Spatial transcriptomic characteristics of gastric cancer in young and the expression and role of TMEM176B in gastric cancer cells by Zhenhua Jiang, Yongfeng Wang, Chi Zhang, Shuangyin Han

“…Methods The surgical specimens of six patients with GCY were included to construct a tissue microarray containing the tumor core region (TCR), cancer-adjacent tissue (CAT), and normal gastric tissue (NGT). …”
Get full text

ANGPTL4 exacerbates pancreatitis by augmenting acinar cell injury through upregulation of C5a by Kyung Hee Jung, Mi Kwon Son, Hong Hua Yan, Zhenghuan Fang, Juyoung Kim, Soo Jung Kim, Jung Hee Park, Ji Eun Lee, Young‐Chan Yoon, Myeong Seong Seo, Beom Seok Han, Soyeon Ko, Young Ju Suh, Joo Han Lim, Don‐Haeng Lee, Ziqiang Teo, Jonathan Wei Kiat Wee, Nguan Soon Tan, Soon‐Sun Hong

“…However, little is known about the genes associated with pancreatitis severity. Our microarray analysis of pancreatic tissues from mild and severe acute pancreatitis mice models identified angiopoietin‐like 4 (ANGPTL4) as one of the most significantly upregulated genes. …”
Get full text

Machine learning reveals CAT gene as a novel potential diagnostic and prognostic biomarker in non-small cell lung cancer by Yi Tian, Wen-ya Zhao, Yi-ru Liu, Wen-wen Song, Qiao-xin Lin, Yan-na Gong, Yi-ting Deng, Dian-na Gu, Ling Tian

“…Furthermore, immunohistochemical staining was performed in an independent cohort from a tissue microarray. Additionally, cell culture and RT-qPCR were employed for external validation. …”
Get full text

SMART: unique splitting-while-merging framework for gene clustering. by Rui Fa, David J Roberts, Asoke K Nandi

“…Moreover, two real microarray gene expression datasets are studied using this approach. …”
Get full text

Delineation of 2q32q35 Deletion Phenotypes: Two Apparent “Proximal” and “Distal” Syndromes by Adrian Mc Cormack, Juliet Taylor, Nerine Gregersen, Alice M. George, Donald R. Love

“…They presented with wide-ranging phenotypic variation including facial dysmorphisms, cleft palate, learning difficulties, behavioural issues and severe heart defects. Microarray analysis confirmed an 8.6 Mb deletion in patients 1 and 2 and a 24.7 Mb deletion in patient 3. …”
Get full text

c-Triadem: A constrained, explainable deep learning model to identify novel biomarkers in Alzheimer's disease. by Sherlyn Jemimah, Ferial Abuhantash, Aamna AlShehhi

“…Alzheimer's disease (AD) is a neurodegenerative disorder that requires early diagnosis for effective management. However, issues with currently available diagnostic biomarkers preclude early diagnosis, necessitating the development of alternative biomarkers and methods, such as blood-based diagnostics. …”
Get full text

QKI-induced circ_0001766 inhibits colorectal cancer progression and rapamycin resistance by miR-1203/PPP1R3C/mTOR/Myc axis by Yulai Zhou, Yan Gao, Yinghui Peng, Changjing Cai, Ying Han, Yihong Chen, Gongping Deng, Yanhong Ouyang, Hong Shen, Shan Zeng, Yangfeng Du, Zemin Xiao

“…Here, we identified and characterized a circular RNA, circ_0001766 (hsa_circ_0001766), through microarray analysis of CRC tissues. Our results showed that circ_0001766 is downregulated in CRC tissues and closely associated with patient survival and metastasis. …”
Get full text

The potential of MCM8 as a biomarker in esophageal carcinoma: a comprehensive analysis integrating m6a methylation and angiogenesis by Xu-Sheng Liu, Yong Xu, Li-Song Dai, Ao Li, Jie Liu, Yu Zhang, Jin Xie, Zhi-Jun Pei

“…MCM8 expression in ESCA tissues was evaluated by immunohistochemical staining on a tissue microarray. …”
Get full text

Bioinformatics-based screening and validation of PANoptosis-related biomarkers in periodontitis by Qing Sun, Qing Sun, JinYue Hu, JinYue Hu, RuYue Wang, RuYue Wang, ShuiXiang Guo, ShuiXiang Guo, GeGe Zhang, GeGe Zhang, Ao Lu, Ao Lu, Xue Yang, Xue Yang, LiNa Wang, LiNa Wang

“…RT-qPCR validation demonstrated that ZBP1 expression was significantly elevated in periodontitis tissues compared to healthy periodontal tissues (P < 0.05).ConclusionThis study provides bioinformatic evidence linking PANoptosis to periodontitis. …”
Get full text

Pan-cancer analysis identifies CD155 as a promising target for CAR-T cell therapy by Xiaohong Liu, Yue Sun, Boxu Lin, Hao Xiong, Xinyue Lu, Binghe Tan, Chenglin Zhang, Mingyao Liu, Juliang Qin, Na Zhang, Bing Du

“…Methods The expression of CD155 was analyzed across various cancer types using data from The Cancer Genome Atlas (TCGA) and validated by tissue microarray analysis. The impact of CD155 on T cell mediated cytotoxicity was analyzed using CD155 over-expression or knockout tumor cells. …”
Get full text

