Oncolytic virotherapy provides a potent therapy option for squamous bladder cancer by Julia Pannhausen, Julia Wirtz, Klaus Mantwill, Per-Sonne Holm, Kristina Schwamborn, Danny D. Jonigk, Jürgen E. Gschwend, Michael Rose, Nadine T. Gaisa, Roman Nawroth

“…Furthermore, immunohistochemical staining of 89 SCC on a tissue microarray confirmed strong YB-1 expression in squamous BLCA (sq-BLCA). …”
Get full text

Targeting insulin-like growth factor 1 receptor restricts development and severity of secondary lymphedema in mice by Yinan Yuan, Sidney M. Levy, Yong Qiang Yeo, Ramin Shayan, Tara Karnezis, Steven A. Stacker, Marc G. Achen

“…Here, using a surgical mouse model of secondary lymphedema and whole-genome microarray, we identified the transcript for insulin-like growth factor binding protein 5 (IGFBP5), a negative regulator of insulin-like growth factor (IGF) signaling, as the most profoundly down-regulated in lymphedematous tissue. …”
Get full text

Integrated Bioinformatics Analysis Identifies ELAVL1 and APP as Candidate Crucial Genes for Crohn’s Disease by Heli Li, Qianru Li, Shiran Sun, Ping Lei, Xiong Cai, Guanxin Shen

“…In this study, three independent microarray studies of CD were integrated and 9912 differentially expressed genes (DEGs) were analysed by NetworkAnalyst to screen candidate crucial genes. …”
Get full text

Matrix stiffness regulates glucose-6-phosphate dehydrogenase expression to mediate sorafenib resistance in hepatocellular carcinoma through the ITGB1-PI3K/AKT pathway by Ruimei Ren, Shan Zhang, Zhan Peng, Xiaomeng Ji, Hao Song, Qiuxiao Wang, Xiangyin Sun, Huiyu Wang, Yinying Dong

“…Further in vitro and in vivo experiments confirmed that ECM stiffness can upregulate G6PD expression through the ITGB1-PI3K/AKT pathway, mediating sorafenib resistance in HCC. Clinical tissue microarray analysis revealed that the expression of collagen I, α-SMA, ITGB1, p-AKT, and G6PD was associated with sorafenib resistance in HCC patients. …”
Get full text

Induction of ER stress in macrophages of tuberculosis granulomas. by Tracie A Seimon, Mi-Jeong Kim, Antje Blumenthal, Jovanka Koo, Sabine Ehrt, Helen Wainwright, Linda-Gail Bekker, Gilla Kaplan, Carl Nathan, Ira Tabas, David G Russell

“…These areas were also positive for numerous apoptotic cells as assayed by TUNEL. Microarray analysis of human caseous TB granulomas isolated by laser capture microdissection reveal that 73% of genes involved in the UPR are upregulated at the mRNA transcript level. …”
Get full text

Distinctive profile of IsomiR expression and novel microRNAs in rat heart left ventricle. by Mary K McGahon, Janet M Yarham, Aideen Daly, Jasenka Guduric-Fuchs, Lyndsey J Ferguson, David A Simpson, Anthony Collins

“…The expression of known miRNAs in the heart has been studied at length by microarray and quantitative PCR but it is becoming evident that microRNA isoforms (isomiRs) are potentially physiologically important. …”
Get full text

High Expression of PDLIM2 Predicts a Poor Prognosis in Prostate Cancer and Is Correlated with Epithelial-Mesenchymal Transition and Immune Cell Infiltration by Songzhe Piao, Lan Zheng, Haihong Zheng, Mengya Zhou, Qin Feng, Suna Zhou, Mang Ke, Haihua Yang, Xuequan Wang

“…The data of RNA-seq, DNA methylation, and clinical features of PRAD patients were collected from The Cancer Genome Atlas (TCGA) database to define the prognostic value of PDLIM gene expression and the association with EMT and immune cell infiltration. A tissue microarray including 134 radical prostatectomy specimens was served as validation by immunohistochemistry (IHC) staining analysis. …”
Get full text

Ectopic overexpression of CD133 in HNSCC makes it resistant to commonly used chemotherapeutics by Junyoung Lee, Mineon Park, Youngjong Ko, Bora Kim, Okjoon Kim, Hoon Hyun, DongHwi Kim, HongMoon Sohn, Young Lae Moon, Wonbong Lim

“…To investigate the role of CD133 in chemoresistance, cell death was analyzed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), Diff-Quick, flow cytometry, and western blot of apoptosis-related protein expression in fluorouracil (5-FU)- or cisplatin-treated cells. In addition, microarray and related protein expression assessments were performed to investigate the mechanism of chemoresistance against 5-FU and cisplatin in KB cells. …”
Get full text

Histopathologic classification and immunohistochemical features of papillary renal neoplasm with potential therapeutic targets by Jeong Hwan Park, Su-Jin Shin, Hyun-Jung Kim, Sohee Oh, Yong Mee Cho

“…We aimed to evaluate immunohistochemical features and possible therapeutic targets of papillary renal neoplasms Methods We collected 140 papillary renal neoplasms from three different hospitals and conducted immunohistochemical studies on tissue microarray slides. We performed succinate dehydrogenase B, fumarate hydratase, and transcription factor E3 immunohistochemical studies for differential diagnosis and re-classified five cases (3.6%) of papillary renal neoplasms. …”
Get full text

Expression signatures with specificity for type I and II IFN response and relevance for autoimmune diseases and cancer by Bogac Aybey, Benedikt Brors, Eike Staub

