1. …”
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Regulation of neutrophil senescence by microRNAs. by Jon R Ward, Paul R Heath, James W Catto, Moira K B Whyte, Marta Milo, Stephen A Renshaw

“…Neutrophils are rapidly recruited to sites of tissue injury or infection, where they protect against invading pathogens. …”
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Machine learning-based single-sample molecular classifier for cancer grading by Zoia Antysheva, Nikita Kotlov, Mariia V. Guryleva, Ivan Valiev, Viktor Svekolkin, Anna Belozerova, Sheila T. Yong, Dmitry Tabakov, Alexander Bagaev, Vladimir Kushnarev

“…While low- and high-grade tumors are predictive of patient survival for many cancers, tumors of intermediate morphological grades are considered unreliable due to interobserver variability and thus do not have clear prognostic significance. To address this issue, we devised a molecular-based classifier that uses gene expression data from RNA sequencing (RNA-seq) or microarray profiling to predict high- and low-grade risk groups for breast, lung, and renal cancers. …”
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A novel polypeptide encoded by circSPIRE1 promotes prostate cancer proliferation and migration by restraining the ubiquitin-dependent degradation of LRP5 by Jintao Hu, Juanyi Shi, Junjie Wang, Yunfei Xiao, Degeng Kong, Mingchao Gao, Tianlong Luo, Shizhong Xu, Zhihan Yuan, Xinyi Ma, Xueseng Dong, Jingang Huang, Cheng Liu, Kewei Xu

“…This study characterizes a novel circRNA-encoded protein, rtSPIRE1, and investigates its mechanistic role in prostate cancer proliferation and migration, as well as its diagnostic and therapeutic potential. Methods RNA microarray identified circSPIRE1 in prostate cancer tissues. …”
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Targeting LINC02320 prevents colorectal cancer growth via GRB7-dependent inhibition of MAPK signaling pathway by Lingwei Zhang, Hong Chen, Yangmei Yang, Liangbo Zhao, Huimin Xie, Peixian Li, Xinrui Lv, Luyun He, Nian Liu, Benyu Liu

“…Results LINC02320 was highly expressed in metastatic colorectal cancer (CRC) tissues based on RNA-sequencing. ISH staining using tissue microarray (TMA) indicated that LINC02320 is associated with the clinical stage and survival rate of patients with CRC. …”
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Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells. by Mark Toshner, Benjamin J Dunmore, Eoin F McKinney, Mark Southwood, Paola Caruso, Paul D Upton, John P Waters, Mark L Ormiston, Jeremy N Skepper, Gerard Nash, Amer A Rana, Nicholas W Morrell

“…Subsequently, we analysed publically available microarrays from a variety of adult cell and tissue types using the whole "HOX transcriptome" of all 39 HOX genes. …”
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Identification and functional analysis of light-responsive unique genes and gene family members in rice. by Ki-Hong Jung, Jinwon Lee, Chris Dardick, Young-Su Seo, Peijian Cao, Patrick Canlas, Jirapa Phetsom, Xia Xu, Shu Ouyang, Kyungsook An, Yun-Ja Cho, Geun-Cheol Lee, Yoosook Lee, Gynheung An, Pamela C Ronald

“…Using a rice NSF45K oligo-microarray to compare 2-week-old light- and dark-grown rice leaf tissue, we identified 365 genes that showed significant 8-fold or greater induction in the light relative to dark conditions. …”
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Identification of Novel Molecular Panel as Potential Biomarkers of PAN-Gastrointestinal Cancer Screening: Bioinformatics and Experimental Analysis by Fatemeh Hajibabaie, Parisa Mohamadynejad, Laleh Shariati, Kamran Safavi, Navid Abedpoor

“…In the present study, using integrated transcriptomics, RNA-Seq and microarray data, from the TCGA and GEO databases, respectively, were combined to discover and validate a global biomarker panel for PAN-gastrointestinal cancers. …”
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Functional characteristics of fresh antitumor immune interferer GDF-15 in multiple cancers by Min Fang, Ziyu Wang, Yuxin Zhou, Fengrui Yang, Zhu Wu, Jian Xiao

“…Besides, immunohistochemistry (IHC)-based tissue microarray analysis of LUAD validated GDF-15 protein expression and its correlation with survival prognosis. …”
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Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma by Sayuri Kondo, Akinobu Ota, Takayuki Ono, Sivasundaram Karnan, Md Wahiduzzaman, Toshinori Hyodo, Md Lutfur Rahman, Kunihiro Ito, Akifumi Furuhashi, Tomio Hayashi, Hiroyuki Konishi, Shinobu Tsuzuki, Yoshitaka Hosokawa, Yoshiaki Kazaoka

“…Our comparative cDNA microarray analysis and gene set enrichment analysis (GSEA) showed that ameloblastoma exhibited a distinct gene expression pattern from the normal tissues: KRAS‐responsive gene set is significantly activated in ameloblastoma. …”
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Expression of lactate dehydrogenase C correlates with poor prognosis in renal cell carcinoma by Yibo Hua, Chao Liang, Jundong Zhu, Chenkui Miao, Yajie Yu, Aimin Xu, Jianzhong Zhang, Pu Li, Shuang Li, Meiling Bao, Jie Yang, Chao Qin, Zengjun Wang

