VPS25 Promotes an Immunosuppressive Microenvironment in Head and Neck Squamous Cell Carcinoma by Li-Guo Chen, Yu-Han Fang, Kui-Ming Wang, Wei Zhang, Gang Chen

“…Bulk RNA-sequencing data and HNSCC tissue microarrays (TMAs) were used to evaluate VPS25 expression and its clinical significance. …”
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C20orf27 promotes hepatocellular carcinoma progression via NT5E by Yu He, Wen Zhang, Ming Chang, Yuanjie Chen, Risheng Lin, Xinyu Ye, Wei Mao, Yubin Lu, Yi Lu, Erbao Chen

“…Immunohistochemistry analysis of tissue microarrays suggested that NT5E expression was significantly associated with C20orf27 levels. …”
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Disruption of DMD gene leads to altered calcium homeostasis and metabolic shift impacting gastric Cancer cell proliferation and migration by Xiaodong Zou, Tong Wu, Tao Su, Hui Xiao, Chuyan Ni, Lijuan Hu, Wenchu Lin, Weilin Chen, Richard D Ye, Jianjiao Lin, Li Xiang

“…Methods We validated DMD gene expression levels in the TIMER2.0 database and human gastric cancer tissue microarrays and constructed gastric precancerous lesion mouse models and DMD gene knockout and overexpression cell lines to investigate the role of DMD gene in gastric cancer development. …”
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TMEM101 expression and its impact on immune cell infiltration and prognosis in hepatocellular carcinoma by Lingyun Kuang, Yilin Pang, Quangang Fang

“…Additionally, differences in TMEM101 expression in HCC cell lines and HCC tissue microarrays were examined using RT-qPCR, western blotting, and in situ hybridization staining. …”
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Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers. by Romina Briffa, Inhwa Um, Dana Faratian, Ying Zhou, Arran K Turnbull, Simon P Langdon, David J Harrison

“…PDCD6 was differentially expressed in all three treatment responses. Tissue microarrays were constructed for a cohort of 118 CRC patients and TRIB1 and MYC amplifications were measured using fluorescence in situ hybridisation. …”
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Quantification of the heterogeneity of prognostic cellular biomarkers in ewing sarcoma using automated image and random survival forest analysis. by Claudia Bühnemann, Simon Li, Haiyue Yu, Harriet Branford White, Karl L Schäfer, Antonio Llombart-Bosch, Isidro Machado, Piero Picci, Pancras C W Hogendoorn, Nicholas A Athanasou, J Alison Noble, A Bassim Hassan

“…Using material from cohorts of genetically diagnosed Ewing sarcoma with EWSR1 chromosomal translocations, confocal images of tissue microarrays were segmented with level sets and watershed algorithms. …”
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Cell-cycle and Apoptosis Regulators (p16INK4A, p21CIP1, α-Catenin, Survivin, and hTERT) and Morphometry-Defined MPECs Predict Metachronous Cancer Development in Colorectal Adenoma... by Kjetil Soreide, Tirza C. E. Buter, Emiel A. Janssen, Einar Gudlaugsson, Ivar Skaland, Hartwig Körner, Jan P. A. Baak

“…Methods: Application of immunohistochemistry on tissue microarrays in consecutive, population-based colorectal adenomas. …”
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Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection. by Anna M Hoy, Rachel J Lundie, Alasdair Ivens, Juan F Quintana, Norman Nausch, Thorsten Forster, Frances Jones, Narcis B Kabatereine, David W Dunne, Francisca Mutapi, Andrew S Macdonald, Amy H Buck

“…Here, we examine the capacity of host and parasite miRNAs to serve as tissue or serum biomarkers of Schistosoma mansoni infection.…”
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Advancing Precision Medicine: The Role of Genetic Testing and Sequencing Technologies in Identifying Biological Markers for Rare Cancers by Joviana Farhat, Lara Alzyoud, Mohammad AlWahsh, Animesh Acharjee, Basem Al‐Omari

“…Results In practice, fluorescence in situ hybridization, karyotype, microarrays and other genetic tests are mainly applied to identify specific genetic alterations and mutations associated with cancer progression. …”
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Tumor immune microenvironment permissive to metastatic progression of ING4-deficient breast cancer. by Emily Tsutsumi, Anne M Macy, Janine LoBello, Karen T Hastings, Suwon Kim

“…To characterize the tumor immune microenvironment associated with ING4-deficient tumors, three approaches were employed in this study: First, tissue microarrays composed of 246 primary breast tumors including 97 ING4-deficient tumors were evaluated for the presence of selective immune markers, CD68, CD4, CD8, and PD-1, using immunohistochemical staining. …”
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TPX2 promotes papillary renal cell carcinoma progression by forming a ceRNA with LINC00894 by Zhenshan Ding, Wenwei Ying, Ye Yan, Ying Zhao, Cheng Liu, Lulin Ma