“…Our IFN-II signature is broader applicable than other published signatures as it demonstrates strong performance in detecting IFN-II response in more cell types. In three SLE microarray datasets our IFN-I signature was highly coherent and correlated with disease severity better than most published signatures. …”
Get full text

Senescence-related circRNA circHIF-1α is associated with pancreatic cancer progression by Hao Hua, Yazu Deng, Dijie Zheng, Changhao Wu, Liwen Chen, Binbin Shi, Zhiwei He, Chao Yu

“…Therefore, we identified circHIF-1α, hsa_circ_0007976, which was downregulated in senescent cells using circRNA microarray analysis. Meanwhile, significantly upregulated expression of circHIF-1α in pancreatic cancer tissue detected by reverse transcription-polymerase chain reaction (RT-qPCR) and in situ hybridization (ISH). …”
Get full text

mRNA-lncRNA gene expression signature in HPV-associated neoplasia and cervical cancer by E. D. Kulaeva, E. S. Muzlaeva, E. V. Mashkina

“…Validation on an independent microarray dataset showed that the differential expression patterns of the CDKN2A and SLC27A6 genes were conserved in the respective gene expression comparisons between groups.…”
Get full text

Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation. by April K Binder, Justin P Kosak, Kyathanahalli S Janardhan, Glenda Moser, Thomas E Eling, Kenneth S Korach

“…Transgenic mice expressing human non-steroidal anti-inflammatory drug activated gene 1 (NAG-1) have less adipose tissue, improved insulin sensitivity, lower insulin levels and are resistant to dietary induced obesity. …”
Get full text

The expression and prognostic value of stem cell markers Bmi-1, HESC5:3, and HES77 in human papillomavirus–positive and –negative oropharyngeal squamous cell carcinoma by Hesham Mohamed, Jaana Hagström, Lauri Jouhi, Timo Atula, Alhadi Almangush, Antti Mäkitie, Caj Haglund

“…Our cohort comprised 202 consecutive oropharyngeal squamous cell carcinoma patients diagnosed and treated with curative intent. We used tissue microarray tumor blocks to study the immunohistochemical expression of Bmi-1, HESC5:3, and HES77. …”
Get full text

Bioinformatics identification of key genes associated with the prognosis of gastric cancer by LIU Zhao, LIU Rui, FAN Haijing, SUN Hui, LYU Jing, ZHANG Zhen

“…Objective To screen and identify key genes and pathways associated with the prognosis of gastric cancer, and to investigate the mechanisms of the development and progression of gastric cancer. Methods Microarray datasets (GSE2685, GSE29272) of gastric cancer gene expression profile were downloaded from the gene expression omnibus, and the online analytical tool GEO2R was used to screen for differentially expressed genes (DEGs) between gastric cancer tissue and normal tissue. …”
Get full text

HDAC1 Mediates Immunosuppression of the Tumor Microenvironment in Non-Small Cell Lung Cancer by Fan Y, Ji X, Yuan K, Wu Q, Lou M

“…However, there are no studies on the immunological aspects of HDAC1 in non-small cell lung cancer (NSCLC).Methods: In this research, we used the Cancer Genome Atlas (TCGA) public database combined with tissue microarray (TMA) to investigate HDAC1 expression and prognosis in NSCLC. …”
Get full text

Thrombospondin-1 induces CD8+ T cell exhaustion and immune suppression within the tumor microenvironment of ovarian cancer by Haiyan Liang, Suwei Zhang

“…Methods We analyzed THBS1 expression and its clinical significance using publicly available datasets (TCGA-OV, GSE14407) and tissue microarrays containing OC and adjacent normal tissues. …”
Get full text

MicroRNA-206: a potential circulating biomarker candidate for amyotrophic lateral sclerosis. by Janne M Toivonen, Raquel Manzano, Sara Oliván, Pilar Zaragoza, Alberto García-Redondo, Rosario Osta

“…Besides their important regulatory role in variety of biological processes, miRNAs can also be released into the circulation by pathologically affected tissues and display remarkable stability in body fluids. …”
Get full text

Serum LncRNAs Profiles Serve as Novel Potential Biomarkers for the Diagnosis of HBV-Positive Hepatocellular Carcinoma. by Kang Wang, Wei Xing Guo, Nan Li, Chun Fang Gao, Jie Shi, Yu Fu Tang, Feng Shen, Meng Chao Wu, Shan Rong Liu, Shu Qun Cheng

“…<h4>Methods</h4>lncRNA microarrays were utilized to measure the differential expression of lncRNAs between tumor tissues and corresponding non-tumor tissues in HBV-positive hapatocellular carcinoma. uc001ncr and AX800134 were selected as candidate lncRNAs and detected in three independent cohorts containing a total of 684 participants (healthy individuals and chronic HBV patients and HBV-positive HCC patients) who were recruited between March 2011 and December 2012. …”
Get full text

Homeobox protein B6 and homeobox protein B8 control immune-cancer cell interactions in pancreatic cancer by Ludivine Bertonnier-Brouty, Sara Bsharat, Kavya Achanta, Jonas Andersson, Thanya Pranomphon, Tania Singh, Tuomas Kaprio, Jaana Hagström, Caj Haglund, Hanna Seppänen, Rashmi B. Prasad, Isabella Artner

“…We described their functions in pancreatic cancer by performing transcriptomic and tumor tissue microarray analyses, in vitro assays in pancreatic and lung cancer cell lines and co-culture experiments with immune cells. …”
Get full text