Prognostic prediction and diagnostic role of Rspondin 1 expression in esophageal squamous cell carcinoma by Xiaoxia Cheng, Jiao Liu, Danye Niu, Changsong Zhang, Yuansheng Lin, Shengjun Li, Jiao Yang, Jiangtao Wen

“…Materials and Methods: A total of 112 paraffin-embedded tumor samples from patients with ESCC, including 68 matched adjacent normal tissues, were collected post-surgery. Subsequently, tissue microarray (TMA) and immunohistochemistry (IHC) techniques were employed to assess the protein levels of Rspo1. …”
Get full text

Morphological features and activity of estrogen receptors of endometrium and foci of adenomyosis in postmenopausal patients by V. A. Sitnikova, L. G. Rosha, G. Y. Honcharenko

“…IHC blocks were produced by the method of Tissue Microarray. The expression of estrogen markers was evaluated according to point system of general staining method for ER-status determining. …”
Get full text

Delineation of 2q32q35 Deletion Phenotypes: Two Apparent “Proximal” and “Distal” Syndromes by Adrian Mc Cormack, Juliet Taylor, Nerine Gregersen, Alice M. George, Donald R. Love

“…They presented with wide-ranging phenotypic variation including facial dysmorphisms, cleft palate, learning difficulties, behavioural issues and severe heart defects. Microarray analysis confirmed an 8.6 Mb deletion in patients 1 and 2 and a 24.7 Mb deletion in patient 3. …”
Get full text

c-Triadem: A constrained, explainable deep learning model to identify novel biomarkers in Alzheimer's disease. by Sherlyn Jemimah, Ferial Abuhantash, Aamna AlShehhi

“…We trained the model with blood genotyping data, microarray, and clinical features from the Alzheimer's Neuroimaging Disease Initiative (ADNI). …”
Get full text

Integrated Genome-Wide Analysis of Gene Expression and DNA Copy Number Variations Highlights Stem Cell-Related Pathways in Small Cell Esophageal Carcinoma by Di Liu, Xinyan Xu, Junmiao Wen, Liyi Xie, Junhua Zhang, Yuxin Shen, Guoliang Jiang, Jiayan Chen, Min Fan

“…High-quality DNA and total RNA were first extracted from both SCEC and normal tissues. Microarray data showed significant upregulation in WNT gene sets and downregulation in the PTEN and notch gene sets in SCEC. …”
Get full text

Dysfunction in mitochondrial electron transport chain drives the pathogenesis of pulmonary arterial hypertension: insights from a multi-omics investigation by Xin Zhang, Jieling Li, Minyi Fu, Xijie Geng, Junjie Hu, Ke-Jing Tang, Pan Chen, Jianyong Zou, Xiaoman Liu, Bo Zeng

“…PAH and control lung tissue samples were collected, and transcriptomic and metabolomic profiling were performed. …”
Get full text

Long Noncoding RNA and mRNA m6A Modification Analyses of Periodontal Ligament Stem Cells from the Periodontitis Microenvironment Exposed to Static Mechanical Strain by Weifu Sun, Jia Liu, Xu Zhang, Xiaochen Zhang, Jie Gao, Xin Chen, Xian Wang, Wen Qin, Zuolin Jin

“…Our previous study demonstrated that periodontal ligament stem cells derived from periodontitis tissue (pPDLSCs) are more sensitive to static mechanical strain (SMS) than those derived from healthy tissue (hPDLSCs) and reported the long noncoding RNA (lncRNA) expression profiles of pPDLSCs exposed to SMS. …”
Get full text

Targeting PRDX2 to inhibit tumor growth and metastasis in triple-negative breast cancer: the role of FN1 and the PI3K/AKT/SP1 pathway by Jiawei Zhou, Anqi Cheng, Jianqiang Guo, Yafeng Liu, Xuan Li, Maoqian Chen, Dong Hu, Jing Wu

“…Methods This study utilized TNBC tissue microarrays to detect Peroxiredoxin 2 (PRDX2) expression levels and analyzed the correlation between PRDX2 and tumor invasion as well as invasion-related gene expression through the TCGA database. …”
Get full text

Expression of apoptotic protease activating factor-1 in adenoid cystic carcinoma of the salivary glands and its clinicopathological relevance by Dožić Branko, Aničić Boban, Sinobad Vladimir, Miković Nikola, Milanović Srđan, Dožić Ivan

“…We used the technique of tissue microarray (TMA blocks). Sections from the TMA mold, 5 μm thick, were stained with the streptavidin-biotin immunohistochemical technique using primary antibodies specific for Apaf-1 (Leica Biosystems, Newcastle, UK). …”
Get full text

FABP4 suppresses proliferation and invasion of hepatocellular carcinoma cells and predicts a poor prognosis for hepatocellular carcinoma by Cheng‐Qian Zhong, Xiu‐Ping Zhang, Ning Ma, Er‐Bin Zhang, Jing‐Jing Li, Ya‐Bo Jiang, Yu‐Zhen Gao, Yan‐Mei Yuan, Shi‐Qian Lan, Dong Xie, Shu‐Qun Cheng

“…In our study, we investigated the expression of FABP4 at both mRNA and protein levels, and by examining 175 cases of patients with cancer of the liver tissue microarray, the significance between the expression of FABP4 and clinical characteristics had been discussed. …”
Get full text

Clinicopathologic implications of Myb and Beta-catenin expression in adenoid cystic carcinoma by Susan Park, Manali Vora, Annemieke van Zante, Joseph Humtsoe, Hyun-Su Kim, Sue Yom, Shweta Agarwal, Patrick Ha