“…Immunohistochemical analysis of tissue microarrays was performed to evaluate the associations between TPX2 expression and clinicopathological characteristics in type 2 pRCC patients. …”
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Effects of pregnancy on breast cancer immunology: immune biomarker and TIL quantification by Kristin Galas, Moritz Gleitsmann, Julia Rey, Christine Solbach, Isabell Witzel, Thomas Karn, Sabine Schmatloch, Christian Schem, Andreas Schneeweis, Bruno Sinn, Tanja Fehm, Carsten Denkert, Peter Fasching, Anne-Sophie Litmeyer, Frederik Marmé, Paul Jank, Volkmar Müller, Sabine Seiler, Elmar Stickeler, Olaf Ortmann, Marion van Mackelenbergh, Valentina Nekljudova, Johannes Holtschmidt, Sibylle Loibl

“…Further understanding of how pregnancy affects the tumor microenvironment (TME) is essential. We constructed Tissue Microarrays (TMA) of tumor specimens from 126 pregnant breast cancer (BC) patients and examined standard BC markers such as ER, PR, Ki67, HER2, tumor infiltrating lymphocytes (TILs), and immunomarkers HLA class I, HLA-G, PD-L1, TIGIT and Nectin-4. …”
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A Transcriptomic Signature of Mouse Liver Progenitor Cells by Adam M. Passman, Jasmine Low, Roslyn London, Janina E. E. Tirnitz-Parker, Atsushi Miyajima, Minoru Tanaka, Helene Strick-Marchand, Gretchen J. Darlington, Megan Finch-Edmondson, Scott Ochsner, Cornelia Zhu, James Whelan, Bernard A. Callus, George C. T. Yeoh

“…A transcriptomic meta-analysis of over 400 microarrays was undertaken to compare LPC lines against datasets of muscle and embryonic stem cell lines, embryonic and developed liver (DL), and HCC. …”
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RPS21 Enhances hepatocellular carcinoma development through GPX4 stabilization by Siyuan Wu, Gaochao Wang, Likai Gu, Yinjie Zhang, Zhihuai Wang

“…Mutation analysis via the cBioPortal showed that primarily amplifications in RPS21 are associated with a poorer prognosis. Tissue microarrays confirmed higher RPS21 levels in tumor samples, which were associated with more advanced clinical stages and grades. …”
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Pan-cancer landscape of ITGAV and its potential role in gastric cancer by Bin Ke, Peng Jin, Xue-Jun Wang, Ru-peng Zhang, Ning Liu, Gang Ma

“…Gene enrichment analysis was performed to explore potential functions of ITGAV in gastric cancer (GC). GC tissue microarrays and in vitro cell experiments were used to verify the prediction results in GC. …”
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Mismatch repair enzyme expression in primary and castrate resistant prostate cancer by Belinda Nghiem, Xiaotun Zhang, Hung-Ming Lam, Lawrence D. True, Ilsa Coleman, Celestia S. Higano, Peter S. Nelson, Colin C. Pritchard, Colm Morrissey

“…Objective: Although the utility of immunohistochemistry (IHC) for assessing mismatch repair (MMR) protein expression has been demonstrated in solid tumors including primary prostate cancer (PCa), its utility has not been assessed in castration-resistant PCa (CRPC). Methods: Tissue microarrays were constructed from 127 radical prostatectomies and 155 CRPC metastases from 50 patients. …”
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High Expression of Somatostatin Receptors 2A, 3, and 5 in Corticotroph Pituitary Adenoma by Felix Behling, Jürgen Honegger, Marco Skardelly, Irina Gepfner-Tuma, Ghazaleh Tabatabai, Marcos Tatagiba, Jens Schittenhelm

“…Paraffin-embedded tumor samples of 88 corticotroph pituitary adenomas and 30 nonadenomatous pituitary biopsies were analyzed after processing into tissue microarrays and immunohistochemical staining for SSTR 1, SSTR2A, SSTR3, SSTR4, and SSTR5. …”
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TRPM4 is highly expressed in human colorectal tumor buds and contributes to proliferation, cell cycle, and invasion of colorectal cancer cells by Sven Kappel, Paulina Stokłosa, Barbara Hauert, Daniela Ross‐Kaschitza, Anna Borgström, Roland Baur, José A. Galván, Inti Zlobec, Christine Peinelt

“…Here, we investigated tumor tissue microarrays from 379 CRC patients and analyzed TRPM4 protein expression, tumor characteristics, and clinical outcome. …”
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Unveiling the impact of C15orf48 on non-small cell lung cancer through NF-kappa B signaling by Wei Wang, Lei Zhang, Ansheng Wang, Xiaohua Wang, Weidong Wu

“…Immunohistochemical staining was used to detect C15orf48 expression in tissue microarrays. Cellular assays, including CCK8, colony formation, wound healing, transwell migration, flow cytometry, and cell adhesion, were conducted to assess cell viability, proliferation, invasion, and apoptosis. …”
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Expression and prognostic value of EGF-like domain multiple 6 in uterine corpus endometrial carcinoma and its correlation with immune cell infiltration by Qiannan Li, Nuerbiya Muheteer, Gulibositan Ayoufu, Xieerwaniguli Abulimiti, Ayimuguli Aini, Bingjie Han, Reyila Fulati, Mieradilijiang Ainiwaer, Ainiwaerjiang Abudourousuli

“…Immunohistochemistry was performed using UCEC tissue microarrays to assess EGFL6 expression. The Kaplan-Meier method and Cox regression analyses were used to evaluate the prognostic significance of EGFL6. …”
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