“…First, a total of 133 cases of renal cell carcinoma samples were analysed in a tissue microarray, and Kaplan–Meier survival curve analyses were performed to investigate the correlation between lactate dehydrogenase C expression and renal cell carcinoma progression. …”
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PM2.5 Exposure in the Respiratory System Induces Distinct Inflammatory Signaling in the Lung and the Liver of Mice by Soi Jeong, Sang A Park, Inwon Park, Pilhan Kim, Nam Hoon Cho, Jin Won Hyun, Young-Min Hyun

“…We then conducted mRNA microarray analysis to further observe how PM2.5 affects gene expression patterns in the lung and the liver. …”
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Identification of GBP6 as a potential prognostic biomarker in esophageal carcinoma by integrated bioinformatics analysis and experiment validation by Shilin Fang, Yang Ding, Yifan Jia, Liping Gao, Yumei Ning, Guifang Wu, Jun Fang, Yongxi Zhang, Haizhou Wang, Hengning Ke

“…Immunohistochemistry was used to validate the results in an ESCA tissue microarray. The proliferative activity of ESCA cells was evaluated using cell counting kit 8 assay. …”
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Elucidating the immune infiltration in acne and its comparison with rosacea by integrated bioinformatics analysis. by Lu Yang, Yan-Hong Shou, Yong-Sheng Yang, Jin-Hua Xu

“…<h4>Methods</h4>Five microarray data-sets (GSE108110, GSE53795, GSE65914, GSE14905 and GSE78097) were downloaded from Gene Expression Omnibus. …”
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MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors. by Long R Jiao, Adam E Frampton, Jimmy Jacob, Loredana Pellegrino, Jonathan Krell, Georgios Giamas, Nicole Tsim, Panagiotis Vlavianos, Patrizia Cohen, Raida Ahmad, Andreas Keller, Nagy A Habib, Justin Stebbing, Leandro Castellano

“…MiRNA profiling was performed using a custom microarray and results were validated using RT-qPCR prior to evaluation of miRNA targets.…”
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Prognostic and immunotherapeutic potential of disulfidptosis-associated signature in pancreatic cancer by Ran Cui, Gaoming Wang, Renhao Hu, Yongkun Wang, Huiling Mu, Yanxiang Song, Bo Chen, Xiaohua Jiang

“…Our investigation aims to elucidate the significance of disulfidptosis in pancreatic ductal adenocarcinoma by integrating diverse datasets, including bulk RNA sequencing data, microarray profiles, single-cell transcriptome profiles, spatial transcriptome data, and biospecimens. …”
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Effects of Benzo[a]Pyrene Exposure on Lung Cancer: A Mechanistic Study of Epigenetic m6A Levels and YTHDF1 by Siyi Xu, Jie Li, Sheng Yang, Panpan Yang, Yiru Niu, Yiling Ge, Geyu Liang

“…TMT labeling-based proteomic analysis and clinical lung tissue microarray assays demonstrated that CDK6 and MAP3K6 were positively correlated with YTHDF1 expression. …”
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Helicobacter pylori is associated with less tumor-infiltrating lymphocytes and a poor prognosis in gastric cancer by Zetian Chen, Zhijun Zhang, Hongxin Huang, Chen Lu, Qingya Li, Mengpei Yan, Chengjun Zhu, Sen Wang, Hongda Liu, Zekuan Xu, Zheng Li

“…Methods In this study, we constructed a tissue microarray (TMA) consisting of GC tissues from patients with or without H. pylori infection. …”
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Potential Canonical Wnt Pathway Activation in High-Grade Astrocytomas by Rebecca Schüle, Christine Dictus, Benito Campos, Feng Wan, Jörg Felsberg, Rezvan Ahmadi, Franz-Simon Centner, Niels Grabe, Guido Reifenberger, Justo L. Bermejo, Andreas Unterberg, Christel Herold-Mende

“…Furthermore, we assessed the prognostic relevance of β-catenin expression in a tissue microarray comprising 283 astrocytomas. Expression of β-catenin, its transcriptional cofactors TCF-1 and TCF-4 as well as GSK-3β and APC, constituents of the β-catenin degradation complex was confirmed by RT-PCR in all cultures. …”
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The Prognostic Significance and Co-Expression of Fibroblast Growth Factor Receptor 2 and c-Met in Endometrial Cancer by Gao H, Lu Q, Zhang J

“…Huiqiao Gao, Qi Lu, Jianxin Zhang Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital Affiliated to Capital Medical University, Beijing, 100020, People’s Republic of ChinaCorrespondence: Jianxin Zhang, Email Jianxin20241031@126.comObjective: We sought to study the expression of FGFR2 and c-Met and evaluate the correlation between the two proteins in a series of endometrial cancer patients as well as the prognostic significance of the two markers in endometrium carcinoma.Methods: Patients who were diagnosed with endometrial cancer and had undergone surgical treatment in Beijing Chao-Yang Hospital, Capital Medical University from November 2004 to June 2011 were included in this study. Tissue microarray construction, immunohistochemical staining and scoring were employed to study the expression of FGFR2 and c-Met. …”
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