Implications of CYP1B1 in the treatment and prognosis of breast cancer by Maria Carolina Stipp, Jeanine Marie Nardin, José Claudio Casali-da-Rocha, Sérgio Ioshii, Alexandra Acco

“…Results The CYP1B1 enzyme was overexpressed in 75% of breast cancer tissues. This result remained consistent regardless of the treatment regimen. …”
Get full text

Construction of a macrophage-related prognostic signature and assessment of immune checkpoint inhibitor efficacy of HCC by Shouge Zang, Hongwei Chen, Yuqian Han, Di Cui, Jiangtao Yu

“…Functional assays were conducted to assess the effect of PLAUR knockdown on macrophage polarization, tumor cell behavior, and PI3K/AKT/mTOR pathway activity. Tissue microarray immunofluorescence validated PLAUR expression in situ. …”
Get full text

Stroma regulates increased epithelial lateral cell adhesion in 3D culture: a role for actin/cadherin dynamics. by Karen F Chambers, Joanna F Pearson, Naveed Aziz, Peter O'Toole, David Garrod, Shona H Lang

“…<h4>Background</h4>Cell shape and tissue architecture are controlled by changes to junctional proteins and the cytoskeleton. …”
Get full text

Involvement of tdTomato-Tagged RPE cells in a mouse PVR model with enzymatically compromised retina by Yao Chen, Xiao Liu, Ashwini Kini, John Y. Liu, Xiaoqin Lu, Ling Gao, Henry J. Kaplan, Douglas C. Dean, Yongqing Liu

“…Gene expression results of the mouse PVR model retinas are consistent with the microarray gene expression profile of human PVR retinas, validating that our mouse PVR model resembles human PVR and is thereby suitable for molecular mechanism and pharmaceutical studies.…”
Get full text

ALDOB is a prognostic biomarker and a potential immunotherapy target for clear cell renal cell carcinoma by Wu Xu, Dali Wu, Cuilian Li, Lingfei Yan, Bo Peng, Yang Luo, Dawei Liu, Qing Li, Tao Wang

“…Immunohistochemistry (IHC) was applied to identify the ALDOB level in a tissue microarray. Results The expression of ALDOB demonstrated a strong association with pathologic T stage, pathologic N stage, pathologic M stage, histologic grade, and gender. …”
Get full text

MicroRNA-135b Regulates Leucine Zipper Tumor Suppressor 1 in Cutaneous Squamous Cell Carcinoma. by Edit B Olasz, Lauren N Seline, Ashley M Schock, Nathan E Duncan, Argelia Lopez, Jozef Lazar, Michael J Flister, Yan Lu, Pengyuan Liu, Olayemi Sokumbi, Catherine A Harwood, Charlotte M Proby, Marcy Neuburg, Zelmira Lazarova

“…Immunohistochemical evaluation of 67 cSCC tumor tissues demonstrated that miR-135b expression inversely correlated with LZTS1 staining intensity and the tumor grade. …”
Get full text

Endothelial periostin regulates vascular remodeling by promoting endothelial dysfunction in pulmonary arterial hypertension by Dawn Lee, Heeyoung Lee, Ha-neul Jo, Eunsik Yun, Byung Su Kwon, Jongmin Kim, Aram Lee

“…Here, we demonstrated that POSTN upregulation correlates with PAH by analyzing a public microarray conducted on the lung tissues of patients with PAH and biological experimental results from in vivo and in vitro models. …”
Get full text

The Novel Action of miR-193b-3p/CDK1 Signaling in HCC Proliferation and Migration: A Study Based on Bioinformatic Analysis and Experimental Investigation by Xue Pang, Wei Wan, Xingxing Wu, Yu Shen

“…A growing number of novel targets underlying HCC pathophysiology have been detected using microarray high throughput screening platforms. This study carried out bioinformatics analysis to explore underlying biomarkers in HCC and assessed the potential action of the miR-193b-3p/CDK1 signaling pathway in HCC progression. …”
Get full text

Rab27a was identified as a prognostic biomaker by mRNA profiling, correlated with malignant progression and subtype preference in gliomas. by Hongjun Wang, Yan Zhao, Chuanbao Zhang, Mingyang Li, Chuanlu Jiang, Yongli Li

“…<h4>Experimental design</h4>We used a whole-genome mRNA expression microarray dataset of 220 glioma samples from the Chinese Glioma Genome Atlas (CGGA) database (http://www.cgga.org.cn) as a discovery set. …”
Get full text

Complex Loci in human and mouse genomes. by Pär G Engström, Harukazu Suzuki, Noriko Ninomiya, Altuna Akalin, Luca Sessa, Giovanni Lavorgna, Alessandro Brozzi, Lucilla Luzi, Sin Lam Tan, Liang Yang, Galih Kunarso, Edwin Lian-Chong Ng, Serge Batalov, Claes Wahlestedt, Chikatoshi Kai, Jun Kawai, Piero Carninci, Yoshihide Hayashizaki, Christine Wells, Vladimir B Bajic, Valerio Orlando, James F Reid, Boris Lenhard, Leonard Lipovich

“…Bidirectional promoters were characterized by variable transcriptional start sites and an identifiable midpoint at which overall sequence composition changed strand and the direction of transcriptional initiation switched. In microarray data covering a wide range of mouse tissues, genes in cis-antisense and bidirectionally promoted arrangement showed a higher probability of being coordinately expressed than random pairs of genes. …”
Get full text