“…In this study, we aim to analyze the impact of Myb and β-catenin expression on prognosis in ACC. Methods A tissue microarray constructed from archival tissue from 64 patients with ACC was stained for Myb and β-catenin; both localization and intensity were evaluated. …”
Get full text

An animal model with a cardiomyocyte-specific deletion of estrogen receptor alpha: functional, metabolic, and differential network analysis. by Sriram Devanathan, Timothy Whitehead, George G Schweitzer, Nicole Fettig, Attila Kovacs, Kenneth S Korach, Brian N Finck, Kooresh I Shoghi

“…Analysis of microarray data revealed differential variations in the expression of 208 genes affecting multiple transcriptional networks. …”
Get full text

Peroxisome proliferator-activated receptor gamma coactivator-1 alpha acts as a tumor suppressor in hepatocellular carcinoma by Rui Liu, Haiyang Zhang, Yan Zhang, Shuang Li, Xinyi Wang, Xia Wang, Cheng Wang, Bin Liu, Ke Zen, Chen-yu Zhang, Chunni Zhang, Yi Ba

“…In addition, the expression levels of 21,400 genes in tissues and cells were detected by microarray. It was shown that peroxisome proliferator-activated receptor gamma coactivator-1 alpha expression was significantly downregulated in hepatocellular carcinoma compared with normal liver tissues. …”
Get full text

Transcriptomic analysis of laser-capture microdissected tumors reveals RAD51AP1 as a tumor-specific marker associated progression from pancreatic intraepithelial neoplasia to invas... by Fereshteh Rezagholizadeh, Adel Salimi, Ali Sharifi-Zarchi, Farid Azmoudeh-Ardalan, Kazem Mousavizadeh, Fatemeh Tajik, Mahshid Panahi, Hossein Khorramdelazad, Masoud Baghai Wadji, Atefeh Kashanizadeh, Alireza Lotfalizadeh, Seyed Javad Mowla, Mohammad Taghi Joghataei

“…Immunohistochemistry (IHC) on 353 PDAC patients, including 73 PanIN lesions and 280 tumor tissues on tissue microarray (TMA) slides, provided further confirmation. …”
Get full text

Identification and Characterization of Cyprinid Herpesvirus-3 (CyHV-3) Encoded MicroRNAs. by Owen H Donohoe, Kathy Henshilwood, Keith Way, Roya Hakimjavadi, David M Stone, Dermot Walls

“…MiRNAs from the two confirmed pre-miRNAs were also detected in gill tissue from CyHV-3-infected carp. We also present evidence that one confirmed miRNA can regulate the expression of a putative CyHV-3-encoded dUTPase. …”
Get full text

Genome-Wide Characterization and Expression Profiles of the Superoxide Dismutase Gene Family in Gossypium by Jingbo Zhang, Bo Li, Yang Yang, Wenran Hu, Fangyuan Chen, Lixia Xie, Ling Fan

“…Moreover, the tissue-specific expression profile reveals the functional divergence of SOD genes in different organs development of cotton. …”
Get full text

Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice. by Dadi Jiang, Catherine I Dumur, H Davis Massey, Viswanathan Ramakrishnan, Mark A Subler, Jolene J Windle

“…Salivary tumors from these mice were characterized with regard to age of tumor onset, tumor growth rates, cell cycle distribution, apoptotic levels, tumor histopathology, as well as response to doxorubicin treatment. Microarray analysis was also performed to profile gene expression. …”
Get full text

Construction of a macrophage-related prognostic signature and assessment of immune checkpoint inhibitor efficacy of HCC by Shouge Zang, Hongwei Chen, Yuqian Han, Di Cui, Jiangtao Yu

“…Functional assays were conducted to assess the effect of PLAUR knockdown on macrophage polarization, tumor cell behavior, and PI3K/AKT/mTOR pathway activity. Tissue microarray immunofluorescence validated PLAUR expression in situ. …”
Get full text

PIWI‐interacting RNA MIABEPIR regulates cerebral endothelial cell function via DAPK2 pathway in offspring following maternal immune activation by Shan‐Shan Li, Miao Guo, Yao Long, Yuang Cai, Ying Zhao, Shaoyuan Huang, Houzhi Yang, Yonggang Fan, Xu Chen, Xin Jin

“…Here, we identify a novel MIA‐associated brain endothelial piRNA (MIABEPIR) involved in regulating BMEC function and BBB integrity. RNA microarray analysis of foetal brain tissue from MIA‐exposed mice revealed significant changes in piRNA expression, including a marked upregulation of MIABEPIR upregulated piRNAs. …”
Get full text

Early-stage immunoexpression of inflammatory, angiogenic, and survival markers in tongue epithelium of mice exposed to hookah smoke. by Aldini Beuting Pereira, Arieli Carini Michels, Sarah Freygang Mendes Pilati, Filipe Modolo, Ana Paula Camargo Martins, Caroline Busatta Vaz De Paula, Seigo Nagashima, Lúcia Noronha, Ana Clara Prado Fonseca, Ariane Jéssica Torres Turmina, Heloisa Franco De Meira, Luisa Gabriela Carneiro Ramos, Thaís Grupp Da Rosa, Thais Maria Dos Santos Eckhardt, Sérgio Aparecido Ignácio, Luciana Reis Azevedo Alanis, Paulo Henrique Couto Souza, Rodrigo Nunes Rached, Bruno Correia Jham, Everdan Carneiro, Emanuela Carla Dos Santos, Aline Cristina Batista Rodrigues Johann

“…Tongues were embedded in paraffin. A tissue microarray was constructed, and immunohistochemistry was performed for Cyclooxygenase 2, NF-kappa B, Vascular Endothelial Growth Factor Receptor 1, and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) for apoptotic analysis. …”
Get full text